Plant-Derived Bioactive Peptides: A Treatment to Cure Diabetes

Evaluation of the antidiabetic activity of hydrolyzed peptides derived from Juglans mandshurica Maxim. fruits in insulin-resistant HepG2 cells and type 2 diabetic mice

(2018) Ji Wang et al.   JOURNAL OF FOOD BIOCHEMISTRY

Effect of Oral Semaglutide Compared With Placebo and Subcutaneous Semaglutide on Glycemic Control in Patients With Type 2 Diabetes

(2017) Melanie Davies et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Biofunctional properties of bioactive peptide fractions from protein isolates of moringa seed (Moringa oleifera)

(2017) Nancy Gisela González Garza et al.   JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE

The Current State of Peptide Drug Discovery: Back to the Future?

(2017) Antoine Henninot et al.   JOURNAL OF MEDICINAL CHEMISTRY

Protein extract from the fruit pulp of Momordica dioica shows anti-diabetic, anti-lipidemic and antioxidant activity in diabetic rats

(2017) Sundar Poovitha et al.   Journal of Functional Foods

Release of dipeptidyl peptidase IV, α-amylase and α-glucosidase inhibitory peptides from quinoa ( Chenopodium quinoa Willd.) during in vitro simulated gastrointestinal digestion

(2017) Rubén Vilcacundo et al.   Journal of Functional Foods

Evaluation of the hypoglycemic potential of a black bean hydrolyzed protein isolate and its pure peptides using in silico, in vitro and in vivo approaches

(2017) Luis Mojica et al.   Journal of Functional Foods

Identification of the bioactive and consensus peptide motif from Momordica charantia insulin receptor-binding protein

(2016) Hsin-Yi Lo et al.   FOOD CHEMISTRY

Enzyme-assisted extraction and identification of antioxidative and α-amylase inhibitory peptides from Pinto beans ( Phaseolus vulgaris cv. Pinto)

(2016) Ying-Yuan Ngoh et al.   FOOD CHEMISTRY

Mcy protein, a potential antidiabetic agent: evaluation of carbohydrate metabolic enzymes and antioxidant status

(2016) Saritha Marella et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Peptides Derived from Soy and Lupin Protein as Dipeptidyl-Peptidase IV Inhibitors: In Vitro Biochemical Screening and in Silico Molecular Modeling Study

(2016) Carmen Lammi et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Characterization of peptides from common bean protein isolates and their potential to inhibit markers of type-2 diabetes, hypertension and oxidative stress

(2016) Luis Mojica et al.   JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

Identification and characterization of two novel α-glucosidase inhibitory oligopeptides from hemp ( Cannabis sativa L.) seed protein

(2016) Yao Ren et al.   Journal of Functional Foods

Extraction, identification, and structure–activity relationship of antioxidative and α-amylase inhibitory peptides from cumin seeds (Cuminum cyminum)

(2016) Hwee-Leng Siow et al.   Journal of Functional Foods

Peptide therapeutics: current status and future directions

(2015) Keld Fosgerau et al.   DRUG DISCOVERY TODAY

Hard-to-cook bean ( Phaseolus vulgaris L.) proteins hydrolyzed by alcalase and bromelain produced bioactive peptide fractions that inhibit targets of type-2 diabetes and oxidative stress

(2015) Miguel E. Oseguera-Toledo et al.   FOOD RESEARCH INTERNATIONAL

Anti-oxidation Activities of Rice-Derived Peptides and Their Inhibitory Effects on Dipeptidylpeptidase-IV

(2015) Tadashi Hatanaka et al.   International Journal of Peptide Research and Therapeutics

Quinoa (Chenopodium quinoa Willd.) protein hydrolysates with in vitro dipeptidyl peptidase IV (DPP-IV) inhibitory and antioxidant properties

(2015) Alice B. Nongonierma et al.   JOURNAL OF CEREAL SCIENCE

Discovery of the Once-Weekly Glucagon-Like Peptide-1 (GLP-1) Analogue Semaglutide

(2015) Jesper Lau et al.   JOURNAL OF MEDICINAL CHEMISTRY

Research Progress in Structure-Activity Relationship of Bioactive Peptides

(2015) Ying Li et al.   JOURNAL OF MEDICINAL FOOD

Chemical cross-linking and native mass spectrometry: A fruitful combination for structural biology

(2015) Andrea Sinz et al.   PROTEIN SCIENCE

Rice Bran Protein Hydrolysates Improve Insulin Resistance and Decrease Pro-inflammatory Cytokine Gene Expression in Rats Fed a High Carbohydrate-High Fat Diet

(2015) Kampeebhorn Boonloh et al.   Nutrients

Glucagon-like peptide-1 receptor agonists for the treatment of type 2 diabetes: Differences and similarities

