Article
Multidisciplinary Sciences
Takao Konishi, Saikat Kumar B. Ghosh, Yu Sato, Rika Kawakami, Kenji Kawai, Aimee E. Vozenilek, Weili Xu, Arielle Bellissard, Robert Giasolli, Diljon Chahal, Renu Virmani, Aloke V. V. Finn
Summary: This study investigated the thickness of the coronary medial and found that it varies depending on the coronary artery itself, its segments, and branches. The findings are important for coronary intervention and product development.
Article
Cardiac & Cardiovascular Systems
Kyung An Kim, Kwan Yong Lee, Byung-Hee Hwang, Do Yeon Kim, Chan Beom Park
Summary: A 77-year-old man underwent PCI with complications of CAP. Initially, the CAP was thought to have resolved, but seven months later, the patient developed progressive symptoms and was found to have increased pericardial effusion. Pericardiectomy was performed with successful recovery and stability three years later.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Hematology
Marc Laine, Vassili Panagides, Corinne Frere, Thomas Cuisset, Caroline Gouarne, Bernard Jouve, Gilles Lemesle, Franck Paganelli, Marie-Christine Alessi, Julien Mancini, Laurent Bonello
Summary: This study aimed to investigate the association between ticagrelor platelet reactivity (PR) and clinical outcomes in ACS patients undergoing PCI. The results showed that PR measured by the VASP was not associated with bleeding or thrombotic events in this clinical setting. Therefore, PR measured by the VASP should not be used as a surrogate endpoint in studies on ticagrelor.
THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Cardiac & Cardiovascular Systems
Akhmetzhan Galimzhanov, Yersyn Sabitov, Erhan Tenekecioglu, Han Naung Tun, Mirvat Alasnag, Mamas A. Mamas
Summary: This study conducted a meta-analysis of 19 studies and found a significant association between baseline platelet count and clinical outcomes in patients undergoing PCI. Low platelet counts were associated with bleeding risk, while high platelet counts were associated with ischemic events.
Article
Cardiac & Cardiovascular Systems
Ersin C. Simsek, Tuncay Kiris
Summary: Early clinical outcomes following CAP, including cardiac tamponade and 30-day cardiovascular mortality, were significantly worse in patients with ACS compared to those with stable CAD. However, there was no significant difference in all-cause mortality between the two groups at the 3-year follow-up.
CORONARY ARTERY DISEASE
(2021)
Article
Cardiac & Cardiovascular Systems
Yuki Obayashi, Hirotoshi Watanabe, Takeshi Morimoto, Ko Yamamoto, Masahiro Natsuaki, Takenori Domei, Kyohei Yamaji, Satoru Suwa, Tsuyoshi Isawa, Hiroki Watanabe, Ruka Yoshida, Hiroki Sakamoto, Masaharu Akao, Yoshiki Hata, Itsuro Morishima, Hideo Tokuyama, Masahiro Yagi, Hiroshi Suzuki, Kohei Wakabayashi, Nobuhiro Suematsu, Tsukasa Inada, Toshihiro Tamura, Hideki Okayama, Mitsuru Abe, Kazuya Kawai, Koichi Nakao, Kenji Ando, Kengo Tanabe, Yuji Ikari, Yoshihiro Morino, Kazushige Kadota, Yutaka Furukawa, Yoshihisa Nakagawa, Takeshi Kimura
Summary: In this study, clopidogrel monotherapy after 1-month dual antiplatelet therapy was found to reduce major bleeding events without increasing cardiovascular events compared to 12-month dual antiplatelet therapy with aspirin and clopidogrel.
