Article
Pharmacology & Pharmacy
Wanlong Zhu, Ke Peng, Yan Zhao, Changjing Xu, Xuemei Tao, Yuanzhi Liu, Yilan Huang, Xuping Yang
Summary: Emerging evidence suggests that supplementation of Sodium butyrate (NaB), a short-chain fatty acid, in mice fed with a high-fat diet (HFD) or chow diet can have beneficial effects in combating obesity and its associated metabolic disorders. NaB treatment was found to reverse the down-regulated expression of thermogenic regulators and attenuate obesity-induced insulin resistance, inflammation, fatty liver, and intestinal dysfunction. Mechanistically, NaB promotes fat thermogenesis through increased sympathetic innervation of adipose tissue, and this effect is abolished by blocking the beta 3-adrenergic signaling pathway. Overall, NaB reveals a potential pharmacological target to combat obesity and metabolic disorders.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Endocrinology & Metabolism
Marina Agueda-Oyarzabal, Brice Emanuelli
Summary: Brown adipose tissue and white adipose tissue are influenced by immune cells, which play a crucial role in maintaining and activating the adipose tissue through complex communication networks.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Pharmacology & Pharmacy
Xuping Yang, Qinhui Liu, Yanping Li, Yi Ding, Yan Zhao, Qin Tang, Tong Wu, Lei Chen, Shiyun Pu, Shihai Cheng, Jinhang Zhang, Zijing Zhang, Ya Huang, Rui Li, Yingnan Zhao, Min Zou, Xiongjie Shi, Wei Jiang, Rui Wang, Jinhan He
Summary: The study shows that treatment with canagliflozin helps resist high-fat diet-induced obesity and its metabolic consequences by reducing fat mass and increasing energy expenditure through enhancing thermogenesis and lipolysis in adipose tissue. Canagliflozin also improves insulin resistance and hepatic steatosis via elevating adipose sympathetic innervation and fat mobilization through a beta(3)-adrenoceptor-cAMP-PKA signaling pathway.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Review
Endocrinology & Metabolism
Anna-Claire Pilkington, Henry A. Paz, Umesh D. Wankhade
Summary: Adipose tissue is classified based on its characteristics, but differentiating beige adipose tissue (BeAT) remains a challenge. Recent research focuses on identifying different types of adipose tissue through transcript markers to advance understanding of their biology. The development of concrete strategies to distinguish types of adipose tissue may be crucial for improving metabolic health and preventing excessive weight gain.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Multidisciplinary Sciences
Violeta I. Gallardo-Montejano, Chaofeng Yang, Lisa Hahner, John L. McAfee, Joshua A. Johnson, William L. Holland, Rodrigo Fernandez-Valdivia, Perry E. Bickel
Summary: Exposure to cold induces significant changes in brown adipose tissue, with a marked increase in PLIN5, which plays a crucial role in maintaining mitochondrial structure and respiratory function. Enhancing PLIN5 function in BAT may lead to healthy remodeling of white adipose tissue and improvements in systemic glucose tolerance and hepatic steatosis, making it a potential therapeutic target for metabolic disorders.
NATURE COMMUNICATIONS
(2021)
Review
Oncology
Bahar Zehra Camurdanoglu Weber, Dilsad H. Arabaci, Serkan Kir
Summary: Cancer cachexia is a disorder characterized by wasting of adipose tissue and skeletal muscle, leading to severe weight loss. There is a limited range of treatment options available for this condition. Changes in metabolic pathways in adipose tissue are associated with cancer cachexia. The energy-wasting circuits in adipose tissue impact whole-body metabolism, particularly skeletal muscle. Targeting key molecular players involved in metabolic reprogramming may help in developing new treatment strategies for cancer cachexia.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Woo Yong Park, Gahee Song, Mina Boo, Hyo In Kim, Ja Yeon Park, Se Jin Jung, Minji Choi, Beomsu Kim, Young Doo Kim, Myung-Ho Kim, Kwan-Il Kim, Hyun Jeong Kwak, Jungtae Leem, Jae-Young Um, Jinbong Park
Summary: Obesity is a global health burden. The AMGB decoction, a multi-herb decoction, has shown clinical anti-obesity effects by suppressing body weight gain and obesity-related parameters, as well as inducing lipolysis in adipose tissues.
