Article
Endocrinology & Metabolism
Wenqiang Li, Tong Liu, Liang Qian, Yiming Wang, Xiangming Ma, Liying Cao, Qingsong Zhang, Jun Qu
Summary: This study found that the association between abdominal obesity and colorectal cancer risk may be mediated by factors such as insulin resistance and inflammation. General and abdominal obesity were associated with an increased risk of colorectal cancer in males, while only abdominal obesity was associated with an increased risk in females. Additionally, the mediation effects of fasting triglyceride-glucose index and C-reactive protein were observed for the association between abdominal obesity and colorectal cancer risk.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Aesha Shah, William C. Dodson, Penny M. Kris-Etherton, Allen R. Kunselman, Christy M. Stetter, Carol L. Gnatuk, Stephanie J. Estes, Kelly C. Allison, David B. Sarwer, Patrick M. Sluss, Christos Coutifaris, Anuja Dokras, Richard S. Legro
Summary: Oral contraceptive pills have a significant impact on the hormones of patients with polycystic ovary syndrome, but this does not correlate with live birth.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Min Xu, Yu-Meng Wang, Wan-Qing Li, Cheng-Long Huang, Jun Li, Wen-Hua Xie, Hong-Xiang Zeng, Lin-Fen Tao, Xi Li
Summary: This study found that Ccrl2 expression is increased in visceral adipose tissue of obese mice. Deletion of Ccrl2 gene exacerbates obesity and insulin resistance, resulting in increased visceral adipose tissue inflammation and M1/M2 macrophage ratio.
Article
Agriculture, Multidisciplinary
Juciane de Abreu Ribeiro Pereira, Maria de Fatima Piccolo Barcelos, Eduardo Valerio Villas Boas, Roberta Hilsdorf Piccoli, Janina de Sales Guilarducci, Rafaela Correa Pereira, Jose Rodrigo Pauli, Eric Batista Ferreira, Michel Cardoso de Angelis-Pereira, Dennys Esper Cintra
Summary: This study found that the combination of yacon flour and yogurt with two strains of probiotics had positive effects on metabolic parameters, inflammatory and insulin signaling proteins in diet-induced obese mice. The combination resulted in decreased body weight, fasting glucose, and triacylglycerol levels, as well as reduced fat accumulation. Additionally, it decreased inflammatory markers and improved insulin signaling. These findings suggest that the use of prebiotics and probiotics in food can counteract obesity-associated inflammation and improve insulin resistance in the short term.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2022)
Article
Endocrinology & Metabolism
Haixia Lin, Kelly E. Mercer, Xiawei Ou, Kori Mansfield, Robert Buchmann, Elisabet Borsheim, Emir Tas
Summary: This study aimed to assess the relationship between serum miRNA profile in children with obesity, insulin resistance (IR), and non-alcoholic fatty liver disease (NAFLD). The results showed that several miRNAs were differentially expressed in children with IR and NAFLD, which may provide new targets for the diagnosis and treatment of pediatric NAFLD.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Guang Ren, Patrick Tae Joon Hwang, Reid Millican, Juhee Shin, Brigitta C. Brott, Thomas van Groen, Craig M. Powell, Sushant Bhatnagar, Martin E. Young, Ho-Wook Jun, Jeong-A Kim
Summary: This study demonstrates the effects of using PANO gel to inject exogenous NO on high-fat diet-induced obesity, insulin resistance, and cognitive functions. The use of PANO gel reduces body weight gain, improves glucose tolerance, decreases insulin and leptin levels, and enhances insulin signaling. Additionally, the PANO gel reduces inflammation, increases lipolysis, decreases serum lipids and liver triglycerides, stimulates the development of brown and beige fat tissues, increases cerebral blood flow, and improves learning and memory abilities.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Immunology
Hui Zhou, Xiyan Liao, Qin Zeng, Haowei Zhang, Jianfeng Song, Wanyu Hu, Xiaoxiao Sun, Yujin Ding, Dandan Wang, Yalun Xiao, Tuo Deng
Summary: Accumulation and activation of immunocytes in adipose tissues are important in obesity-induced inflammation and insulin resistance. Chemokines, especially CCL5, play a crucial role in recruiting immunocytes to adipose tissue during obesity. CCL5 deficiency exacerbates adipose inflammation and impairs insulin sensitivity in obese mice. This study provides insights into the role of CCL5 in obesity-induced adipose inflammation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Tatsuo Kawai, Michael Autieri, Rosario Scalia
Summary: Chronic low-grade inflammation of adipose tissue is linked to metabolic disease and organ complications, mainly caused by the secretion of inflammatory substances by adipocytes and infiltration of immune cells. Despite being low-grade, this inflammation negatively impacts remote organ function and is considered a causative factor of obesity-related complications.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Hyun Jeong Kim, Dooreh Kim, Soong June Bae, Sung Gwe Ahn, Joon Jeong, Woo-Chan Park, Young Hoon Ryu, Tae Joo Jeon, Yangkyu Lee, Yoon Jin Cha, Chang Ik Yoon
Summary: This study investigated the correlation between glucose metabolism in visceral adipose tissue (VAT) and survival outcomes in breast cancer patients. The findings suggest that high glucose metabolism in VAT, as measured by F-18-FDG PET/CT, may serve as a prognostic biomarker for adverse outcomes in breast cancer.
