Review
Chemistry, Multidisciplinary
Majid M. Heravi, Vahideh Zadsirjan
Summary: The Hantzsch reaction is a well-known multi-component reaction for synthesizing 1,4-dihydropyridines, and microwave irradiation has been successfully utilized as a green energy source to promote this organic transformation. Literature survey shows that construction and aromatization of 1,4-DHPs can be effectively carried out under microwave irradiation in solution or dry media.
Article
Chemistry, Physical
Nikolai Wurzer, Urszula Klimczak, Tobias Babl, Sebastian Fischer, Ricardo A. Angnes, Dominik Kreutzer, Aryaman Pattanaik, Julia Rehbein, Oliver Reiser
Summary: In this study, a versatile approach for endocyclic ring opening of bicyclic vinylcyclopropanes triggered by Heck arylations was reported. The key step of this transformation involves a beta-C-elimination allowing the ring expansion of various cyclopropanated compounds. Additionally, gem-disubstituted cyclopropanated furans exhibited unexpected behavior by giving diastereoselectively asymmetrically substituted dienes. Mechanistic studies suggest a facile beta-C-elimination with a concomitant shift of Pd along the cyclopropane moiety as a competitive pathway in the Heck reaction.
Review
Chemistry, Multidisciplinary
Majid M. Heravi, Vahideh Zadsirjan
Summary: This review summarizes recent advances in the synthesis and aromatization of Hantzsch 1,4-dihydropyridines under microwave irradiation, highlighting the use of this green approach.
Article
Chemistry, Multidisciplinary
Parichehr Kamalzare, Behrooz Mirza, Somayeh Soleimani-Amiri
Summary: An environmentally friendly and efficient method for the synthesis of biologically active 1,4-dihydropyridine derivatives using chitosan magnetic nanocomposite as a recyclable catalyst under solvent-free conditions has been developed. The method offers advantages such as mild reaction conditions, high efficiency, and catalyst reusability.
JOURNAL OF NANOSTRUCTURE IN CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Cristina Blazquez-Barbadillo, Juan Francisco Gonzalez, Andrea Porcheddu, David Virieux, Jose Carlos Menendez, Evelina Colacino
Summary: This study investigated the solvent-free preparation of unsymmetrical N-aryl-5,6-unsubstituted-1,4-dihydropyridines (DHPs) using ball-milling. The results showed that the physical state of reactants and intermediates influenced the choice of catalyst and work-up method for recovering the final products.
GREEN CHEMISTRY LETTERS AND REVIEWS
(2022)
Article
Chemistry, Physical
Padmini Gupta, Swati Rani, Digvijay Sah, Bholey Surabhi, Javaid Shabir, Bholey Singh, Balaram Pani, Subho Mozumdar
Summary: In this study, magnetic nanoparticles functionalized with basic ionic liquid based on immobilized Fe3O4 @SiO2 (FS) and 1,4-diazabicyclo[2.2.2]octane (DABCO) were synthesized. The synthesized nanocomposite was characterized using various physicochemical and morphological techniques. It was found to be a thermally stable and highly cost-effective catalyst for green base-promoted organic transformations, resulting in excellent yields in short reaction times. Additionally, the magnetic nanocomposite could be easily recovered and recycled multiple times without significant loss in performance. (c) 2022 Elsevier B.V. All rights reserved.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Multidisciplinary
Kaier Wu, Yuye Bai, Dewei Chen, Lu Chen, Yubing Huang, Shuli Bai, Yibiao Li
Summary: Heterocyclic compounds are widely found in nature and drug molecules, with many nitrogen-containing heterocyclic compounds exhibiting unique activity. 1,4-dihydropyridines, for example, have good antitumor and antibacterial effects and can be used as calcium channel blockers in the treatment of cardiovascular diseases. This study successfully designed cobalt carbon nanotubes as a catalyst for the efficient synthesis of 1,4-dihydropyridines under mild conditions, with advantages including high yields, low catalyst loading, short reaction time, and recyclability.
ENVIRONMENTAL CHEMISTRY LETTERS
(2021)
Article
Chemistry, Applied
Fatemeh Sameri, Mohammad Ali Bodaghifard, Akbar Mobinikhaledi
Summary: In this study, a Zn(II) Schiff base was covalently anchored onto the surface of CaO@SiO2 nanoparticles. The organic-inorganic hybrid nanostructure showed excellent catalytic activity for the green synthesis of 4H-pyran derivatives, with high yields obtained. Additionally, the material exhibited stability and high performance under reaction conditions.
APPLIED ORGANOMETALLIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Santosh T. Shinde, Kaluram G. Kanade, Ramesh B. Gawade, Vikram B. Hinge, Manish D. Shinde, Digambar B. Bankar, Nitin M. Thorat, Dinesh P. Amalnerkar
Summary: AlCl3-loaded ZnO nanoparticles were used as an efficient catalyst for 1,4-dihydropyridine synthesis under ambient temperature and solvent-free conditions. The nanoparticles were synthesized by precipitation and the catalyst was prepared by loading AlCl3 on ZnO nanoparticles. The catalyst showed high efficiency with a 92% yield for the synthesis of 1,4-dihydropyridine.
Article
Chemistry, Multidisciplinary
Lalhruaizela, Brilliant N. Marak, Balkaran S. Sran, Ved Prakash Singh
Summary: In this study, a series of 4H-pyrans were synthesized and characterized through X-ray diffraction, Hirshfeld surface analysis, Pass prediction, and molecular docking. The compounds exhibited good antiischemic activity and binding affinity towards the target receptors.
Article
Chemistry, Physical
Mehmet Ersatir, Murat Turk, Elife Sultan Giray
Summary: A simple and eco-friendly method has been developed for synthesizing 1,4-dihydropyridine compounds in sub-critical ethanol with excellent yields, short reaction time, and easy work-up conditions.
JOURNAL OF SUPERCRITICAL FLUIDS
(2021)
Article
Chemistry, Physical
David F. F. Brossault, Thomas M. McCoy, Alexander F. Routh
Summary: A green approach for producing magnetic photocatalysts via direct agglomeration of commercial nanoparticles in emulsion was successfully demonstrated in this study. The aggregation was attributed to charge screening by salt addition. The experiment resulted in magnetically responsive beads with good adsorption and photodegradation properties, and they could be reused after magnetic separation.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Article
Materials Science, Multidisciplinary
Mohsen Bakhtiarian, Mohammad Mehdi Khodaei
Summary: In this study, a bio-derived magnetic nanocomposite was prepared based on citrus pectin, modified with 1-amino-8-naphthol-3,6-disulfonic acid. The nanocomposite was used for ultrasonic-assisted synthesis of biologically active compounds, showing high efficiency and stability. Characterization methods confirmed the structure and stability of the nanocomposite, indicating its potential for further applications in organic synthesis.
MATERIALS TODAY COMMUNICATIONS
(2021)
Article
Chemistry, Organic
Behrooz Maleki, Hengameh Atharifar, Oliver Reiser, Reihaneh Sabbaghzadeh
Summary: The Fe3O4-supported glutathione catalyst showed excellent catalytic activity in synthesizing 1,4-dihydropyridine derivatives, with easy separation and consecutive reuse in six runs. Other advantages include short reaction time, high yield, simple work-up procedure, easy catalyst handling, and high catalyst stability, making the protocol economical and sustainable.
