期刊
GENOME BIOLOGY AND EVOLUTION
卷 11, 期 8, 页码 2099-2106出版社
OXFORD UNIV PRESS
DOI: 10.1093/gbe/evz139
关键词
whole-genome sequencing; genome annotation; comparative genomics; RNA-seq transcriptome; energy homeostasis; starvation
资金
- Natural Sciences and Engineering Research Council [NIH: 2R24OD011198-04A1]
- German Research Foundation (DFG) [261414-03]
- University of Wurzburg
The piranha enjoys notoriety due to its infamous predatory behavior but much is still not understood about its evolutionary origins and the underlying molecular mechanisms for its unusual feeding biology. We sequenced and assembled the red-bellied piranha (Pygocentrus nattereri) genome to aid future phenotypic and genetic investigations. The assembled draft genome is similar to other related fishes in repeat composition and gene count. Our evaluation of genes under positive selection suggests candidates for adaptations of piranhas' feeding behavior in neural functions, behavior, and regulation of energy metabolism. In the fasted brain, we find genes differentially expressed that are involved in lipid metabolism and appetite regulation as well as genes that may control the aggression/boldness behavior of hungry piranhas. Our first analysis of the piranha genome offers new insight and resources for the study of piranha biology and for feeding motivation and starvation in other organisms.
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