Eukaryotic elongation factor 2 kinase promotes angiogenesis in hepatocellular carcinoma via PI3K/Akt and STAT3

EGF is highly expressed in hepatocellular carcinoma (HCC) and promotes motility of HCC cells via fibronectin

(2018) Zongcai Liu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Mechanisms underlying the relaxation by A484954, a eukaryotic elongation factor 2 kinase inhibitor, in rat isolated mesenteric artery

(2018) Tomoko Kodama et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

miR-214-5p targets KLF5 and suppresses proliferation of human hepatocellular carcinoma cells

(2018) Jinzhong Pang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Eukaryotic elongation factor 2 kinase upregulates the expression of proteins implicated in cell migration and cancer cell metastasis

(2017) Jianling Xie et al.   INTERNATIONAL JOURNAL OF CANCER

MiRNA199a-3p suppresses tumor growth, migration, invasion and angiogenesis in hepatocellular carcinoma by targeting VEGFA, VEGFR1, VEGFR2, HGF and MMP2

(2017) Alip Ghosh et al.   Cell Death & Disease

Eukaryotic Elongation Factor 2 Kinase (eEF2K) in Cancer

(2017) Xuemin Wang et al.   Cancers

Placental growth factor inhibition modulates the interplay between hypoxia and unfolded protein response in hepatocellular carcinoma

(2016) Yves-Paul Vandewynckel et al.   BMC CANCER

hTERT promotes tumor angiogenesis by activating VEGF via interactions with the Sp1 transcription factor

(2016) Ning Liu et al.   NUCLEIC ACIDS RESEARCH

Argonaute 2 promotes angiogenesis via the PTEN/VEGF signaling pathway in human hepatocellular carcinoma

(2015) Zhen-long Ye et al.   ACTA PHARMACOLOGICA SINICA

Eukaryotic elongation factor 2 kinase mediates monocrotaline-induced pulmonary arterial hypertension via reactive oxygen species-dependent vascular remodeling

(2015) Satoshi Kameshima et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Regulated stability of eukaryotic elongation factor 2 kinase requires intrinsic but not ongoing activity

(2015) Xuemin Wang et al.   BIOCHEMICAL JOURNAL

Regulation and roles of elongation factor 2 kinase

(2015) Christopher G. Proud   BIOCHEMICAL SOCIETY TRANSACTIONS

A pivotal role of Krüppel-like factor 5 in regulation of cancer stem-like cells in hepatocellular carcinoma

(2015) Osamu Maehara et al.   CANCER BIOLOGY & THERAPY

Surgical Resection and Liver Transplantation for Hepatocellular Carcinoma

(2015) Mohamed E. Akoad et al.   Clinics in Liver Disease

Targeting Kruppel-Like Factor 5 (KLF5) for Cancer Therapy

(2015) Yu Gao et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Elongation Factor 2 Kinase Is Regulated by Proline Hydroxylation and Protects Cells during Hypoxia

(2015) Claire E. J. Moore et al.   MOLECULAR AND CELLULAR BIOLOGY

Molecular Mechanism for the Control of Eukaryotic Elongation Factor 2 Kinase by pH: Role in Cancer Cell Survival

(2015) Jianling Xie et al.   MOLECULAR AND CELLULAR BIOLOGY

Targeting Angiogenesis in Cancer Therapy: Moving Beyond Vascular Endothelial Growth Factor

(2015) Y. Zhao et al.   ONCOLOGIST

eEF-2 Phosphorylation Down-Regulates P-Glycoprotein Over-Expression in Rat Brain Microvessel Endothelial Cells

(2015) Xing Hua Tang et al.   PLoS One

MiR-324-5p Suppresses Hepatocellular Carcinoma Cell Invasion by Counteracting ECM Degradation through Post-Transcriptionally Downregulating ETS1 and SP1

(2015) Liangqi Cao et al.   PLoS One

Eukaryotic elongation factor 2 kinase controls proliferation and migration of vascular smooth muscle cells

(2014) T. Usui et al.   Acta Physiologica

The clinical management of hepatocellular carcinoma in the United States, Europe, and Asia: A comprehensive and evidence-based comparison and review

(2014) Zhi Ven Fong et al.   CANCER

A Regulatory Loop Involving miR-22, Sp1, and c-Myc Modulates CD147 Expression in Breast Cancer Invasion and Metastasis

(2014) L.-M. Kong et al.   CANCER RESEARCH

VEGF-Mediated Angiogenesis Links EMT-Induced Cancer Stemness to Tumor Initiation

(2014) A. Fantozzi et al.   CANCER RESEARCH

Survivin expression promotes VEGF-induced tumor angiogenesis via PI3K/Akt enhanced β-catenin/Tcf-Lef dependent transcription

(2014) Jaime G Fernández et al.   Molecular Cancer

Krüppel-like factor 5 as potential molecular marker in cervical cancer and the KLF family profile expression

(2014) Daniel Marrero-Rodríguez et al.   TUMOR BIOLOGY

Naturally derived factors and their role in the promotion of angiogenesis for the healing of chronic wounds

(2013) Claire Morgan et al.   ANGIOGENESIS

Inhibition of VEGF expression through blockade of Hif1α and STAT3 signalling mediates the anti-angiogenic effect of melatonin in HepG2 liver cancer cells

(2013) S Carbajo-Pescador et al.   BRITISH JOURNAL OF CANCER

The eEF2 Kinase Confers Resistance to Nutrient Deprivation by Blocking Translation Elongation

(2013) Gabriel Leprivier et al.   CELL

VEGF in Tumor Progression and Targeted Therapy

(2013) Vladimir P. Chekhonin et al.   CURRENT CANCER DRUG TARGETS

Identification of autophosphorylation sites in eukaryotic elongation factor-2 kinase

(2012) Sébastien Pyr Dit Ruys et al.   BIOCHEMICAL JOURNAL

Investigating the Kinetic Mechanism of Inhibition of Elongation Factor 2 Kinase by NH125: Evidence of a Common in Vitro Artifact

(2012) Ashwini K. Devkota et al.   BIOCHEMISTRY

A functional family-wide screening of SP/KLF proteins identifies a subset of suppressors ofKRAS-mediated cell growth

(2011) Martin E. Fernandez-Zapico et al.   BIOCHEMICAL JOURNAL

1-Benzyl-3-cetyl-2-methylimidazolium iodide (NH125) Induces Phosphorylation of Eukaryotic Elongation Factor-2 (eEF2)

(2011) Zehan Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of side population cells in human hepatocellular carcinoma cell lines with stepwise metastatic potentials

(2008) Guo-Ming Shi et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY