Article
Nutrition & Dietetics
Karl Michaelsson, Susanna C. Larsson
Summary: Recent cohort studies have shown a causal link between increased circulating alpha-tocopherol and greater bone mineral density, with no association with the odds of fractures. This suggests the need for intervention studies targeting individuals with low dietary intake of alpha-tocopherol, as well as Mendelian randomization studies focusing on fragility fractures as an outcome.
Article
Endocrinology & Metabolism
Bin He, Lifeng Yin, Muzi Zhang, Qiong Lyu, Zhengxue Quan, Yunsheng Ou
Summary: Genetically high pulse pressure (PP) was found to have a significant improvement effect on forearm bone mineral density (FA-BMD) in this MR study, while the causal relationship between other bone densities, falls, and fractures needs further investigation.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Baoshan Ma, Chongyang Li, Jianqiao Pan, Shuzheng Zhang, Heng Dong, Yiming Wu, Jun Lv
Summary: The study investigated causal relationships between anthropometric measurements and bone mineral density (BMD) or fracture risk using Mendelian randomization (MR) methods. The results showed that an increase in height was associated with higher fracture risk and lower estimated BMD, while BMI was only causally associated with BMD. Other anthropometric measurements like WHR, HC, and WC adjusted for BMI were not found to be related to fracture occurrence or BMD.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Endocrinology & Metabolism
Johan Quester, Maria Nethander, Anna Eriksson, Claes Ohlsson
Summary: This study uses Mendelian randomization to show a causal association between genetically predicted DHEAS levels and increased lumbar spine bone density and decreased forearm fracture risk in women.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Maki Yokomoto-Umakoshi, Hironobu Umakoshi, Norifusa Iwahashi, Yayoi Matsuda, Hiroki Kaneko, Masatoshi Ogata, Tazuru Fukumoto, Eriko Terada, Yui Nakano, Ryuichi Sakamoto, Yoshihiro Ogawa
Summary: The study conducted Mendelian randomization analysis to investigate the role of DHEAS in age-related changes in bone mineral density and fracture risk. Results showed that an increase in serum DHEAS concentrations was associated with increased BMD and decreased fracture risk. BMD was identified as the main mediating factor for the association between DHEAS and fracture, which was observed in men but not in women.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Nutrition & Dietetics
Yuehui Liang, Ming-Gang Deng, Qinghong Jian, Minjie Zhang, Shuai Chen
Summary: This study used Mendelian randomization methods to investigate the causal relationship between childhood obesity and bone health. The findings suggest that childhood obesity is causally associated with increased bone density and decreased risk of leg fracture in adults.
FRONTIERS IN NUTRITION
(2022)
Article
Medicine, General & Internal
Ziang Li, Bin Zhang, Qingrong Liu, Zhihang Tao, Lu Ding, Bo Guo, Erli Zhang, Haitong Zhang, Zhen Meng, Shuai Guo, Yang Chen, Jia Peng, Jinyue Li, Can Wang, Yingbo Huang, Haiyan Xu, Yongjian Wu
Summary: This Mendelian randomisation study aimed to explore the causal role of lipid traits in non-alcoholic fatty liver disease (NAFLD) and evaluate the potential effect of lipid-lowering drug targets on NAFLD. The results showed no significant effect of lipid traits on NAFLD risk, but genetic mimicry of lipoprotein lipase (LPL) enhancement was associated with lower NAFLD risks, suggesting LPL as a promising candidate drug target for NAFLD.
Article
Endocrinology & Metabolism
Huajie Dai, Longyi Zheng, Zheng Zhu, Xin Geng, Tianzhichao Hou, Qi Wang, Yijie Zhu, Hong Lin, Shuangyuan Wang, Ruizhi Zheng, Zhiyun Zhao, Mian Li, Jieli Lu, Yu Xu, Tiange Wang, Jianmin Liu, Guang Ning, Weiqing Wang, Yufang Bi, Jie Zheng, Min Xu
Summary: This study aimed to evaluate the causal effect of SGLT2 inhibition on BMD, osteoporosis, and fracture risk using genetics. The results showed little evidence of association between genetically proxied SGLT2 inhibition and BMD, osteoporosis, or most types of fracture. Only a nominal significance was found for fracture of the lower leg and shoulder and upper arm. This study does not support an effect of genetically proxied SGLT2 inhibition on fracture risk.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Jidong Song, Tun Liu, Jiaxin Zhao, Siyuan Wang, Xiaoqian Dang, Wei Wang
Summary: This study found a positive causal relationship between hand grip strength and lumbar bone mineral density, with no causal relationship found for other sites. Additionally, hand grip strength did not significantly impact fracture risk.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Shaofeng Wu, Zhen Ye, Yi Yan, Xinli Zhan, Liang Ren, Chenxing Zhou, Tianyou Chen, Yuanlin Yao, Jichong Zhu, Siling Wu, Fengzhi Ma, Lu Liu, Binguang Fan, Chong Liu
Summary: This study explores the causal relationship between autoimmune diseases and bone mineral density, falls, and fractures using Mendelian randomization. The results show a negative causal relationship between ulcerative colitis (UC) and forearm and total body BMD, as well as between inflammatory bowel disease (IBD) and total body BMD at the age of 45-60 years. These findings have implications for future research and the development of public health interventions for osteoporosis.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Xiaoxiao Ji, Jianqiao Hong, Zihao Qu, Weinan Yang, Yibo Wang, Jiyan Lin, Congsun Li, Jie Wang, Haochen Mou, Mingmin Shi, Chenhe Zhou, Wei Wang, Changjian Lin, Shigui Yan, Haobo Wu
Summary: This study revealed a significant causal effect of HbA1c on eBMD, and suggested that this causal link may be achieved through non-glycemic pathways (erythrocytic indices).
