期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 133, 期 -, 页码 693-701出版社
ELSEVIER
DOI: 10.1016/j.ijbiomac.2019.04.148
关键词
Konjac glucomannan; Carbon nanotubes; Poly(dopamine); Aerogel; Controlled release
资金
- National Natural Science Foundation of China [31471704, 31772045]
- Scientific Research Foundation of Graduate School of Fujian Agriculture and Forestry University [324-1122yb034]
In this study, a facile marine bioinspired surface modification approach for carboxyl-functionalized multiwalled carbon nanotube (CCNT) and enhanced interfacial adhesion with the konjac glucomannan (KGM) matrix were illustrated to develop aerogels. Combined with FT-IR, XRD, Raman, TGA, XPS and SEM results, it was indicated that functionalized CCNT (PCCNT) is a reinforcer through hydrogen bond interactions in the aerogel formation process, which could be the main reason for the enhancement. The swelling and vitro release behavior of KGM/PCCNT aerogels were studied under two conditions using the drug 5-fluorouracil (5-FU). The release amount of 5-FU incorporated into KGM/PCCNT4 aerogel was about 48% at pH 1.2 and 62% at pH 6.8 afterl 1 h, respectively. The results showed that the release rate of 5-FU from the KGM/PCCNT4 aerogel using PCCNT could be effectively controlled, suggesting potential applications for it as a drug carrier in targeted delivery in the biomedical filed. (C) 2019 Elsevier B.V. All rights reserved.
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