CIRCULATION-CARDIOVASCULAR INTERVENTIONS
(2022)
Article
Medicine, General & Internal
Fahad B. Tahir, Sualeha Zulfiqar, Muhammad Umair Rana, Fawad Haroon
Summary: Rotational atherectomy (RA) is a procedure used in complex percutaneous coronary intervention (PCI) to remove calcified plaque, but it carries an increased risk of complications. Coronary perforation is a major complication of RA, which is usually identified and managed during the procedure. However, there are rare cases where delayed complications occur, leading to significant morbidity and mortality.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Review
Cardiac & Cardiovascular Systems
Davide Capodanno, Deepak L. Bhatt, C. Michael Gibson, Stefan James, Takeshi Kimura, Roxana Mehran, Sunil Rao, Philippe Gabriel Steg, Philip Urban, Marco Valgimigli, Stephan Windecker, Dominick J. Angiolillo
Summary: As the field of PCI advances, the importance of bleeding in treatment is increasingly recognized, being seen as having equally unfavorable prognostic implications as ischemic or thrombotic complications. Therefore, strategies focusing on maximizing treatment efficacy while minimizing safety concerns such as bleeding have become increasingly important.
NATURE REVIEWS CARDIOLOGY
(2022)
Article
Hematology
Shqipdona Lahu, Kristin Adler, Katharina Mayer, Ralph Hein-Rothweiler, Isabell Bernlochner, Gjin Ndrepepa, Stefanie Schuepke, Stefan Holdenrieder, Dario Bongiovanni, Karl-Ludwig Laugwitz, Heribert Schunkert, Meinrad Gawaz, Steffen Massberg, Adnan Kastrati, Gotz Muench
Summary: In patients with chronic coronary syndrome undergoing percutaneous coronary intervention, plasma levels of sGPVI did not correlate with platelet aggregation but patients with higher baseline levels of sGPVI had an increased risk of bleeding at 30 days after PCI.
THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Cardiac & Cardiovascular Systems
Deevia Kotecha, Marcos Garcia-Guimaraes, Diluka Premawardhana, Dario Pellegrini, Clare Oliver-Williams, Vasiliki Bountziouka, Alice Wood, Nalin Natarajan, Robert Jackson, Nathan Chan, Jan Ziaullah, Roby D. Rakhit, Stephen P. Hoole, Tom W. Johnson, Jacek Kadziela, Peter Ludman, Nilesh J. Samani, Angela H. E. M. Maas, Robert-Jan van Geuns, Fernando Alfonso, David Adlam
Summary: This study investigated the practice of PCI in SCAD patients and found that despite the higher risk associated with PCI in these patients, it can lead to improvements in coronary flow and positive long-term outcomes.
Review
Cardiac & Cardiovascular Systems
Alexander G. Truesdell, Mirvat A. Alasnag, Prashant Kaul, Syed Tanveer Rab, Robert F. Riley, Michael N. Young, Wayne B. Batchelor, Akiko Maehara, Frederick G. Welt, Ajay J. Kirtane, ACC Interventional Counci
Summary: Coronary angiography has been the standard for diagnosing coronary artery disease and guiding percutaneous coronary intervention (PCI). Intravascular imaging (IVI) technologies are used in conjunction with angiography to better assess plaque morphology and optimize PCI. IVI has utility in preintervention assessment, procedural guidance, and postintervention evaluation. IVI's role in reducing major adverse cardiac events in complex lesions is emerging, and further studies are underway. This paper provides an overview of available IVI technologies, reviews evidence supporting their use in PCI, and advocates for broader utilization.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Endocrinology & Metabolism
D. T. W. Lui, C. H. Wong, A. Ip, A. K. Y. Ng
Summary: This study compared the fracture risks associated with ticagrelor and clopidogrel in dual anti-platelet therapy (DAPT) among adults who underwent first-ever PCI for ACS. The results showed that ticagrelor use was associated with a lower risk of major osteoporotic fractures compared with clopidogrel use, supporting the use of ticagrelor in DAPT for better bone health.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Cardiac & Cardiovascular Systems
Ioannis Lianos, Charalampos Varlamos, Despoina-Rafailia Benetou, Christos Mantis, Konstantinos Kintis, Vassiliki-Maria Dragona, Ioannis Kanakakis, Dimitrios Sionis, Sotirios Patsilinakos, Dimitrios Alexopoulos
Summary: Platelet function testing (PFT) has potential clinical applications in guiding individualized antithrombotic treatment for patients with atrial fibrillation. Ticagrelor administration leads to lower platelet reactivity and reduced incidence of high on-treatment platelet reactivity compared to clopidogrel.
