Article
Oncology
Yadong Zhou, Zhiwei Han, Fafu Dou, Tao Yan
Summary: The study evaluated the diagnostic performance of CTC for pre-colectomy tumor location and staging in colon cancer patients. The results showed that CTC has high accuracy and sensitivity in determining tumor location and differentiating between different tumor stages, providing valuable information for treatment decisions.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Editorial Material
Gastroenterology & Hepatology
Anastasios Koulaouzidis, Gunnar Baatrup
Summary: Colon capsule endoscopy (CCE) is currently used for specific indications. The increasing demand for outpatient treatment along with advancements in technology and clinical quality may allow for broader use of CCE. Artificial intelligence-based analysis and quality assessment could enhance the quality and affordability of CCE.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2023)
Review
Gastroenterology & Hepatology
Andrew R. Reinink, Ashish Malhotra, Aasma Shaukat
Summary: Age is a significant risk factor for colorectal cancer, but there is little guidance on when to stop screening. Current recommendations primarily focus on age, but individualized recommendations should consider comorbidities, functional status, screening history, and gender. Patient and caregiver preferences should also be taken into account. Current models struggle to incorporate other colorectal cancer risk factors, but machine learning and electronic health record prediction-based approaches may improve this.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Review
Immunology
Giovanni Monteleone, Claudia Maresca, Marco Colella, Teresa Pacifico, Daniele Congiu, Edoardo Troncone, Irene Marafini
Summary: This article reviews the current understanding of the involvement of interleukin-34 (IL-34) and its receptor, macrophage colony-stimulating factor-1 receptor (MCSF-1R), in colorectal cancer (CRC). It highlights the role of the IL-34/MCSF-1R axis in controlling tumor-associated macrophages (TAMs) and promoting cancer resistance to chemotherapy and immunotherapy. The findings suggest that targeting IL-34/MCSF-1R could be a potential therapeutic intervention in CRC.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Gastroenterology & Hepatology
Fanny E. R. Vuik, Stella A. Nieuwenburg, Sarah Moen, Cristiano Spada, Carlo Senore, Cesare Hassan, Marco Pennazio, Emanuele Rondonotti, Silvia Pecere, Ernst J. Kuipers, Manon C. W. Spaander
Summary: CCE shows potential advantages in CRC screening, with comparable accuracy to colonoscopy in detecting CRC and polyps. Its sensitivity is superior to CTC, but improvement is needed in completion rates.
Article
Oncology
Yangyang Zhang, Lingxiu Zeng, Meng Wang, Zhenwei Yang, Hailin Zhang, Liping Gao, Ranran Zhang, Jialong Liu, Wenqing Shan, Ying Chang, Lan Liu, Qiu Zhao, Yong Li, Jing Liu
Summary: The study found that RIG-I plays an important role in the immunotherapy of colon cancer by maintaining the stability of PD-L1 to promote immune evasion. Silencing RIG-I increases the sensitivity of tumor cells to T cell killing and slows down the growth of colon tumors. High expression of RIG-I promotes tumor progression and enhances the sensitivity to PD-1 therapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Biochemistry & Molecular Biology
Ping Li, Yang Yang, Xinyu Yang, Yifei Wang, Chon-Kit Chou, Mengmeng Jiang, Jingbin Zheng, Fengyang Chen, Xin Chen
Summary: The study found that TNF receptor type II (TNFR2) is expressed in a wide range of tumor cells. Knocking out TNFR2 in mouse colon cancer cells MC38 and CT26 using CRISPR/Cas9 technology inhibited in vitro proliferation and colony formation of cancer cells through inhibition of AKT phosphorylation and promotion of autophagy-induced cell death. In addition, TNFR2 deficiency significantly impaired the in vivo growth of MC38 or CT26 tumors in mice, accompanied by a decrease in soluble TNFR2 levels in the circulation and an increase in the number of tumor-infiltrating IFN gamma+ CD8 cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Oncology
Laetitia Marisa, Yuna Blum, Julien Taieb, Mira Ayadi, Camilla Pilati, Karine Le Malicot, Come Lepage, Ramon Salazar, Daniela Aust, Alex Duval, Helene Blons, Valerie Taly, David Gentien, Audrey Rapinat, Janick Selves, Sophie Mouillet-Richard, Valerie Boige, Jean-Francois Emile, Aurelien de Reynies, Pierre Laurent-Puig
Summary: The study demonstrates that intratumor heterogeneity (ITH) in colon cancer, decoded based on consensus molecular subtypes (CMS), is common and impacts prognosis. Combinations of different CMSs are associated with poorer outcomes, with ITH being a significant factor in disease-free survival variance. Additionally, cellular analysis suggests that ITH could reflect distinct functional statuses of colon cancer cells, implying potential plasticity between different cell populations related to CMS. Further evaluation of transcriptomic ITH is warranted in the context of personalized medicine.
