Article
Nanoscience & Nanotechnology
Chen-Yo Fan, Sachin Kisan Kawade, Avijit K. Adak, Chien Cho, Kui-Thong Tan, Chun-Cheng Lin
Summary: The fabrication of Ag-coated cuprous oxide (Cu2O) NP slides promotes metal-enhanced fluorescence effect and enables external copper ion-free CuAAC reaction, providing a practical and alternative sensing platform for biological or diagnostic applications; the immobilization of antibodies on these newly developed slide surfaces using a specific pathway shows better sensitivity compared to the random antibody immobilization method.
ACS APPLIED NANO MATERIALS
(2021)
Article
Chemistry, Organic
Laura Holzhauer, Chloe Liagre, Olaf Fuhr, Nicole Jung, Stefan Braese
Summary: The conversion of tetrazolo[1,5-a]quinoxalines to 1,2,3-triazoloquinoxalines and triazoloimidazoquinoxalines under typical conditions of a CuAAC reaction has been investigated. Derivatives of the novel compound class of triazoloimidazoquinoxalines (TIQ) and rhenium(I) triazoloquinoxaline complexes as well as a new TIQ rhenium complex were synthesized. A small 1,2,3-triazoloquinoxaline library was obtained and the method could be expanded towards 4-substituted tetrazoloquinoxalines.
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Alisha Rani, Parveen Saini, Gurjaspreet Singh, Sushma, Harminder Singh, Gurpreet Kaur, Jandeep Singh
Summary: The synthesis of 1,2,3-triazole merged 9H-carbazole derivative was reported with excellent yield and reduced reaction time. The synthesized 1,2,3-triazole linker showed efficient detection capability towards Hg(II) and Mn(II) ions, while the triazolyl product can efficiently sense Cu(II) ions. UV-Vis spectral technique was used for analysis.
INORGANICA CHIMICA ACTA
(2021)
Article
Cell Biology
Levente Kollar, Martina Gobec, Matic Proj, Lara Smrdel, Damijan Knez, Timea Imre, Agnes Gomory, Laszlo Petri, Peter Abranyi-Balogh, Dorottya Csanyi, Gyoergy G. Ferenczy, Stanislav Gobec, Izidor Sosic, Gyoergy M. Keseru
Summary: Constitutive- and immunoproteasomes are vital components of the protein homeostasis system. Selective inhibition of immunoproteasomes shows promise for treating various diseases, and two series of compounds targeting proteasomes have been described in this study. The compounds exhibit significant inhibitory activities against specific subunits of the proteasomes, highlighting their potential for developing selective immunoproteasome inhibitors or compounds targeting multiple subunits.
Article
Polymer Science
Aurora Pacini, Andrea Nitti, Guido Sangiovanni, Marcello Vitale, Dario Pasini
Summary: This study presents the synthesis and characterization of two aliphatic AB(2) monomers containing one alkyne group and two azide functionalities, with adjustable distance between polymerizable groups to meet steric demands during polymerization. The monomers polymerize through the Copper(I)-catalyzed Azide-Alkyne Cycloaddition (CuAAC reaction), yielding hyperbranched polymers with good yields, molecular weights, and moderate degrees of branching.
JOURNAL OF POLYMER SCIENCE
(2021)
Article
Polymer Science
Franziska Marx, Malte Beccard, Alessandro Ianiro, Andrea Dodero, Laura N. Neumann, Gregory Stoclet, Christoph Weder, Stephen Schrettl
Summary: The solid-state properties of supramolecular polymers based on metal-ligand complexes are significantly influenced by the choice of ligand and metal salt. Different components can be used to modify various properties of the polymers. The study presents metallosupramolecular polymers based on a bidentate ligand, which can form coordination complexes with transition metal ions. The polymers exhibit microphase separation and different morphologies depending on the metal ion and thermal history, along with the ability to heal defects and UV-light responsiveness.
Article
Chemistry, Physical
Ivy L. Librando, Abdallah G. Mahmoud, Sonia A. C. Carabineiro, M. Fatima C. Guedes da Silva, Carlos F. G. C. Geraldes, Armando J. L. Pombeiro
Summary: A group of Cu(I) complexes with DAPTA phosphine ligands were immobilized on activated carbon and multi-walled carbon nanotubes for efficient catalysis in the one-pot synthesis of 1,2,3-triazoles via azide-alkyne cycloaddition reaction. The immobilized catalysts showed high catalytic activity and could be easily recovered and reused up to four consecutive cycles.