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
(2023)
Article
Cardiac & Cardiovascular Systems
Bjorn Redfors, Ajay J. Kirtane, Mengdan Liu, Daniel R. Musikantow, Bernhard Witzenbichler, Michael J. Rinaldi, D. Christopher Metzger, Giora Weisz, Thomas D. Stuckey, Bruce R. Brodie, Ori Ben-Yehuda, Roxana Mehran, Gregg W. Stone
Summary: This study assessed the association between premature dual antiplatelet therapy (DAPT) discontinuation and the risk of thrombotic events. The study found that unplanned DAPT discontinuation was associated with an increased risk of major adverse cardiac events (MACEs), particularly within 3 months after percutaneous coronary intervention (PCI).
JACC-CARDIOVASCULAR INTERVENTIONS
(2022)
Article
Medicine, General & Internal
Roberta De Rosa, Nuccia Morici, Giuseppe De Luca, Leonardo De Luca, Luca A. Ferri, Luigi Piatti, Giovanni Tortorella, Daniele Grosseto, Nicoletta Franco, Leonardo Misuraca, Paolo Sganzerla, Michele Cacucci, Roberto Antonicelli, Claudio Cavallini, Laura Lenatti, Chiara Leuzzi, Ernesto Murena, Amelia Ravera, Maurizio Ferrario, Elena Corrada, Delia Colombo, Francesco Prati, Federico Piscione, A. Sonia Petronio, Gennaro Galasso, Stefano De Servi, Stefano Savonitto
Summary: In elderly ACS patients aged 75 and older treated with PCI, there is no overall sex disparity in 1-year outcomes, but women exhibit higher cardiovascular mortality after STEMI. After adjusting for different baseline variables, female sex does not predict cardiovascular mortality.
AMERICAN JOURNAL OF MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Zahra Raisi-Estabragh, Ofer Kobo, Phillip Freeman, Steffen E. Petersen, Louis Kolman, Robert J. H. Miller, Ariel Roguin, Harriette G. C. Van Spall, Jacqueline Vuong, Eric H. Yang, Mamas A. Mamas
Summary: This study reports disease-specific cardiovascular causes of mortality among cancer patients in the USA between 1999 and 2019, considering temporal trends by age, sex, and cancer site. Ischaemic heart disease was the most common cardiovascular cause of death across all cancer types, followed by cerebrovascular disease and hypertensive diseases. Differential cardiovascular mortality risk was observed based on cancer site and demographics.
EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES
(2023)
Article
Cardiac & Cardiovascular Systems
Nicholas Weight, Saadiq Moledina, Giuseppe Biondi Zoccai, Sarah Zaman, Triston Smith, Jolanta Siller-Matula, Mohamed Dafaalla, Muhammad Rashid, James Nolan, Mamas A. Mamas
Summary: Little is known about the care outcomes and processes of patients with non-ST-segment myocardial infarction (NSTEMI) who have polyvascular disease. A study analyzed 287,279 NSTEMI patients and found that those with polyvascular disease had higher rates of major adverse cardiovascular events and in-hospital mortality. Patients without a history of vascular disease were less likely to receive statins or ACE inhibitors/ARBs, but more likely to receive dual antiplatelet therapy.
EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES
(2023)
Article
Cardiac & Cardiovascular Systems
Ofer Kobo, Majdi Saada, Clemens von Birgelen, Pim A. L. Tonino, Andres Iniguez-Romo, Ole Frobert, Majdi Halabi, Rohit M. Oemrawsingh, Jawed Polad, Alexander J. J. IJsselmuiden, Marco Roffi, Adel Aminian, Mamas A. Mamas, Ariel Roguin
Summary: Patients with previously known vascular disease have an increased risk of adverse cardiovascular events and mortality after percutaneous coronary intervention (PCI), with the highest risk among patients with multisite artery disease.
EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES
(2023)
Article
Cardiac & Cardiovascular Systems
Ioannis Merinopoulos, Tharusha Gunawardena, Natasha Corballis, U. Bhalraam, Tim Gilbert, Clint Maart, Paul Richardson, Alisdair Ryding, Toomas Sarev, Chris Sawh, Sreekumar Sulfi, Upul Wickramarachchi, Trevor Wistow, Mohamed O. Mohamed, Mamas A. Mamas, Vassilios S. Vassiliou, Simon C. Eccleshall
Summary: This study aimed to compare the safety of drug-coated balloon (DCB)-only angioplasty and drug-eluting stent (DES) as part of routine clinical practice. The results showed that DCB-only angioplasty is safe compared to DES for stable angina and predominantly large vessels.
CLINICAL RESEARCH IN CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Suleman Aktaa, Gorav Batra, Stefan K. James, Daniel J. Blackman, Peter F. Ludman, Mamas A. Mamas, Mohamed Abdel-Wahab, Gianni D. Angelini, Martin Czerny, Victoria Delgado, Giuseppe De Luca, Agricola Eustachio, Dan Foldager, Christian W. Hamm, Bernard Iung, Norman Mangner, Julinda Mehilli, Gavin J. Murphy, Darren Mylotte, Radoslaw Parma, Anna Sonia Petronio, Bodgan A. Popescu, Lars Sondergaard, Rui C. Teles, Manel Sabate, Christian J. Terkelsen, Luca Testa, Jianhua Wu, Aldo P. Maggioni, Lars Wallentin, Barbara Casadei, Chris P. Gale
Summary: The EuroHeart project aims to create pan-European data standards for cardiovascular diseases and interventions, including TAVI, to quantify quality of care and patient outcomes.
EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Gianluca Castaldi, Mamas A. Mamas
CARDIOVASCULAR REVASCULARIZATION MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Gemina Doolub, Pim A. L. Tonino, Sasko Kedev, Jacques Monsegu, Valeria Paradies, David Austin, Fabrizio Spano, Marco Roffi, Ole Frobert, Clemens Von Birgelen, Louise Buchanan, Mamas A. Mamas
Summary: This study found no significant differences in clinical outcomes between women and men who underwent complex PCI. Despite higher age and more cardiovascular risk factors in female patients, the occurrence rates of target lesion failure, target vessel failure, and cardiac death were comparable between women and men within 12 months.
AMERICAN JOURNAL OF CARDIOLOGY
(2023)
Article
Medicine, General & Internal
Magdalena Nowakowska, Salwa S. Zghebi, Li-Chia Chen, Darren M. Ashcroft, Evangelos Kontopantelis
Summary: This study used data from the Health Survey for England waves 1997-2014 to analyze the relationship between age and prescription opioid use in different socioeconomic groups. The findings showed that the association between age and opioid use varies across income and education levels. Higher income and education were associated with a lower probability of reported opioid use. The highest probability of opioid use was observed in the 40-60 age group among those with lower income and education. Employment status did not significantly affect opioid use. Further research is needed to understand opioid use patterns in older people, especially those from disadvantaged socioeconomic backgrounds.
Article
Medicine, General & Internal
Christos Grigoroglou, Kieran Walshe, Evangelos Kontopantelis, Jane Ferguson, Gemma Stringer, Darren Ashcroft, Thomas Allen
Summary: This study aimed to quantify and describe the use of locum doctors in NHS trusts in England from 2019 to 2021. The results showed significant variations in locum use among different trusts, with lower-rated and smaller trusts using locums more intensively. The study also highlighted a growing demand for locum doctors, as evidenced by the increasing number of unfilled shifts.
