期刊
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
卷 44, 期 2, 页码 559-568出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/ijmm.2019.4242
关键词
bioresource; agricultural by-product; anti-photoaging; matrix metalloproteinase; HR-1 hairless mouse
资金
- Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry and Fisheries, the High Value-added Food Technology Development Program [314076-3]
- Kangwon National University
- National Research Foundation of Korea - Korean Government [NRF-2018 H1A2A1062634]
Processed products from agricultural produce generate a large number of agricultural by-products that contain a number of functional substances. These are often discarded owing to the lack of suitable processing methods. The present study investigated the anti-photoaging properties of fermented rice bran (FRB), soybean cake (FSB) and sesame seed cake (FSC) on ultraviolet B (UVB)-irradiated hairless mouse skin. Results indicated that the oral administration of FRB, FSB and FSC effectively inhibited the UVB irradiation-induced expression of matrix metalloproteinase (MMP)-2, MMP-9, MMP-3 and MMP-13. Reverse transcription-quantitative polymerase chain reaction results also demonstrated that FRB, FSB and FSC significantly inhibited the UVB-induced expression of the genes encoding tumor necrosis factor-alpha, inducible nitric oxide synthase, interleukin (IL)-6 and IL-1 beta when compared with the UVB-vehicle group (P<0.05). Additionally, collagen degradation and mast cell infiltration were reduced in hairless mouse skin. Furthermore, UVB-induced wrinkle formation was also significantly reduced in mouse skin compared with the UVB-vehicle group (P<0.05). These results reveal that fermented agricultural by-products may serve as potential functional materials with anti-photoaging activities.
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