Article
Chemistry, Multidisciplinary
Fan Yu, Zhaoman Zhou, Jiajia Song, Yanying Zhao
Summary: This study rationalized the mechanism of Cu(I)-catalyzed 5-enamine-functionalized fully substituted 1,2,3-triazole synthesis using density functional theory (DFT) and multicomponent artificial force-induced reaction (MC-AFIR) methods. The research provided important mechanistic insights for the interrupted CuAAC reaction and identified the rate-determining step as the transmetalation process along the triplet state potential energy surface. Further predictions suggest the role of solvent and extra strong ligand coordination in competitive reactions.
Article
Chemistry, Inorganic & Nuclear
Arruri Sathyanarayana, Francois Reveret, Laurent Jouffret, Damien Boyer, Genevieve Chadeyron, Federico Cisnetti
Summary: Using imidazolium chlorides bearing bulky nitrogen donors, a series of luminescent coordination polymers were obtained directly as products by simple filtration. The synthetic procedure is simple, eco-friendly, robust, and reproducible. The chloride in the coordination polymers can be easily exchanged with other halides/pseudohalides, allowing slight modulation of the emitted color while conserving the polymeric structure, except for azide for which a dimer was obtained.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Inorganic & Nuclear
Arruri Sathyanarayana, Francois Reveret, Laurent Jouffret, Damien Boyer, Genevieve Chadeyron, Federico Cisnetti
Summary: A series of coordination polymers were obtained directly from imidazolium chlorides bearing bulky nitrogen donors, showing a simple, eco-friendly, robust, and reproducible synthetic procedure. The polymeric species displayed remarkable stability and retained their photoluminescence properties even after thermal treatment.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Multidisciplinary
Kyeonghun Kim, Saira Nayab, Yerim Cho, Hyewon Jung, Hyeonuk Yeo, Hyosun Lee, Sang-Ho Lee
Summary: A series of Co(ii) complexes supported by Schiff base ligands were designed and synthesized. After activation with modified methyl aluminoxane (MMAO), all the Co(ii) complexes catalyzed the polymerization of norbornene (NB) to yield vinyl-type polynorbornenes (PNBs) with high activities at 25°C.
Article
Chemistry, Multidisciplinary
Pavel G. Shangin, Irina V. Krylova, Andrey V. Lalov, Anna Y. Kozmenkova, Evgeniya A. Saverina, Petr A. Buikin, Alexander A. Korlyukov, Alyona A. Starikova, Elena N. Nikolaevskaya, Mikhail P. Egorov, Mikhail A. Syroeshkin
Summary: This paper presents the reverse side of the commonly used approach in organometallic chemistry, showing a significant change in the redox properties of ligands under the influence of a redox-inert metal. The germanium derivatives based on specific ligands exhibit unique HOMO and LUMO distributions, impacting the overall redox behavior of the complexes. Additionally, the high thermal stability of these derivatives and the potential for forming supramolecular structures suggest promising prospects for new functional materials.
Article
Chemistry, Multidisciplinary
Eugene Zviagin, Vyacheslav Saraev, Dmytro Sysoiev, Blanka Klepetarova, Maryna Mazur, Oleksii Zhelavskyi, Yuliia Shliapkina, Thomas J. J. Mueller, Valentyn Chebanov
Summary: This research introduces a novel synthetic strategy for the preparation of polyazoles containing three or four nitrogen atoms in each azole cycle. Known procedures have been optimized to enhance conversion, selectivity, and overall efficiency.
