Article
Environmental Sciences
Ying Qing, Jiaqi Yang, Yuanshen Zhu, Yongzhen Li, Weiwei Zheng, Min Wu, Gengsheng He
Summary: This study established the relationship between U-Cd and renal injury biomarkers, and calculated the dietary Cd exposure limit for Chinese residents based on toxicokinetic model. The findings contribute to improving Chinese Cd exposure risk assessment and setting reasonable exposure standards.
ENVIRONMENTAL HEALTH
(2021)
Article
Environmental Sciences
Kazuhiro Nogawa, Yasushi Suwazono, Yuuka Watanabe, Carl-Gustaf Elinder
Summary: This study aimed to determine the NOAEL, LOAEL, and BMDL of cadmium exposure by re-evaluating the dose-response relationship between cumulative cadmium exposure and renal tubular damage. The results provide valuable information to enhance the reliability of limit values and make a significant contribution to preventing the health effects of Cd in exposed workers.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Environmental Sciences
Peng Shi, Huanchang Yan, Xingjun Fan, Shuhua Xi
Summary: Research has revealed a strong positive association between urinary cadmium levels and type 2 diabetes mellitus (T2DM), although the corresponding threshold has not yet been established. Benchmark dose analysis based on population data showed that the risk of T2DM associated with urinary cadmium levels is low and should be considered in the development of regulatory limits for safe exposure to cadmium.
ENVIRONMENTAL POLLUTION
(2021)
Article
Environmental Sciences
Junfei Zhan, Shuang Wang, Fei Li, Chenglong Ji, Huifeng Wu
Summary: The study investigated the dose-dependent effects of cadmium (Cd) on clams and identified peptide cross-linking as the most sensitive biological process to Cd exposure. The research also highlighted certain differentially expressed genes (DEGs) such as transglutaminases (TGs), metallothionein (MT), STEAP2-like and laccase as potential biomarkers for Cd in clams.
ENVIRONMENTAL POLLUTION
(2021)
Article
Environmental Sciences
Yiyi Cao, Tongshuai Wang, Jing Xi, Wei Tian, Weiying Liu, Yuan Sun, Wuzhong Liu, Xinyue You, Anqi Li, Guanghui Zhang, XinYu Zhang, Zhao-lin Xia, Yang Luan
Summary: Based on previous exposure studies, benzene (BZ) has been classified as a human carcinogen and the current occupational exposure limit (OEL) of 1 ppm may not sufficiently protect against health hazards. This study used genotoxicity assessments to determine the hazards of benzene exposure below the OEL. The results indicated that lower OELs are necessary to better protect workers, with a proposed value of less than 0.07 ppm.
ENVIRONMENTAL POLLUTION
(2023)
Article
Environmental Sciences
Chu-Chih Chen, Yin-Han Wang, Chia-Fang Wu, Chia -Jung Hsieh, Shu-Li Wang, Mei -Lien Chen, Hui-Ju Tsai, Sih-Syuan Li, Chia-Chu Liu, Yi-Chun Tsai, Tusty-Jiuan Hsieh, Ming-Tsang Wu
Summary: This study assessed the relationships between exposure to melamine and DEHP and their combined exposure on early renal injury in pregnant women. The results showed that the current recommended tolerable daily intake levels for these chemicals were much lower than the levels of exposure in pregnant women, especially when considering coexposure to both chemicals.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Ying Qing, Jiaqi Yang, Yanfeng Chen, Chengjie Shi, Qianrong Zhang, Zhongping Ning, Ying Yu, Yanfei Li
Summary: This study conducted a systematic meta-analysis of global epidemiological studies to explore the association between Cd exposure and bone damage, finding that gender, BMI, age, and race have significant impacts on BMD. The results provided reference for the risk assessment of Cd exposure and the formulation of dietary exposure standards.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Review
Biochemistry & Molecular Biology
Estefani Yaquelin Hernandez-Cruz, Isabel Amador-Martinez, Ana Karina Aranda-Rivera, Alfredo Cruz-Gregorio, Jose Pedraza Chaverri
Summary: Cadmium (Cd) is a toxic metal that can accumulate in living organisms, especially in the kidney. The mitochondria play a crucial role in Cd-induced kidney damage, leading to chronic kidney disease. Current therapies for Cd nephrotoxicity have limitations, and there is a need for new treatment approaches. Mitochondrial transplantation has shown promising results in reversing mitochondrial alterations caused by oxidative stress, and it is proposed as a novel therapy for Cd-induced kidney damage.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Biology
Muhammad Umar Ijaz, Moazama Batool, Afsheen Batool, K. A. Al-Ghanimd, Sara Zafar, Asma Ashraf, F. Al-Misned, Z. Ahmed, Sabahat Shahzadi, Abdul Samad, Usman Atique, N. Al-Mulhm, S. Mahboob
Summary: The study demonstrated that cadmium exposure led to renal dysfunction in rats by increasing urea and creatinine levels, reducing antioxidant enzyme activities, elevating reactive oxygen species levels, and compromising mitochondrial enzyme activities. Treatment with vitexin showed potential in ameliorating the detrimental effects of cadmium-induced renal toxicity.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Environmental Sciences
Yingjun Li, Liuyuan Zhang, Jin Liu, Meiqiong Wu, Changqing Li, Jia Yang, Li Wang
Summary: This study evaluated the levels of cadmium (Cd) and zinc (Zn) in urine samples from pregnant women and examined the associated changes in urine metabolomics. The results showed that the number of pregnancies was closely related to urinary Cd levels, and pregnant women with morning sickness had lower urinary Zn levels. Additionally, several metabolites exhibited significant differential expression in the high Cd and Zn group compared to the low Cd and Zn group. The study also suggested that excessive Zn intake may have harmful effects on human health. These findings are important for assessing the potential risks of combined Cd-Zn effects and interactions in pregnant women.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Multidisciplinary Sciences
Jung-Yeon Kwon, Seungho Lee, Ulziikhishig Surenbaatar, Hyoun-Ju Lim, Byoung-Gwon Kim, Sang-Yong Eom, Yong Min Cho, Woo Jin Kim, Byeng-Chul Yu, Kwan Lee, Young-Seoub Hong
Summary: This study examined the association between heavy metal exposure and renal function indicators in abandoned metal mines and refineries. Blood and urine samples were collected from 298 participants for analysis, revealing higher levels of lead and cadmium in the exposure areas. The study found correlations between cadmium exposure and renal function indicators.
SCIENTIFIC REPORTS
(2023)
Article
Public, Environmental & Occupational Health
Victor O. Martinez, Lorena S. Nunes, Gustavo S. Viana, Nathalia R. dos Santos, Jose A. Menezes-Filho
Summary: The study aimed to assess cadmium exposure and its association with renal function in adults living in two estuarine communities in Aratu bay, Bahia, Brazil. Results showed a significant association between age, smoking, lower income, and elevated cadmium levels in urine. Additionally, there was consistent evidence of an association between cadmium exposure and increased tubular cell biomarker excretion in villagers living near an industrial site.
INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH
(2022)
Article
Multidisciplinary Sciences
Sarah E. Vidal Yucha, Doug Quackenbush, Tiffany Chu, Frederick Lo, Jeffrey J. Sutherland, Guray Kuzu, Christopher Roberts, Fabio Luna, S. Whitney Barnes, John Walker, Pia Kuss
Summary: Human cell-based in vitro tools are essential for drug development, and the development of robust, accurate, and predictive models is of great importance. This study presents a 3D human cell-based assay using RPTEC-TERT1 cells to investigate nephrotoxicity. The study demonstrates that the 3D "tubuloids" have distinct morphological features, increased sensitivity to nephrotoxins, and a higher degree of similarity to native human kidney tissue. The altered Na+/K+-ATPase signal intensity in tubuloids incubated with nephrotoxins also shows potential for a high-throughput, translatable nephrotoxicity assay.
Article
Medicine, General & Internal
Yuan-Hong Jiang, Jia-Fong Jhang, Hann-Chorng Kuo
Summary: This study used a cluster of urinary biomarkers to identify LUTDs in women with frequency and urgency symptoms. The urine levels of biomarkers were compared between groups with bladder dysfunctions and controls to test the sensitivity in identifying total pathological bladder diseases and specific bladder diseases.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Engineering, Environmental
Kan Shao, Chao Ji, Weihsueh Chiu
Summary: The study aims to support BMD estimation using informative prior with dichotomous data and provides a practical method for advanced Bayesian BMD modeling. The study found that using informative prior can significantly reduce uncertainty in BMD estimation.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Acoustics
Tengjiao Jiang, Anders Ronnquist, Yang Song, Gunnstein Thomas Froseth, Petter Navik
Summary: This study focuses on the dynamic behavior of the catenary span in electrified railways and successfully estimates the spatially distributed damping using a vision-based line-tracking system. The findings provide recommendations for future numerical simulations.
JOURNAL OF SOUND AND VIBRATION
(2022)
Article
Engineering, Mechanical
Yang Song, Mingjie Zhang, Ole Oseth, Anders Ronnquist
Summary: This paper evaluates the wind deflection of railway catenary under crosswind through wind tunnel experiments and numerical simulations, finding that the wind deflection exceeds safety limits when the turbulence intensity is above 15%, and adjustments to system parameters can reduce the deflection.
MECHANISM AND MACHINE THEORY
(2022)
Article
Engineering, Electrical & Electronic
Yang Song, Fuchuan Duan, Zhigang Liu
Summary: This paper provides a theoretical explanation for the relationship between speed and interaction performance in the pantograph-catenary system. It is found that increasing speed can improve interaction performance in certain local speed regions. A validated model is used to reproduce this phenomenon, and a simple indicator is proposed to determine the local optimal speed based on the analysis of contact wire amplitude.
IEEE TRANSACTIONS ON VEHICULAR TECHNOLOGY
(2022)
Article
Engineering, Mechanical
Mingjie Zhang, Yang Song, Abdessattar Abdelkefi, Haiyan Yu, Junlei Wang
Summary: This study proposes a method to predict the VIV responses of a circular cylinder with nonlinear stiffness using harmonically forced vibration data, and validates its accuracy by comparing with free vibration CFD simulations. The results indicate that forced vibration data can qualitatively and to some extent quantitatively predict the VIV responses of the considered nonlinear systems.
NONLINEAR DYNAMICS
(2022)
Article
Engineering, Mechanical
Long Chen, Fuchuan Duan, Yang Song, Zeyao Hu, Zhigang Liu
Summary: In this paper, a three-dimensional contact formulation for the pantograph-OCR system (POCRs) based on the Lagrange multiplier method is proposed. The contact forces can be accurately obtained without the need to determine the contact stiffness value. The effectiveness and accuracy of the proposed contact formulation are verified by comparing the simulation results with in-line measured data.
VEHICLE SYSTEM DYNAMICS
(2023)
Article
Energy & Fuels
Xiaohe Feng, Shibin Gao, Yang Song, Zeyao Hu, Long Chen, Tao Liang
Summary: The study focuses on improving the dynamic interaction performance between the contact wire and the pantograph in tunnels. By developing new types of conductor rail with large moments of inertia, the sag of the contact wire is significantly reduced. Static and dynamic analyses show that the conductor rail with a large moment of inertia performs the best, reducing the sag by 28.37% and the stress by 27.76% compared to the conventional conductor. Furthermore, the results demonstrate that the contact force fluctuation is significantly reduced with the introduction of conductor rails with large moments of inertia, especially the conductor rail of case 1.
Article
Engineering, Electrical & Electronic
Fuchuan Duan, Yang Song, Shibin Gao, Yuhui Liu, Wenping Chu, Xiaobing Lu, Zhigang Liu
Summary: This paper investigates the aerodynamic instability of overhead contact lines (OCL) on electric railways under different wear levels and wind angles through wind tunnel tests and numerical simulations. It is found that the galloping amplitude of the contact line is large at wind attack angles of 8 degrees and 9 degrees for wear levels of 20% and 30%, respectively. The study also recommends the installation of damping droppers on railway OCLs to reduce the detrimental effects of galloping under strong wind fields.
IEEE TRANSACTIONS ON VEHICULAR TECHNOLOGY
(2023)
Article
Acoustics
Yang Song, Anders Ronnquist, Tengjiao Jiang, Petter Navik
Summary: This paper presents a systematic investigation of the dynamic behaviours of the pantograph-catenary in an overlap section. It includes mathematical modeling, model validation, and numerical analysis. The results indicate a strong dependence of the dynamic behavior in an overlap section on the train speed.
JOURNAL OF SOUND AND VIBRATION
(2023)
Article
Green & Sustainable Science & Technology
Ke Chen, Yang Song, Xiaobing Lu, Fuchuan Duan
Summary: This paper aims to improve the speed of rigid overhead systems by studying the impact of key parameters and the pantograph on the interaction performance. A rigid overhead system model is built using the finite element method, and a three-stage lumped mass pantograph model is used for the simulation. The sensitivity analysis reveals that span length, bending stiffness, linear density of the conductor rail, and masses of the pantograph head and upper frame are the most relevant variables for the contact force standard deviation. The optimization analysis shows a significant reduction in the contact force standard deviation at different speeds.
Article
Food Science & Technology
Yanjun Zhou, Haixia Sui, Yibaina Wang, Ling Yong, Lei Zhang, Jiang Liang, Jing Zhou, Lili Xu, Yanxu Zhong, Jinyao Chen, Yan Song
Summary: A duplicate diet collection method was used to estimate dietary exposure to glutamates in children aged 2-5 years in selected provinces of China. Results showed that glutamates content was highest in mixed meals, followed by powdered formula and milk and dairy products. The total mean daily dietary exposure for subjects was below the recommended daily intake by regulatory authorities, indicating a low risk of glutamates exposure in this group.
Article
Engineering, Electrical & Electronic
Bing Lu, Zhigang Liu, Xufan Wang, Yang Song, Qiao Zhang, Siqi Wu, Gongquan Tao
Summary: This article investigates the influence of harmonics and interharmonics on the vibration of key locomotive components. It establishes an electromechanical coupling model to analyze the generation mechanisms of interharmonics and their resulting pulsating torque in the electric traction drive system (TDS). The research shows that the vibrations of the locomotive can be significantly influenced by the pulsating torque caused by interharmonics.
IEEE TRANSACTIONS ON VEHICULAR TECHNOLOGY
(2023)
Article
Chemistry, Analytical
Xiaohe Feng, Zeyao Hu, Shibin Gao, Fuchuan Duan, Wenping Chu, Yang Song
Summary: This study develops a comprehensive model of a rigid overhead system, incorporating essential components and using finite element theory and beam elements to accurately represent system characteristics. Various suspension structures and positioning line clamps are evaluated, and the expansion joint undergoes detailed analysis. The primary findings indicate a high level of safety but suggest optimizing the installation deflection angle and geometric design of the expansion joint to improve stress distribution and service reliability, and reducing the mass of the expansion joint to mitigate negative impacts on the current collection quality.
Article
Nutrition & Dietetics
Ya Yuan, Ignatius Man-Yau Szeto, Na Li, Hua Yang, Yunzheng Zhou, Biao Liu, Fang He, Lishi Zhang, Sufang Duan, Jinyao Chen
Summary: The study aimed to investigate the effects of dietary menaquinone-7 (MK-7) on bone accrual in growing Sprague-Dawley rats under calcium restriction. It was found that calcium deficiency reduced microbiome richness, disrupted microbiome composition, and increased the relative abundance of Parasutterella. Additionally, calcium insufficiency affected metabolite levels and metabolic profiles. MK-7 supplementation improved bone density, calcium content, and bone quality through modulation of metabolic pathways and gut microbiota composition. The gut-bone axis and MK-7 supplementation show promise in ameliorating calcium deficiency in children's bone quality.
Review
Environmental Sciences
Yue Cao, Jinyao Chen, Qian Bian, Junyu Ning, Ling Yong, Tong Ou, Yan Song, Sheng Wei
Summary: This meta-analysis investigates the genotoxicity of titanium dioxide nanoparticles (TiO2 NPs) and explores influencing factors. The results suggest that TiO2 NPs can induce DNA damage, chromosomal damage, and gene mutations, with rats and cancer cells showing higher susceptibility. The DNA damage response mechanism plays a key role in the genotoxicity induced by TiO2 NPs.
Article
Engineering, Electrical & Electronic
Xufan Wang, Zhigang Liu, Yang Song, Wei Jin, Zhao Xu, Jiaming Xiong, Sheng Zhou
Summary: The electric shoegear-conductor rail system is an important device for collecting electric energy in metro vehicles. This study aims to investigate the interaction performance between the shoegear and conductor rail by considering the disturbances from conductor rail irregularities and vehicle-track excitations. The results show that the maximum contact force exceeds the safety threshold at high speeds, and resonance caused by frequency match should be avoided. The analysis also reveals that the contact force standard deviation increases with track irregularities, leading to a potential safety issue.
IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT
(2023)