SCIENTIFIC REPORTS
(2022)
Article
Pharmacology & Pharmacy
Jiali Yang, Yunhui Ran, Yonghui Yang, Shuyi Song, Yahong Wu, Yuanming Qi, Yanfeng Gao, Guodong Li
Summary: The study found that 4-HIL can inhibit obesity-related insulin resistance by reducing inflammation and regulating the state of macrophages associated with obesity.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Benjamin Brustolin, Nina Touly, Marine Maillefer, Lola Parisot, Elisa Di Pillo, Marc Derive, Sebastien Gibot
Summary: This study demonstrates that TREM-1 plays a significant role in obesity and its associated complications. In the mouse model of high-fat diet-induced obesity, suppressing TREM-1 reduces weight gain, insulin resistance, and inflammation in white adipose tissue and liver. Therefore, TREM-1 could be a potential therapeutic target for obesity.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Nutrition & Dietetics
Federico Carbone, Elisa Nulli Migliola, Aldo Bonaventura, Alessandra Vecchie, Stefano De Vuono, Maria Anastasia Ricci, Gaetano Vaudo, Marcello Boni, Stefano Ministrini, Graziana Lupattelli, Fabrizio Montecucco
Summary: The study found that baseline serum levels of sclerostin are correlated with anthropometric measures of obesity and insulin resistance, particularly with peripheral insulin sensitivity. This suggests a close association between serum sclerostin and glycemic improvements after bariatric surgery.
Article
Biochemistry & Molecular Biology
Alessandra Feraco, Stefania Gorini, Caterina Mammi, Mauro Lombardo, Andrea Armani, Massimiliano Caprio
Summary: This study found that high-fat diet impairs glucose tolerance in mice and that the MR antagonist Spironolactone improves glucose tolerance. The expression of MR protein in skeletal muscle is downregulated by high-fat diet, but this effect can be partially reversed by Spironolactone.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Elena Rodriguez-Rodriguez, M. Dolores Salas-Gonzalez, Rosa M. Ortega, Ana M. Lopez-Sobaler
Summary: The aim of this study was to investigate the relationship between markers of inflammation and insulin resistance (IR) in overweight/obese children. The results showed that elevated white blood cell values and NLR may serve as indicators of the presence of IR in these subjects.
FRONTIERS IN NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Ailec Ho-Plagaro, Cristina Rodriguez-Diaz, Concepcion Santiago-Fernandez, Carlos Lopez-Gomez, Sara Garcia-Serrano, Flores Martin-Reyes, Francisca Rodriguez-Pacheco, Alberto Rodriguez-Canete, Guillermo Alcain-Martinez, Luis Vazquez-Pedreno, Sergio Valdes, Lourdes Garrido-Sanchez, Eduardo Garcia-Fuentes
Summary: This study found that regardless of the degree of insulin resistance, morbid obesity is associated with altered expression of genes related to intestinal defenses, antimicrobial and immune responses, and gastrointestinal cancer.
