Article
Obstetrics & Gynecology
Ugochinyere Vivian Ukah, Robert W. Platt, Nathalie Auger, Sarka Lisonkova, Joel G. Ray, Isabelle Malhame, Aimina Ayoub, Darine El-Chaar, Natalie Dayan
Summary: Women who have experienced severe maternal morbidity have a relatively high risk of recurrent morbidity in the subsequent pregnancy, especially if multiple types of severe maternal morbidity occurred in their first delivery. Women with cardiac complications during their first delivery have the highest risk of severe maternal morbidity in the next delivery.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Lyazzat Kaldygulova, Talshyn Ukybassova, Gulzhanat Aimagambetova, Andrey Gaiday, Akylbek Tussupkaliyev
Summary: The rationale and importance of folic acid supplementation during pregnancy for preventing fetal congenital defects are widely accepted. Adequate folate levels can reduce the risk of spontaneous abortions and support normal placental blood flow, promoting appropriate fetal growth. Additionally, there is emerging evidence that long-term folic acid supplementation can effectively prevent preeclampsia, a complication unique to humans during pregnancy that contributes to worldwide maternal and perinatal mortality. Folate supplementation helps to decrease elevated levels of homocysteine, which is associated with the risk of preeclampsia.
Article
Peripheral Vascular Disease
Anna Kivioja, Elli Toivonen, Jaakko Tyrmi, Sanni Ruotsalainen, Samuli Ripatti, Heini Huhtala, Tiina Jaaskelainen, Seppo Heinonen, Eero Kajantie, Juha Kere, Katja Kivinen, Anneli Pouta, Tanja Saarela, Hannele Laivuori
Summary: The study found that the polygenic risk score for blood pressure (BP-PRS) is associated with an increased risk of preeclampsia and its severe subtypes, with women with high BP-PRS presenting higher blood pressure values during pregnancy.
Article
Peripheral Vascular Disease
Eva G. Mulder, Chahinda Ghossein-Doha, Ella Cauffman, Veronica A. Lopes van Balen, Veronique M. M. M. Schiffer, Robert-Jan Alers, Jolien Oben, Luc Smits, Sander M. J. van Kuijk, Marc E. A. Spaanderman
Summary: Tailored circulatory normalization of nonphysiological hemodynamic changes during pregnancy can reduce the risk of recurrent preeclampsia in high-risk populations. This simple and innovative treatment strategy shows no adverse effects on offspring outcomes.
Review
Immunology
Qi Zhou, Yunhe Xiong, Bing Qu, Anyu Bao, Yan Zhang
Summary: DNA methylation plays a crucial role in the occurrence of RPL, while the maternal-fetal immune microenvironment is essential for maintaining pregnancy.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Obstetrics & Gynecology
Kushaan Khambata, Sanketa Raut, Sharvari Deshpande, Sweta Mohan, Shobha Sonawane, Reshma Gaonkar, Zakiya Ansari, Mamata Datar, Vandana Bansal, Anushree Patil, Himangi Warke, Nafisa H. Balasinor
Summary: Aberrant sperm DNA methylation status and certain polymorphisms in imprinted genes are associated with recurrent pregnancy loss (RPL), suggesting a potential role of paternal genetic and epigenetic factors in the etiology of RPL.
HUMAN REPRODUCTION
(2021)
Article
Environmental Sciences
Min Zhang, Chong Liu, Wen-Ding Li, Xue-Dan Xu, Fei-Peng Cui, Pan-Pan Chen, Yan-Ling Deng, Yu Miao, Qiong Luo, Jia-Yue Zeng, Ting-Ting Lu, Tian Shi, Qiang Zeng
Summary: This study found that prenatal exposure to metals is associated with increased oxidative stress among pregnant women, especially in the case of selenium exposure. However, there was no evidence of associations between urinary metals as individual chemicals or mixtures and DNA methylation.
