Article
Biochemistry & Molecular Biology
Julian Hackler, Kamil Demircan, Thilo Samson Chillon, Qian Sun, Nino Geisler, Michael Schupp, Kostja Renko, Lutz Schomburg
Summary: Selenium is an essential trace element that affects the expression of SELENOP. A drug screening was performed to identify inhibitors of SELENOP expression, and resveratrol was found to be the most potent inhibitor. The results suggest that resveratrol may increase liver Se levels and selenoprotein expression.
Article
Nutrition & Dietetics
Arlene C. P. Kiyohara, Daniel J. Torres, Ayaka Hagiwara, Jenna Pak, Rachel H. L. H. Rueli, C. William R. Shuttleworth, Frederick P. Bellinger
Summary: SELENOP1 plays an important role in regulating Zn2+ levels in the brain, with knockout mice showing altered Zn2+ distribution and impaired release in response to neuron depolarization. Additionally, SELENOP1 deficiency may lead to increased levels of tau phosphorylation, possibly due to changes in intracellular zinc content.
FRONTIERS IN NUTRITION
(2021)
Article
Immunology
A. Skesters, D. Kustovs, A. Lece, E. Moreino, E. Petrosina, K. D. Rainsford
Summary: This study aimed to assess the tendency of oxidative stress in COVID-19 patients depending on severity. The results showed that patients with severe disease had significantly lower selenium and seleno-protein P levels and higher oxidative stress levels.
INFLAMMOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Amra Jujic, John Molvin, Lutz Schomburg, Oliver Hartmann, Andreas Bergmann, Olle Melander, Martin Magnusson
Summary: A recent study found that high selenium levels are associated with reduced mortality and incidence of heart failure (HF), but only in non-smokers. This study aimed to investigate whether selenoprotein P (SELENOP) is associated with incident HF. The results showed that low SELENOP levels are associated with a higher risk of incident HF in the general population.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Medicine, General & Internal
Yuki Nakahata, Tatsunori Hanai, Takao Miwa, Toshihide Maeda, Kenji Imai, Atsushi Suetsugu, Koji Takai, Masahito Shimizu
Summary: This study found that selenium deficiency is highly prevalent in patients with chronic liver disease (CLD) and is associated with an increased risk of overt hepatic encephalopathy (OHE) development. The serum selenium levels were lower in patients with cirrhosis compared to those with chronic hepatitis, and they were negatively correlated with several disease severity indicators. The ALBI score remained significantly associated with selenium deficiency, and selenium deficiency was associated with the occurrence of OHE during the follow-up period.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Lionel Tarrago, Alaattin Kaya, Hwa-Young Kim, Bruno Manta, Byung-Cheon Lee, Vadim N. Gladyshev
Summary: Methionine sulfoxide reductases (MSR) are enzymes that reduce methionine sulfoxide (MetO) back to methionine. MSRB1, a selenoprotein found in mammals, uses selenocysteine as a catalytic residue. It plays a crucial role in oxidative stress protection, neuronal cell maintenance, cognition, cancer cell proliferation, and immune response.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Shuang Liu, Xing Wen, Qihan Huang, Minghui Zhu, Jun Lu
Summary: Cisplatin is an effective chemotherapy drug for solid tumors but also causes various side effects, especially nephrotoxicity. Previous studies have shown a correlation between selenoenzymes and cisplatin-induced renal damage. This study established mouse models with different selenium intake levels and found that selenium deficiency increased sensitivity to cisplatin-induced damage, while selenium supplementation protected against renal injury.
Article
Biochemistry & Molecular Biology
Zhong-Hao Zhang, Xian-Chun Cao, Jia-Ying Peng, Shao-Ling Huang, Chen Chen, Shi-Zheng Jia, Jia-Zuan Ni, Guo-Li Song
Summary: This study demonstrates the therapeutic potential of combined supplementation of selenium and folic acid in Alzheimer's disease. The treatment regimen improves synaptic plasticity and cognitive ability by modulating brain lipid metabolism, potentially through antioxidant effects and promoting homocysteine metabolism.
Review
Endocrinology & Metabolism
Fei Wang, Chunyu Li, Shaoxin Li, Lili Cui, Junyu Zhao, Lin Liao
Summary: Selenium is an essential micronutrient for the biosynthesis of selenoproteins in the thyroid, and its deficiency can increase the prevalence of thyroid diseases. Selenium treatment has shown benefits in delaying disease progression and improving quality of life in patients with Graves' orbitopathy. Supplementation with selenium has also been associated with decreased levels of anti-thyroid antibodies and improved thyroid structure in Hashimoto's thyroiditis. However, the anticancer activity of selenium supplements in thyroid cancer remains conflicting and more clinical evidence is needed.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Nutrition & Dietetics
Lilly Johanna Schmalbrock, Gregor Weiss, Eddy Rijntjes, Nina Reinschissler, Qian Sun, Michael Schenk, Lutz Schomburg
Summary: The study examined the relationship between trace elements and female subfertility influenced by assisted reproductive technologies, revealing a direct connection between TE in serum and follicular fluid, as well as high variability between follicular fluid samples from the same woman. The results suggest that TE assessment may aid in optimal oocyte selection and impact the success of ART.
