Article
Pharmacology & Pharmacy
Hang Su, Yu Mei, Shuangxue Luo, Haixia Wu, Yan He, Yasunaga Shiraishi, Pingping Hu, Richard A. Cohen, Xiaoyong Tong
Summary: The substitution of SERCA2 C674 thiol accelerates the development of atherosclerosis by inducing ER stress and inflammation. This study highlights the importance of SERCA2 C674 redox state in the context of atherosclerosis and proposes a novel therapeutic strategy to combat atherosclerosis.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Yonghua Lei, Ming Yang, Hong Li, Rongjuan Xu, Junbao Liu
Summary: The study revealed that miR-130b is downregulated in diabetic encephalopathy, and exerts a protective effect against oxidative stress injury by activating the PI3K/Akt signaling pathway through regulating PTEN.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Health Care Sciences & Services
Chiao-Yun Lin, Ren-Chin Wu, Lan-Yan Yang, Shih-Ming Jung, Shir-Hwa Ueng, Yun-Hsin Tang, Huei-Jean Huang, Hsiu-Jung Tung, Cheng-Tao Lin, Hsuan-Yu Chen, Angel Chao, Chyong-Huey Lai
Summary: Diagnostic agreement among pathologists for endometrial hyperplasia is poor. This study identified miR-30a-3p, miR-141, miR-200a, miR-200b, and complete PTEN loss as useful tissue biomarkers for predicting endometrial cancer risk in patients with simple or complex hyperplasia without atypia.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Fatemeh Yarmohammadi, Zainab Ebrahimian, Gholamreza Karimi
Summary: This manuscript reviews the regulation of the PI3K/Akt/p53 and the Sirt1/Nrf2 pathways by miRNAs in DOX-induced cardiotoxicity.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Gastroenterology & Hepatology
Miao-Miao Lu, Yue Ren, Yu-Wei Zhou, Ling-Ling Xu, Meng-Meng Zhang, Lin-Ping Ding, Wei-Xin Cheng, Xi Jin
Summary: Obesity is closely related to the occurrence and development of non-alcoholic steatohepatitis (NASH). The study found that miR-103 derived from adipose tissue may aggravate NASH by interacting with PTEN and inhibiting autophagy.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Review
Medicine, Research & Experimental
Qirui Duan, Ying Zhou, Dong Yang
Summary: Airway hyperresponsiveness is a major clinical phenomenon in lung diseases and can lead to severe complications during the perioperative period. This review focuses on the effects of endoplasmic reticulum stress on immune cells, inflammation, and remodeling in the airways, with the aim of understanding the mechanisms and finding prevention strategies.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Medicine, Research & Experimental
Colin Carlock, Yunpeng Bai, Allison Paige-Hood, Qinglin Li, Frederick Nguele Meke, Zhong-Yin Zhang
Summary: Overexpression of PRL2 and reduced PTEN protein are frequently observed in patients with acute myeloid leukemia (AML). Inhibiting PRL2 can prolong animal survival and slow the accumulation of leukemia blasts in the bone marrow niche. This study provides evidence for the viability of PRL2 inhibition as a therapeutic strategy for improving clinical outcomes in AML and other PTEN-deficient cancers.
Article
Fisheries
Xiaojing Li, Yichen Bai, Yanju Bi, Qian Wu, Shiwen Xu
Summary: Chlorpyrifos (CPF) pollution is widespread and harmful to non-target organisms. Baicalein (BAI) is a flavonoid extract with antioxidant and anti-inflammatory properties. The study finds that BAI can alleviate gill damage caused by CPF exposure, through the inhibition of inflammation and necroptosis pathways.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Nianxue Wang, Bin Yang, Jiao Jin, Yu He, Xijun Wu, Yichen Yang, Weijun Zhou, Zhixu He
Summary: This study identified circ_0040823/miR-516b/PTEN as a new therapeutic target for AML, as circ_0040823 inhibited proliferation and induced apoptosis of AML cells by sponging miR-516b, thereby diminishing the regulatory effect of miR-516b on PTEN.
JOURNAL OF GENE MEDICINE
(2022)
Article
Medical Laboratory Technology
Lina Wu, Xinpeng Zhang, Lin Luo, Xiaoying Li, Yong Liu, Xiaosong Qin
Summary: The study found that miR-106a, miR-19b, miR-17, and PTEN are involved in the pathogenesis of IMN and may serve as new biomarkers for the diagnosis of IMN.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2021)
Article
Clinical Neurology
Jiaxu Wang, Meng Li, Jing Zhang, Qing Gao, Zhaoxi Ding, Jinhao Sun
Summary: The aim of this animal study was to investigate the mechanisms underlying the efficacy of paliperidone, an antipsychotic drug approved by the US FDA for the treatment of schizophrenia. The results showed that paliperidone alleviated neuronal damage induced by MK-801 through the PP2A/PTEN pathway.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Biochemistry & Molecular Biology
Vagner Ramon R. Silva, Angela Molinaro, Andrea Usseglio Gaudi, Emanuel Fryk, Claudia Sardi, Maria Hammarlund, Filip Mjornstedt, Maria E. Johansson, Barbara Becattini, Per-Anders Jansson, Giovanni Solinas
Summary: This study investigates the role of IKK beta signaling in obesity. The results show that the deletion of IKK beta in the liver and leukocytes is not tolerated in obese mice exposed to TLR3 agonists. However, selective hepatic IKK beta ablation improves fatty liver and insulin sensitivity.
Article
Medicine, Research & Experimental
Gefei Wu, Jiasheng Hu, Hongmin Zhu, Shuhua Wu, Sheng Huang, Zhisheng Liu
Summary: The study demonstrated the therapeutic effect of melatonin (MT) on febrile convulsion (FC) by modulating the MEG3/miR-223/PTEN/AKT pathway, suggesting MT as a novel strategy for FC treatment.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Monisha Prasad, Selvaraj Jayaraman, Ponnulakshmi Rajagopal, Vishnu Priya Veeraraghavan, Praveen Kumar Kumar, Shanmughavel Piramanayagam, Leelavinothan Pari
Summary: The study found that diosgenin reduces dyslipidemia, hypertension, and pro-inflammatory cytokines in the aorta of diabetic rats by regulating the iRhom2/TACE signaling pathway. Molecular docking analysis confirmed the potential binding interaction of diosgenin with key signaling molecules. The results indicate that diosgenin can attenuate ER stress-induced inflammation in diabetic rat aorta.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Review
Chemistry, Medicinal
Ali Ahmadi, A. Wallace Hayes, Gholamreza Karimi
Summary: The endoplasmic reticulum (ER) performs essential functions in cellular biology, such as synthesizing lipids and controlling protein folding. Inflammation and oxidative stress can lead to protein misfolding in the ER. Resveratrol (RSV) has various bioactive properties and is known for its potential beneficial effects on health.
PHYTOTHERAPY RESEARCH
(2021)