Article
Medicine, General & Internal
Daniel R. Morales, Mark Minchin, Evangelos Kontopantelis, Martin Roland, Matt Sutton, Bruce Guthrie
Summary: This study aimed to compare the impact of the withdrawal of the Quality and Outcomes Framework (QOF) scheme in primary care in Scotland in 2016 on the recorded quality of care, compared with England where the scheme continued. The results showed a significant decrease in performance for most quality of care indicators in Scotland after the abolition of QOF.
BMJ-BRITISH MEDICAL JOURNAL
(2023)
Article
Medicine, General & Internal
Rathi Ravindrarajah, Matt Sutton, David Reeves, Sarah Cotterill, Emma Mcmanus, Rachel Meacock, William Whittaker, Claudia Soiland-Reyes, Simon Heller, Peter Bower, Evangelos Kontopantelis
Summary: This study examines whether adults referred to the NHS Healthier You Diabetes Prevention Programme in England are less likely to develop type 2 diabetes mellitus. The findings show that people referred to the programme have a 20% lower risk of developing type 2 diabetes compared to those who were not referred. These results support the rapid implementation of the programme in England and suggest its continuation and expansion to other parts of the United Kingdom.
Article
Health Care Sciences & Services
Nicholas W. S. Chew, Bryan Chong, Si Min Kuo, Jayanth Jayabaskaran, Mingshi Cai, Huili Zheng, Rachel Goh, Gwyneth Kong, Yip Han Chin, Syed Saqib Imran, Michael Liang, Patrick Lim, Thon Hon Yong, Boon Wah Liew, Pow Li Chia, Hee Hwa Ho, David Foo, Deanna Khoo, Zijuan Huang, Terrance Chua, Jack Wei Chieh Tan, Khung Keong Yeo, Derek Hausenloy, Hui Wen Sim, Jieli Kua, Koo Hui Chan, Poay Huan Loh, Toon Wei Lim, Adrian F. Low, Ping Chai, Chi Hang Lee, Tiong Cheng Yeo, James Yip, Huay Cheem Tan, Mamas A. Mamas, Stephen J. Nicholls, Mark Y. Chan
Summary: The incidence of AMI is projected to continue rising, with overweight/obesity emerging as the fastest-growing metabolic risk factor and the leading risk factor for AMI-related mortality. Individuals of Indian and Malay descent bear a disproportionate burden of overweight/obesity incidence and AMI-related mortality.
LANCET REGIONAL HEALTH-WESTERN PACIFIC
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Enkhtsogt Sainbayar, Ramzi Ibrahim, Hoang Nhat Pham, Wisam Beauti, Mahek Shahid, Natalie Hickerson, Mohammed Salih, Joao Paulo Ferreira, Mamas A. Mamas
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Nicholas Weight, Saadiq Moledina, Muhammad Rashid, Nicholas Chew, Silvia Castelletti, Gill Louise Buchanan, Sonja Salinger, Chris P. Gale, Mamas A. Mamas
Summary: The incidence of NSTEACS in young patients under fifty in the UK has not decreased over the past seven years. Despite a reduction in smoking and family history of coronary artery disease, there has been an increase in the proportion of patients from ethnic minority backgrounds, those with diabetes, and female patients. In-hospital mortality from NSTEACS remains unchanged.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Gianluca Castaldi, Aditya S. Bharadwaj, Rodrigo Bagur, Harriette G. C. Van Spall, Ofer Kobo, Mamas A. Mamas
Summary: This study investigated the prevalence, clinical characteristics, and outcomes of type 2 myocardial infarction (T2AMI) in patients with and without cancer. The results showed that T2AMI patients with cancer had a higher incidence of acute respiratory failure, acute pulmonary embolism, major bleeding, and renal failure compared to those without cancer. They also had higher rates of in-hospital all-cause death.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
