期刊
FEBS LETTERS
卷 593, 期 13, 页码 1468-1482出版社
WILEY
DOI: 10.1002/1873-3468.13478
关键词
frameshifting; protein synthesis; recoding; regulation; ribosome; RNA; translation; tRNA
资金
- Boehringer Ingelheim Fonds Funding Source: Medline
- Deutsche Forschungsgemeinschaft [SFB 860] Funding Source: Medline
Some proteins are expressed as a result of a ribosome frameshifting event that is facilitated by a slippery site and downstream secondary structure elements in the mRNA. This review summarizes recent progress in understanding mechanisms of -1 frameshifting in several viral genes, including IBV 1a/1b, HIV-1 gag-pol, and SFV 6K, and in Escherichia coli dnaX. The exact frameshifting route depends on the availability of aminoacyl-tRNAs: the ribosome normally slips into the -1-frame during tRNA translocation, but can also frameshift during decoding at condition when aminoacyl-tRNA is in limited supply. Different frameshifting routes and additional slippery sites allow viruses to maintain a constant production of their key proteins. The emerging idea that tRNA pools are important for frameshifting provides new direction for developing antiviral therapies.
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