(2014) Asger Lund et al.   European Journal of Internal Medicine

Amylase inhibitors and their biomedical applications

(2014) Sujatha Jayaraj et al.   STARCH-STARKE

α-Glucosidase inhibitory activity of protein-rich extracts from extruded adzuki bean in diabetic KK-Ay mice

(2014) Yang Yao et al.   Food & Function

Anti-hyperglycaemic globulins from selected Cucurbitaceae seeds used as antidiabetic medicinal plants in Africa

(2013) Clautilde Mofor Teugwa et al.   BMC Complementary and Alternative Medicine

Non-peptidyl insulin mimetics as a potential antidiabetic agent

(2013) Rakesh P. Nankar et al.   DRUG DISCOVERY TODAY

Enhancement of glucose uptake in muscular cell by soybean charged peptides isolated by electrodialysis with ultrafiltration membranes (EDUF): Activation of the AMPK pathway

(2013) Cyril Roblet et al.   FOOD CHEMISTRY

Anti-diabetic and antihypertensive activities of two flaxseed protein hydrolysate fractions revealed following their simultaneous separation by electrodialysis with ultrafiltration membranes

(2013) Alain Doyen et al.   FOOD CHEMISTRY

Characterization of Antidiabetic and Antihypertensive Properties of Canary Seed (Phalaris canariensis L.) Peptides

(2013) Patricia A. Estrada-Salas et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Connectivity maps for biosimilar drug discovery in venoms: The case of Gila Monster Venom and the anti-diabetes drug Byetta®

(2013) Lavakumar Reddy Aramadhaka et al.   TOXICON

The Future of Peptide-based Drugs

(2012) David J. Craik et al.   Chemical Biology & Drug Design

Hypoglycemic effects of cocoa (Theobroma cacao L.) autolysates

(2012) Bahareh Sarmadi et al.   FOOD CHEMISTRY

Production of dipeptidyl peptidase IV inhibitory peptides from defatted rice bran

(2012) Tadashi Hatanaka et al.   FOOD CHEMISTRY

In vitro inhibition of dipeptidyl peptidase IV by peptides derived from the hydrolysis of amaranth (Amaranthus hypochondriacus L.) proteins

(2012) Aída J. Velarde-Salcedo et al.   FOOD CHEMISTRY

The soybean peptide aglycin regulates glucose homeostasis in type 2 diabetic mice via IR/IRS1 pathway

(2012) Jingli Lu et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Proof of concept for next-generation nanoparticle drugs in humans

(2012) Cormac Sheridan   NATURE BIOTECHNOLOGY

Small Signaling Peptides in Arabidopsis Development: How Cells Communicate Over a Short Distance

(2012) E. Murphy et al.   PLANT CELL

Soymorphin-5, a soy-derived μ-opioid peptide, decreases glucose and triglyceride levels through activating adiponectin and PPARα systems in diabetic KKAy mice

(2011) Yuko Yamada et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

A novel approach to control hyperglycemia in type 2 diabetes: Sodium glucose co-transport (SGLT) inhibitors. Systematic review and meta-analysis of randomized trials

(2011) Giovanni Musso et al.   ANNALS OF MEDICINE

Role of Sodium-Glucose Cotransporter 2 (SGLT 2) Inhibitors in the Treatment of Type 2 Diabetes

(2011) Muhammad A. Abdul-Ghani et al.   ENDOCRINE REVIEWS

Anti-Oxidant, Anti-Diabetic, and Anti-Hypertensive Effects of Extracted Phenolics and Hydrolyzed Peptides from Barley Protein Fractions

(2011) Muhammad H. Alu'datt et al.   INTERNATIONAL JOURNAL OF FOOD PROPERTIES

Intercellular Communication during Plant Development

(2011) J. M. Van Norman et al.   PLANT CELL

GLP-1 secretion is enhanced directly in the ileum but indirectly in the duodenum by a newly identified potent stimulator, zein hydrolysate, in rats

(2009) Tohru Hira et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Isolation and characterization of a novel antihyperglycemic protein from the fruits of Momordica cymbalaria

(2009) Maddirela Dilip Rajasekhar et al.   JOURNAL OF ETHNOPHARMACOLOGY

Medical Management of Hyperglycemia in Type 2 Diabetes: A Consensus Algorithm for the Initiation and Adjustment of Therapy: A consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes

(2008) D. M. Nathan et al.   DIABETES CARE

Bioactive peptides and proteins from foods: indication for health effects

(2008) Niels Peter Möller et al.   EUROPEAN JOURNAL OF NUTRITION

Purification and characterisation of a hypoglycemic peptide from Momordica Charantia L. Var. abbreviata Ser.

(2008) Xiaoqing Yuan et al.   FOOD CHEMISTRY