Article
Chemistry, Multidisciplinary
Seyyedeh Ameneh G. Alavi, Mohammad Ali Nasseri, Milad Kazemnejadi, Ali Allahresani, Mandi HussainZadeh
Summary: The magnetic Cu-Co bimetallic nanoparticles catalyst shows excellent performance in various cross-coupling reactions, with high efficiency and recyclability. It is characterized by its simplicity, lack of heavy metals, and environmental friendliness.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Mohammad Hassan Maleki, Mahsa Rezaie, Mohammad Dinari
Summary: A green and facile method was developed to prepare catalysts with copper fixed on a magnetic carrageenan surface. The structure and morphology of the catalysts were analyzed, and their excellent performance in reducing nitrophenol compounds was confirmed. Due to the magnetic properties, the catalysts could be easily separated and used multiple times.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Multidisciplinary
Mina Zare, Leila Moradi
Summary: In this study, magnetic mesoporous N-doped silica nanospheres decorated by CuO nanoparticles (M-MNS/CuO) were prepared and used for the green and efficient synthesis of [3.3.3] propellane indeno[1,2-b] indole derivatives. The catalyst has dual acidic and basic properties due to the presence of nitrogen atoms and copper oxide nanoparticles in its structure.
Article
Chemistry, Inorganic & Nuclear
Neha Sharma, Bushra Chowhan, Monika Gupta, Mobina Kouser
Summary: A facile method for the formation of nickel ferrite immobilized over B,N,F tridoped mesoporous cerium oxide nanostructures was designed and characterized. The mesoporous nanomaterial showed great potential as a heterogeneous nanocatalyst and an adsorbent for methyl orange dye.
DALTON TRANSACTIONS
(2022)
Article
Plant Sciences
Bruno Oliveira Moreira, Vanessa Lima Souza Vilar, Ramine Nascimento Santos de Almeida, Lorena Lobo Brito Morbeck, Bruno Silva Andrade, Rafael Gomes Moreno Barros, Breno Magalhaes Neves, Anaildes Lago de Carvalho, Mariluze Peixoto Cruz, Regiane Yatsuda, Jorge Mauricio David
Summary: Schinopsis brasiliensis, an endemic tree of Brazil, has been widely used in Brazilian folk medicine for its anti-inflammatory and analgesic activities. This study isolated two new compounds and reported their acetylcholinesterase inhibitory activity for the first time. Molecular docking studies suggested that these compounds may interact with anti-inflammatory targets.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Plant Sciences
Ci-Qin Li, Jin-Hui Shi, Jie Mu, An-Qi Wang, Li-Wei Zou, Guang-Bo Ge
Summary: A set of 22 analogs of licochalcone A was designed and synthesized to explore their potentials as dipeptidyl peptidase 4 (DPP4) inhibitors with anti-inflammatory effects. The most potent activity was exhibited by the nitro-substituted analogue 27. The structure-activity relationship investigation revealed the importance of 4-hydroxyl and 5-chloro substituents for DPP4 inhibition, while the 3'-nitro substituent improved both DPP4 inhibition and microsomal stability. Furthermore, compound 27 showed good selectivity for DPP4 over other proteases and demonstrated no toxicity to normal cells and weak toxicity to cancer cells.
JOURNAL OF NATURAL PRODUCTS
(2023)
Article
Chemistry, Physical
Siran Xu, Xin Yu, Li Luo, Wenjing Li, Yeshuang Du, Qingquan Kong, Qi Wu
Summary: This study proposes a versatile multiscale manipulating strategy to construct a V-NiFe2O4@Ni2P/NF heterostructure with superior activity and stability. The in-situ generated Ni2P phase induced by selective phosphorylation of the NiFe-precursor exhibits excellent catalytic activity. In addition, metal V doping stimulates the activity by modulating the electronic structure. The binder-free catalyst, built with a large active surface and robust scaffold, demonstrates outstanding OER activity and long-term stability.
