Review
Cell Biology
Dipanwita Das, Nandini Karthik, Reshma Taneja
Summary: Inflammation is a crucial immune response against infection and tissue damage, but chronic inflammation is linked to cancer development. Immune cells produce inflammatory mediators to facilitate tumor growth, while aberrant expression of inflammatory factors by tumor cells recruits immune cells for mutual crosstalk, creating a conducive environment for tumor growth.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Andrew Liaw, Chun Liu, Saso Ivanovski, Pingping Han
Summary: The scoping review evaluates evidence of global and specific epigenetic changes in periodontitis, indicating that DNA methylation patterns and histone protein modification play a role in inflammatory response modulation. Future research may focus on developing targeted epi-drugs and diagnostic tools for early detection and monitoring of susceptible individuals.
Review
Biochemistry & Molecular Biology
Rodopi Emfietzoglou, Evangelos Pachymanolis, Christina Piperi
Summary: Epigenetic mechanisms play a significant role in the pathogenesis of oral diseases, including Oral Squamous Cell Carcinoma, pulpitis, periodontitis, dental caries, and congenital orofacial malformations. These mechanisms involve promoter methylation, abnormal expression of microRNAs, and histone modifications. Epigenetic changes not only affect the aggressiveness of cancers, but also regulate cytokine production, contributing to the development of dental caries and orofacial malformations.
CURRENT MEDICINAL CHEMISTRY
(2021)
Article
Cell Biology
Saikat Bhattacharya, Divya Reddy, Ning Zhang, Hua Li, Jerry L. L. Workman
Summary: The methyltransferase SETD2 plays a crucial role in regulating transcription, splicing, and other processes through the deposition of the H3K36me3 histone mark. Its stability is controlled by proteasome-mediated degradation to maintain low levels. Excessive SETD2 leads to upregulation of cell cycle-associated pathways, resulting in increased cell proliferation and migration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Futaba Inoue, Kenbun Sone, Yusuke Toyohara, Yu Takahashi, Asako Kukita, Aki Hara, Ayumi Taguchi, Michihiro Tanikawa, Tetsushi Tsuruga, Yutaka Osuga
Summary: Epigenetic changes play a crucial role in endometrial cancer, including DNA methylation and histone modification. There are currently inhibitors targeting epigenetic regulators in preclinical studies and clinical trials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Charalabos Antonatos, Katerina Grafanaki, Paschalia Asmenoudi, Panagiotis Xiropotamos, Paraskevi Nani, Georgios K. Georgakilas, Sophia Georgiou, Yiannis Vasilopoulos
Summary: This review provides an overview of the environmental factors, epigenetic modifications, and non-coding RNAs associated with the onset and progression of psoriasis. It also discusses therapeutic applications targeting the epigenome to suppress the inflammatory cutaneous cascade.
Review
Oncology
Jiaxin Liu, Jia-nan Li, Hongyu Wu, Panpan Liu
Summary: Epigenetic regulation plays a crucial role in lymphoma development and is closely associated with various malignancies. Understanding these epigenetic mechanisms can guide the development of clinical treatments.
FRONTIERS IN ONCOLOGY
(2022)
Review
Immunology
Sudhir Verma, Aastha Singh, Akhil Varshney, R. Arun Chandru, Manisha Acharya, Jyoti Rajput, Virender Singh Sangwan, Amit K. Tiwari, Tuhin Bhowmick, Anil Tiwari
Summary: Epigenetic mechanisms play a crucial role in regulating gene expression and cellular responses, influencing various cell types during development. In the field of ophthalmology, epigenetic mechanisms may have significant impact on the pathogenesis of complex eye diseases, offering new insights for the development of novel treatments.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Yoshitaka Kubota, Hidekazu Nagano, Kentaro Kosaka, Hideyuki Ogata, Akitoshi Nakayama, Masataka Yokoyama, Kazutaka Murata, Shinsuke Akita, Motone Kuriyama, Nobutaka Furuyama, Masayuki Kuroda, Tomoaki Tanaka, Nobuyuki Mitsukawa
Summary: Ceiling culture-derived preadipocytes (ccdPAs) and adipose-derived stem cells (ASCs) were isolated from human subcutaneous fat tissue and showed differences in adipogenic potential due to variations in methylation and histone modification levels of adipogenesis-related genes, such as PPARc, fatty acid-binding protein 4, and leptin. Genomewide epigenetic analysis revealed distinct patterns in CpG methylation and H3K4me3 modification between ccdPAs and ASCs, suggesting epigenetic mechanisms underlying adipogenic differentiation capabilities of these cell types.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2021)
Article
Cell Biology
Bei Yin, Qingge Ma, Lingyi Zhao, Chenghao Song, Chenglin Wang, Fanyuan Yu, Yu Shi, Ling Ye
Summary: The study identified JMJD3, a histone demethylase, as a regulator of key autophagy genes by demethylating H3K27me3 at gene promoters. This highlights the epigenetic regulation of autophagy genes during pulpitis, potentially leading to novel therapeutic strategies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Disha Agarwal, Ruchika Kumari, Ashal Ilyas, Shweta Tyagi, Rajnish Kumar, Nitesh Kumar Poddar
Summary: Epigenetics has opened a new dimension in exploring unanswered questions in genetics, particularly in neurodegenerative diseases like Alzheimer's and cancers. The alterations in DNA methylation levels, histone acetylation, and methylation play a significant role in conditions such as Alzheimer's disease. Studying the interplay between the mTOR regulatory pathway and epigenetic machinery may lead to early diagnosis and novel therapeutic strategies for Alzheimer's disease.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Cell Biology
Bei Yin, Qingge Ma, Lingyi Zhao, Chenghao Song, Chenglin Wang, Fanyuan Yu, Yu Shi, Ling Ye
Summary: The study identified that histone demethylase JMJD3 regulates the expression of key autophagy genes by demethylating H3K27me3 at gene promoters. This highlights the epigenetic regulation of autophagy genes during pulpitis and may potentially offer a novel therapeutic strategy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Genetics & Heredity
Merrick S. Fallah, Dora Szarics, Clara M. Robson, James H. Eubanks
Summary: Epigenetic processes play a critical role in regulating gene expression patterns in neurodevelopment, including the dynamic network of post-translational histone modifications. Mutations in histone-modifying enzymes can disrupt this system and lead to developmental consequences. This review examines neurodevelopmental conditions associated with histone methylation and acetylation, discussing clinical phenotypes, genetic bases, and model systems for studying pathological mechanisms.
FRONTIERS IN GENETICS
(2021)
Review
Biochemistry & Molecular Biology
Young-Su Yi
Summary: Inflammasome, activated in response to infection and damage, triggers inflammatory responses, while methylation, a critical biological process, modulates gene expression. The functional relationship between inflammasome regulation and methylation may play a key role in inflammatory responses and disease development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Plant Sciences
Diego Ornelas-Ayala, Carlos Cortes-Quinones, Jose Olvera-Herrera, Berenice Garcia-Ponce, Adriana Garay-Arroyo, Elena R. Alvarez-Buylla, Maria de la Paz Sanchez
Summary: The Trithorax Group (TrxG) is a conserved complex that regulates transcriptional activation in plants. Recent research has identified new TrxG components and interactions, highlighting their importance in specific tissues.