期刊
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
卷 23, 期 9, 页码 5949-5955出版社
WILEY
DOI: 10.1111/jcmm.14415
关键词
microbiota; microenvironment; skin; wound healing
资金
- National Institute of Health [1R01CA179072-01A1]
- Instituto Serrapilheira [Serra-1708-15285]
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico [405977/2018-2, 465669/2014-0]
- Fundacao de Amparo a Pesquisa do Estado de Minas Gerais [RED-00570-16, RED-00313-16]
- American Cancer Society [124443-MRSG-13-121-01-CDD]
- Universidade Federal de Minas Gerais [05/2016]
Wound healing is a complex dynamic physiological process in response to cutaneous destructive stimuli that aims to restore the cutaneous' barrier role. Deciphering the underlying mechanistic details that contribute to wound healing will create novel therapeutic strategies for skin repair. Recently, by using state-of-the-art technologies, it was revealed that the cutaneous microbiota interact with skin immune cells. Strikingly, commensal Staphylococcus epidermidis-induced CD8+ T cells induce re-epithelization of the skin after injury, accelerating wound closure. From a drug development perspective, the microbiota may provide new therapeutic candidate molecules to accelerate skin healing. Here, we summarize and evaluate recent advances in the understanding of the microbiota in the skin microenvironment.
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