POLYCYCLIC AROMATIC COMPOUNDS
(2021)
Article
Chemistry, Multidisciplinary
Kanyarat Sarageng, Wanpawee Wongprom, Weesuda Noorith, Panjaphong Lertsathitphong, Jessica Crawford, Norased Nasongkla, Anthony P. O'Mullane, Benchaporn Lertanantawong
Summary: This study reports a simple and rapid method for synthesis of fluorescent gallium oxyhydroxide (GaOOH) nanoparticles from liquid Ga. The aspect ratio of the GaOOH nanoparticles can be controlled by varying the concentration of H2O2, solution pH, probe energy, and sonication time. Surface modification with cyclodextrin is also demonstrated to achieve biocompatibility for potential biomedical applications such as cell uptake and fluorescence imaging.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Organic
Zahra Najahi Mohammadizadeh, Mahdia Hamidinasab, Najmieh Ahadi, Mohammad Ali Bodaghifard
Summary: A novel organic-inorganic hybrid nanomaterial was prepared and its catalytic properties were investigated for green synthesis applications.
POLYCYCLIC AROMATIC COMPOUNDS
(2022)
Article
Chemistry, Multidisciplinary
Mohammad Ali Bodaghifard, Saeideh Shafi
Summary: A novel hybrid nanostructure (CoFe2O4@SiO2@PAF-IL) was investigated for catalyzing the synthesis of benzothiazole and benzimidazole derivatives, showing good yields and short reaction times. The nanomaterial offers solvent-free and environmentally-friendly conditions, and can be easily separated and reused with an external magnetic field.
JOURNAL OF THE IRANIAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Multidisciplinary
Fatemeh Sameri, Akbar Mobinikhaledi, Mohammad Ali Bodaghifard
Summary: Novel and efficient CaO@SiO2@AIL hybrid nanocatalyst synthesized for the synthesis of pharmaceutically valuable compounds with high yields and green conditions, showing good recycling capabilities without significant loss of performance.
RESEARCH ON CHEMICAL INTERMEDIATES
(2021)
Article
Biochemistry & Molecular Biology
Mahdia Hamidinasab, Alieh Ameri, Azadeh Hekmat, Hamid Forootanfar, Tohid Mortezazadeh, Mohammad Ali Bodaghifard, Fariba Peytam, Rezvan Esmaeili, Alireza Foroumadi, Mohammad Sharifzadeh, Akbar Mobinikhaledi, Mehdi Khoobi
Summary: Several mono- and bis-pyrazolophthalazines were synthesized efficiently and evaluated for their cytotoxic activities against human cancer cell lines. Compounds 4e and 6c showed significant cytotoxic effects, interacting with DNA and HSA. They have potential as lead structures for further studies in cancer therapy.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Physical
Fatemeh Sameri, Akbar Mobinikhaledi, Mohammad Ali Bodaghifard
Summary: Core/shell CaO@SiO2-SO3H nanoparticles were prepared by stabilizing sulfonic acid on the surface of silica-coated CaO nanoparticles. The catalyst was used for the green synthesis of dihydropyrano[2,3-c]pyrazoles and tetrahydrobenzo[b]pyrans with good to excellent yields. It could be recycled and reused for six runs without significant loss of activity.
Article
Chemistry, Inorganic & Nuclear
Mohammad Ali Bodaghifard, Somayeh Safari
Summary: The research indicates that silica-coated cobalt ferrite nanoparticles exhibit significant stability of magnetic core and - OH functional groups on the surface, making them suitable for functionalization and catalytic applications. A Cu(II) complex-modified magnetic solid support was successfully prepared and evaluated for catalytic activity in the synthesis of 2,3-dihydroquinazolin-4(1H)-ones, resulting in high yields of desired products.
JOURNAL OF COORDINATION CHEMISTRY
(2021)
Article
Chemistry, Organic
Fatemeh Sameri, Mohammad Ali Bodaghifard, Akbar Mobinikhaledi
Summary: The novel ionic liquid-coated nanomaterials exhibit efficient catalytic performance, environmental friendliness, and reusability, making them a promising candidate for sustainable synthesis of heterocyclic compounds.