Article
Chemistry, Medicinal
Liping Jiang, Bo Liu, Shengjie Hou, Tiande Su, Qiyun Fan, Eman Alyafeai, Yaqin Tang, Mengqi Wu, Xiaohua Liu, Jing Li, Yu Hu, Wulan Li, Zhiwei Zheng, Yuan Liu, Jianzhang Wu
Summary: This study synthesized chalcone derivatives and found that half of them exhibited good anti-Toxoplasma activity, with four compounds showing potent anti-T. gondii activity and low cytotoxicity. These findings provide promising compounds for the development of anti-Toxoplasma agents.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Physical
Marimuthu Karpuraranjith, Yuanfu Chen, Bin Wang, Jeyagopal Ramkumar, Dongxu Yang, Katam Srinivas, Wei Wang, Wanli Zhang, Ramadoss Manigandan
Summary: A highly efficient dual-functional catalyst for electrocatalytic oxygen evolution reaction and dye pollutant degradation was developed using a bandgap matching and interfacial coupling strategy. The catalyst showed low overpotential and high Tafel slope, demonstrating superior performance for both reactions.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Article
Chemistry, Medicinal
Huashen Xu, Jianmin Wang, Yuanguang Chen, Yang Du, Lu Chen, Chunfu Wu, Lihui Wang, Guoliang Chen
Summary: In this study, a series of chalcone-based compounds with 2,2-dimethylbenzopyran were designed and synthesized. Compound 16e showed the strongest HIF-1 inhibitory activity, as well as significant suppression of cell migration and VEGF-induced invasion, and anti-angiogenesis activity. The compound also demonstrated no toxic adverse effects in animal tests, suggesting its potential as an anti-invasive and anti-angiogenic agent.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Physical
Yitao Zhao, Lei Tao, Yan Nie, Zhiyong Qiao, Changming Ding
Summary: A novel nanocomposite of anti-spinel NiFe2O4 nanocrystals and reduced graphene oxide (RGO) was successfully developed for enhancing the hydroxylation of phenol. The optimal NiFe2O4-RGO(20) catalyst exhibited a phenol conversion of 28.2%, a selectivity of 93.3%, and a molar ratio of catechol to hydroquinone of 2.6. The catalyst maintained good activity after 6 reaction cycles, and its superior performance was attributed to the uniform dispersion of NiFe2O4 nanocrystals on the RGO surface, which prevented sheet stacking and increased active site exposure. Additionally, the NiFe2O4-RGO(20) composite accelerated the decomposition of H2O2 into & BULL;OH, thereby improving the reaction efficiency of phenol hydroxylation.
Article
Multidisciplinary Sciences
Elham Arefi, Amir Khojastehnezhad, Ali Shiri
Summary: A core-shell magnetic metal organic framework (MOF) catalyst based on Fe3O4 magnetic nanoparticles (MNPs) and copper organic frameworks was introduced in this study, and its core-shell structures and catalytic efficiency were confirmed with various analyses methods. The Cu moieties in MOF and shell structures showed high catalytic activity in the synthesis of 1,2,3-triazole derivatives with good to excellent yields, using water as a green solvent. Moreover, the catalyst demonstrated high reusability due to its super paramagnetic properties.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Inorganic & Nuclear
Nibedita Sinha, Poulomi Roy
Summary: This study has developed a trimetallic nitride porous microsphere as a bifunctional electrocatalyst for urea oxidation reaction and hydrogen evolution reaction, achieving high activity and stability. The optimized catalyst exhibits high current density at lower electrode potential, leading to energy saving compared to water electrolysis through water oxidation.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Mehraneh Aghaei-Hashjin, Asieh Yahyazadeh, Esmayeel Abbaspour-Gilandeh
Summary: The study synthesized Zr@IL-Fe3O4 MNPs as a new magnetically recoverable heterogeneous catalyst and characterized it using various techniques. The catalytic behavior of Zr@IL-Fe3O4 MNPs in the synthesis of pyran derivatives was efficient, showing potential for practical applications.
Article
Chemistry, Applied
Peng Xu, Zhenguo Wu, Wei Dai, Yang Wang, Mengke Zheng, Xiaodan Su, Zhaogang Teng
Summary: This study presents a soft-to-hard templating approach for the synthesis of multiple Ag nanoparticles loaded hollow mesoporous carbon spheres (Ag@HMCSs). The method offers advantages such as simple and efficient preparation, excellent catalytic activity, and stability of the prepared Ag@HMCSs.
MICROPOROUS AND MESOPOROUS MATERIALS
(2021)
Article
Chemistry, Inorganic & Nuclear
Faizah S. Aljohani, Omran A. Omran, Eman A. Ahmed, Eida S. Al-Farraj, Elham F. Elkady, Arwa Alharbi, Nashwa M. El-Metwaly, Ibrahim Omar Barnawi, Ahmed M. Abu-Dief
Summary: A novel bis(1H-benzo[d]imidazol-2-yl)methanone (H2L) ligand and its metal chelates of Zinc (II), Nickel (II), Copper (II), and Iron (III) were synthesized. The metal chelates demonstrated better biomedical efficiency than the ligand alone. The most effective agent, BIMCu, showed outstanding antiproliferative efficacy against cancer cells.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Article
Chemistry, Physical
Abdulrhman A. A. Al-Shamry, Mai M. M. Khalaf, Hany M. Abd El-Lateef, Tarek A. A. Yousef, Gehad G. G. Mohamed, Kariman M. Kamal El-Deen, Mohamed Gouda, Ahmed M. M. Abu-Dief
Summary: A Schiff base ligand was synthesized through the condensation of isatin and aniline, and a series of metal complexes derived from the ligand were characterized. The metal complexes exhibited different geometries and thermal decomposition behaviors. The metal complexes showed stronger antibacterial properties and anticancer activities compared to the ligand alone. A DFT investigation provided information on the electronic features of the ligand and its metal complexes. The drug-likeness and ADME characteristics of the compounds were also calculated.