CLINICAL CANCER RESEARCH
(2021)
Article
Multidisciplinary Sciences
Francesco Vitali, Katia Tortora, Monica Di Paola, Gianluca Bartolucci, Marta Menicatti, Carlotta De Filippo, Giovanna Caderni
Summary: This study examined the fecal and colon mucosal associated microbiota in a model of colorectal cancer in rats. The results showed that age played a significant role in the distribution of the samples, with young rats without tumors being separated from older rats with tumors. There were significant differences in the microbiota between older rats with tumors and younger rats, as well as between the tumor microbiota and both types of rats, indicating a specific relationship between the gut microbiota profile and colorectal cancer. Additionally, the study found correlations between CRC biomarkers, fecal short chain fatty acids, and both the fecal and mucosal microbiota, suggesting the need for further investigation into these functional mucosal parameters.
SCIENTIFIC REPORTS
(2022)
Review
Cell Biology
Thinzar M. Lwin, Michael A. Turner, Siamak Amirfakhri, Hiroto Nishino, Robert M. Hoffman, Michael Bouvet
Summary: This narrative review discusses the principles and methods of using fluorescence targeting technology for the diagnosis and surgical treatment of colorectal cancer (CRC), as well as the current progress of nonspecific dyes and tumor-specific targeting agents in clinical trials.
Article
Biotechnology & Applied Microbiology
Qi Zhang, Xiao Feng, Mingming Zhang, Wenjing Sun, Yuqing Zhai, Shuangshuang Qing, Ying Liu, Haoran Zhao, Jing Sun, Yi Zhang, Chaoqun Ma
Summary: This study systematically analyzed the gene expression and clinical information of colon cancer patients, identifying five pivotal genes related to plasma cells that have excellent prognostic value and significance in immunotherapy.
Article
Surgery
Anne-Line Volden Havshoi, Ulrik Deding, Sofie Sajan Jensen, Per Vadgaard Andersen, Lasse Kaalby, Issam Al-Najami
Summary: CCE had lower completion rates compared to CT colonography and AA colonoscopy, but showed higher polyp detection rates. The completion rate of CCE following incomplete colonoscopy was suboptimal in this study.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Biochemical Research Methods
Steffen Lange, Richard Mogwitz, Denis Huenniger, Anja Voss-Boehme
Summary: Cancer development is a complex process involving multiple steps, and the early phase of tumor growth and progression plays a major role in determining the fate of tumor development. In this study, a cell-based model focusing on the competition between wild-type and tumor cells in colonic crypts was proposed, which successfully reproduced the epidemiological incidence rates of colon cancer and predicted the fraction of cancerous tumors with precancerous lesions.
PLOS COMPUTATIONAL BIOLOGY
(2022)
Article
Infectious Diseases
Juan Corredoira, Enrique Miguez, Lara Maria Mateo, Ricardo Fernandez-Rodriguez, Jose Francisco Garcia-Rodriguez, Alexandre Perez-Gonzalez, Ana Sanjurjo, Maria Victoria Pulian, Blanca Ayuso-Garcia
Summary: The relationship between Streptococcus bovis bacteremia and colorectal neoplasms in cirrhotic patients is unclear. A retrospective cohort study found no difference in the prevalence of colorectal neoplasms between cirrhotic and non-cirrhotic patients with S. bovis bacteremia. However, among cirrhotic patients, those with S. gallolyticus bacteremia had a higher prevalence of colorectal neoplasms compared to those with S. bovis biotype II bacteremia. The findings suggest a higher risk of colorectal neoplasms in cirrhotic patients with S. gallolyticus bacteremia.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2023)
Article
Cell Biology
Hanmin Tang, Jing Wang, Xuehui Luo, Qi Wang, Jie Chen, Xinyue Zhang, Qiuting Li, Chengyi Gao, Yuesen Li, Suxia Han
Summary: The apoptosis-related gene prognostic index (ARGPI) can serve as a promising biomarker for determining the risk of colon cancer progression, as well as molecular and immune characteristics and chemotherapeutic benefit. Through molecular analysis, it is a reliable method to predict the prognosis of colon cancer patients and assist doctors in formulating more effective treatment strategies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Nelleke P. M. Brouwer, Dave E. W. Van der Kruijssen, Niek Hugen, Ignace H. J. T. de Hingh, Iris D. Nagtegaal, Rob H. A. Verhoeven, Miriam Koopman, Johannes H. W. de Wilt