POLYCYCLIC AROMATIC COMPOUNDS
(2022)
Article
Chemistry, Applied
Fatemeh Sameri, Mohammad Ali Bodaghifard, Akbar Mobinikhaledi
Summary: In this study, a Zn(II) Schiff base was covalently anchored onto the surface of CaO@SiO2 nanoparticles. The organic-inorganic hybrid nanostructure showed excellent catalytic activity for the green synthesis of 4H-pyran derivatives, with high yields obtained. Additionally, the material exhibited stability and high performance under reaction conditions.
APPLIED ORGANOMETALLIC CHEMISTRY
(2021)
Article
Chemistry, Organic
Mohammad Ali Bodaghifard, Mojgan Zendehdel, Mahdia Hamidinasab, Najmieh Ahadi, Raziyeh Zandi
Summary: In this study, an organic-inorganic hybrid material was prepared by surface functionalization of mesoporous MCM-41. The hybrid material exhibited mild and efficient catalytic activity under environmentally friendly conditions, allowing for the synthesis of specific products in multicomponent reactions, and it showed good recyclability.
POLYCYCLIC AROMATIC COMPOUNDS
(2023)
Article
Chemistry, Organic
Mahdia Hamidinasab, Meisam Ghasemi, Mohammad Ali Bodaghifard
Summary: A novel organic-inorganic hybrid material was prepared and used as a green catalyst in this study; the catalyst showed excellent catalytic activity in synthesizing the target products with high yields in a short reaction time; moreover, the catalyst could be recycled multiple times with only a slight loss of activity.
SYNTHETIC COMMUNICATIONS
(2021)
Article
Chemistry, Organic
Mahdia Hamidinasab, Najmieh Ahadi, Mohammad Ali Bodaghifard, Goutam Brahmachari
Summary: The design and development of eco-friendly procedures for synthesizing organic compounds is crucial in synthetic chemistry. Catalysts increase reaction rates and offer advantages such as reduced energy input, diminished environmental impact, and financial benefit. Combining multicomponent reactions (MCRs) with natural catalysts is a strategic approach for sustainable organic synthesis.
POLYCYCLIC AROMATIC COMPOUNDS
(2023)
Article
Engineering, Electrical & Electronic
Rezvan Ahangarani-Farahani, Mohammad Ali Bodaghifard
Summary: A dendrimer-coated magnetic nanomaterial was successfully synthesized and characterized. It showed excellent adsorption performance for the removal of heavy metal contaminants, with good binding ability and high adsorption efficiency. The adsorption process followed Freundlich isotherm and pseudo-second-order kinetic model.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
(2022)
Article
Chemistry, Organic
Zahra Faraki, Mohammad Ali Bodaghifard
Summary: A novel cationic covalent organic framework (CCOF) with high porosity and crystallinity was synthesized and characterized. The synthesized cationic COF showed good removal efficiency as an adsorbent for dyes.
POLYCYCLIC AROMATIC COMPOUNDS
(2023)
Article
Chemistry, Multidisciplinary
Mohammad Ali Bodaghifard, Mahdia Hamidinasab, Niusha Soleimani
Summary: Researchers synthesized a hybrid nanomaterial by grafting a heteropoly acid-based ionic liquid on the surface of NiFe2O4@SiO2 magnetic nanoparticles. The resulting nanocatalyst showed excellent performance in the oxidative desulfurization process and could be recycled multiple times.
RESEARCH ON CHEMICAL INTERMEDIATES
(2023)
Article
Environmental Sciences
Mohammad Ali Bodaghifard, Mahdia Hamidinasab, Pegah Bayat
Summary: Magnetic nanoparticles surrounded with a silica shell were functionalized with a heteropolyacid to create a hybrid nanomaterial for catalyzing the oxidative desulfurization (ODS) of fuels. The nanocatalyst exhibited high removal efficiency for benzothiophene (BT) and dibenzothiophene (DBT), removing 97% and 98% respectively. It also demonstrated effective desulfurization of real crude oil (600 ppm) with a sulfur removal rate of 96%, and maintained its catalytic activity over five consecutive oxidation runs.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
