Alzheimer’s disease: future drug development and the blood-brain barrier

ABBY

(2018) Jeffrey L. Cummings et al.   NEUROLOGY

Neurocognitive and somatic stabilization in pediatric patients with severe Mucopolysaccharidosis Type I after 52 weeks of intravenous brain-penetrating insulin receptor antibody-iduronidase fusion protein (valanafusp alpha): an open label phase 1-2 trial

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Gantenerumab: A Novel Human Anti-Aβ Antibody Demonstrates Sustained Cerebral Amyloid-β Binding and Elicits Cell-Mediated Removal of Human Amyloid-β

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A Brain Penetrating Bifunctional Erythropoietin-Transferrin Receptor Antibody Fusion Protein for Alzheimer’s Disease

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Amyloid positron emission tomography and cerebrospinal fluid results from a crenezumab anti-amyloid-beta antibody double-blind, placebo-controlled, randomized phase II study in mild-to-moderate Alzheimer’s disease (BLAZE)

(2018) Stephen Salloway et al.   Alzheimers Research & Therapy

Are antibodies directed against amyloid-β (Aβ) oligomers the last call for the Aβ hypothesis of Alzheimer's disease?

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Iduronate-2-Sulfatase with Anti-human Transferrin Receptor Antibody for Neuropathic Mucopolysaccharidosis II: A Phase 1/2 Trial

(2018) Torayuki Okuyama et al.   MOLECULAR THERAPY

Blood–Brain Barrier Penetrating Biologic TNF-α Inhibitor for Alzheimer’s Disease

(2017) Rudy Chang et al.   MOLECULAR PHARMACEUTICS

Re-engineering therapeutic antibodies for Alzheimer’s disease as blood-brain barrier penetrating bi-specific antibodies

(2016) William M. Pardridge   EXPERT OPINION ON BIOLOGICAL THERAPY

CSF, blood-brain barrier, and brain drug delivery

(2016) William M. Pardridge   Expert Opinion on Drug Delivery

The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease

(2016) Jeff Sevigny et al.   NATURE

Focused Ultrasound Enhances Central Nervous System Delivery of Bevacizumab for Malignant Glioma Treatment

(2016) Hao-Li Liu et al.   RADIOLOGY

Safety and tolerability of BAN2401 - a clinical study in Alzheimer’s disease with a protofibril selective Aβ antibody

(2016) Veronika Logovinsky et al.   Alzheimers Research & Therapy

Targeted delivery of protein and gene medicines through the blood-brain barrier

(2015) WM Pardridge   CLINICAL PHARMACOLOGY & THERAPEUTICS

Comparative Physiology of Mice and Rats: Radiometric Measurement of Vascular Parameters in Rodent Tissues

(2014) C. Andrew Boswell et al.   MOLECULAR PHARMACEUTICS

Disaggregation of Amyloid Plaque in Brain of Alzheimer’s Disease Transgenic Mice with Daily Subcutaneous Administration of a Tetravalent Bispecific Antibody That Targets the Transferrin Receptor and the Abeta Amyloid Peptide

(2013) Rachita K. Sumbria et al.   MOLECULAR PHARMACEUTICS

A Therapeutic Antibody Targeting BACE1 Inhibits Amyloid-  Production in Vivo

(2011) J. K. Atwal et al.   Science Translational Medicine

Selective targeting of a TNFR decoy receptor pharmaceutical to the primate brain as a receptor-specific IgG fusion protein

(2010) Ruben J. Boado et al.   JOURNAL OF BIOTECHNOLOGY

Drug Targeting of Erythropoietin Across the Primate Blood-Brain Barrier with an IgG Molecular Trojan Horse

(2010) R. J. Boado et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS