Article
Biochemistry & Molecular Biology
Kenji Watanabe, Shuichi Shibuya, Yusuke Ozawa, Toshihiko Toda, Takahiko Shimizu
Summary: The study showed that p53 regulated ROS-mediated apoptotic cell death and tumorigenesis, but did not affect ROS-mediated tissue degeneration in SOD-deficient models.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Edurne Tellechea, Aaron C. Asensio, Paula Ciaurriz, Javier Buezo, Pedro Lopez-Gomez, Marina Urra, Jose F. Moran
Summary: This study investigates the characteristics of the recombinant cowpea FeSOD immobilized onto gold nanoparticles (AuNPs) and the effects of NP surface chemistry and biofunctionalization methods on enzyme activity. The results highlight the importance of the biomolecule and AuNP interaction for the functionality of the hybrid and demonstrate the potential of these strategies in biomedical applications.
Article
Multidisciplinary Sciences
Ping Luo, Tingting Zhao, Hong He
Summary: The study demonstrates that IL-38 can alleviate inflammatory responses in chondrocytes by inhibiting the expression of inflammatory cytokines and related pathways. IL-38 limits inflammation and delays cartilage degeneration in the TMJ.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2022)
Article
Genetics & Heredity
Monika Oldakowska, Milena Sciskalska, Marta Kepinska, Grzegorz Marek, Halina Milnerowicz
Summary: Interleukin-6 plays a key role in acute pancreatitis, while superoxide dismutase isoenzyme SOD1 may protect against oxidative damage.
Article
Environmental Sciences
Bo Wang, Yanqi Li, Shouye Hu, Kan Peng
Summary: This study reveals the important role of CTRP9 in osteoarthritis. By inhibiting the activation of NLRP3 inflammasome, CTRP9 protects chondrocytes from IL-1 beta-induced inflammatory injury.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Plant Sciences
Giovanna Salbitani, Angela Perrone, Luigi Rosati, Carmen Laezza, Simona Carfagna
Summary: This study investigates the effects of sulfur deprivation on Galdieria sulphuraria and reveals that it leads to a decrease in total protein content and an increase in soluble protein fraction. The glutathione content in Galdieria sulphuraria remains high even under sulfur deprivation.
Article
Biology
ShylajaNaciyar Mohandass, Mangalalakshmi Ragavan, Dineshbabu Gnanasekaran, Uma Lakshmanan, Prabaharan Dharmar, Sushanta Kumar Saha
Summary: Synthetic azo dyes are widely used but their improper discharge poses a threat to the environment. Genetically modified cyanobacteria with enhanced H2O2 accumulation through SOD overexpression can effectively degrade these dyes, suggesting a valuable bioremediation strategy.
Article
Fisheries
Min Yang, Luchuanyang Sun, Yasunosuke Kawabata, Takahiro Maegawa, Shigeto Taniyama, Katsuyasu Tachibana, Katsuya Hirasaka
Summary: Balenine, an endogenous imidazole dipeptide composed of beta-alanine and 3-methyl-l-histidine, is found mainly in muscles and the brain. Studies have shown that balenine exhibits antioxidant activity by increasing SOD activity without affecting other antioxidant enzymes. This suggests that balenine contributes to antioxidant effects through activation of SOD.
Article
Forestry
Ya Chen, Hua Wu, Zhaodong Hao, Liming Zhu, Lu Lu, Jisen Shi, Jinhui Chen
Summary: This study systematically identified and analyzed the SOD gene family of woody plant Liriodendron chinense, and investigated the transcriptional responses of LcSOD genes to abiotic stresses. A total of eight SOD genes were identified and divided into two subgroups. The gene expression analysis revealed the response of LcSOD genes to abiotic stresses, providing potential targets for improving stress tolerance in L. chinense.
