Article
Dermatology
K. Wolk, T. -C. Brembach, D. Simaite, E. Bartnik, S. Cucinotta, A. Pokrywka, M. L. Irmer, J. Triebus, E. Witte-Haendel, G. Salinas, T. Leeuw, H. -D. Volk, K. Ghoreschi, R. Sabat
Summary: The expression of G-CSF is high in HS skin, especially in inflamed nodules and abscesses. IL-1 and IL-17 induce G-CSF production, and G-CSF blood levels correlate with the severity of HS.
BRITISH JOURNAL OF DERMATOLOGY
(2021)
Review
Dermatology
J. Karim Ead, David G. Armstrong
Summary: GM-CSF is a glycoprotein with immunomodulatory properties derived from both hemopoietic and nonhemopoietic sources. In patients with diabetic foot ulcers, GM-CSF activation is impaired, leading to impaired inflammatory response. Correcting macrophage immune dysfunction with exogenous GM-CSF may help restore immune balance and promote wound healing.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Pharmacology & Pharmacy
Shao-Yu Tang, Yi-Chin Lee, Chien-Wei Tseng, Po-Hsun Huang, Ko-Lin Kuo, Der-Cherng Tarng
Summary: This study found that G-CSF can improve angiogenic function in patients with peripheral arterial disease (PAD) associated with chronic kidney disease (CKD) through a hypoxia/IL-10 signaling cascade.
Article
Neurosciences
Shirley Marino Lee, Jacob Hudobenko, Louise D. McCullough, Anjali Chauhan
Summary: Microglia play a crucial role in ischemic injury response, with aged microglia showing increased inflammation after stroke. Depletion of microglia in aged mice led to increased infarct volume and infiltrating monocytes post-stroke, indicating a differential immune response. Treatment with PLX5622 and AFS98 resulted in depleted microglia but increased neuroinflammation in aged animals following ischemic stroke.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Clinical Neurology
Alexander Wall, Olof Anger, Katarina Jood, Christian Blomstrand, Ulf Andreasson, Kaj Blennow, Henrik Zetterberg, Jorgen Isgaard, Christina Jern, N. David Aberg, Johan Svensson
Summary: The study revealed that the acute S-GCSF level was 23% higher than at 3-month post-stroke, and acute G-CSF was weakly correlated with stroke severity and inflammatory markers. It was also found that S-GCSF was associated with poor functional outcomes at 3 months, but post-stroke changes in S-GSCF and absolute 3-month S-GCSF did not impact functional outcomes after stroke.
NEUROLOGICAL RESEARCH
(2021)
Article
Medicine, General & Internal
Slawomir Lewicki, Monika Lesniak, Agnieszka Sobolewska-Ruta, Aneta Lewicka, Marta Grodzik, Eugeniusz K. Machaj, Marek Saracyn, Jacek Z. Kubiak, Zygmunt Pojda
Summary: Encapsulation of cytokines in liposomes is an efficient method to deliver cytokines to cells at working concentrations without affecting cell morphology or proliferation. This method has great potential and important applications in tissue regeneration and other fields.
ARCHIVES OF MEDICAL SCIENCE
(2022)
Review
Pharmacology & Pharmacy
Xiuqi Chen, Wenbo Sun, Ping Zhong, Danhong Wu
Summary: This meta-analysis investigated the safety and efficacy of CSF therapy for stroke patients, finding no statistical differences in prognosis but an increase in CD34(+) cell counts in the periphery blood at day 5. These results suggest that CSF may play a role in stroke recovery, although its efficacy in this regard requires further examination.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Virology
Sarah Stonedahl, J. Smith Leser, Penny Clarke, Huntington Potter, Timothy D. D. Boyd, Kenneth L. L. Tyler
Summary: West Nile virus (WNV) is the main cause of epidemic arboviral encephalitis in the United States. Depleting microglia in WNV-infected mice enhances viral replication and tissue injury, while augmenting microglial activation through GM-CSF administration reduces viral titers and apoptotic activity and increases survival. Stimulation of microglial activation may be a viable therapeutic approach for WNV neuroinvasive disease.