ANNALS OF SURGICAL ONCOLOGY
(2020)
Article
Genetics & Heredity
D. J. J. M. de Gouw, M. Rijpkema, T. J. J. de Bitter, V. M. Baart, C. F. M. Sier, S. Hernot, G. M. van Dam, I. D. Nagtegaal, B. R. Klarenbeek, C. Rosman, R. S. van der Post
MOLECULAR DIAGNOSIS & THERAPY
(2020)
Article
Oncology
Inti Zlobec, Heather E. Dawson, Annika Blank, John-Melle Bokhorst, Martin D. Berger, Iris D. Nagtegaal, Alessandro Lugli
EUROPEAN JOURNAL OF CANCER
(2020)
Article
Oncology
Amy C. Lord, Nikki Knijn, Gina Brown, Iris D. Nagtegaal
EUROPEAN JOURNAL OF CANCER
(2020)
Review
Cell Biology
Javier Quezada-Marin, Alfred K. Lam, Atsushi Ochiai, Robert D. Odze, Kay M. Washington, Masashi Fukayama, Massimo Rugge, David S. Klimstra, Iris D. Nagtegaal, Puay-Hoon Tan, Mark J. Arends, John R. Goldblum, Ian A. Cree, Manuel Salto-Tellez
Article
Gastroenterology & Hepatology
Richarda M. de Voer, Illja J. Diets, Rachel S. van der Post, Robbert D. A. Weren, Eveline J. Kamping, Tessa J. J. de Bitter, Lisa Elze, Rob H. A. Verhoeven, Elisa Vink-Borger, Astrid Eijkelenboom, Arjen Mensenkamp, Iris D. Nagtegaal, Marjolijn C. J. Jongmans, Marjolijn J. L. Ligtenberg
Summary: This study analyzed clinical, molecular, and genetic features of colorectal cancers in adolescents and young adults, finding that 39% of patients had a genetic tumor risk syndrome. The study highlights differences in CRC characteristics between young patients and older patients, suggesting the need for new clinical management strategies.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Review
Oncology
Mary Kay Washington, Richard M. Goldberg, George J. Chang, Paul Limburg, Alfred K. Lam, Manuel Salto-Tellez, Mark J. Arends, Iris D. Nagtegaal, David S. Klimstra, Massimo Rugge, Peter Schirmacher, Alexander J. Lazar, Robert D. Odze, Fatima Carneiro, Masashi Fukayama, Ian A. Cree
Summary: The WHO Classification of Tumours provides international standards for classification and diagnosis, with the latest fifth edition going digital and including a series of books. This article summarizes major diagnostic innovations from the past decade that have been incorporated into the classification.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Rheumatology
M. den Braber-Ymker, M. C. Vonk, K. Grunberg, M. Lammens, I. D. Nagtegaal
Summary: The histological evaluation of intestinal involvement in systemic sclerosis (SSc) revealed differences in vascular changes, muscle layer fibrosis, and neuronal reduction between SSc patients and controls. The diversity among patients suggests parallel pathological processes, explaining the variety of histological features and clinical symptoms observed in SSc.
CLINICAL RHEUMATOLOGY
(2021)
Review
Oncology
Alessandro Lugli, Inti Zlobec, Martin D. Berger, Richard Kirsch, Iris D. Nagtegaal
Summary: Tumour budding serves as an emerging prognostic biomarker in colorectal cancer and other solid cancers, with its predictive accuracy being widely supported by evidence. The standardized scoring system agreed upon at the International Tumour Budding Consensus Conference allows for an independent prediction of pathological features and unfavorable survival outcomes in patients.
NATURE REVIEWS CLINICAL ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
M. J. van Amerongen, A. M. Vos, W. van der Woude, I. D. Nagtegaal, J. H. W. de Wilt, J. J. Futterer, J. J. Hermans
Summary: This study aimed to evaluate the relationship between CTP and histological biomarkers in CRLM patients. The results showed no significant correlation between CTP and pathological markers, but CTP may potentially non-invasively evaluate the prognostic marker of hypoxia in CRLM.
Editorial Material
Oncology
N. P. M. Brouwer, I. D. Nagtegaal
ANNALS OF ONCOLOGY
(2021)
Letter
Surgery
Y. J. van Herwaarden, A. Madani, R. S. van der Post, V. E. P. P. Lemmens, I. D. Nagtegaal
BRITISH JOURNAL OF SURGERY
(2021)
Meeting Abstract
Oncology
Carlijn Bruggeling, Vera Witjes, Daniel Garza, Milou Fransen, Joyce Krekels, Tanya Bisseling, Mariette van Kouwen, Nicoline Hoogerbrugge, Sebastian Lucker, Bas Dutilh, Iris Nagtegaal, Annemarie Boleij
Meeting Abstract
Oncology
Rahwa Taddese, Daniel R. Garza, Lilian Ruiter, Clara Belzer, Steven Aalvink, Iris D. Nagtegaal, Bas E. Dutilh, Annemarie Boleij
Meeting Abstract
Gastroenterology & Hepatology
M. De Jong, S. Vos, I. Nagtegaal, Y. van Herwaarden, L. Derikx, F. Hoentjen
JOURNAL OF CROHNS & COLITIS
(2020)