Article
Obstetrics & Gynecology
Shogo Imanaka, Hiroshi Shigetomi, Naoki Kawahara, Hiroshi Kobayashi
Summary: This study identified clinicopathological risk factors and imaging findings associated with adenomyosis-related symptoms. The maximum length from the cervix to the uterine fundus and adenomyosis lesion thickness are independent predictors for menorrhagia and dysmenorrhea, respectively. Infertility may be more related to the coexistence of endometriosis rather than adenomyosis itself.
REPRODUCTIVE MEDICINE AND BIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Qi Zhang, Ye Chen, Mao Lai, Yajie Li, Qing Li, Caixia Fu, Zhenwei Yao, Junhai Zhang
Summary: This study investigated the feasibility of magnetic resonance imaging-guided focused ultrasound surgery (MRgFUS) for the treatment of adenomyosis in a Bama pig model, and the changes in OTR, VEGF, and COX-2 levels in the myometrium tissues after MRgFUS. The results showed that MRgFUS is a feasible treatment for adenomyosis in Bama pigs, and the expression levels of OTR, COX-2, and VEGF decreased in the local myometrium after MRgFUS.
ACADEMIC RADIOLOGY
(2023)
Article
Obstetrics & Gynecology
Lisa Calderon, Antoine Netter, Anais Grob-Vaillant, Julien Mancini, Pascale Siles, Vincent Vidal, Aubert Agostini
Summary: A 3-month treatment course of daily 5 mg doses of UPA could lead to short-term progression or emergence of typical adenomyosis intramyometrial cysts on MRI examinations.
REPRODUCTIVE BIOMEDICINE ONLINE
(2021)
Review
Medicine, General & Internal
Sun-Wei Guo, Giuseppe Benagiano, Marc Bazot
Summary: Adenomyosis is a complicated gynecological disease that is poorly understood. The diagnosis used to rely solely on histology after hysterectomy, but now imaging techniques like transvaginal ultrasound and MRI are increasingly used. However, the lack of a consensus on a classification system makes it difficult to relate imaging findings with disease severity or histopathological features, which hampers patient and clinician communication and comparative studies.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Johanna K. Andersson, Raffaella Pozzi Mucelli, Margit Dueholm, Susanne Fridsten, Aristeidis Grigoriadis, Stefano Guerriero, Francesco Paolo Leone, Lil Valentin, Thierry Van den Bosch, Nikolaos Voulgarakis, Kristina Gemzell-Danielsson, Elisabeth Epstein
Summary: This study aims to compare the inter-rater agreement of transvaginal ultrasonography (TVS) and magnetic resonance imaging (MRI) in diagnosing adenomyosis and assessing imaging features. The results showed that TVS had higher agreement in diagnosing adenomyosis, while MRI had higher agreement in assessing specific features.
Article
Obstetrics & Gynecology
Louis Marcellin, Ludivine Legay, Pietro Santulli, Anne Elodie Millischer, Corinne Bordonne, Lorraine Maitrot Mantelet, Chloe Maignien, Mathilde Bourdon, Antoine Gaudet Chardonnet, Bruno Borghese, Francois Goffinet, Charles Chapron
Summary: The research aimed to investigate whether there is a change in MRI criteria for diffuse and focal phenotypes of adenomyosis before and after pregnancy. The study found that the frequency of isolated diffuse adenomyosis on MRI was significantly lower before pregnancy, while the frequency of isolated focal adenomyosis was significantly higher before pregnancy. The mean volume of all focal adenomyosis lesions on MRI decreased significantly after pregnancy. These findings suggest that there is an increase in diffuse adenomyosis and a decrease in focal adenomyosis after pregnancy.