JOURNAL OF VIROLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Atsushi Takamatsu, Kotaro Yoshida, Fumihito Toshima, Kazuto Kozaka, Naho Yamamoto, Yoshimichi Sai, Toshifumi Gabata
Summary: This study aims to clarify the incidence and clinicoradiologic characteristics of pegfilgrastim-induced aortitis. The results of the study found that the incidence of pegfilgrastim-induced aortitis may be higher than previously reported and may be more common in patients with esophageal cancer and those who received specific anticancer drugs. Furthermore, CT findings indicated that pegfilgrastim-induced aortitis is often characterized by involvement of the aortic arch and proximal branches.
Article
Oncology
Chong Wei, Yan Zhang, Wei Wang, Wei Zhang
Summary: Substituting PEG-rhG-CSF for short-acting rhG-CSF in the DA-EPOCH regimen significantly reduces the incidence of febrile neutropenia and related hospitalization, while simplifying management for both patients and healthcare providers.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Neurosciences
Lillian J. Brady, Kirsty R. Erickson, Kelsey E. Lucerne, Aya Osman, Drew D. Kiraly, Erin S. Calipari
Summary: Cocaine use disorder is associated with alterations in immune function and changes in peripheral cytokine expression, impacting responses to drug-related cues and highlighting the critical interaction between the brain and immune system. Upregulation of granulocyte colony-stimulating factor (G-CSF) by cocaine enhances the drug's effects on dopamine terminals through a release-based mechanism, indicating a potential role of immune factors in altering drug responses.
PSYCHOPHARMACOLOGY
(2021)
Article
Oncology
Takeo Fujii, Hasan Rehman, Su Yun Chung, Janice Shen, James Newman, Vernon Wu, Adam Hines, Elham Azimi-Nekoo, Fatima Fayyaz, Meeyoung Lee, George Raptis, Mikala Egeblad, Xinhua Zhu
Summary: The study found that G-CSF use was not associated with an increased risk of brain metastasis in patients with de novo Stage IV breast cancer. However, pulmonary embolism/deep venous thrombosis may be related to brain metastasis. Further research is needed to determine if DVT/PE with or without elevated NETs levels in the blood can predict the development of brain metastasis in these patients.
Article
Immunology
An-ran Xi, Yi-jun Luo, Jin-Tao Guan, Wei-Jie Wang, Zheng-Hao Xu
Summary: This study analyzed the efficacy and safety of granulocyte-macrophage colony-stimulating factor (GM-CSF) antibodies in COVID-19 patients. The results showed that GM-CSF antibody treatment can reduce the incidence of invasive mechanical ventilation and have slight but not significant effects on mortality and ventilation improvement. Sensitivity analysis revealed statistically significant results for mortality and ventilation improvement rate when one study was excluded. Furthermore, GM-CSF antibodies did not increase the risks of secondary infection and adverse events.
INFLAMMOPHARMACOLOGY
(2023)
Article
Endocrinology & Metabolism
Guang-Yin Shen, Jeong-Hun Shin, Yi-Sun Song, Hyun-Woo Joo, In-Hwa Park, Jin-Hee Seong, Na-Kyoung Shin, A-Hyeon Lee, Young Jong Cho, Yonggu Lee, Young-Hyo Lim, Hyuck Kim, Kyung-Soo Kim
Summary: The study showed that G-CSF can reduce cardiomyocyte apoptosis in diabetic cardiomyopathy by increasing autophagy levels. The anti-apoptotic effect of G-CSF was found to be abrogated by autophagy inhibitors, indicating the significance of autophagy up-regulation in mediating the protective effects of G-CSF.
DIABETES & METABOLISM JOURNAL
(2021)
Article
Oncology
Vincenzo Adamo, Lorenzo Antonuzzo, Marco Danova, Michelino De Laurentiis, Paolo Marchetti, Carmine Pinto, Giovanni Rosti
Summary: This study aims to improve adherence to guideline recommendations for the prevention of febrile neutropenia and to enhance patient care.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Agriculture, Dairy & Animal Science
R. Manoochehri, M. R. Jafarzadeh Shirazi, A. Akhlaghi, K. Tsutsui, M. R. Namavar, M. J. Zamiri, F. M. Rezazadeh
Summary: The study found that GnIH neurons play an important role in regulating reproductive events in British United Turkey hens, with prepubertal turkeys having a significantly higher abundance of GnIH neurons compared to pubertal and postpubertal turkeys.