Article
Chemistry, Physical
Mohamed Ali Ibrahim Al-Gaber, Hany M. Abd El-Lateef, Mai M. Khalaf, Saad Shaaban, Mohamed Shawky, Gehad G. Mohamed, Aly Abdou, Mohamed Gouda, Ahmed M. Abu-Dief
Summary: A new heterocyclic azo dye ligand (L) was synthesized and coordinated with various metal ions to form complexes. The structures of the complexes were determined using multiple techniques. The ligand exhibited tri-dentate behavior and coordinated to the metal ions through multiple functional groups. The complexes showed good antimicrobial activity and potential for future study.
Article
Chemistry, Applied
Ahmed M. Abu-Dief, Musa A. Said, Omar Elhady, Hessah A. Al-Abdulkarim, Seraj Alzahrani, Thomas Nady A. Eskander, Mahmoud Abd El Aleem Ali Ali El-Remaily
Summary: A simple and highly tunable BSI ligand was synthesized, along with three new coordinating substances. The structures of these compounds were clarified using various spectroscopic and analytical methods. The thermal degradation behavior of the BSI complexes was investigated, and their antibacterial and anticancer properties were evaluated.
APPLIED ORGANOMETALLIC CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Eman M. Azmy, Ibrahim F. Nassar, Mohamed Hagras, Iten M. Fawzy, Maghawry Hegazy, Mahmoud Mohamed Mokhtar, Amr Mohamed Yehia, Nasser S. M. Ismail, Walaa H. Lashin
Summary: This study designed and synthesized thirteen novel indole derivatives as potential treatments for Alzheimer's disease. In vitro assays were conducted to assess their enzyme inhibitory activity, antioxidant activity, and cytotoxicity. Molecular docking and simulations confirmed their binding mode with esterases. In silico studies on absorption, distribution, metabolism, excretion, and toxicity were also performed. Results showed that compounds 5, 7, and 11 exhibited superior inhibitory activity against acetylcholinesterase and butyrylcholinesterase compared to donepezil.
FUTURE MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Ahmed M. Abu-Dief, Musa A. Said, O. Elhady, Nadiyah Alahmadi, Seraj Alzahrani, Thomas Nady A. Eskander, Mahmoud Abd El Aleem Ali Ali El-Remaily
Summary: A new class of bio-active Pd(II), Ni(II) and Fe(III) complexes were synthesized using the guanidine-based ligand (BSG). The structural characteristics were validated by various analytical techniques and the complexes were evaluated for their anticancer, antioxidant, antibacterial, and antifungal activities. Among them, the Pd(II) complex showed significant anticancer activity in MCF-7 breast carcinoma cells.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
M. Alahmadi, Wael. H. Alsaedi, W. S. Mohamed, Hassan M. A. Hassan, Mohammed Ezzeldien, Ahmed M. Abu-Dief
Summary: Here, we demonstrate the sample and low-cost hydrothermal synthesis of a nanocomposite of Bi2O3/MoSe2 for hybrid photocatalyst. The structure of the synthesized samples was characterized using various techniques, and the Bi2O3/MoSe2 nanocomposite showed enhanced photocatalytic activity due to its high crystallinity, surface area, and small particle size. The results indicate that the Bi2O3/MoSe2 sample exhibited the highest photocatalytic degradation efficiency for the disintegration of methylene blue under visible illumination.
JOURNAL OF TAIBAH UNIVERSITY FOR SCIENCE
(2023)
Article
Chemistry, Applied
Mahmoud Abd El Aleem Ali Ali El-Remaily, Tarek El-Dabea, Rafat M. El-Khatib, Aly Abdou, Mohamed A. El Hamd, Ahmed M. Abu-Dief
Summary: Three GUBZCu, GUBZVO, and GUBZPd chelates were synthesized and characterized in terms of their molecular formula, stability constant, and catalytic performance. The results confirmed the promising catalytic activity and selectivity of these chelates in environmentally friendly synthesis reactions.
APPLIED ORGANOMETALLIC CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Eman M. Azmy, Mohamed Hagras, Menna A. Ewida, Ahmed S. Doghish, Emad Gamil Khidr, Ahmed A. El-Husseiny, Maher H. Gomaa, Hanan M. Refaat, Nasser S. M. Ismail, Ibrahim F. Nassar, Walaa H. Lashin
Summary: Novel compounds were designed and synthesized, and they exhibited significant antiproliferative activity against breast cancer and hepatocellular carcinoma in vitro. Moreover, these compounds showed potent inhibition of CDK2/CyclinA2, indicating their potential as CDK2 inhibitors.
