Toxoplasma gondii excreted‐secreted antigens suppress Foxp3 via PI3K‐AKT‐mTOR signaling pathway

Reduction in Regulatory T Cells in Early Pregnancy Causes Uterine Artery Dysfunction in MiceNovelty and Significance

(2018) Alison S. Care et al.   HYPERTENSION

Isoviolanthin Extracted from Dendrobium officinale Reverses TGF-β1-Mediated Epithelial–Mesenchymal Transition in Hepatocellular Carcinoma Cells via Deactivating the TGF-β/Smad and PI3K/Akt/mTOR Signaling Pathways

(2018) Shangping Xing et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The PI3K/AKT signaling pathway in regulatory T-cell development, stability, and function

(2018) Saige L. Pompura et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Estradiol Attenuates the Severity of Primary Toxoplasma gondii Infection-Induced Adverse Pregnancy Outcomes Through the Regulation of Tregs in a Dose-Dependent Manner

(2018) Jingfan Qiu et al.   Frontiers in Immunology

Inhibition of the PI3K-Akt-mTOR signaling pathway in T lymphocytes in patients with active tuberculosis

(2017) XueXuan Zhang et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Chinese 1 strain of Toxoplasma gondii excreted-secreted antigens negatively modulate Foxp3 via inhibition of the TGFßRII/Smad2/Smad3/Smad4 pathway

(2017) Jinling Chen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Differential effects of inhibitors of the PI3K/mTOR pathway on the expansion and functionality of regulatory T cells

(2016) Charlotte M. Huijts et al.   CLINICAL IMMUNOLOGY

Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression

(2016) Valerie A Gerriets et al.   NATURE IMMUNOLOGY

Cimetidine down-regulates stability of Foxp3 protein via Stub1 in Treg cells

(2016) Yizhi Zhang et al.   Human Vaccines & Immunotherapeutics

The molecular mechanism of polygalasaponin F-mediated decreases in TNFα: emphasizing the role of the TLR4-PI3K/AKT-NF-κB pathway

(2015) Wen-Fen Yan et al.   JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

Defects in Regulatory T Cells Due to CD28 Deficiency Induce a Qualitative Change of Allogeneic Immune Response in Chronic Graft-versus-Host Disease

(2015) Yuki Akieda et al.   JOURNAL OF IMMUNOLOGY

Diagnosis of toxoplasmosis and typing of Toxoplasma gondii

(2015) Quan Liu et al.   Parasites & Vectors

The signaling symphony: T cell receptor tunes cytokine-mediated T cell differentiation

(2014) Weishan Huang et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Picking the Point of Inhibition: A Comparative Review of PI3K/AKT/mTOR Pathway Inhibitors

(2014) R. Dienstmann et al.   MOLECULAR CANCER THERAPEUTICS

The role of TLR4-mediated PTEN/PI3K/AKT/NF-κB signaling pathway in neuroinflammation in hippocampal neurons

(2014) M. Zhao et al.   NEUROSCIENCE

Toll-Like Receptor 4–Mediated Nuclear Factor Kappa B Activation Is Essential for Sensing Exogenous Oxidants to Propagate and Maintain Oxidative/Nitrosative Cellular Stress

(2013) Rajendra Karki et al.   PLoS One

The Dysfunction of CD4+CD25+ Regulatory T Cells Contributes to the Abortion of Mice Caused by Toxoplasma gondii Excreted-Secreted Antigens in Early Pregnancy

(2013) Jin-ling Chen et al.   PLoS One

Deletion of Foxp3+ regulatory T cells in genetically targeted mice supports development of intestinal inflammation

(2012) Franziska Boehm et al.   BMC GASTROENTEROLOGY

Combined effect of sCD40L and PI3K siRNA on transplanted tumours growth and microenvironment in nude mice with gastric cancer

(2012) Rui Li et al.   MOLECULAR BIOLOGY REPORTS

Inflammation and pregnancy: the role of the immune system at the implantation site

(2011) Gil Mor et al.   Annals of the New York Academy of Sciences

A class IA PI3K controls inflammatory cytokine production in human neutrophils

(2011) Carl F. Fortin et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Metabolic consequences of treatment with AKT inhibitor perifosine in breast cancer cells

(2011) Judy S. Su et al.   NMR IN BIOMEDICINE

PI3 kinase signalling blocks Foxp3 expression by sequestering Foxo factors: Figure 1.

(2010) Matthias Merkenschlager et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Viral Infection of the Placenta Leads to Fetal Inflammation and Sensitization to Bacterial Products Predisposing to Preterm Labor

(2010) I. Cardenas et al.   JOURNAL OF IMMUNOLOGY

Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells

(2010) Weiming Ouyang et al.   NATURE IMMUNOLOGY

Perifosine Inhibits Mammalian Target of Rapamycin Signaling through Facilitating Degradation of Major Components in the mTOR Axis and Induces Autophagy

(2009) L. Fu et al.   CANCER RESEARCH

T regulatory cells and their counterparts: masters of immune regulation

(2009) C. Ozdemir et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Cutting Edge: Depletion of Foxp3+ Cells Leads to Induction of Autoimmunity by Specific Ablation of Regulatory T Cells in Genetically Targeted Mice

(2009) J. Kim et al.   JOURNAL OF IMMUNOLOGY

T cell–intrinsic role of Nod2 in promoting type 1 immunity to Toxoplasma gondii

(2009) Michael H Shaw et al.   NATURE IMMUNOLOGY

Therapeutic Targeting of Toll-Like Receptors for Infectious and Inflammatory Diseases and Cancer

(2009) L. A. J. O'Neill et al.   PHARMACOLOGICAL REVIEWS

Toxoplasma gondii-induced foetal resorption in mice involves interferon-γ-induced apoptosis and spiral artery dilation at the maternofoetal interface

(2008) A. Senegas et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

The AKT–mTOR axis regulates de novo differentiation of CD4+Foxp3+cells

(2008) Sokol Haxhinasto et al.   JOURNAL OF EXPERIMENTAL MEDICINE

T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR

(2008) S. Sauer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA