期刊
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
卷 95, 期 11, 页码 1564-1572出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/09553002.2019.1642534
关键词
Drosophila; acute irradiation; transposons; DNA damage; survival rate; mutability; reproduction system
资金
- theme of research 'Radionuclides Biogenic Migration Mechanisms and Induced Long-Term Effects in Plants and Animals under the Chronic Radiation and Chemical Effects' [0414-2018-0002, AAAA-A18-118011190102-7]
Purpose: The role of transposable elements in formation of radiobiological effects is understudied and contradictory. The aim of this study was to investigate the response of Drosophila melanogaster to irradiation depending on the level of activity hobo transposons and the role of hobo transposons in formation of ionizing radiation late effects. Materials and methods: The individuals of Drosophila melanogaster with different level activity of hobo-elements were exposed to acute irradiation in doses of 1-100 Gy at early ontogenesis stages. The reaction of individuals to exposure was studied using the larvae survival rate, morphological parameters of reproduction system, DNA damage rate, and mutability of mini-white locus. Results: We found the pronounced linear deferred effects of irradiation for animals with a high activity level of full-size hobo copies. The radiosensitivity of individuals with a mean level of activity transposon was whether higher or did not differ from the radiosensitivity of animals with a low activity hobo. Conclusion: The obtained results suggest that full-size hobo-elements with a high activity level (less often with a mean activity level) are responsible for delayed deleterious irradiation effects.
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