Article
Nutrition & Dietetics
Jeong-Geon Mun, Hee Dong Jeon, Dae Hwan Yoon, Yoon Seung Lee, Shin Young Park, Jong-Sik Jin, Noh-Joon Park, Ji-Ye Kee
Summary: The supercritical extract of Cannabis sativa has been shown to inhibit the proliferation and metastasis of colorectal cancer cells, suggesting its potential as a therapeutic option for colorectal cancer treatment.
Article
Medicine, General & Internal
Vivian Kosmidou, Margarita Vlassi, Kyriakos Anagiotos, Sofia Raftopoulou, Eirini Kalogerakou, Salomi Skarmalioraki, Chrysanthi Aggeli, Theodosia Choreftaki, George Zografos, Alexander Pintzas
Summary: NOXA and MCL1 are overexpressed in CRC tumors and show significant differences compared to normal colorectal tissue. The mRNA expressions of NOXA, Mcl1, DR5, cIAP1, and cIAP2 are significantly deregulated in CRC, providing a panel of markers with significant discriminatory value between CRC and normal colorectal tissue.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Plant Sciences
Xiaochun Zheng, Xiuli Yang, Jingyang Lin, Feifeng Song, Yanfei Shao
Summary: The study demonstrated a synergistic effect of curcumin in combination with 5-FU on inhibiting proliferation and migration, increasing apoptosis rate, and extending survival in CRC cells. Curcumin enhanced chemosensitivity of CRC cells to 5-FU by downregulating L1 expression. This combination therapy could potentially reduce the toxicity and adverse effects of 5-FU in clinical applications.
Article
Plant Sciences
Kaichun Wang, Wei Liu, Qinfen Xu, Chao Gu, Daode Hu
Summary: This study found that Tenacissoside G (TG) exhibited dose-dependent growth inhibitory activity and cell cycle arrest induction in colorectal cancer cells, enhancing the anticancer effects of 5-fluorouracil (5-FU). The synergistic effects may be attributed to increased activation of caspase cascade, enhancement of DNA damage, and induction of p53 phosphorylation at Serine 46.
Article
Pathology
Yu-Ling Qu, Xiao-Li Liu, Shan-Yu Zhao, Xue-Feng Zhai
Summary: This study found that SPOCK1 is upregulated in 5-FU-resistant CRC cells and that knockdown of SPOCK1 increases their sensitivity to 5-FU. Conversely, overexpression of SPOCK1 enhances CRC cell resistance to 5-FU and reduces cell apoptosis.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Oncology
Martina Lepore Signorile, Valentina Grossi, Candida Fasano, Giovanna Forte, Vittoria Disciglio, Paola Sanese, Katia De Marco, Francesca La Rocca, Raffaele Armentano, Anna Maria Valentini, Gianluigi Giannelli, Cristiano Simone
Summary: c-MYC is a crucial factor in the development of colorectal cancer, with high expression in most sporadic cases. In this study, researchers discovered that the kinase p38 alpha contributes to the stability of c-MYC protein, which is involved in CRC metabolism and survival. Furthermore, p38 alpha prevents ubiquitination of c-MYC, leading to increased levels of the protein. These findings suggest that p38 alpha could be a potential therapeutic target for countering CRC proliferation, metastasis, and chemoresistance mediated by c-MYC.
Article
Medicine, Research & Experimental
Rinad A. Algehani, Raefa Abou Khouzam, Gehan A. Hegazy, Aliaa A. Alamoudi, Ali M. El-Halawany, Riham S. El Dine, Ghada A. Ajabnoor, Fahad A. Al-Abbasi, Mohammed A. Baghdadi, Ibrahim Elsayed, Masao Hattori, Ahmed M. Al-Abd
Summary: A synergistic effect in terms of anticancer properties was observed when colossolactone-G was combined with 5-FU and GCB, influencing both apoptosis and autophagic cell death mechanisms.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Pharmacology & Pharmacy
Buse Ardil, Mehlika Alper
Summary: This study aimed to investigate the effects of commercial Bru and Erio used in combination with the anticancer drug 5-FU on cell viability and apoptosis in human colorectal cancer cells. Results showed that Bru, alone or in combination with 5-FU, increased apoptosis in HT-29 cells compared to Erio. Additionally, combinations of Bru and 5-FU at IC50 concentrations led to an increase in bax and caspase-3 apoptotic genes.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2022)
Article
Cell Biology
Shoufang Xu, Yilei Ma, Qingchao Tong, Jun Yang, Jia Liu, Yanzhong Wang, Guoli Li, Jin Zeng, Sining Fang, Fengying Li, Xinyou Xie, Jun Zhang
Summary: PRDX1 plays a crucial role in regulating NOXA protein degradation in colorectal cancer cells, maintaining cellular homeostasis and contributing to resistance to DNA damage-inducing chemotherapeutics. Targeting PRDX1 could be an effective strategy to overcome drug resistance in colorectal cancer.