Article
Biochemistry & Molecular Biology
Scott W. Walsh, Marwah Al Dulaimi, Kellie J. Archer, Jerome F. Strauss
Summary: The study found that gene expression profiles of neutrophils can distinguish different preeclampsia phenotypes, with changes occurring before clinical symptoms in mild cases. Severe preeclampsia showed gene expression patterns that mirrored normal pregnancy, while mild preeclampsia had distinct gene expression profiles. DNA methylation levels in circulating neutrophils were extremely low, and did not mediate gene expression differences in either mild or severe preeclampsia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Obstetrics & Gynecology
Maeliss Peigne, Jacques de Mouzon, Amelie Khiel, Alice Fraissinet, Victoria Maget, Jacqueline Saias-Magnan, Emmanuelle Mathieu-D'Argent, Olivia Gervereau, Helene Letur
Summary: This study compared the risk of complications between pregnancies with donated embryos and autologous frozen-thawed embryo transfer (FET). The results showed that pregnancies with donated embryos had a significantly higher incidence of hypertensive disorders of pregnancy (HDP), particularly the severe forms. Additionally, the rate of C-sections was higher in donated-embryo pregnancies, while there were no significant differences in newborn outcomes between the two groups.
FERTILITY AND STERILITY
(2023)
Article
Biochemistry & Molecular Biology
Fatma Dogan, Rakad M. Kh Aljumaily, Mark Kitchen, Nicholas R. Forsyth
Summary: Pluripotent stem cells are sensitive to oxygen concentration, and a low oxygen environment can enhance their functional profile and epigenetic regulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Gaolian Xu, Hao Yang, Jiani Qiu, Julien Reboud, Linqing Zhen, Wei Ren, Hong Xu, Jonathan M. M. Cooper, Hongchen Gu
Summary: The authors propose a method called STEM-PCR for rapid and facile detection of specific nucleic acid modifications. This method utilizes a simple and widely accessible PCR-based workflow, and exhibits sensitivity 20 times greater than current gold-standard techniques by using a bisulfite-free process. They successfully demonstrate the clinical applicability of this method by detecting methylation of SEPTIN9 and SFRP2 genes, which are key biomarkers in tumor prognosis and diagnosis.
NATURE COMMUNICATIONS
(2023)
Review
Obstetrics & Gynecology
Jagyashila Das, Arindam Maitra
Summary: Multiple factors influence pregnancy, including environmental, behavioral, and hereditary factors. Recent studies indicate that DNAm modifications can impact maternal and fetal health, leading to clinical adversities. Changes in DNAm in promoter and enhancer regions can modulate gene expression and play a vital physiological role.
REPRODUCTIVE SCIENCES
(2021)
Article
Genetics & Heredity
Suniti Yadav, Imnameren Longkumer, Shipra Joshi, Kallur Nava Saraswathy
Summary: The study found an association between global DNA hypomethylation and hypertension, and that antihypertensive drugs can improve methylation levels. Individuals with the TT genotype for MTHFR gene, not on medication, are more likely to experience global DNA hypomethylation in the context of hypertension.
BMC MEDICAL GENOMICS
(2021)
Article
Multidisciplinary Sciences
Hubert Wolski, Grazyna Kurzawinska, Marcin Ozarowski, Aleksandra E. Mrozikiewicz, Krzysztof Drews, Tomasz M. Karpinski, Anna Bogacz, Agnieszka Seremak-Mrozikiewicz
Summary: It was found that VDR BsmI genetic polymorphism may play a role in the etiology of recurrent miscarriages (RM), while specific maternal haplotypes were shown to prevent RM occurrence.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Michelle Z. L. Kee, Ai Ling Teh, Andrew Clappison, Irina Pokhvisneva, Julie L. MacIssac, David T. S. Lin, Katia E. Ramadori, Birit F. P. Broekman, Helen Chen, Mary Lourdes Daniel, Neerja Karnani, Michael S. Kobor, Peter D. Gluckman, Yap Seng Chong, Jonathan Y. Huang, Michael J. Meaney
Summary: This study found an association between prenatal maternal depressive symptoms and inter-individual genome-wide DNA methylation, specifically in mothers carrying female fetuses. It also revealed sex-dependent associations with depression-related genes and signaling pathways, suggesting the potential role of maternal-fetal interactions in intergenerational transmission.
Article
Pharmacology & Pharmacy
Atanu Sen, Himani Thakkar, Vinnyfred Vincent, Sandeep Rai, Archna Singh, Sujata Mohanty, Ambuj Roy, Lakshmy Ramakrishnan
Summary: This study investigated the relationship between biopterins levels of endothelial colony forming cells (ECFCs) and endothelial progenitor cells (EPCs) in circulation, as well as the functional potential of ECFCs. The results suggest that biopterins play an important role in maintaining the functional integrity of EPCs and ECFCs in circulation.
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2022)
Article
Cell Biology
Himani Thakkar, Vinnyfred Vincent, Ambuj Roy, Ajay Kumar Gautam, Rintu Kutum, Lakshmy Ramakrishnan, Sandeep Singh, Archna Singh
Summary: Impairments in high-density lipoprotein (HDL) function are linked to coronary artery disease development. This study found distinct lipid and protein profiles in HDL from ACS patients, suggesting a potential contribution to HDL dysfunction beyond inflammatory conditions.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Md Asadullah, Roopa Shivashankar, Shalimar, Devasenathipathy Kandasamy, Dimple Kondal, Garima Rautela, Ariba Peerzada, Bhanvi Grover, Ritvik Amarchand, Baibaswata Nayak, Raju Sharma, Lakshmy Ramakrishnan, Dorairaj Prabhakaran, Anand Krishnan, Nikhil Tandon
Summary: The prevalence of non-alcoholic fatty liver disease (NAFLD) is high among adults in both urban and rural North India, including fibrosis and elevated liver enzymes. The study also confirmed a strong association between NAFLD and diabetes, central obesity, and insulin resistance.
Article
Multidisciplinary Sciences
Atanu Sen, Archna Singh, Ambuj Roy, Sujata Mohanty, Nitish Naik, Mani Kalaivani, Lakshmy Ramakrishnan
Summary: This study found that ECFCs from CAD patients exhibited impaired functionality and lower BH4 level. Cell proliferation, wound healing, and angiogenesis were positively correlated with ECFC's BH4. Oxidative stress may be a determinant of intracellular biopterin levels.
SCIENTIFIC REPORTS
(2022)
Article
Nutrition & Dietetics
Mohamad Tarik, Lakshmy Ramakrishnan, Nidhi Bhatia, Ravindra Goswami, Devasenathipathy Kandasamy, Atanu Roy, Dinu S. Chandran, Archna Singh, Ashish Datt Upadhyay, Mani Kalaivani, Jayanthi Neelamraju, Ratna Sudha Madempudi, Reena Rajan
Summary: The effect of Bacillus coagulans Unique IS-2 supplementation on protein absorption and utilization in resistance-trained males was assessed in this study. The results showed that Bacillus coagulans Unique IS-2 supplementation significantly increased protein absorption and intake of branched chain amino acids (BCAA), while also improving lower body muscle strength.
EUROPEAN JOURNAL OF NUTRITION
(2022)
Article
Pediatrics
Mohamad Tarik, Lakshmy Ramakrishnan, Sikha Sinha, H. P. S. Sachdev, Nikhil Tandon, Ambuj Roy, Santosh Kumar Bhargava
Summary: This study found that birth weight and BMI are associated with cellular senescence in adulthood. Small birth size is linked to accelerated cellular senescence in adult life, which may contribute to the development of chronic diseases.
INDIAN JOURNAL OF PEDIATRICS
(2023)
Article
Pediatrics
Abraar Sheriff, Georgie Mathew, Aditi Sinha, Smriti Hari, Nandita Gupta, Lakshmy Ramakrishnan, Pankaj Hari, Arvind Bagga
Summary: Vitamin D supplementation increases serum cFGF23 and phosphate levels in children with chronic kidney disease (CKD), but has no adverse effects on bone health and flow-mediated dilation (FMD) of the brachial artery.
INDIAN JOURNAL OF PEDIATRICS
(2022)
Article
Endocrinology & Metabolism
Ranjit Mohan Anjana, Seshadhri Srinivasan, Vasudevan Sudha, Shashank R. Joshi, Banshi Saboo, Nikhil Tandon, Ashok Kumar Das, Puthiyaveettil Kottayam Jabbar, Sri Venkata Madhu, Arvind Gupta, Sarita Bajaj, Subhankar Chowdhury, Sanjay Kalra, Rajagopal Gayathri, Kuzhandaivelu Abirami, Valangaiman Sriram Manasa, Thamotharan Padmapritha, Nagarajan Lakshmipriya, Gunasekaran Geetha, Mohan Deepa, Rajendra Pradeepa, Ranjit Unnikrishnan, Anura Viswanath Kurpad, Kamala Krishnaswamy, Tanvir Kaur, Rupinder Singh Dhaliwal, Viswanathan Mohan
Summary: A data-driven optimization approach was used to derive macronutrient recommendations for remission and prevention of type 2 diabetes in Asian Indians. Reduction in carbohydrates and an increase in protein intake were recommended for both T2D remission and for prevention of progression to T2D in prediabetes and normal glucose tolerance groups. These results highlight the importance of new dietary guidelines to address the burden of diabetes in South Asia.
Article
Immunology
Sudhasini Panda, Diravya M. Seelan, Shah Faisal, Alisha Arora, Kalpana Luthra, Jayanth Kumar Palanichamy, Anant Mohan, Naval K. Vikram, Neeraj Kumar Gupta, Lakshmy Ramakrishnan, Archana Singh
Summary: Hyperglycemia in diabetes mellitus has a negative impact on macrophage functions, including decreased phagocytic capacity and altered expression pattern of key pattern recognition receptors, in tuberculosis infection. These altered macrophage functions are positively correlated with increasing disease severity.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Anand Krishnan, Ritvik Amarchand, Mohamad Tarik, Harshal Ramesh Salve, Pankaja Raghav, Binod Kumar Patro, Prabu Rajkumar, Kusum Sekhawat, Pradeep Joshi, Prashant Mathur, Fikru Tullu, Lakshmy Ramakrishnan
Summary: This study examined the performance of equations in estimating 24-hour urinary sodium levels from morning fasting urine samples in India. The Tanaka equation provided acceptable estimates of salt intake at the population level, but all equations showed poor performance overall, highlighting the need for better methods to measure sodium intake at the population level.
NATIONAL MEDICAL JOURNAL OF INDIA
(2022)
Article
Allergy
Arvind Kumar, Kana Ram Jat, Jhuma Sankar, R. Lakshmy, Rakesh Lodha, S. K. Kabra
Summary: The study found that there is a correlation between serum hs-CRP levels and asthma control levels in children. Children with uncontrolled asthma have higher hs-CRP levels.
Article
Cell Biology
Lovejeet Kaur, Deepali Sundrani, Kinjal Dave, Karuna Randhir, Savita Mehendale, Swati Bayyana, Kumaran Kalyanaraman, Giriraj R. R. Chandak, Sadhana Joshi
Summary: This study found that DNA methylation and expression of HIF1 alpha and HIF3 alpha were altered in preeclampsia placentae and were associated with preeclampsia, placental weight, and birth outcomes. Specifically, there was significant hypermethylation at cg22891070 of HIF3 alpha in preeclampsia placentae, and marginal hypomethylation at CpG8 in the promoter region of HIF1 alpha in preterm preeclampsia. Furthermore, HIF1 alpha expression was significantly lower in preterm preeclampsia compared to controls. The study also showed a negative correlation between DNA methylation in the HIF1 alpha promoter region and its expression levels, as well as associations between several CpG sites in HIF1 alpha and placental weight and birth outcomes.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Genetics & Heredity
Neha Singh, Vineet Chaudhary, Kevingu Khate, Debashis Bhattacharjee, Imnameren Longkumer, Suraj Kataria, Gurjinder Kaur, Naorem Kiranmala Devi, Nandita Babu, Kallur Nava Saraswathy
Summary: This study investigated the association between MTR A2756G, MTRR A66G, and CBS 844ins68 polymorphisms in the one-carbon metabolic pathway (OCMP) and cognitive impairment (CI). The findings showed that MTR A2756G and CBS 844ins68 polymorphisms were not associated with CI, but the AG and AA+AG genotypes of MTRR A66G polymorphism increased the risk of CI. This association became non-significant when vitamin B12 and homocysteine levels were normal. MDR analysis indicated the involvement of the methionine cycle in OCMP in CI.
