Review
Cell Biology
Ji-Ung Jung, Ankita B. Jaykumar, Melanie H. Cobb
Summary: In this review, the role of WNK1 in tumor malignancy, metastasis, angiogenesis, and mesenchymal transition is discussed, providing evidence for its unique association with a subset of invasive cancers.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Aparna Cherukunnath, Ravichandra S. Davargaon, Rahail Ashraf, Urja Kamdar, Amit K. Srivastava, Prem P. Tripathi, Nabanita Chatterjee, Sanjay Kumar
Summary: KLF8 is overexpressed in ovarian cancer and promotes cancer progression. TGF-beta 1 activates KLF8 expression through the Smad2 pathway and regulates epithelial-mesenchymal transition (EMT), contributing to OC progression.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2022)
Review
Medicine, General & Internal
Masao Saitoh
Summary: Epithelial-mesenchymal transition (EMT) plays a crucial role in cancer progression, associated with invasion, metastasis, generation of tumor stem cells, and resistance to therapy. Transforming growth factor (TGF)-beta acts as a key mediator in the EMT process, initiating and maintaining EMT through signaling pathways and transcription factors.
Article
Oncology
Qiuju Liang, Zhijie Xu, Yuanhong Liu, Bi Peng, Yuan Cai, Wei Liu, Yuanliang Yan
Summary: NR2F1 regulates platinum sensitivity and immune response in ovarian cancer by modulating TGF-beta 1-mediated EMT.
Review
Oncology
Valeria Ramundo, Giuliana Giribaldi, Elisabetta Aldieri
Summary: Metabolic changes in the tumor microenvironment play a critical role in cancer by affecting signaling pathways that control cellular metabolism. The deregulation of cancer metabolism is closely related to oxidative stress control and the involvement of cytokines like transforming growth factor beta (TGF-beta) in tumorigenesis and cancer progression. The crosstalk between TGF-beta and oxidative stress contributes significantly to tumorigenesis and cancer invasiveness by affecting redox imbalance and cellular metabolism.
Article
Oncology
Xuecong Wang, Pieter Johan Adam Eichhorn, Jean Paul Thiery
Summary: TGF-beta signaling regulates embryonic development, wound-healing, and immune homeostasis, but it is altered during tumor progression, leading to enhanced epithelial cell plasticity and a reprogramming of epithelial cells into mesenchymal lineages through EMT. This contributes to increased carcinoma cell invasion, metastasis, and immune evasion.
SEMINARS IN CANCER BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Cheng-Yi Huang, Jenq-Lin Yang, Jih-Jung Chen, Shun-Ban Tai, Yu-Hsuan Yeh, Pei-Feng Liu, Ming-Wei Lin, Chih-Ling Chung, Chun-Lin Chen
Summary: The study showed that FQs inhibit MMP-9 expression in cancer cells, leading to a decrease in cell migration and invasion, demonstrating their potential value in cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Qingjie Kang, Xudong Peng, Xiangshu Li, Denghua Hu, Guangxu Wen, Zhengqiang Wei, Baohong Yuan
Summary: The study reveals that ORAI1 mediates TGF-beta-induced EMT in colorectal cancer cells by promoting Ca2+ entry and calpain activity.
FRONTIERS IN ONCOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Caijiao Wang, Luyao Dong, Ziqi Zhao, Zeqing Zhang, Yutong Sun, Chonglong Li, Guoqing Li, Xuefu You, Xinyi Yang, Hao Wang, Wei Hong
Summary: Protein arginine methyltransferase 1 (PRMT1) is an enzyme that catalyzes protein arginine methylation and is involved in various biological processes such as EMT and cancer cell migration. This study designed and synthesized a series of compounds targeting the substrate binding site of PRMT1, and identified compound 1r (WCJ-394) as the most potent inhibitor. WCJ-394 affected the expression of PRMT1-related proteins and inhibited TGF-beta 1-induced EMT and cancer cell migration.