Review
Biochemistry & Molecular Biology
Maria Elisabeth Street, Sergio Bernasconi
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Public, Environmental & Occupational Health
Serena Broccoli, Olivera Djuric, Laura Bonvicini, Anna Maria Davoli, Elena Ferrari, Francesca Ferrari, Maria Elisabeth Street, Paolo Giorgi Rossi
PREVENTIVE MEDICINE
(2020)
Review
Pediatrics
Lorenzo Iughetti, Laura Lucaccioni, Maria E. Street, Sergio Bernasconi
CURRENT OPINION IN PEDIATRICS
(2020)
Review
Pediatrics
Maria E. Street, Francesca Cirillo, Cecilia Catellani, Marco Dauriz, Pietro Lazzeroni, Chiara Sartori, Paolo Moghetti
MINERVA PEDIATRICA
(2020)
Editorial Material
Biochemistry & Molecular Biology
Maria E. Street, Karine Audouze, Juliette Legler, Hideko Sone, Paola Palanza
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Vincenza Frisardi, Carmela Matrone, Maria Elisabeth Street
Summary: Metabolic syndrome is influenced by genetic, environmental, and lifestyle factors, with defects in the autophagy machinery playing a role in its dysfunction; there is a mutual regulation between autophagy and MetS, with the HMGB1 protein playing a key role in this interaction.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Environmental Sciences
Enza Mozzillo, Eugenio Zito, Valeria Calcaterra, Nicola Corciulo, Mario Di Pietro, Anna Di Sessa, Roberto Franceschi, Maria Rosaria Licenziati, Giulio Maltoni, Giuseppe Morino, Barbara Predieri, Maria Elisabeth Street, Giuliana Trifiro, Francesca Galle, Adriana Franzese, Giuliana Valerio
Summary: This study demonstrated the negative impact of unhealthy lifestyle behaviors and obesity on HRQOL in adolescents, while adherence to the Mediterranean Diet and higher levels of physical activity were associated with better HRQOL. These findings suggest that improving diet quality and increasing exercise may have a positive effect on adolescent obesity treatment and HRQOL.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Review
Endocrinology & Metabolism
Cecilia Catellani, Gloria Ravegnini, Chiara Sartori, Sabrina Angelini, Maria E. Street
Summary: Growth hormone and the insulin-like growth factor system play crucial roles in cell proliferation, differentiation, apoptosis, and angiogenesis, while miRNAs and lncRNAs regulate gene expression and have been linked to diseases such as cancer.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Pediatrics
Maria E. Street, Chiara Sartori, Cecilia Catellani, Beatrice Righi
Summary: Italy has seen an increase in precocious puberty during the pandemic, which may be attributed to lifestyle changes, alterations in central nervous mediators, and exposure to endocrine disruptors. Further research is needed to better understand and address this phenomenon.
FRONTIERS IN PEDIATRICS
(2021)
Article
Biochemistry & Molecular Biology
Maria Elisabeth Street, Paolo Moghetti, Francesco Chiarelli
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Medicine, General & Internal
Maria Elisabeth Street
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Nutrition & Dietetics
Serafina Perrone, Chiara Caporilli, Federica Grassi, Mandy Ferrocino, Eleonora Biagi, Valentina Dell'Orto, Virginia Beretta, Chiara Petrolini, Lucia Gambini, Maria Elisabeth Street, Andrea Dall'Asta, Tullio Ghi, Susanna Esposito
Summary: Bone health in the fetus and newborn is influenced by maternal health and nutrition. The 'foetal programming' of oxidative stress and endocrine systems plays a role in skeletal growth and development. The use of technologies like radiofrequency ultrasound spectrometry can help assess bone mineral density and prevent conditions like osteoporosis.
Article
Endocrinology & Metabolism
Cecilia Catellani, Gloria Ravegnini, Chiara Sartori, Beatrice Righi, Pietro Lazzeroni, Laura Bonvicini, Silvia Poluzzi, Francesca Cirillo, Barbara Predieri, Lorenzo Iughetti, Paolo Giorgi Rossi, Sabrina Angelini, Maria Elisabeth Street
Summary: This study found that the expression of miR-199a-5p, miR-335-5p, and miR-494-3p changed after 3 months of GH treatment in patients with IIGHD, which might reflect the degree of GH deficiency and the sensitivity to treatment. Furthermore, these miRNA changes were of considerable importance in predicting growth response.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Pediatrics
Maria Elisabeth Street, Sergio Bernasconi
ITALIAN JOURNAL OF PEDIATRICS
(2021)
Article
Obstetrics & Gynecology
Maria E. Street
MINERVA GINECOLOGICA
(2020)
