期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 130, 期 -, 页码 68-78出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2019.02.097
关键词
NAFLD; MP-A; Gut microbiota; Dysbiosis; Gut-liver axis; Metabolism
资金
- Natural Science Foundation of Shandong Province [ZR2017BH051]
- Major R&D Program of Shandong Province [2018GHY115009]
- Special Project Fund of Taishan Scholars of Shandong Province
We isolated and characterized a Mussel polysaccharide, a-D-glucan (MP-A), from Mytilus coruscus earlier. In this work, the pharmacological activity and mechanisms of MP-A as an oral supplement for non-alcoholic fatty liver disease (NAFLD) were explored. High fat diet (HFD) was utilized to induce NAFLD in Sprague Dawley male rats and MP-A (0.6 g/kg) was supplemented for 4 weeks. The results showed that MP-A supplementation reduced blood lipid levels, intrahepatic lipid accumulation and NAFLD activity score in HFD-fed rats. Additionally, the analysis of 16S rDNA sequencing on gut microbiota samples revealed that HFD could induce microbial dysbiosis. However, MP-A supplementation could remodel gut microbiota structure, inhibit LPS-TLR4-NF-KB pathway activation, and restrain subsequent inflammation factors secretion. Furthermore, MP-A regulated the lipid metabolism by promoting the production of short chain fatty acids and suppressing PPAR gamma and SREBP-1c expression. Our results support that MP-A can prevent against NAFLD and act as an oral supplementation for hepatoprotection via modulating gut microbiota and related gut-liver axis signaling pathways. (C) 2019 Published by Elsevier B.V.
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