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Xin Huang, Tianxin Zhang, Ping Guo, Weiming Gong, Hengchao Zhu, Meng Zhao, Zhongshang Yuan
Summary: In this study, researchers conducted a comprehensive drug-target Mendelian randomization analysis to explore the associations between genetic proxies for antihypertensive drugs and bone health-related traits. The results showed that genetic proxies for angiotensin receptor blockers (ARBs) were associated with a reduced risk of fracture and higher bone mineral density (BMD). On the other hand, genetic proxies for calcium channel blockers (CCBs) were associated with an increased risk of fracture, while genetic proxies for potassium sparing diuretics (PSDs) were associated with lower BMD. The study highlights the potential effects of different antihypertensive drugs on bone health.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Shuai Yuan, Zi-Hao Wan, Shi-Le Cheng, Karl Michaelsson, Susanna C. Larsson
Summary: The study suggests that higher levels of circulating IGF-1 are associated with increased bone mineral density and reduced fracture risk. The positive association between IGF-1 and fracture persisted even after adjustment for bone mineral density, indicating a potentially independent role of IGF-1 in preventing fractures.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Dentistry, Oral Surgery & Medicine
Yang Yu, Tengda Chu, Jingya Dong, Hui Deng, Yihuai Pan, Yi Wang
Summary: This study used Mendelian randomization to investigate the causal association between bone mineral density (BMD) and periodontitis. The results did not show any evidence of a causal association between BMD and periodontitis or loose teeth.
Article
Endocrinology & Metabolism
Liwan Fu, Yuquan Wang, Yue-Qing Hu
Summary: Using a two-sample Mendelian randomization design, this study inferred the inverse causal effects of homocysteine and vitamin B12 on bone mineral density (BMD) in certain body sites and age strata. These findings provide novel clues for intervening bone-related diseases in public health and nutrition.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Psychology, Clinical
Gloria Hoi-Yee Li, Ching-Lung Cheung, Albert Kar-Kin Chung, Bernard Man-Yung Cheung, Ian Chi-Kei Wong, Marcella Lei Yee Fok, Philip Chun-Ming Au, Pak-Chung Sham
Summary: This study aims to investigate the causal relationship between genetic predisposition to depression and cardiovascular disease (CVD). The results show a genetic correlation between depression and myocardial infarction (MI) and atrial fibrillation (AF), and causality between genetically doubling the odds of depression and increased risk of CAD and MI. Adjustment for blood lipid levels and smoking status attenuated the causal relationship between depression and CAD/MI.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Virology
Suhas Krishnamoorthy, Gloria H-Y Li, Ching-Lung Cheung
Summary: This study used summary data-based Mendelian randomization analysis to identify 309 significant gene-trait associations potentially causally associated with severe COVID-19. These genes are involved in multiple biological processes and improve our understanding of the mechanism of COVID-19, providing insights for the development of therapeutic agents for treating severe COVID-19. Additionally, unique genes and biological processes were identified for hospitalized COVID-19 and SARS-CoV-2 infection.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Public, Environmental & Occupational Health
Wang Chun Kwok, Terence Chi Chun Tam, Chor Wing Sing, Esther Wai Yin Chan, Ching-Lung Cheung
Summary: This study evaluated the validity of the ICD-9 code algorithm for identifying bronchiectasis in the CDARS database in Hong Kong. Among 19,617 patients in public hospitals and 1,866 patients in Queen Mary Hospital, the overall positive predictive value (PPV) for the ICD-9 code 494 diagnosis of bronchiectasis was 92.7%.
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
(2023)
Article
Multidisciplinary Sciences
Francisco Tsz Tsun Lai, Min Fan, Caige Huang, Celine Sze Ling Chui, Eric Yuk Fai Wan, Xue Li, Carlos King Ho Wong, Ching-Lung Cheung, Ian Chi Kei Wong, Esther Wai Yin Chan
Summary: Extending the interval between doses of mRNA Covid-19 vaccines has been linked with a reduced risk of myocarditis in children and adolescents, but impacts on vaccine effectiveness are not known.
NATURE COMMUNICATIONS
(2023)
Review
Endocrinology & Metabolism
Kat-Tik Lau, Suhas Krishnamoorthy, Chor-Wing Sing, Ching Lung Cheung
Summary: The purpose of this review was to systematically examine recent studies on the association between metabolites and bone mineral density (BMD) in humans. A total of 16 articles were included in this review after screening 170 studies. More than 400 unique metabolites in blood were found to be significantly associated with BMD, and valine and glycine were consistently associated with BMD, while leucine showed inconsistent associations.
CURRENT OSTEOPOROSIS REPORTS
(2023)
Article
Medicine, General & Internal
Gloria Hoi-Yee Li, Ching -Lung Cheung, Kathryn Choon-Beng Tan, Annie Wai-Chee Kung, Timothy Chi-Yui Kwok, Wallis Cheuk-Yin Lau, Janus Siu-Him Wong, Warrington W. Q. Hsu, Christian Fang, Ian Chi-Kei Wong
Summary: Sex-specific hip fracture prediction models were developed using electronic health records (EHR) without bone mineral density (BMD) data. The logistic regression (LR) model showed better discrimination and classification performance than machine learning (ML) algorithms in both internal and independent validation cohorts for both females and males. The LR models could be integrated into routine clinical workflow to identify high-risk individuals for DXA scan.
Article
Endocrinology & Metabolism
Ching-Lung Cheung, Gloria HY. Li, Hang-Long Li, Constance Mak, Kathryn CB. Tan, Annie WC. Kung
Summary: To enhance public awareness and facilitate diagnosis of osteoporosis, a new Chinese Osteoporosis Screening Algorithm (COSA) was developed to identify individuals at high risk of osteoporosis. This algorithm demonstrated improved reclassification performance compared to existing tools and showed significant associations with fracture risk. The COSA was specific for Hong Kong Chinese and can serve as an effective screening tool in this population.
OSTEOPOROSIS AND SARCOPENIA
(2023)
Article
Medicine, General & Internal
Xi Xiong, David Tak Wai Lui, Matthew Shing Hin Chung, Ivan Chi Ho Au, Francisco Tsz Tsun Lai, Eric Yuk Fai Wan, Celine Sze Ling Chui, Xue Li, Franco Wing Tak Cheng, Ching-Lung Cheung, Esther Wai Yin Chan, Chi Ho Lee, Yu Cho Woo, Kathryn Choon Beng Tan, Carlos King Ho Wong, Ian Chi Kei Wong
Summary: This study aimed to investigate the risk of incident diabetes following COVID-19 vaccination. The results showed no increased risk of incident diabetes after COVID-19 vaccination. However, SARS-CoV-2 infection was associated with a significantly higher risk of incident diabetes, especially type 2 diabetes.
Article
Endocrinology & Metabolism
Suhas Krishnamoorthy, Gloria Hoi-Yee Li, Kelvin Shun-Cheong Ho, Yin-Pan Chau, Constance Mak, Donna Ng, Albert Kar-Kin Chung, Jody Kwok-Pui Chu, Kathryn Choon-Beng Tan, Ruby Lai-Chong Hoo, Ching-Lung Cheung
Summary: Illicit drug use is associated with lower bone mineral density and bone strength.
OSTEOPOROSIS AND SARCOPENIA
(2023)
Letter
Endocrinology & Metabolism
Ching-Lung Cheung
OSTEOPOROSIS AND SARCOPENIA
(2023)
Article
Medicine, General & Internal
David Tak Wai Lui, Ivan Chi Ho Au, Eric Ho Man Tang, Ching Lung Cheung, Chi Ho Lee, Yu Cho Woo, Tingting Wu, Kathryn Choon Beng Tan, Carlos King Ho Wong
Summary: This study compared the impacts of SGLT2i and GLP1RA on kidney outcomes in patients with type 2 diabetes and found that SGLT2i may be superior to GLP1RA in reducing kidney outcomes. In real-world application, SGLT2i users had a lower risk of composite kidney outcomes and a slower decline in eGFR.