Article
Medicine, Research & Experimental
Joeke L. Nollet, Per Cajander, Lara F. Ferris, Jordache Ramjith, Taher Omari, Johanna Savilampi
Summary: The study aimed to investigate the effects of bolus volume and viscosity on pharyngeal swallow using circumferential pressure sensor technology and found that larger volumes increased intrabolus pressure and all upper esophageal sphincter metrics, while thicker viscosity decreased UES relaxation time and flow timing metrics. The use of this technology provides consistent results with previous reports, offering insights into aberrant pharyngo-esophageal motor responses over time.
Article
Gastroenterology & Hepatology
Jeanine Wakim El-Khoury, John E. Pandolfino, Peter J. Kahrilas, Bidemi Godo, Domenico A. Farina, Wenjun Kou, Dustin A. Carlson
Summary: This study aimed to describe the changes in FLIP metrics during FLIP emptying, that is, reduced volume distension. The results showed that isotonic or auxotonic relaxation of the lower esophageal sphincter occurs with reduced volume distension in patients with achalasia and normal motility. The study also supports the importance of utilizing a standardized FLIP motility study protocol to provide reliable and generalizable FLIP metrics to facilitate diagnosis of esophageal motility disorders.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Gastroenterology & Hepatology
Lara Ferris, Sebastian Doeltgen, Charles Cock, Nathalie Rommel, Mistyka Schar, Silvia Carrion, Ingrid Scholten, Taher Omari
Summary: The study evaluated the neuromodulation of healthy oropharyngeal swallowing using high-resolution pharyngeal manometry with impedance, finding significant modulation effects of bolus volume and viscosity on hypopharyngeal intrabolus pressure and upper esophageal sphincter metrics. Increased bolus volumes led to elevated pharyngeal contractility and postswallow pressures, while bolus viscosity only affected UES preopening pressure. These findings contribute to the diagnostic framework for oropharyngeal dysphagia.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2021)
Article
Gastroenterology & Hepatology
Benjamin D. Rogers, Daniel Cisternas, Arvind Rengarajan, Ingrid Marin, Luiz Abrahao, Albis Hani, Ana M. Lequizamo, Jose M. Remes-Troche, Julio Perez de la Serna, Antonio Ruiz de Leon, Frank Zerbib, Jordi Serra, C. Prakash Gyawali
Summary: In healthy asymptomatic subjects, breaks in peristaltic integrity predict abnormal bolus clearance better than DCI or IRP.
NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Otorhinolaryngology
Sophia M. Colevas, Lily N. Stalter, Corinne A. Jones, Timothy M. McCulloch
Summary: This study investigated factors influencing self-selected swallow volume and found that age, gender, and pharyngeal hold area were significantly associated with an increase in self-selected bolus volume. Self-selected swallows showed differences in swallowing pressures and timing events compared to predetermined volume swallows.
Article
Gastroenterology & Hepatology
Dustin A. Carlson, Christina Shehata, Nirmala Gonsalves, Ikuo Hirano, Stephanie Peterson, Jacqueline Prescott, Domenico A. Farina, Jacob M. Schauer, Wenjun Kou, Peter J. Kahrilas, John E. Pandolfino
Summary: This study evaluated the characteristics of secondary peristalsis in patients with EoE and found that abnormal esophageal contractions were associated with disease severity.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Surgery
Maggie M. Hodges, Melissa L. DeSouza, Kevin M. Reavis, Daniel Davila Bradley, Christy M. Dunst
Summary: The clinical significance of multiple rapid swallows (MRS) during high-resolution manometry (HRM) prior to fundoplication is limited, and the response to MRS is not significantly associated with dysphagia after surgery. When using a tailored approach, standard HRM metrics can effectively predict post-operative dysphagia.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Otorhinolaryngology
Kei Aoyama, Kenjiro Kunieda, Takashi Shigematsu, Tomohisa Ohno, Ichiro Fujishima
Summary: This study investigated the effect of different body positions on esophageal motility using high-resolution manometry. Results showed stronger esophageal contractions in the bridge position compared to upright, with shorter peristaltic breaks and longer distal latency. Further research is needed to examine the effectiveness of swallowing in the bridge position.
Review
Gastroenterology & Hepatology
Santosh Sanagapalli, Andrew Plumb, Reginald V. Lord, Rami Sweis
Summary: This review aims to clarify the rationale for components of the barium swallow protocol, provide guidance on interpretation of findings, and describe the current role of the barium swallow in the diagnostic paradigm for esophageal dysphagia in relation to other esophageal investigations. The barium swallow protocol, interpretation, and reporting terminology are subjective and non-standardized. Common reporting terminology and an approach to their interpretation are provided. Rating: 8 out of 10.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Review
Gastroenterology & Hepatology
Taher Omari, Ali Zifan, Charles Cock, Ravinder K. Mittal
Summary: Esophageal peristalsis is a complex process involving both inhibition and excitation. Abnormalities in this process can lead to dysphagia and other swallowing difficulties. Studying the distensibility and contraction characteristics of the esophagus during peristalsis can provide valuable insights for the development of new treatments for patients with swallowing disorders.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2022)
Article
Otorhinolaryngology
S. Saboori, M. Jarvis, J. Baker, B. Seminara, D. Vickers, T. Pacicco, B. Moshiree
Summary: A quality improvement study was conducted at a large community hospital to assess and improve procedural adherence and interpretation of esophageal manometry studies based on the ANMS quality measures. Results showed significant improvement in procedural compliance among nursing staff, but mixed results in data interpretation by physicians, indicating the need for formal HRM education for community gastroenterologists.
Review
Pharmacology & Pharmacy
Sawangpong Jandee, Annelies Geeraerts, Hannelore Geysen, Nathalie Rommel, Jan Tack, Tim Vanuytsel
Summary: Esophageal hypomotility, particularly ineffective esophageal motility according to the Chicago criteria, is a common motility disorder diagnosed on high resolution manometry. Most patients present with GERD symptoms or dysphagia. Prokinetic agents are commonly prescribed but their beneficial effects are limited to certain drugs.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Gastroenterology & Hepatology
Shiko Kuribayashi, Junichi Akiyama, Haruo Ikeda, Kazue Nagai, Hiroko Hosaka, Mariko Hamada, Manabu Onimaru, Noriyuki Kawami, Kunihiko Hayashi, Katsuhiko Iwakiri, Haruhiro Inoue, Motoyasu Kusano, Toshio Uraoka
Summary: This study aimed to evaluate the accuracy of a new automated diagnostic program for HREM, which showed high diagnostic accuracy and time-saving benefits in clinical practice.
JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Medicine, General & Internal
Hang Viet Dao, Long Bao Hoang, Hue Thi Minh Luu, Hoa Lan Nguyen, Robert Joel Goldberg, Jeroan Allison, An Thi Minh Dao, Hong Thi Van Nguyen, Tomoaki Matsumura, Long Van Dao
Summary: This study investigated the clinical symptoms, endoscopic findings, and LES characteristics of adult patients with absent contractility, as well as factors associated with erosive esophagitis. The results showed that male sex and low IRP4s were significantly associated with erosive esophagitis.
Review
Gastroenterology & Hepatology
Pierfrancesco Visaggi, Matteo Ghisa, Brigida Barberio, Elisa Marabotto, Nicola de Bortoli, Edoardo Savarino
Summary: Esophageal motor abnormalities are common in patients with eosinophilic esophagitis (EoE) and may contribute to symptoms. Eosinophils influence esophageal motility, and some motility abnormalities can be improved after medical treatment.
DIGESTIVE AND LIVER DISEASE
(2022)