BIOORGANIC CHEMISTRY
(2023)
Article
Construction & Building Technology
M. S. Amin, Mohamed Heikal, H. H. Negm, Ahmed M. Abu-Dief, O. A. Mohamed
Summary: This study investigates the potential of utilizing Egyptian industrial solid wastes to create sustainable construction materials. The findings reveal that the inclusion of silica fume improves the densification and compressive strength of the concrete paste.
CONSTRUCTION AND BUILDING MATERIALS
(2023)
Article
Chemistry, Inorganic & Nuclear
M. Alahmadi, W. S. Mohamed, Arcady Zhukov, Mohamed Salaheldeen, Wael. H. Alsaedi, Dalal Alhashmialameer, Khalaf Al-Ghamdi, Ahmed M. Abu-Dief
Summary: The pharmaceutical applications of metal oxide nanoparticles have gained global attention due to their ability to specifically target and kill bacteria, fungi, and cancer cells. In this study, VS2, MoS2, and VS2@MoS2 nanoparticles were synthesized using a simple, low-cost, and eco-friendly hydrothermal method. The structural and microstructural characteristics of the nanoparticles were analyzed using Raman spectroscopy, Scanning Electron Microscopy, and X-ray diffraction techniques. The results showed that the VS2/MoS2 nanocomposite exhibited synergistic antibacterial and anticancer properties, with potent activity against different types of bacteria and breast carcinoma cells.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Mostafa F. Al-Hakkani, Nourhan Ahmed, Alaa A. Abbas, Mohammad H. A. Hassan, Hossameldin A. Aziz, Ali M. Elshamsy, Hazim O. Khalifa, Mohamed A. Abdelshakour, Mohammed S. Saddik, Mahmoud M. A. Elsayed, Marwa A. Sabet, Mohamed A. El-Mokhtar, Mosa Alsehli, M. S. Amin, Ahmed M. Abu-Dief, Hamada H. H. Mohammed
Summary: A novel derivative of ciprofloxacin (Cpx) was synthesized and showed enhanced antibacterial properties compared to Cpx itself. The derivative demonstrated increased activity against S. aureus and B. subtilis. Docking studies supported these findings by showing stronger binding interactions with the gyrase enzyme.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Physical
Ahmed M. Abu-Dief, Rafat M. El-Khatib, Tarek El-Dabea, Aly Abdou, Faizah S. Aljohani, Eida S. Al-Farraj, Ibrahim Omar Barnawi, Mahmoud Abd El Aleem Ali Ali El-Remaily
Summary: New medicinally active chelates were synthesized from Cu(II), VO(II), Ag(I), and Pd(II) ions using the N-(1H-Benzoimidazol-2-yl)-guanidine (BIG) ligand. The compounds were characterized using various techniques and theoretical studies were conducted to identify important features. The chelates exhibited good stability in solution and showed promising biological activities, including antimicrobial, antioxidant, and anticancer properties. These results suggest that the studied chelates have the potential to be used as bioactive agents.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Chemistry, Physical
Mahmoud Abd El Aleem Ali Ali El-Remaily, O. Elhady, Aly Abdou, Dalal Alhashmialameer, Thomas Nady A. Eskander, Ahmed M. Abu-Dief
Summary: We established new imidazole complexes using Pd2+, Fe3+, and Ni2+ ions, with the exception of the Pd (II) chelate (BIL-Pd) which has a square-planer configuration, the octahedral geometry was recommended for the other examined complexes. The condensation reaction of three components resulted in the synthesis of 5-amino-2-oxo-3,7-dihydro2H-pyrano[2,3-d]thiazole-6-carbonitrile derivatives under controlled and environmentally friendly conditions. The BIL-Pd complex showed effectiveness as a recyclable and promising heterogeneous solid catalyst.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Physics, Multidisciplinary
Eida S. Al-Farraj, M. Alahmadi, W. S. Mohamed, Wael H. Alsaedi, Ahmed M. Abu-Dief
Summary: Nanoparticles of VSe2, Cu2Se and VSe2@Cu2Se were synthesized using a one-pot hydrothermal method, demonstrating their potential as chemotherapeutic agents. Structural and microstructural analysis showed that the nanoparticles have a pure crystalline cubic structure, with varying crystallite sizes depending on the composition. Antibacterial and anticancer experiments revealed that the nanocomposite exhibited a synergistic effect, with VSe2/Cu2Se showing the highest antibacterial efficacy against both Gram-positive and Gram-negative bacteria.