Article
Psychiatry
Vineet Chaudhary, Gagandeep Kaur Walia, Naorem Kiranmala Devi, Lokesh Singh Shekhawat, Kallur Nava Saraswathy
Summary: This study aims to understand the overall and domain-specific impact of ACEs on current depression, anxiety, stress, and well-being among young adults in the Delhi-NCR region of India. The results indicate that exposure to ACEs increases the likelihood of moderate/severe depression, moderate/severe anxiety, and high stress, while decreasing the likelihood of good well-being.
INTERNATIONAL JOURNAL OF SOCIAL PSYCHIATRY
(2023)
Article
Public, Environmental & Occupational Health
Debashis Bhattacharjee, Vineet Chaudhary, Kevingu Khate, Naorem Kiranmala Devi, Nandita Babu, Kallur Nava Saraswathy
Summary: This study is the first follow-up study on cognitive impairment in India, revealing a high incidence rate of cognitive impairment and its association with illiteracy, high waist-hip ratio, and high percentage body fat.
CLINICAL EPIDEMIOLOGY AND GLOBAL HEALTH
(2023)
Article
Genetics & Heredity
Xiangge Meng, Chengping Li, Yu Hei, Xiang Zhou, Guoli Zhou
Summary: The study used IVT-SAPAS sequencing to analyze the dynamic changes of APA sites during adipogenesis in bovine subcutaneous preadipocytes and intramuscular preadipocytes. The results showed that APA plays an important role in adipocyte differentiation, and UTR-APA switching genes have different trends, with intramuscular preadipocytes tending to use shorter 3'UTR for differentiation. TRIB3, WWTR1, and INSIG1 play important roles in intramuscular preadipocyte differentiation.
Article
Genetics & Heredity
S. Alizadeh, S. Khamse, N. Tajeddin, H. R. Khorram Khorshid, A. Delbari, M. Ohadi
Summary: This study identifies a specific genotype at a CG-rich trinucleotide short tandem repeat (STR) locus that is associated with late-onset neurocognitive disorders such as Alzheimer's disease (AD).
Article
Genetics & Heredity
Shougang Liu, Zhe Zhuang, Fanghua Liu, Xiuqing Yuan, Zeqiao Zhang, Xiaoqian Liang, Xinhui Li, Yongfeng Chen
Summary: This study investigated the effect and mechanism of RPL9 and TIFA in scalp psoriasis, and identified RPL9 as a potential therapeutic target for scalp psoriasis.
Article
Genetics & Heredity
Shiting Wang, Jiaqi Chen, Zhichao Jin, Ying Xing, Ruiping Wang
Summary: This study suggests a causal association between hair color and skin cancers, with light hair colors (red, blonde, and light brown) being associated with an increased risk and dark brown hair being associated with a decreased risk.
Article
Genetics & Heredity
Joseph Hawadak, Loick Pradel Kojom Foko, Rodrigue Roman Dongang Nana, Karmveer Yadav, Veena Pande, Aparup Das, Vineeta Singh
Summary: This study investigates the genetic diversity and natural selection of the Pfama-1 gene in Plasmodium falciparum isolates from Cameroon. The study finds a considerable nucleotide and haplotype diversity, as well as specific mutations in Cameroonian isolates. Positive diversifying selection and the identification of selected codon sites suggest the potential implication of these genetic variations in host immune pressure and parasite-binding complex modulation. The findings provide valuable baseline data for malaria vaccine design.
Article
Genetics & Heredity
Emily Biernat, Mansi Verma, Chhabi K. Govind
Summary: RSC is an essential ATP-dependent chromatin remodeling complex in Saccharomyces cerevisiae. It regulates nucleosome-depleted regions (NDRs) by sliding flanking nucleosomes away from NDRs. Depletion of RSC leads to nucleosome encroachment in NDRs and transcription initiation defects. The study compared the effects of catalytic-dead Sth1 and rapid depletion of Sth1 on transcription. Rapid depletion of Sth1 reduces recruitment of TBP and Pol II, while the catalytic-dead mutant exhibits a severe reduction in TBP binding but accumulates Pol II in coding regions. The results suggest a role for RSC in transcription elongation and termination processes.
Article
Genetics & Heredity
Yunxiao Wei, Yuhan Song, Muhammad Aamir Khan, Chengzhen Liang, Zhigang Meng, Yuan Wang, Sandui Guo, Rui Zhang
Summary: This study analyzed the GhTPP protein family in upland cotton for the first time and identified the important role of GhTPPA_2 in regulating sugar metabolism, improving soluble sugar accumulation, and drought stress tolerance.
Article
Genetics & Heredity
Yannan Geng, Rui Shao, Tiantong Xu, Lilong Zhang
Summary: A novel risk model based on SCUBE3, TNNC1, SPON1, SEPT12 and ULBP1 genes was developed for predicting PMOP risk, with higher risk score indicating higher risk of suffering from PMOP. Significant differences in signaling pathway activities were observed between the high-risk score group and the low-risk score group.
Article
Genetics & Heredity
Randy P. Williams, Corina Lesseur, Haoxiang Cheng, Qian Li, Maya Deyssenroth, Christopher D. Molteno, Ernesta M. Meintjes, Sandra W. Jacobson, Joseph L. Jacobson, Helen Wainwright, Ke Hao, Jia Chen, R. Colin Carter
Summary: The study suggests that heavy alcohol exposure during pregnancy may impact the proportion of fetal placental villi macrophages and increase the expression of inflammatory genes. Further research is needed to explore these effects and evaluate the potential functional roles of placental inflammation in FASD.
Article
Genetics & Heredity
Lvjing Luo, Lishuang Sun, Shu Li, Huiting Liu, Zhengyu Chen, Shi Huang, Yinyin Mo, Genliang Li
Summary: This study analyzed the expression of Ptpn1 and miR-124-3p in testicular tissues of mice and investigated their regulatory relationship. The results showed that Ptpn1 expression was up-regulated in adult mouse testis compared to juvenile mouse testis, while miR-124-3p expression showed an opposite pattern. Further analysis suggested that the down-regulation of miR-124-3p may contribute to the high expression of Ptpn1 in adult mouse testis.
Article
Genetics & Heredity
Gairui Li, Dan Zhao, Xiaolin Peng, Yashuang Zhao
Summary: MiRNA-22 shows potential as a candidate for early diagnosis of colorectal cancer (CRC). The study found higher miR-22 expression levels in the CRC and CRA groups, suggesting its potential as a biomarker for CRC early screening.
Article
Genetics & Heredity
Zhongqiu Zhu, Qianting Yang, Xiaoying Tian, Da Man, Jian Wang, Junfang Zhang, Bingshe Han
Summary: This study constructed a ceRNA network mediated by lncRNAs in cold-acclimated zebrafish ZF4 cells and revealed that upregulation of MSTRG3207 promotes apoptosis by sponging dre-miR-736 during cold acclimation.
Article
Genetics & Heredity
Weitao Chen, Denggao Xiang, Shang Gao, Shuli Zhu, Zhi Wu, Yuefei Li, Jie Li
Summary: Dam construction has negatively impacted the genetic diversity and structure of fish populations. This case study on the endangered Hemibagrus guttatus found low genetic diversity, high levels of inbreeding, and decreasing population size in fragmented populations. Genetic structure and differentiation were also observed, indicating the influence of dams on these fish populations.
Article
Genetics & Heredity
Pooja Singh, Debleena Guin, Bijay Pattnaik, Ritushree Kukreti
Summary: Through systematic literature review and meta-analysis, it was found that idiopathic pulmonary fibrosis is significantly associated with 222 polymorphisms in 118 genes. Four polymorphisms - rs35705950/MUC5B, rs2736100/TERT, rs2076295/DSP, and rs111521887/TOLLIP, exhibited substantial epidemiological evidence supporting their association with IPF risk.
Article
Genetics & Heredity
Jianping Zhang, Zhijun Cai, Fanzhe Feng, Yufeng Peng, Yi Cui, Yongiqing Xu
Summary: This study found that exosomes secreted by young BMSCs can promote the healing of tendon-bone interface after rotator cuff tears. These exosomes can improve extracellular matrix remodeling, osteogenic differentiation, angiogenesis, and stemness of tendon-derived stem cells (TDSCs). The exosomes from young BMSCs have better effects compared to those from aged BMSCs.