CELL DEATH & DISEASE
(2021)
Article
Pharmacology & Pharmacy
Jiali Yuan, Luke Mo, Yiqun Mo, Yuanbao Zhang, Yue Zhang, Qunwei Zhang
Summary: This study evaluated the toxic effects and mechanisms of fine airborne particulate matter (PM2.5) on human glioblastoma LN-229 cells. The results showed that PM2.5 exposure reduced cell viability and increased autophagy, apoptosis, and ROS production. Further experiments revealed that PM2.5-induced autophagy and apoptosis were mainly caused by ROS generation, particularly by mitochondria, and JNK activation.
Review
Chemistry, Multidisciplinary
Julia M. Salamat, Kodye L. Abbott, Patrick C. Flannery, Elizabeth L. Ledbetter, Satyanarayana R. Pondugula
Summary: Cannabinoids can have unexpected effects on cancer patients, either enhancing or suppressing the growth and progression of different types of cancers. However, the underlying mechanisms of these differential effects, as well as the interaction between cannabinoids and miRNAs, remain poorly understood.
Article
Biochemistry & Molecular Biology
Bo Sun, Beverly Tomita, Ari Salinger, Ronak R. Tilvawala, Ling Li, Hana Hakami, Tao Liu, Konstantin Tsoyi, Ivan O. Rosas, Dieter P. Reinhardt, Paul R. Thompson, I-Cheng Ho
Summary: Elastic fiber formation is impacted by citrullination, with PAD2-mediated citrullination of FBLN5 protecting its elastogenic activity. Loss of PAD2 results in attenuated elastogenesis and age-dependent emphysema.
Review
Pharmacology & Pharmacy
Xia Li, Yan Ma, Junzhou Wu, Maowei Ni, Aiping Chen, Yun Zhou, Wumin Dai, Zhongjian Chen, Ruibin Jiang, Yutian Ling, Qinghua Yao, Wei Chen
Summary: 5-Fluorouracil (5-Fu) is a first-line drug for colorectal cancer (CRC) therapy. However, the development of 5-Fu resistance limits its effectiveness and leads to poor prognosis. Transglutaminase 2 (TGM2) is associated with chemoresistance in CRC and is regulated by thiol oxidative stress. Upregulation of thiol oxidative stress reverses 5-Fu resistance through downregulation of TGM2 and enhances apoptosis. TGM2 may serve as a potential therapeutic target for treating 5-Fu-resistant CRC.
DRUG RESISTANCE UPDATES
(2023)
Article
Medicine, Research & Experimental
Yongji Yan, Xujie Liu, Xuanchen Li, Xuan Zhou, Chaozhi Yang, Jintao Tian, Jun Pu, Xiaoqun Niu
Summary: The study found that fibulin-5 inhibits aldosterone-induced apoptosis in HA-VSMC cells, and this effect is influenced by the concentration of aldosterone.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Oncology
Qiaoqi Sui, Jianhong Peng, Kai Han, Junzhong Lin, Rongxin Zhang, Qingjian Ou, Jiayi Qin, Yuxiang Deng, Wenhao Zhou, Lingheng Kong, Jinghua Tang, Binyi Xiao, Yuan Li, Long Yu, Yujing Fang, Pei-Rong Ding, Zhizhong Pan
Summary: Na(v)1.5, encoded by SCN5A, plays a significant role in metastasis of colorectal cancer (CRC). Upregulation of Na(v)1.5 is associated with poor prognosis in CRCs, while it stabilizes the KRas-calmodulin complex to modulate Ras signaling and promote Ca2+ influx, leading to enhanced 5-FU-stimulated apoptosis in CRCs. CRC patients with elevated SCN5A expression may benefit more from 5-FU-based chemotherapy.