Article
Endocrinology & Metabolism
Vitor Ferreira, Cintia Folgueira, Maria Guillen, Pablo Zubiaur, Marcos Navares, Assel Sarsenbayeva, Pilar Lopez-Larrubia, Jan W. Eriksson, Maria J. Pereira, Francisco Abad-Santos, Guadalupe Sabio, Patricia Rada, Angela M. Valverde
Summary: This study evaluated the effects of olanzapine on body weight and energy balance in mice and proposed a new perspective on the crosstalk between the hypothalamus and adipose tissue. The results showed that activation of hypothalamic AMPK can prevent olanzapine-induced weight gain by promoting BAT thermogenesis and iWAT browning.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2022)
Article
Biochemistry & Molecular Biology
Prasanna K. R. Allu, Esther Paulo, Ambre M. Bertholet, Gavin Situ, Seung-Hwan Lee, Yixuan Wu, Catherine E. Gleason, Bidisha Saha, Ajay Chawla, Biao Wang, David Pearce
Summary: This passage discusses the importance of nonshivering thermogenesis in mammals and its mechanism. The core mechanism involves skin thermoreceptors sensing temperature, nerve signals transmitted to the hypothalamus to generate signals that activate brown adipocytes. In response to mild cold, beta-adrenergic signals not only stimulate fatty acid oxidation but also promote lipogenesis through the mTORC2-Akt signaling module.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Lupeng Chen, Yi Jin, Jian Wu, Zhuqing Ren
Summary: This article reviews the important role of lipid droplets (LDs) in thermogenesis, including the mechanisms of fatty acid release and UCP1 activation, as well as the interactions between LDs and mitochondria and the process of lipophagy. These research advances contribute to a better understanding of the functions of LDs in regulating body temperature.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Review
Endocrinology & Metabolism
Alev Eroglu Altinova
Summary: The browning of white adipose tissue (WAT), which refers to the emergence of beige adipocytes, can be influenced by various factors such as cold, beta (3)-adrenergic stimulation, and excess adiposity. Recent studies suggest that therapies targeting the browning of WAT can be effective in reducing obesity.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Nutrition & Dietetics
Annett Hoffmann, Thomas Ebert, Mohammed K. Hankir, Gesine Flehmig, Nora Kloeting, Beate Jessnitzer, Ulrike Lossner, Michael Stumvoll, Matthias Bluher, Mathias Fasshauer, Anke Toenjes, Konstanze Miehle, Susan Kralisch
Summary: Lipodystrophy syndromes are rare disorders characterized by a lack of adipose tissue and metabolic dysfunction. Treatment with leptin can stimulate brown adipose tissue thermogenesis, providing metabolic benefits.
Article
Biochemistry & Molecular Biology
Haopeng Xiao, Luiz H. M. Bozi, Yizhi Sun, Christopher L. Riley, Vivek M. Philip, Mandy Chen, Jiaming Li, Tian Zhang, Evanna L. Mills, Margo P. Emont, Wenfei Sun, Anita Reddy, Ryan Garrity, Jiani Long, Tobias Becher, Laura Potano Vitas, Dina Laznik-Bogoslavski, Martha Ordonez, Xinyue Liu, Xiong Chen, Yun Wang, Weihai Liu, Nhien Tran, Yitong Liu, Yang Zhang, Aaron M. Cypess, Andrew P. White, Yuchen He, Rebecca Deng, Heiko Schoder, Joao A. Paulo, Mark P. Jedrychowski, Alexander S. Banks, Yu-Hua Tseng, Paul Cohen, Linus T. Tsai, Evan D. Rosen, Samuel Klein, Maria Chondronikola, Fiona E. McAllister, Nick Van Bruggen, Edward L. Huttlin, Bruce M. Spiegelman, Gary A. Churchill, Steven P. Gygi, Edward T. Chouchani
Summary: By studying a genetically diverse cohort of mice, researchers have identified the functional architecture of brown adipose tissue (BAT) proteome and discovered key regulators of BAT. They also found proteins that are associated with protection from or sensitivity to metabolic diseases. These findings provide important insights into the conserved mechanisms of BAT regulation over metabolic physiology.