DOMESTIC ANIMAL ENDOCRINOLOGY
(2021)
Article
Neurosciences
Maryam Owjfard, Mohammad Reza Bigdeli, Anahid Safari, Masoud Haghani, Mohammad Reza Namavar
Summary: The study found that DMF treatment for three days following cerebral ischemia did not significantly reduce neurological and motor function deficits or infarct volume. However, it did decrease neuronal area and death, while preserving their spatial distribution in a normal regular pattern.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2021)
Article
Behavioral Sciences
Farshid Bagheri, Anahid Safari, Mohammad Reza Namavar
Summary: The link between maternal immune activation (MIA) and the risk of developing schizophrenia (SCZ) has been a major research focus, with studies showing that MIA can lead to behavioral abnormalities and changes in cell structure. Treatment with the anti-inflammatory drug dimethyl fumarate (DMF) has been found to prevent these changes and show therapeutic effects in patients with schizophrenia.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Neurosciences
Amir Reza Heidarzadegan, Asadollah Zarifkar, Narges Sotoudeh, Mohammad Reza Namavar, Amir Hossein Zarifkar
Summary: The study compared the effects of four main paradigms of tES on collagenase-induced sensorimotor impairments and striatum tissue damage in male rats. Results showed that tDCS, tACS, tRNS, and tPCS significantly reversed motor disorders in the ICH groups, with tACS and tRNS showing higher improvement in wire hanging and rotarod tests. Structural changes and stereological evaluations confirmed the behavioral function results, suggesting that tACS and tRNS may be considered as add-on therapeutic strategies in stroke treatment.
Article
Biochemistry & Molecular Biology
Maryam Owjfard, Zohreh Taghadosi, Mohammad Reza Bigdeli, Anahid Safari, Asadollah Zarifkar, Afshin Borhani-Haghighi, Mohammad Reza Namavar
Summary: Nicorandil treatment after cerebral ischemia had significant effects on neurobehavioral outcomes and neuronal density, but did not preserve the normal spatial distribution of M1 cortical neurons. Its impact on improving motor function was also limited.
JOURNAL OF CHEMICAL NEUROANATOMY
(2021)
Article
Neurosciences
Saman Saedi, Mohammad Reza Namavar, Mohammad Reza Jafarzadeh Shirazi, Farzad Mohammad Rezazadeh, Kazuyoshi Tsutsui
Summary: Exposure to cadmium during the prepubertal period alters neuroanatomical development in the hypothalamus and disrupts the regulatory mechanisms of the hypothalamic-pituitary-gonadal axis.
NEUROTOXICITY RESEARCH
(2022)
Article
Behavioral Sciences
Narges Sotoudeh, Mohammad Reza Namavar, Farshid Bagheri, Asadollah Zarifkar
Summary: This study investigated the effect of aging and sex on the connectivity between the medial prefrontal cortex (mPFC) and medial amygdala (MeA) and its association with anxiety-like behavior. The results showed that old individuals had less anxiety-like behavior and a stronger mPFC-MeA connection. Young female rats were less anxious and had a stronger mPFC-amygdala connection than young males. The study suggests a negative relationship between anxiety levels and the mPFC-MeA connection based on the rat's performance in the open field test apparatus.
BRAIN AND BEHAVIOR
(2022)
Article
Veterinary Sciences
Narges Sotoudeh, Mohammad Reza Namavar
Summary: This study investigated the effects of different doses of K-X on young and aged rats, and found that with aging, the onset time of anesthesia was longer, the duration was shorter, and the number of mature dendritic spines decreased, while sex had no significant effect.
VETERINARY MEDICINE AND SCIENCE
(2022)
Review
Neurosciences
Maryam Owjfard, Farzaneh Karimi, Arashk Mallahzadeh, Seyed Ali Nabavizadeh, Mohammad Reza Namavar, Mahdiyar Iravani Saadi, Etrat Hooshmandi, Mohammad Saied Salehi, Seyedeh Shaghayegh Zafarmand, Mahnaz Bayat, Sedigheh Karimlou, Afshin Borhani-Haghighi
Summary: Dimethyl fumarate (DMF) is an immunomodulatory drug approved for multiple sclerosis and psoriasis, but its potential role in ischemic stroke treatment has gained attention. Animal studies have shown that DMF improves stroke outcomes, possibly through immune response modulation, blood-brain barrier permeability, and hemodynamic adjustments. The impact of DMF on blood pressure management, a crucial factor in stroke treatment, should be considered.