FRONTIERS IN CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Jisu Jeong, Jiyeon Kim
Summary: EMT plays a crucial role in the development of lung cancer, and targeting EMT could inhibit cancer cell invasion and metastasis. This study found that combination treatment with erlotinib and cilengitide showed enhanced inhibitory effects on EMT in lung cancer cells, suggesting that cilengitide could improve the efficacy of anticancer drugs and contribute to improved treatment strategies for inhibiting EMT-based cancer progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Weiqin Lv, Hongrui Guo, Junxia Wang, Rui Ma, Lina Niu, Yun Shang
Summary: The expression of PDLIM2 is low in ovarian cancer. Upregulation of PDLIM2 can attenuate the proliferation, migration, and invasion of ovarian cancer cells by inactivating the TGF-beta/Smad pathway. Therefore, PDLIM2 may be a useful target for ovarian cancer treatment.
CELL BIOCHEMISTRY AND FUNCTION
(2023)
Article
Oncology
Yu Liu, Mingxu Da
Summary: This study found that WTAP is significantly overexpressed in gastric carcinoma tissue, and its high expression is closely associated with poor prognosis in gastric cancer patients. Overexpression of WTAP can promote migration and EMT of GC cells, as well as the expression of TGF-beta and mRNA stability. Knockdown of WTAP inhibits migration of GC cells, decreases TGF-beta expression, and reduces mRNA stability. In addition, WTAP also promotes multiple chemotherapy and radiotherapy resistance in GC.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Cell Biology
Kevin Bevant, Matthis Desoteux, Abdel Hady A. Abdel Wahab, Sabrin A. Abdel Wahab, Ayman Mohamed Metwally, Cedric Coulouarn
Summary: The study found that DNA methylation may affect the activity of TGF beta in liver cancer, promoting EMT and tumor progression. By using decitabine, the transcriptional response of HCC cells to TGF beta was impaired, inducing the expression of EMT-related transcription factors, and hypomethylation of the SNAI1 promoter associated with poor prognosis in human HCC was identified.
Article
Multidisciplinary Sciences
Abhilasha Srivastava, Harshita Sharma, Shibasish Chowdhury, Rajdeep Chowdhury, Sudeshna Mukherjee
Summary: Hepatocellular carcinoma (HCC) often develops under inflammatory conditions with various cytokines present. Transforming growth factor-beta (TGF-beta) is a major cytokine in the tumor environment and is involved in promoting epithelial to mesenchymal transition (EMT) in tumor cells. However, the cellular events and molecular regulation of TGF-beta-induced EMT are still unclear. In this study, HCC cells were treated with TGF-beta and it was found that EMT induced by TGF-beta is associated with cytostasis and altered cellular metabolism. TGF-beta down-regulates cell cycle-associated transcripts and metabolic genes through epigenetic silencing, and this process is mediated by TGF-beta downstream signaling mediator-SMAD and chromatin repressive complex member-EZH2.
Article
Oncology
Lukas Krauss, Bettina C. Urban, Sieglinde Hastreiter, Carolin Schneider, Patrick Wenzel, Zonera Hassan, Matthias Wirth, Katharina Lankes, Andrea Terrasi, Christine Klement, Filippo M. Cernilogar, Rupert Oellinger, Niklas de Andrade Kraetzig, Thomas Engleitner, Roland M. Schmid, Katja Steiger, Roland Rad, Oliver H. Kraemer, Maximilian Reichert, Gunnar Schotta, Dieter Saur, Guenter Schneider
Summary: The mortality of patients with pancreatic ductal adenocarcinoma (PDAC) is strongly associated with metastasis, and transcriptional and epigenetic rewiring can contribute to the metastatic process. This study shows that HDAC2 plays a crucial role in undifferentiated PDAC by controlling cell cycle and metastasis. HDAC2 maintains the metastatic program by controlling the expression of several prosurvival receptor tyrosine kinases connected to mesenchymal PDAC, and impairs the tumor-suppressive arm of the TGFI3 pathway.