Review
Endocrinology & Metabolism
Khanyisani Ziqubu, Phiwayinkosi V. Dludla, Sinenhlanhla X. H. Mthembu, Bongani B. Nkambule, Sihle E. Mabhida, Babalwa U. Jack, Tawanda M. Nyambuya, Sithandiwe E. Mazibuko-Mbeje
Summary: Brown adipose tissue (BAT) has been extensively studied as a potential avenue to combat obesity due to its thermoregulatory function and energy expenditure promotion. In obesity, BAT and beige adipose tissue exhibit whitening characteristics, which are associated with various factors including diet, age, genetics, thermoneutrality, and chemical exposure. Whitening is marked by the accumulation of large unilocular lipid droplets, mitochondrial degeneration, and collapsed thermogenic capacity, by the virtue of mitochondrial dysfunction, devascularization, autophagy, and inflammation.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Juliane Weiner, Lisa Roth, Mathias Kranz, Peter Brust, Anita Boelen, Nora Kloeting, John T. Heiker, Matthias Blueher, Anke Toenjes, Paul T. Pfluger, Michael Stumvoll, Jens Mittag, Kerstin Krause
Summary: This study identified a previously unknown endocrine loop where leptin acts in concert with the HPT axis to stabilize body temperature in hypothyroid mice. Leptin regulates body temperature not only by directly affecting heat production, but also by stimulating the HPT axis to maintain TH serum levels.
MOLECULAR METABOLISM
(2021)
Review
Endocrinology & Metabolism
Minqian Shen, Haifei Shi
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
(2015)
Review
Endocrinology & Metabolism
Xian Liu, Haifei Shi
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
(2015)
Editorial Material
Endocrinology & Metabolism
Haifei Shi, Lynda M. Brown, Roshanak Rahimian
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
(2015)
Article
Multidisciplinary Sciences
Manu Kalyani, Kathryn Hasselfeld, James M. Janik, Phyllis Callahan, Haifei Shi
Article
Biochemistry & Molecular Biology
Manu Kalyani, Phyllis Callahan, James M. Janik, Haifei Shi
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2017)
Article
Biochemistry & Molecular Biology
Jingyi Cao, Qi Zhu, Lin Liu, Bradley J. Glazier, Benjamin C. Hinkel, Chun Liang, Haifei Shi
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2018)
Article
Psychology, Biological
Xian Liu, Zheng Zhu, Manu Kalyani, James M. Janik, Haifei Shi
PHYSIOLOGY & BEHAVIOR
(2014)
Article
Endocrinology & Metabolism
Minqian Shen, Jingyi Cao, Haifei Shi
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Sydney Pence, Qi Zhu, Erin Binne, Min Liu, Haifei Shi, Chunmin C. Lo
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Biochemistry & Molecular Biology
Sydney Pence, Zachary LaRussa, Zhijun Shen, Min Liu, Karen T. Coschigano, Haifei Shi, Chunmin C. Lo
Summary: The study found that centrally administered Apolipoprotein A-IV regulates thermogenesis in brown adipose tissue through sympathetic and sensory nerves.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Minqian Shen, Mengyang Xu, Fanyi Zhong, McKenzie C. Crist, Anjali B. Prior, Kundi Yang, Danielle M. Allaire, Fouad Choueiry, Jiangjiang Zhu, Haifei Shi
Summary: This study investigates the role of estrogen and its receptors in regulating gene expression and metabolism in HCC cells, suggesting that estrogen acts through its receptors to suppress liver cancer cell growth by altering metabolism.
Review
Cell Biology
Kristen N. Krolick, Haifei Shi
Summary: Estrogens play a crucial role in the neuroendocrine regulation of energy homeostasis, contributing to sex differences induced by chronic stress. Females are more susceptible to the psychological consequences of stress, while males are more vulnerable to metabolic consequences. Researchers hypothesize that gonadal hormones are key factors in stress studies, with estrogens recognized for their protective effects on metabolic dysregulation.
Article
Nutrition & Dietetics
Hsuan-Chih N. Kuo, Zachary LaRussa, Flora Mengyang Xu, Kathryn West, Leslie Consitt, William Sean Davidson, Min Liu, Karen T. T. Coschigano, Haifei Shi, Chunmin C. C. Lo
Summary: Long-chain fatty acids induce apolipoprotein A4 (APOA4) production, leading to increased thermogenesis and triglyceride clearance in brown adipose tissue (BAT). Continuous infusion of recombinant APOA4 protein stimulates sympathetic activity and thermogenesis in BAT, and improves lipid and glucose metabolism.