JOURNAL OF NEUROSCIENCE RESEARCH
(2023)
Article
Neurosciences
Tahereh Esmaeilpour, Azam Lotfealian, Morteza Anvari, Mohammadreza Namavar, Narges Karbalaei, Abbas Shahedi, Istvan Bokkon, Vahid Salari, Daniel Oblak
Summary: All living cells produce ultra-weak photon emission (UPE) during biological activity, including neurons in the brain. The intensity of UPE can be influenced by various internal and external factors. This study examines the effects of Methamphetamine (METH) on UPE and reactive oxygen species (ROS) levels in the prefrontal, motor, and visual cortex. The results indicate that METH increases UPE and ROS in all three areas, suggesting a direct relationship between UPE intensity and ROS production. These findings have implications for monitoring oxidative metabolism and researching METH.
NEUROSCIENCE LETTERS
(2023)
Article
Cell & Tissue Engineering
Zohre Aghaei, Narges Karbalaei, Mohammad Reza Namavar, Masoud Haghani, Mahboobeh Razmkhah, Mahdi Khorsand Ghaffari, Marzieh Nemati
Summary: This study aimed to investigate the effects of Wharton's jelly-derived mesenchymal stem cell-conditioned medium (WJMSC-CM) on cognitive impairment, oxidative stress, apoptosis, and histological changes in the hippocampus of diabetic rats. The results showed that WJMSC-CM significantly reduced blood glucose levels and increased insulin levels, improved cognitive ability and anxiety-like behavior in diabetic rats, reduced oxidative stress, and increased the number of neurons and non-neurons in the hippocampus.
STEM CELLS INTERNATIONAL
(2023)
Article
Neurosciences
Nahid Jashire Nezhad, Anahid Safari, Mohammad Reza Namavar, Mohammad Nami, Saeideh Karimi-Haghighi, Sareh Pandamooz, Mehdi Dianatpour, Negar Azarpira, Zahra Khodabandeh, Shahrokh Zare, Etrat Hooshmandi, Mahnaz Bayat, Maryam Owjfard, Seyedeh Shaghayegh Zafarmand, Nima Fadakar, Abbas Rahimi Jaberi, Mohammad Saied Salehi, Afshin Borhani-Haghighi
Summary: Cell therapy, particularly the use of stem cell-based derivatives like cell-free secretome, is gaining increasing attention in regenerative medicine. This study evaluated the short-term therapeutic effects of human dental pulp stem cells (DPSCs) and their secretome in a rat model of mild ischemic stroke.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2023)
Article
Endocrinology & Metabolism
Hamzeh Badeli Sarkala, Mehrdad Jahanshahi, Leila Kamali Dolatabadi, Mohammad Reza Namavar
Summary: This study investigated the effects of granulocyte colony-stimulating factor (G-CSF) on memory and dendritic morphology in hippocampal CA1 pyramidal neurons after middle cerebral artery occlusion (MCAO). The results showed that G-CSF improved learning and memory deficits caused by stroke, and also enhanced dendritic length, arborization, spine density, and mature spines in the CA1 neurons.
METABOLIC BRAIN DISEASE
(2023)
Article
Neurosciences
Amin Firoozi, Aliakbar Alizadeh, Asadollah Zarifkar, Tahereh Esmaeilpour, Mohammad Reza Namavar, Omid Alavi, Farzaneh Dehghani
Summary: This study aimed to investigate the effects of conditioned medium of human umbilical cord mesenchymal stem cells and platelet-rich plasma on AD model rats. The results showed that CM improved learning and memory impairments as well as the structure of the hippocampus.
IBRO NEUROSCIENCE REPORTS
(2023)
Article
Pharmacology & Pharmacy
Maryam Owjfard, Mohammad Reza Bigdeli, Anahid Safari, Mohammad Reza Namavar
Summary: The treatment with DMF did not significantly affect the infarction size, but improved neurobehavioral function, BBB disruption, cerebral edema, increased number of neurons, and expression of Nrf2. It also decreased the number of dead neurons and the expression of NF-kappa B. DMF beneficial effects on stroke may be mediated through both increase of the Nrf2 and decrease of NF-kappa B expression.
BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)