Article
Biochemistry & Molecular Biology
Farshad Amirkhizi, Mahdiyeh Taghizadeh, Banafshe Khalese-Ranjbar, Soudabeh Hamedi-Shahraki, Somayyeh Asghari
Summary: Polycystic ovary syndrome (PCOS) is a common endocrine disorder in reproductive-age women, characterized by reproductive and metabolic disorders. Oxidative stress (OS) plays a role in the pathogenesis of PCOS, and the study aimed to investigate the relationship between selenium (Se) and selenoprotein P (SELENOP) levels with OS markers. The results showed that higher Se and SELENOP levels were associated with lower TBARS levels and higher TAC levels and erythrocytes GPx activity.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Review
Physiology
Zi-Meng Li, Xiu-Li Wang, Xiao-Min Jin, Jia-Qiang Huang, Lian-Shun Wang
Summary: Adverse conditions, such as crowding stress, hypoxia, and malnutrition, arise during the intensive aquaculture farming, leading to oxidative stress. Selenium plays a crucial role as an effective antioxidant in fish's defense system against oxidative stress. This paper reviews the physiological functions of selenoproteins, mechanisms of different selenium forms, and the harmful effects of low and high selenium levels in aquaculture. It summarizes the application and research progress of selenium in oxidative stress in aquatic animals, providing scientific references for its anti-oxidative stress application in aquaculture.
FRONTIERS IN PHYSIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Jeremy Lamarche, Luisa Ronga, Joanna Szpunar, Ryszard Lobinski
Summary: SELENOP as an emerging marker for selenium nutritional status and various diseases still requires further investigation on its chemical characteristics and improvement in accurate quantitation methods; the presence of multiple isoforms and post-translationally modified variants of SELENOP poses challenges for accurate quantification; mass spectrometry techniques offer many advantages and complementary features in the characterization and quantification of SELENOP and should be carefully evaluated.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
Victor Toro-Roman, Ignacio Bartolome, Jesus Siquier-Coll, Maria C. Robles-Gil, Diego Munoz, Marcos Maynar-Marino
Summary: This study analyzed the concentrations of selenium in athletes and subjects with low levels of physical training, and found that physical training can modify selenium metabolism. Deficiencies in selenium concentrations may exist at the intracellular level.
Article
Multidisciplinary Sciences
Donghyun Kang, Jeeyeon Lee, Jisu Jung, Bradley A. Carlson, Moon Jong Chang, Chong Bum Chang, Seung-Baik Kang, Byung Cheon Lee, Vadim N. Gladyshev, Dolph L. Hatfield, Byeong Jae Lee, Jin-Hong Kim
Summary: Osteoarthritis is caused by the accumulation of oxidative stress. This study reveals that dysregulation of the selenium metabolic pathway disrupts redox homeostasis in chondrocytes, leading to the development of osteoarthritis. The downregulation of SEPHS1 impairs the synthesis of oxidoreductase selenoproteins, increases reactive oxygen species levels, and induces chondrocyte senescence.
NATURE COMMUNICATIONS
(2022)
Article
Biochemical Research Methods
Victoria Chuchina, Anna Gubal, Yegor Lyalkin, Oleg Glumov, Ivan Trefilov, Angelina Sorokina, Sergey Savinov, Nikolay Solovyev, Alexander Ganeev
RAPID COMMUNICATIONS IN MASS SPECTROMETRY
(2020)
Article
Crystallography
Anna Gubal, Victoria Chuchina, Ivan Trefilov, Oleg Glumov, Viktor Yakobson, Alexander Titov, Nikolay Solovyev, Alexander Ganeev
Review
Spectroscopy
Anna Gubal, Victoria Chuchina, Angelina Sorokina, Nikolay Solovyev, Alexander Ganeev
Summary: This paper mainly discusses the application of mass spectrometric techniques for the quantification of N, O, F, Cl, and Br in solid samples, pointing out the issues with conventional techniques and emphasizing the flexibility and robustness of mass spectrometry techniques.
MASS SPECTROMETRY REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Galina Kireeva, Stepan Kruglov, Mikhail Maydin, Ekaterina Gubareva, Elena Fedoros, Ekaterina Zubakina, Natalya Ivanenko, Marina Bezruchko, Nikolay Solovyev
Article
Biochemistry & Molecular Biology
Nikolay Solovyev, Ahmed H. El-Khatib, Marta Costas-Rodriguez, Karima Schwab, Elizabeth Griffin, Andrea Raab, Bettina Platt, Franz Theuring, Jochen Vogl, Frank Vanhaecke
Summary: Isotopic analysis revealed significant alterations in the isotopic compositions of iron and zinc in the brains of mouse models of Alzheimer's disease, serving as potential markers for proteinopathies underlying AD and other types of dementia.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Review
Neurosciences
Nikolay Solovyev, Evgenii Drobyshev, Bastian Blume, Bernhard Michalke
Summary: Selenium plays crucial roles in various physiological functions in mammals and needs to cross the blood-brain barrier to reach the brain. Additionally, selenoproteins have key functions in brain function, presenting an important area for further research.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Spectroscopy
Anna Gubal, Victoria Chuchina, Yegor Lyalkin, Natalya Ivanenko, Nikolay Solovyev, Alexander Stroganov, Alexander Ganeev
Summary: Recent studies have shown that glow discharge analysis is capable of effectively ionizing volatile organic compounds, enabling the analysis of VOCs in ambient air and gas mixtures. Direct determination of different classes of VOCs in ambient air using microsecond pulsed glow discharge time-of-flight mass spectrometry was demonstrated, with low fragmentation benefitting quantitative determination.