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)
Article
Obstetrics & Gynecology
Connie O. Rees, Iris A. M. Rupert, Joost Nederend, Dimitri Consten, Massimo Mischi, Huib A. A. M. van Vliet, Benedictus C. Schoot
Summary: The combined adenomyosis and endometriosis women had lower pregnancy and live birth rates during IVF/ICSI, likely due to the more severe nature of their diseases leading to increased chances of implantation failure and miscarriage.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2022)
Review
Genetics & Heredity
Gaby Moawad, Mira H. Kheil, Jean Marc Ayoubi, Jordan S. Klebanoff, Sara Rahman, Fady Sharara
Summary: This review examines the relationship between adenomyosis and infertility, finding that adenomyosis patients have lower clinical pregnancy rates, lower live birth rates, higher miscarriage rates, and higher odds of adverse obstetric outcomes. Treatment appears to improve fertility outcomes.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2022)
Review
Obstetrics & Gynecology
Juan Luis Alcazar, Julio Vara, Claudia Usandizaga, Silvia Ajossa, Maria A. Pascual, Stefano Guerriero
Summary: This study compared the diagnostic accuracy of transvaginal ultrasound (TVS) and magnetic resonance imaging (MRI) for adenomyosis. The results showed that both TVS and MRI had similar performances in diagnosing adenomyosis. Rating: 8/10.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Medicine, General & Internal
Youn-Jee Chung, Sung Eun Rha, Mee-Ran Kim, Yu Ri Shin
Summary: This study aimed to explore the correlation between MRI features, clinical risk factors, and symptoms associated with adenomyosis. The findings showed that patients with operated adenomyosis had younger age, larger lesions, more frequent diffuse type and posterior localization, as well as the presence of coexisting ovarian endometriosis, deep infiltrating endometriosis, myometrial cysts, and diffusion restriction compared to non-operated lesions. Additionally, there were significant associations between MRI parameters and clinical presentations, including VAS scores, CA-125 levels, hemoglobin levels, and parity.
Article
Obstetrics & Gynecology
Chloe Higgins, Hugo Fernandes, Fabricio Da Silva Costa, Wellington P. Martins, Beverley Vollenhoven, Martin Healey
Summary: This study found that adenomyosis does not significantly impact IVF outcomes, after adjusting for confounding factors. It suggests that screening and treating adenomyosis may be less important in improving IVF success rates than previously thought.
HUMAN REPRODUCTION OPEN
(2021)
Article
Obstetrics & Gynecology
Paolo Vercellini, Paola Vigano, Veronica Bandini, Laura Buggio, Nicola Berlanda, Edgardo Somigliana
Summary: This review synthesized systematic reviews and meta-analyses published in the last 5 years to explore the association between endometriosis and adenomyosis with reproductive and obstetric outcomes. The findings suggest that women with endometriosis and adenomyosis have reduced pregnancy and live birth rates, increased miscarriage rates, and higher risks of various adverse obstetric outcomes. Women with deep infiltrating endometriosis and severe adenomyosis should be considered at high obstetric risk and referred to tertiary care centers for safe management during pregnancy and delivery. It is uncertain whether the same applies to pregnant women with minimal endometriosis and adenomyosis forms. Emerging evidence suggests that some adverse outcomes observed in women with endometriosis are associated with coexisting adenomyosis.
FERTILITY AND STERILITY
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Weizhao Lu, Yuanyuan Sun, Hui Gao, Jianfeng Qiu
Summary: The increasing number of women in the perimenopausal phase due to global population ageing highlights the importance of studying the perimenopausal brain. Magnetic resonance imaging (MRI) has been widely used to reveal brain alterations associated with perimenopausal symptoms. This review collects literature on perimenopausal brain using MRI techniques, describes the changes in brain structure, function, perfusion, and metabolic compounds, and provides a perspective on future multi-modal MRI studies in the perimenopausal brain. Further research is needed to address the neural heterogeneity in the perimenopausal brain for precise diagnosis and personalized treatment of perimenopausal symptoms.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hye Mi Gweon, Na Lae Eun, Ji Hyun Youk, Joon Jeong, Soong June Bae, Sung Gwe Ahn, Jeong-Ah Kim, Eun Ju Son
Summary: The study demonstrates that abbreviated breast magnetic resonance imaging (MRI) provides significant diagnostic value for patients with suspicious microcalcifications on screening mammography, leading to increased positive predictive value and a reduction in false-positive diagnoses.
EUROPEAN RADIOLOGY
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Athina C. Tsili, Loukas Astrakas, Nikolaos Sofikitis, Maria I. Argyropoulou
Summary: Proton magnetic resonance spectroscopy provides information on testicular metabolism and pathological changes. It has been used in conjunction with scrotal MRI to gain insights into the biochemical environment of normal and abnormal testes.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Obstetrics & Gynecology
Tina Tellum, Staale Nygaard, Else K. Skovholt, Erik Qvigstad, Marit Lieng
FERTILITY AND STERILITY
(2018)
Article
Obstetrics & Gynecology
Tina Tellum, Erik Qvigstad, Else Kathrine Skovholt, Marit Lieng
JOURNAL OF MINIMALLY INVASIVE GYNECOLOGY
(2019)
Review
Obstetrics & Gynecology
Tina Tellum, Staale Nygaard, Marit Lieng
JOURNAL OF MINIMALLY INVASIVE GYNECOLOGY
(2020)
Review
Obstetrics & Gynecology
Tina Tellum, Malcolm G. Munro
Summary: There is a lack of widely accepted and validated classification and reporting system for adenomyosis, although several new proposals have emerged in recent years. The differentiation of diffuse and focal adenomyosis still lacks consensus, and only a few authors have advocated imaging-based definitions.
