期刊
IET NANOBIOTECHNOLOGY
卷 13, 期 8, 页码 786-799出版社
WILEY
DOI: 10.1049/iet-nbt.2019.0146
关键词
nanocomposites; magnetic particles; biomedical materials; antibacterial activity; nanofabrication; nanoparticles; drugs; precipitation (physical chemistry); reviews; nanomagnetics; superparamagnetism; nanomedicine; drug-resistant bacteria; fatal bacterial infections; bacterial strains; conventional synthesis methods; antibacterial applications; antibacterial activity; exotic nanoparticle applications; antibacterial mechanisms; antimicrobial magnetic nanomaterials; antibacterial MNP; biocompatible MNP; in vivo magnetic nanoparticle; review; hydrothermal techniques; superparamagnetism; nanocomposites; surface modifications
Along with the extensive range of exotic nanoparticle (NPs) applications, investigation of magnetic NPs (MNPs) in vitro has ushered modern antibacterial studies into an increasingly attractive research area. A great number of microorganisms exist in the size scales from nanometre to micrometre regions. The enormous potential of engineered MNPs in therapeutic procedures against various drug-resistant bacteria has declined the menace of fatal bacterial infections. Many biocompatible MNPs have been introduced that possess remarkable impacts on various bacterial strains. Conventional synthesis methods such as co-precipitation or hydrothermal techniques have been widely adopted in the production of MNPs. The MNPs for antibacterial applications are mainly required to be superparamagnetic, recyclable and biocompatible. To implement novel strategies in developing new generation antimicrobial magnetic nanomaterials, it is essential to obtain a comprehensive preview of recent achievements in synthesis, proposed antibacterial mechanisms and characterisation techniques of these nanomaterials. This review highlights notable aspects of antibacterial activity in engineered MNPs and nanocomposites including their particle properties (size, shape and saturation magnetisation), antibacterial mechanisms, synthesis methods, testing methods, surface modifications and minimum inhibitory concentrations.
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