期刊
BIOMEDICAL CHROMATOGRAPHY
卷 30, 期 1, 页码 81-84出版社
WILEY-BLACKWELL
DOI: 10.1002/bmc.3518
关键词
metabolomics; GC; MS; ketamine; abuse
类别
资金
- Zhejiang Provincial Education Department [Y201432003, Y201431334]
- Science and Technology Committee of Shanghai Municipality, China [KF1405, KF1504]
In this study, we developed a brain metabolomic method, based on gas chromatography-mass spectrometry (GC/MS), to evaluate the effect of ketamine on rats. Pattern recognition analysis, including both principal component analysis and partial least squares-discriminate analysis revealed that ketamine induced metabolic perturbations. Compared with the control group, the levels of glycerol, uridine, cholesterol in rat brain of the ketamine group (50 mg/kg, 14 days) decreased, while the urea levels increased. Our results indicate that metabolomic methods based on GC/MS may be useful to elucidate ketamine abuse through the exploration of biomarkers. Copyright (c) 2015 John Wiley & Sons, Ltd.
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