Article
Plant Sciences
Chunsong Huo, Linshen He, Ting Yu, Xue Ji, Rui Li, Shunqin Zhu, Fangyuan Zhang, He Xie, Wanhong Liu
Summary: This study systematically characterized the SOD gene family in the tobacco genome, identifying 15 NtSOD genes classified into three subgroups. Functional predictions were consistent with subcellular localization, indicating a protective role against ROS induced by heavy metal stress.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Engineering, Biomedical
Tao Gui, Lijun Luo, Bonirath Chhay, Leilei Zhong, Yulong Wei, Lutian Yao, Wei Yu, Jun Li, Charles L. Nelson, Andrew Tsourkas, Ling Qin, Zhiliang Cheng
Summary: Oxidative stress and reactive oxygen species play important roles in the development and progression of osteoarthritis (OA). This study utilized SOD-loaded nanoparticles to deliver antioxidant enzymes to mouse knee joints, demonstrating the accumulation of nanoparticles in the synovium and reduction of oxidative damage. Intra-articular injections of the nanoparticles were effective in attenuating OA initiation and progression, via reduction of reactive oxygen species production and catabolic protease synthesis.
Article
Immunology
Yusha Wang, Jun Wang, Wenjie Zheng, Jiahui Zhang, Jinbo Wang, Taijie Jin, Panfeng Tao, Yibo Wang, Chenlu Liu, Jiqian Huang, Pui Y. Lee, Xiaomin Yu, Qing Zhou
Summary: A novel missense variant in IL-1R1 was identified in a patient with CRMO, leading to unopposed IL-1 signaling. Researchers designed an IL-1 therapeutic that effectively targets IL-1-driven diseases.
Article
Chemistry, Medicinal
Akhtar Ali, YoungJoon Park, Jeonghoon Lee, Hyo-Jin An, Jong-Sik Jin, Jong-Hyun Lee, Jaeki Chang, Dong-Keun Kim, Bonhyuk Goo, Yeon Cheol Park, Kang-Hyun Leem, Shin Seong, Wonnam Kim
Summary: This study investigated the regulatory effect of Glycyrrhiza new variety, Wongam (WG), on chondrocyte hypertrophy-like changes induced by IL-1 beta. The results showed that WG could inhibit chondrocyte hypertrophy by targeting HDAC4 activation and the SOX9/beta-catenin signaling pathway. In silico analysis revealed that licorice contains 21 active compounds that can bind to 11 targets related to chondrocyte hypertrophy.
Article
Immunology
Miao Zhang, Leming Mou, Shiwei Liu, Fengyi Sun, Mingzhi Gong
Summary: The study revealed that circ_0001103 alleviated IL-1 beta-induced chondrocyte injuries by regulating the miR-375/SIRT1 axis, suggesting circ_0001103 as a potential promising biomarker in the pathogenesis of OA.
CLINICAL IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yi-Jen Peng, Jeng-Wei Lu, Chian-Her Lee, Herng-Sheng Lee, You-Hsiang Chu, Yi-Jung Ho, Feng-Cheng Liu, Chun-Jung Huang, Chia-Chun Wu, Chih-Chien Wang
Summary: Cardamonin has been shown to significantly reduce inflammation in chondrocyte cells, inhibiting the release of inflammatory mediators and pro-inflammatory proteins. It also activates the Nrf2 signaling pathway and increases levels of antioxidant proteins, showing potential as an Nrf2 activator for treating and preventing OA related to inflammation and oxidative stress.
Article
Veterinary Sciences
D. Bardell, P. I. Milner, K. Goljanek-Whysall, M. J. Peffers
EQUINE VETERINARY JOURNAL
(2019)
Review
Biochemical Research Methods
Mandy Jayne Peffers, Aibek Smagul, James Ross Anderson
EXPERT REVIEW OF PROTEOMICS
(2019)
Article
Cell Biology
Katarzyna Goljanek-Whysall, Ana Soriano-Arroquia, Rachel McCormick, Caroline Chinda, Brian McDonagh
Review
Geriatrics & Gerontology
Alice Shally, Brian McDonagh
Article
Biochemical Research Methods
James R. Anderson, Marie M. Phelan, Luis M. Rubio-Martinez, Matthew M. Fitzgerald, Simon W. Jones, Peter D. Clegg, Mandy J. Peffers
JOURNAL OF PROTEOME RESEARCH
(2020)
Article
Cell Biology
Ioannis Kanakis, Moussira Alameddine, Leighton Folkes, Simon Moxon, Ioanna Myrtziou, Susan E. Ozanne, Mandy J. Peffers, Katarzyna Goljanek-Whysall, Aphrodite Vasilaki
Summary: Maternal diet can impact the development and health of offspring's skeletal muscles, with small non-coding RNAs playing a role in nutrition-associated programming. Maternal low protein diet was found to affect offspring skeletal muscle development, leading to decreased muscle fiber size in weanling offspring groups. The differential expression of multiple miRs, snoRNAs, and snRNAs suggests their involvement in key muscle-specific biological processes.
Article
Cell Biology
Ana Soriano-Arroquia, John Gostage, Qin Xia, David Bardell, Rachel McCormick, Eugene McCloskey, Ilaria Bellantuono, Peter Clegg, Brian McDonagh, Katarzyna Goljanek-Whysall
Summary: The decline in satellite cell-dependent skeletal muscle regeneration with aging is associated with alterations in miR-24 expression and its target gene Prdx6. Changes in miR-24 levels impact mitochondrial ROS generation, DNA damage pathways, and the viability and myogenic potential of myogenic progenitors, with more pronounced effects observed in old mice. The downregulation of miR-24 and subsequent upregulation of Prdx6 in response to aging may represent an adaptive mechanism to maintain satellite cell function in muscle.
Article
Biology
Sidrah Jahangir, Peter John, Attya Bhatti, Muhammad Muaaz Aslam, Javaid Mehmood Malik, James R. Anderson, Mandy J. Peffers
Summary: This study aimed to identify potential serum biomarkers for rheumatoid arthritis in the Pakistani population. A total of 10 differentially expressed proteins were identified and pathway analysis predicted macrophage-related signaling pathways.
Article
Biochemistry & Molecular Biology
Qin Xia, Jose C. Casas-Martinez, Eduardo Zarzuela, Javier Munoz, Antonio Miranda-Vizuete, Katarzyna Goljanek-Whysall, Brian McDonagh
Summary: Exercise increases Reactive Oxygen Species (ROS) in muscle, promoting changes in gene transcription and mitochondrial biogenesis. Peroxiredoxin 2 (Prdx2) is necessary for the adaptive response to physiological levels of H2O2 and exercise. H2O2 improves mitochondrial capacity and myogenesis in myoblasts, which is suppressed when Prdxs expression is decreased. Swimming exercise in C. elegans enhances mitochondrial content, fitness, survival, and longevity, but these benefits are diminished in prdx-2 mutant worms. Prdx-2 plays a key regulatory role in the redox signalling cascade following endogenous ROS generation.
Article
Biochemistry & Molecular Biology
Panagiotis Balaskas, Katarzyna Goljanek-Whysall, Peter D. Clegg, Yongxiang Fang, Andy Cremers, Aibek Smagul, Tim J. M. Welting, Mandy J. Peffers
Summary: Osteoarthritis, the most common degenerative joint disorder, was studied using microarray analysis to identify differentially expressed microRNAs in cartilage. The role of miR-107 and miR-143-3p in chondrocyte mechanisms regulating proliferation, hypertrophy, and protein translation was confirmed through experiments in human primary chondrocytes.
Meeting Abstract
Pathology
P. Balaskas, K. Whysall, P. Clegg, T. Welting, M. Peffers
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY
(2019)
Meeting Abstract
Pathology
Y. A. Kharaz, E. Comerford, M. Peffers
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY
(2019)
Meeting Abstract
Pathology
M. J. Peffers, A. Smaghul, P. Balaska, Y. Fang, S. T. M. Welting
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY
(2019)
Meeting Abstract
Pathology
A. Smagul, D. Simpson, S. Tew, M. J. Peffers
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY
(2019)