IRF1 is critical for the TNF-driven interferon response in rheumatoid fibroblast-like synoviocytes

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mTOR Senses Environmental Cues to Shape the Fibroblast-like Synoviocyte Response to Inflammation

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A Positive Feedback Amplifier Circuit That Regulates Interferon (IFN)-Stimulated Gene Expression and Controls Type I and Type II IFN Responses

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Interferon gene expression signature in rheumatoid arthritis neutrophils correlates with a good response to TNFi therapy

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Endothelial TNF Receptor 2 Induces IRF1 Transcription Factor-Dependent Interferon-β Autocrine Signaling to Promote Monocyte Recruitment

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The interferon signature andSTAT1expression in rheumatoid arthritis synovial fluid macrophages are induced by tumor necrosis factor α and counter-regulated by the synovial fluid microenvironment

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Interferon type I signature may predict non response upon rituximab in rheumatoid arthritis patients

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Blocking of interferon regulatory factor 1 reduces tumor necrosis factor α-induced interleukin-18 bioactivity in rheumatoid arthritis synovial fibroblasts by induction of interleukin-18 binding protein a: Role of the nuclear interferon regulatory factor 1

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Association of the response to tumor necrosis factor antagonists with plasma type I interferon activity and interferon-β/α ratios in rheumatoid arthritis patients: A post hoc analysis of a predominantly Hispanic cohort

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Synovial fibroblasts self-direct multicellular lining architecture and synthetic function in three-dimensional organ culture

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Fibroblast-like synoviocytes: key effector cells in rheumatoid arthritis

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The role and therapeutic implications of fibroblast-like synoviocytes in inflammation and cartilage erosion in rheumatoid arthritis

(2008) Erika H. Noss et al.   IMMUNOLOGICAL REVIEWS

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Mesenchymal cell targeting by TNF as a common pathogenic principle in chronic inflammatory joint and intestinal diseases

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TNF activates an IRF1-dependent autocrine loop leading to sustained expression of chemokines and STAT1-dependent type I interferon–response genes

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