期刊
JOURNAL OF BIOPHOTONICS
卷 12, 期 12, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jbio.201900065
关键词
bioimaging; nonlinear optical materials; second harmonic generation; self-assembly; ultrashort peptides
资金
- Special Funds of the Central Government Guiding Local Science and Technology Development [2017L3009]
- Natural Science Foundation of Fujian Province [2018J07004]
- National Natural Science Foundation of China [81771881]
- SMART Scholars Programme
- Institute of Bioengineering and Nanotechnology
Amyloid-like peptides are an ideal model for the mechanistic study of amyloidosis, which may lead to many human diseases, such as Alzheimer disease. This study reports a strong second harmonic generation (SHG) effect of amyloid-like peptides, having a signal equivalent to or even higher than those of endogenous collagen fibers. Several amyloid-like peptides (both synthetic and natural) were examined under SHG microscopy and shown they are SHG-active. These peptides can also be observed inside cells (in vitro). This interesting property can make these amyloid-like peptides second harmonic probes for bioimaging applications. Furthermore, SHG microscopy can provide a simple and label-free approach to detect amyloidosis. Lattice corneal dystrophy was chosen as a model disease of amyloidosis. Morphological difference between normal and diseased human corneal biopsy samples can be easily recognized, proving that SHG can be a useful tool for disease diagnosis.
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