ATOMIC SPECTROSCOPY
(2021)
Article
Engineering, Chemical
Anna I. Kuzminova, Mariia E. Dmitrenko, Daria Y. Poloneeva, Artem A. Selyutin, Anton S. Mazur, Alexei V. Emeline, Vladimir Y. Mikhailovskii, Nikolay D. Solovyev, Sergey S. Ermakov, Anastasia V. Penkova
Summary: Novel dense and supported mixed matrix membranes based on biopolymer sodium alginate (SA) modified by Zr-MOFs were developed to enhance the pervaporation dehydration properties. The addition of UiO-66 into the membrane showed the best transport properties for dehydration of water/isopropanol mixtures, with significant improvements in permeation flux and water content in the permeate.
JOURNAL OF MEMBRANE SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Mariia Dmitrenko, Vladislav Liamin, Anna Kuzminova, Erkki Lahderanta, Nikolay Solovyev, Anastasia Penkova
Summary: Transport characteristics of sodium alginate membranes were improved by cross-linking with CaCl2 and modification with fullerenol and fullerene derivative with L-arginine for pervaporation dehydration. Various approaches, such as creating a thin selective layer and depositing nano-sized polyelectrolyte layers, were applied. The impact of different porous substrates and PEL combinations on membrane properties were studied, showing the best performance in a PAN-supported SA/fullerenol membrane with five PSS/SA bilayers.
Article
Biochemical Research Methods
Yaroslav Dubrovskii, Timur Krivul'ko, Liudmila Gavrilenko, Nikolay Solovyev
Summary: A broadband collision-induced dissociation (bbCID) technique was proposed for mass spectrometric analysis of tryptic peptides obtained from paint coating samples. By combining with analytical chromatography, this technique maintains a balance between the quantity of data acquired and the sensitivity of the method. The study demonstrated that the required level of sensitivity can be achieved through the use of data-independent MS/MS strategy.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Polymer Science
Mariia Dmitrenko, Anastasia Chepeleva, Vladislav Liamin, Anton Mazur, Konstantin Semenov, Nikolay Solovyev, Anastasia Penkova
Summary: In this study, graphene oxide (GO) nanoparticles were introduced into a poly(2,6-dimethyl-1,4-phenylene oxide) (PPO) membrane to improve its pervaporation performance in the dehydration of ethylene glycol (EG). Through a series of experiments and tests, researchers successfully developed a PPO/GO composite membrane and found that the supported PPO/GO/MFFC membrane exhibited the best permeation properties in the dehydration of ethylene glycol.
Article
Chemistry, Multidisciplinary
Elena Fedoros, Sergey Pigarev, Natalya Ivanenko, Megan Westbury, Nikolay Solovyev
Summary: The study investigated the ex vivo protein binding of the novel platinum-containing antineoplastic agent BP-C1. Results showed a medium degree of binding of platinum to macromolecular species of approximately 60%, indicating the maintenance of a high fraction of free BP-C1 in the bloodstream, facilitating its pharmacological activity.
APPLIED SCIENCES-BASEL
(2021)
Article
Biochemistry & Molecular Biology
Elena Fedoros, Margarita L. Tyndyk, Irina G. Popovich, Ivan Anikin, Maria N. Yurova, Ekaterina A. Gubareva, Sergey E. Pigarev, Andrey Panchenko, Nikolay D. Solovyev, Vladimir N. Anisimov
Summary: This study evaluated the antitumor activity of BP-C1 in different tumor models and found that it exhibited a wide spectrum of efficacy, especially when used in combination with cyclophosphamide.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Denis Kravtsov, Anna Gubal, Victoria Chuchina, Natalya Ivanenko, Nikolay Solovyev, Alexander Stroganov, Han Jin, Alexander Ganeev
Summary: This study investigated the effect of discharge conditions on VOC fragmentation using a combination of pulsed glow discharge and time-of-flight mass spectrometer. The use of discharge afterglow significantly reduced VOC fragmentation and provided low detection limits.
Editorial Material
Chemistry, Multidisciplinary
Bernhard Michalke, Tamara Garcia-Barrera, Volker Nischwitz, Nikolay Solovyev
FRONTIERS IN CHEMISTRY
(2022)