CURRENT OBSTETRICS AND GYNECOLOGY REPORTS
(2022)
Article
Obstetrics & Gynecology
T. Tellum, J. Naftalin, C. Chapron, M. Dueholm, S-W Guo, M. Hirsch, E. R. Larby, M. G. Munro, E. Saridogan, Z. M. van der Spuy, D. Jurkovic
Summary: This study identified a set of core outcomes for all studies investigating uterus-sparing interventions for treating uterine adenomyosis. These core outcomes cover a wide range of domains, including pain, uterine bleeding, reproductive outcomes, haematology, urinary system, life impact, delivery of care, adverse events, and reporting items.
HUMAN REPRODUCTION
(2022)
Article
Public, Environmental & Occupational Health
Marianne Omtvedt, Elisabeth Bean, Kirsten Hald, Elisabeth Raasholm Larby, Guri B. Majak, Tina Tellum
Summary: This survey shows similar perceptions and a high level of agreement regarding the needs of individuals with endometriosis and/or adenomyosis. The results support recommendations by experts that specialized, multidisciplinary centers should be established for endometriosis and adenomyosis care.
Article
Acoustics
T. Tellum, B. Bracco, L. V. De Braud, J. Knez, R. Ashton-Barnett, T. Amin, P. Chaggar, D. Jurkovic
Summary: This study aimed to investigate the reproductive outcomes of women with a unicornuate uterus compared to those with no congenital uterine anomaly. The results showed that women with a unicornuate uterus had lower live-birth rates and higher rates of miscarriage, ectopic pregnancy, preterm delivery, and Cesarean delivery.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Review
Acoustics
M. J. Harmsen, L. M. Trommelen, R. A. de Leeuw, T. Tellum, L. J. M. Juffermans, A. W. Griffioen, I. Thomassin-Naggara, T. Van den Bosch, J. A. F. Huirne
Summary: The uterine junctional zone is an area in the myometrium that aids in peristalsis and transport of spermatozoa and blastocysts. Alterations in its appearance on imaging are associated with adenomyosis, but the lack of standardization and ill-defined boundaries hinder its diagnosis. This review investigates the definition of the junctional zone and how imaging findings can be linked to histological findings in diagnosing adenomyosis.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Jure Knez, Elisabeth Bean, Simrit Nijjar, Tina Tellum, Prubpreet Chaggar, Davor Jurkovic
Summary: This study aimed to evaluate the progression of deep endometriosis in women who were managed expectantly without any medical or surgical intervention. The study found that over a third of women with deep endometriosis experienced disease progression, but asymptomatic or mildly symptomatic patients are unlikely to have worsening disease over time.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Article
Acoustics
P. Chaggar, T. Tellum, N. Thanatsis, L. V. De Braud, T. Setty, D. Jurkovic
Summary: This prospective observational cohort study assessed the prevalence of deep and ovarian endometriosis in premenopausal women using transvaginal ultrasound. The study also investigated the association between endometriosis and demographic factors as well as other pelvic abnormalities. The results showed that 18.9% of the women had sonographic evidence of deep and/or ovarian endometriosis. Endometriosis was significantly associated with adenomyosis and pelvic adhesions, while higher parity and history of Cesarean section were negatively associated with its occurrence.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Review
Obstetrics & Gynecology
T. Tellum, M. Omtvedt, J. Naftalin, M. Hirsch, D. Jurkovic
Summary: A total of 38 studies were reviewed, reporting on 203 outcomes using 133 outcome measures. Heterogeneity in outcome evaluation and reporting was found in interventional trials evaluating the treatment of adenomyosis, highlighting the need for a core outcome set to improve research quality.
HUMAN REPRODUCTION OPEN
(2021)
Article
Obstetrics & Gynecology
Emma Kirk, Pim Ankum, Attila Jakab, Nathalie Le Clef, Artur Ludwin, Rachel Small, Tina Tellum, Mira Toyli, Thierry Van den Bosch, Davor Jurkovic
HUMAN REPRODUCTION OPEN
(2020)