Article
Chemistry, Multidisciplinary
Mairead E. Bartlett, Scott A. Shuler, Daniel J. Rose, Lindsey M. Gilbert, Rachel A. Hegab, Thomas J. Lawton, Reid E. Messersmith
Summary: The study presents a novel approach to rapidly applying bioactive coatings on surfaces while maintaining protein bioactivity. By conjugating proteins into an adhesive network using an oPA-based linker, a higher retention rate of proteins on the surface was achieved, allowing for the creation of new functional materials with properties typically found in the biological domains.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Physical
Oussama Chebout, Chahrazed Trifa, Sofiane Bouacida, Mhamed Boudraa, Habila Imane, Moufida Merzougui, Wissam Mazouz, Kamel Ouari, Chaouki Boudaren, Hocine Merazig
Summary: Two new copper(II) complexes of sulfanilamide were synthesized and characterized, showing different 1D polymeric structures and thermal stability. The electrochemical study revealed a diffusion controlled process for the Cu(II)/Cu(I) redox system. Antimicrobial activity testing demonstrated varying responses to different strains and compound concentrations.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Microbiology
Dominik Wuellner, Maren Gesper, Annika Haupt, Xiaofei Liang, Pei Zhou, Pascal Dietze, Franz Narberhaus, Julia E. Bandow
Summary: This study investigated the physiological response of Pseudomonas aeruginosa to various antibiotics, revealing cellular defense strategies and similarities in response profiles. The findings provide insights into the effects of commonly used antibiotics on P. aeruginosa and contribute to the evaluation of novel compounds.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Biotechnology & Applied Microbiology
Abdulkadir Yayci, Nathalie Bachmann, Tim Dirks, Eckhard Hofmann, Julia E. Bandow
Summary: This study identified and characterized novel DyP-type peroxidases from Streptomyces chartreusis NRRL 3882, and found that they exhibited distinct preferences in operating conditions and stability. The findings suggest that having different DyP variants in one organism may confer evolutionary benefits. DyP-type peroxidases can be applied in biocatalysis and bioremediation.
JOURNAL OF APPLIED MICROBIOLOGY
(2022)
Article
Biochemical Research Methods
Christoph H. R. Senges, Helen L. Warmuth, Melissa Vazquez-Hernandez, Huriye Deniz Uzun, Leonie Sagurna, Pascal Dietze, Claudia Schmidt, Brix Muecher, Stefan Herlitze, Ute Kraemer, Ingo Ott, Thomas Gunther Pomorski, Julia E. Bandow
Summary: Ionophores are small molecules or peptides that transport metal ions across biological membranes. In this study, the effects of the semisynthetic polyether ionophore 4-Br-A23187 on the model organism Bacillus subtilis were investigated. The treatment led to an increase in intracellular copper levels and a decrease in intracellular manganese and magnesium, which resulted in oxidative stress and disturbance of proteostasis. A liposome model confirmed the ionophore's role as a copper transporter in vitro.
Article
Chemistry, Multidisciplinary
Daniel Obitz, Karmel S. Gkika, Marvin Heller, Tia E. Keyes, Nils Metzler-Nolte
Summary: A lanthanide(iii) complex connected to a light harvesting antenna was synthesized and tested as a potential photosensitizer in photodynamic therapy. The complex showed significant phototoxic activity on cancer cells upon irradiation, with ROS production identified as the compound's phototoxic mode of action. In cell viability assays, a 10-fold decrease in IC50 value was observed compared to the dark control.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Inorganic & Nuclear
Marion Graf, Jasmine Ochs, Nils Metzler-Nolte, Peter Mayer, Hans-Christian Bottcher
Summary: This paper describes the synthesis and characterization of six new organometallic half-sandwich iridium(III) compounds with modified bipyridine ligands. The cytotoxic properties of the compounds against two cancer cell lines were evaluated, and compound 3 showed the most remarkable biological activity with significantly enhanced toxicity compared to cisplatin.
ZEITSCHRIFT FUR ANORGANISCHE UND ALLGEMEINE CHEMIE
(2023)
Article
Chemistry, Multidisciplinary
Paramita Sarkar, Kathakali De, Malvika Modi, Geetika Dhanda, Richa Priyadarshini, Julia E. Bandow, Jayanta Haldar
Summary: Resistance to vancomycin requires developing alternative therapeutics. In this study, vancomycin derivatives with mechanisms beyond d-Ala-d-Ala binding were reported. The lead molecule, VanQAmC(10), inhibits bacterial cell division, which is a previously unknown property for glycopeptide antibiotics.
Article
Chemistry, Medicinal
Irina Kollmorgen, Nathalie Bachmann, Michael Dal Molin, Carsten Degenhart, Eldar Zent, Vikram Pareek, Uwe Koch, Jan Rybniker, Nils Metzler-Nolte, Raphael Stoll, Bert Klebl, Julia Elisabeth Bandow, Jurgen Scherkenbeck
Summary: Due to increasing resistances, there is a need for antibacterial compounds with unique modes of action. One such compound, moiramide B, shows strong activity against gram-positive bacteria but weaker activity against gram-negative bacteria. The structure-activity relationship of moiramide B presents a challenge for optimization strategies, while the fatty acid tail is considered as a transport vehicle. However, the sorbic acid unit is found to be relevant for ACC inhibition and allows the development of moiramide derivatives with altered antibacterial profiles.
Article
Biochemical Research Methods
Melissa Vazquez-Hernandez, Stephanie L. Leedom, Kenneth C. Keiler, Julia Elisabeth Bandow
Summary: Trans-translation is the most effective ribosome rescue system in bacteria, but Bacillus subtilis possesses two alternative ribosome rescue mechanisms. In this study, the proteomes of B. subtilis 168 and a ssrA mutant were compared using quantitative proteomics. The mutant strain showed lower growth rate and protein synthesis rates, altered motility and chemotaxis phenotype, and alterations in the abundance of ribosomal proteins and proteins related to amino acid biosynthesis, reflecting slow ribosome recycling.
Article
Infectious Diseases
Leonie Sagurna, Sascha Heinrich, Lara-Sophie Kaufmann, Christian Rueckert-Reed, Tobias Busche, Alexander Wolf, Jan Eickhoff, Bert Klebl, Joern Kalinowski, Julia E. Bandow
Summary: Bacteria of the genus Streptomyces produce various specialized metabolites. Single biosynthetic gene clusters (BGCs) can give rise to different products with varying biological activities. In this study, alnumycin and 1,6-dihydro 8-propylanthraquinone were isolated from a Streptomyces strain containing the alnumycin BGC. Both compounds exhibited antimicrobial activity, with 1,6-dihydro 8-propylanthraquinone showing higher activity against E. coli & UDelta;tolC compared to alnumycin. The modes of action of these compounds are worth further investigation.
Article
Multidisciplinary Sciences
Tim Dirks, Marco Krewing, Katharina Vogel, Julia E. Bandow
Summary: Cold atmospheric pressure plasmas have a significant impact on protein aggregation, and Hsp33 plays an important role in preventing protein aggregation. It has been found that over-production of Hsp33 can increase bacterial resistance to cold plasmas.
JOURNAL OF THE ROYAL SOCIETY INTERFACE
(2023)
Article
Multidisciplinary Sciences
Tim Dirks, Abdulkadir Yayci, Sabrina Klopsch, Marco Krewing, Wuyuan Zhang, Frank Hollmann, Julia E. Bandow
Summary: This study demonstrates that immobilization universally protects enzymes under plasma-operating conditions and improves their activity, opening up new possibilities for emerging applications.
JOURNAL OF THE ROYAL SOCIETY INTERFACE
(2023)
Article
Biology
Huriye D. Uzun, Melissa Vazquez-Hernandez, Julia E. Bandow, Thomas Guenther Pomorski
Summary: Ion homeostasis is crucial for cellular processes and relies on lipid membranes as ion permeability barriers. Ionophores facilitate ion transport across cell membranes and allow manipulation of cellular ion composition. A calcein quenching assay based on large unilamellar vesicles was developed to evaluate divalent cation transport of 4-Br-A23187, an ionophore. This assay provides a well-defined platform to study metal transport by ionophores and membrane proteins.
Review
Chemistry, Multidisciplinary
Karolina Kaminska, Andrzej Mular, Evgenia Olshvang, Nils Metzler Nolte, Henryk Kozlowski, Elzbieta Wojaczynska, Elzbieta Gumienna-Kontecka
Summary: Siderophores are specific iron chelators produced and secreted by organisms under iron deficiency conditions. These molecules have high affinity and specificity for Fe3+ and other metal ions, and have potential applications in antibiotics delivery. Total synthesis of siderophores is necessary due to their low natural concentrations.
Correction
Chemistry, Multidisciplinary
Christine N. Morrison, Kathleen E. Prosser, Ryjul W. Stokes, Anna Cordes, Nils Metzler-Nolte, Seth M. Cohen
Summary: The study introduces a novel approach using metallofragments as 3D scaffolds for fragment-based drug discovery. This method has great potential in the field of medicinal chemistry and provides a new direction for drug development.