Moderate activation of Wnt/β‐catenin signaling promotes the survival of rat nucleus pulposus cells via regulating apoptosis, autophagy, and senescence

Critical contribution of RIPK1 mediated mitochondrial dysfunction and oxidative stress to compression-induced rat nucleus pulposus cells necroptosis and apoptosis

(2018) Songfeng Chen et al.   APOPTOSIS

LncRNA H19 targets miR-22 to modulate H2 O2 -induced deregulation in nucleus pulposus cell senescence, proliferation, and ECM synthesis through Wnt signaling

(2018) Xiaobin Wang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Effect of the Wnt/β-catenin signaling pathway on apoptosis, migration, and invasion of transplanted hepatocellular carcinoma cells after transcatheter arterial chemoembolization in rats

(2018) Bao-Ming Wang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

DIDS inhibits overexpression BAK1-induced mitochondrial apoptosis through GSK3β/β-catenin signaling pathway

(2018) Xiayun Yang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

CsA attenuates compression-induced nucleus pulposus mesenchymal stem cells apoptosis via alleviating mitochondrial dysfunction and oxidative stress

(2018) Zhiliang Li et al.   LIFE SCIENCES

Sirt6 overexpression suppresses senescence and apoptosis of nucleus pulposus cells by inducing autophagy in a model of intervertebral disc degeneration

(2018) Jian Chen et al.   Cell Death & Disease

Long non-coding RNA HOTAIR promotes osteoarthritis progression via miR-17-5p/FUT2/β-catenin axis

(2018) Jialei Hu et al.   Cell Death & Disease

MicroRNA-300 promotes apoptosis and inhibits proliferation, migration, invasion and epithelial-mesenchymal transition via the Wnt/β-catenin signaling pathway by targeting CUL4B in pancreatic cancer cells

(2017) Jia-Qiang Zhang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

WNT/β-catenin signaling regulates mitochondrial activity to alter the oncogenic potential of melanoma in a PTEN-dependent manner

(2017) K Brown et al.   ONCOGENE

Upregulation of DACT2 suppresses proliferation and enhances apoptosis of glioma cell via inactivation of YAP signaling pathway

(2017) Ying Tan et al.   Cell Death & Disease

Disc cell senescence in intervertebral disc degeneration: Causes and molecular pathways

(2016) Chencheng Feng et al.   CELL CYCLE

Inflammatory cytokines induce caveolin-1/β-catenin signalling in rat nucleus pulposus cell apoptosis through the p38 MAPK pathway

(2016) Jianxi Wang et al.   CELL PROLIFERATION

Pigment Epithelium-derived Factor (PEDF) Blocks Wnt3a Protein-induced Autophagy in Pancreatic Intraepithelial Neoplasms

(2016) Jingjing Gong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intermittent cyclic mechanical tension promotes endplate cartilage degeneration via canonical Wnt signaling pathway and E-cadherin/β-catenin complex cross-talk

(2016) H.-g. Xu et al.   OSTEOARTHRITIS AND CARTILAGE

Aging and age related stresses: a senescence mechanism of intervertebral disc degeneration

(2016) F. Wang et al.   OSTEOARTHRITIS AND CARTILAGE

Blocking Wnt Secretion Reduces Growth of Hepatocellular Carcinoma Cell Lines Mostly Independent of β-Catenin Signaling

(2016) Wenhui Wang et al.   NEOPLASIA

Current trends in biologics delivery to restore intervertebral disc anabolism

(2015) Gianluca Fontana et al.   ADVANCED DRUG DELIVERY REVIEWS

Activation of autophagy via Ca2+-dependent AMPK/mTOR pathway in rat notochordal cells is a cellular adaptation under hyperosmotic stress

(2015) Li-Bo Jiang et al.   CELL CYCLE

Wnt/β-catenin signalling and podocyte dysfunction in proteinuric kidney disease

(2015) Lili Zhou et al.   Nature Reviews Nephrology

Mechanics and biology in intervertebral disc degeneration: a vicious circle

(2015) P.-P.A. Vergroesen et al.   OSTEOARTHRITIS AND CARTILAGE

ISSLS Prize Winner

(2015) Sarah E. Gullbrand et al.   SPINE

Novel diagnostic and prognostic methods for disc degeneration and low back pain

(2015) Dino Samartzis et al.   Spine Journal

Recombinant human SIRT1 protects against nutrient deprivation-induced mitochondrial apoptosis through autophagy induction in human intervertebral disc nucleus pulposus cells

(2015) Shingo Miyazaki et al.   ARTHRITIS RESEARCH & THERAPY

Reflecting on the global burden of musculoskeletal conditions: lessons learnt from the Global Burden of Disease 2010 Study and the next steps forward

(2014) Damian G Hoy et al.   ANNALS OF THE RHEUMATIC DISEASES

The Responses of Autophagy and Apoptosis to Oxidative Stress in Nucleus Pulposus Cells: Implications for Disc Degeneration

(2014) Jiang-Wei Chen et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Enhancement of Runx2 Expression Is Potentially Linked to β-Catenin Accumulation in Canine Intervertebral Disc Degeneration

(2014) Munetaka Iwata et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Targeting Wnt signaling at the neuroimmune interface for dopaminergic neuroprotection/repair in Parkinson's disease

(2014) Francesca L'Episcopo et al.   Journal of Molecular Cell Biology

Lactate down-regulates matrix systhesis and promotes apoptosis and autophagy in rat nucleus pulposus cells

(2013) Wei Wu et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Autophagy is activated in compression-induced cell degeneration and is mediated by reactive oxygen species in nucleus pulposus cells exposed to compression

(2013) K.-G. Ma et al.   OSTEOARTHRITIS AND CARTILAGE

A complex interaction between Wnt signaling and TNF-α in nucleus pulposus cells

(2013) Akihiko Hiyama et al.   ARTHRITIS RESEARCH & THERAPY

Wnt/β-Catenin Signaling Triggers Neuron Reprogramming and Regeneration in the Mouse Retina

(2013) Daniela Sanges et al.   Cell Reports

Role of mitochondrial pathway in compression-induced apoptosis of nucleus pulposus cells

(2012) Fan Ding et al.   APOPTOSIS

Canonical Wnt signaling in the notochordal cell is upregulated in early intervertebral disk degeneration

(2011) Lucas A. Smolders et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Complex loading affects intervertebral disc mechanics and biology

(2011) B.A. Walter et al.   OSTEOARTHRITIS AND CARTILAGE

Real-world practice patterns, health-care utilization, and costs in patients with low back pain: the long road to guideline-concordant care

(2011) Jasmina I. Ivanova et al.   Spine Journal

Enhancement of intervertebral disc cell senescence by WNT/β-catenin signaling-induced matrix metalloproteinase expression

(2010) Akihiko Hiyama et al.   ARTHRITIS AND RHEUMATISM