Review
Medicine, General & Internal
Rossella Reddavid, Silvia Sofia, Lucia Puca, Jacopo Moro, Simona Ceraolo, Rosa Jimenez-Rodriguez, Maurizio Degiuli
Summary: This meta-analysis examined the feasibility and safety of robotic surgery for elderly patients (>70 years old) undergoing curative treatment for rectal cancer. The study found that elderly patients can undergo robotic resection with similar surgical quality and outcomes as young patients, without increasing postoperative mortality and morbidity. Therefore, robotic surgery is a viable option for elderly patients with rectal cancer.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Chien-Yi Yang, Min-Hsuan Yen, Kee-Thai Kiu, Yu-Ting Chen, Tung-Cheng Chang
Summary: This study compared the outcomes of right-sided colon cancer (RCC) and left-sided colon cancer (LCC). The results showed no significant difference in overall survival or time to recurrence between patients with RCC and LCC. However, in stage II colon cancer patients, RCC was associated with shorter time to recurrence.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Takehito Yamamoto, Meiki Fukuda, Yoshihisa Okuchi, Yoshiki Oshimo, Yuta Nishikawa, Koji Hisano, Takayuki Kawai, Kohta Iguchi, Yukihiro Okuda, Ryo Kamimura, Eiji Tanaka, Hiroaki Terajima
Summary: Cancer-related systemic inflammation affects postoperative outcomes in rectal cancer patients. Lymphocyte count/C-reactive protein ratio (LCR) is a useful marker for predicting short- and long-term postoperative outcomes in these patients.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Maud T. A. Strous, Charlotte J. L. Molenaar, Ruud F. W. Franssen, Frits van Osch, Eric Belgers, Johanne G. Bloemen, Gerrit D. Slooter, Jarno Melenhorst, Jeroen Heemskerk, Adriaan P. de Bruine, Maryska L. G. Janssen-Heijnen, F. Jeroen Vogelaar
Summary: This study aims to investigate whether a prolonged treatment interval in colon cancer treatment is associated with a clinically significant deterioration in overall and cancer-free survival. The results suggest that even a treatment interval over 49 days is non-inferior to the current waiting-time target of <= 35 days in terms of cancer-free survival. However, the results for overall survival are inconclusive.
BRITISH JOURNAL OF CANCER
(2023)
Article
Surgery
Rachel Gefen, Sameh Hany Emile, Nir Horesh, Zoe Garoufalia, Steven D. Wexner
Summary: By analyzing a large database, this study found age-related disparities in characteristics, treatments, and outcomes of colorectal cancer.
Article
Gastroenterology & Hepatology
Zhi-Peng Liu, Wei-Yue Chen, Yan-Qi Zhang, Yan Jiang, Jie Bai, Yu Pan, Shi-Yun Zhong, Yun-Ping Zhong, Zhi-Yu Chen, Hai-Su Dai
Summary: This study evaluated the impact of postoperative morbidity on tumor recurrence and mortality in patients with HCCA following curative resection. The results showed that postoperative morbidity is associated with decreased overall survival and recurrence-free survival, especially in cases of major morbidity.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Oncology
Hartwig Korner, Marianne G. Guren, Inger Kristin Larsen, Dagny Faksvag Haugen, Kjetil Soreide, Leif Roland Korner, Jon Arne Soreide
Summary: This study analyzed data from the Norwegian Colorectal Cancer Registry to describe treatment pathways and survival of rectal cancer patients not eligible for curative treatment. The study found that almost 40% of patients did not receive curative-intent treatment, and there were significant variations in treatment journeys and outcomes.
Article
Oncology
Astrid Louise Bjorn Bennedsen, Luyi Cai, Rune Petring Hasselager, Aysun Avci Ozcan, Khadra Bashir Mohamed, Jens Ole Eriksen, Susanne Eiholm, Michael Bzorek, Anne-Marie Kanstrup Fiehn, Thomas Vauvert F. Hviid, Ismail Gogenur
Summary: The study revealed that positive HLA-G expression was associated with higher colon cancer recurrence rates, while preserved CDX2 expression was linked to a lower risk of recurrence. Combining certain tumor tissue biomarkers may be associated with colorectal cancer recurrence.
Article
Oncology
Ramakrishnan Ayloor Seshadri, Arya C. Soman, Ajit Aggrawal, Anand Karnawat, Shailesh Patidar, Rajaraman Swaminathan
Summary: Conditional survival provides the probability of additional years survived for patients who have already survived a certain number of years after treatment. This study aimed to investigate the conditional survival of patients with gastric cancer. The analysis included patients who underwent curative intent treatment for gastric cancer between 2007 and 2018, and the probability of surviving additional years was calculated based on the number of years survived. The results showed that the probability of surviving an additional 3 years for patients who had already survived 1, 2, 3, 4, and 5 years after treatment were 64.2%, 74.5%, 81.6%, 83.2%, and 88.2%, respectively.
JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Surgery
Thomas W. A. Koedam, Boukje T. Bootsma, Charlotte L. Deijen, Tim van de Brug, Geert Kazemier, Miguel A. Cuesta, Alois Furst, Antonio M. Lacy, Eva Haglind, Jurriaan B. Tuynman, Freek Daams, Hendrik J. Bonjer
Summary: Anastomotic leakage after rectal cancer surgery negatively affects long-term oncological outcomes, leading to increased local recurrences and decreased disease-free survival. However, its impact on outcomes after colon cancer surgery remains inconclusive.
Article
Oncology
Marco Ceresoli, Corrado Pedrazzani, Luca Pellegrino, Andrea Muratore, Ferdinando Ficari, Roberto Polastri, Marco Scatizzi, Mauro Totis, Nicolo Tamini, Lorenzo Ripamonti, Marco Braga
Summary: This study investigates the adherence and compliance to the enhanced recovery pathway in rectal cancer surgery patients. The results emphasize the importance of early postoperative compliance to the pathway in relation to complication development. Factors such as advanced age, longer surgery duration, open surgery, and diverting stoma were found to be predictive of low compliance. Failure to remove the urinary catheter on postoperative day 2 was significantly correlated with postoperative complications. Low compliance on postoperative day 2 was associated with higher morbidity and major complications.
Article
Oncology
Qi Li, Tailai An, Jianbin Wu, Weiqi Lu, Yan Wang, Jia Li, Lina Yang, Yiqi Chen, Lizhu Lin, Zhenjiang Yang
Summary: This study aimed to evaluate the impact of sarcopenia on the outcome of patients with left-sided colon and rectal cancer. The results showed that preoperative sarcopenia leads to longer hospital stay, more complications, and poorer survival rates after surgery. Therefore, preoperative nutrition supplementation may help improve the short-term and long-term outcomes of these patients.
Article
Oncology
Li-Chun Chang, Chia-Tung Shun, Been-Ren Lin, Silvia Sanduleanu, Weng-Feng Hsu, Ming-Shiang Wu, Han-Mo Chiu
Summary: A study conducted at the National Taiwan University Hospital from 2005 to 2014 compared the disease-free survival of T1 cancer arising from the rectum versus the colon. The results showed that T1 rectal cancer had a higher risk of recurrence compared to T1 colon cancer, with rectal location being an independent risk factor for recurrence. Further research is needed to explore whether adjuvant therapy or closer surveillance can reduce the risk of recurrence in T1 rectal cancer.
Article
Gastroenterology & Hepatology
Daniel Rydbeck, David Bock, Eva Haglind, Eva Angenete, Aron Onerup
Summary: The aim of this study was to determine if a delayed start to curative treatment for colon cancer, within 29-56 days after diagnosis, was equally effective as starting treatment within 28 days. The results showed that a delay of up to 56 days did not lead to worse overall survival in patients with colon cancer.
COLORECTAL DISEASE
(2023)
Article
Oncology
M. Margaret Kemeny, Fengmin Zhao, Arlene A. Forastiere, Paul Catalano, Stanley R. Hamilton, Brent W. Miedema, Nancy A. Dawson, Louis M. Weiner, Brian D. Smith, Bernard A. Mason, Stephen L. Graziano, Paul B. Gilman, Alan P. Venook, Harlan A. Pinto, Robert P. Whitehead, Peter J. O'Dwyer, Al B. Benson
Summary: This phase III trial evaluated the effect of perioperative chemotherapy on overall survival for colon cancer patients. The results showed no significant difference in survival rates and disease-free survival between patients who received perioperative chemotherapy and those who did not, regardless of their stage.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Surgery
Sanne-Marije Hazen, Tania Sluckin, Geerard Beets, Roel Hompes, Pieter Tanis, Miranda Kusters
Summary: There is significant variation among Dutch colorectal surgeons in the assessment and treatment of lateral lymph nodes in rectal cancer patients, highlighting the need for further research and international guidelines.
ACTA CHIRURGICA BELGICA
(2023)
Editorial Material
Oncology
Amaia Gantxegi, B. Feike Kingma, Jelle P. Ruurda, Grard A. P. Nieuwenhuijzen, Misha D. P. Luyer, Richard van Hillegersberg
ANNALS OF SURGICAL ONCOLOGY
(2022)
Review
Oncology
Amaia Gantxegi, B. Feike Kingma, Jelle P. Ruurda, Grard A. P. Nieuwenhuijzen, Misha D. P. Luyer, Richard van Hillegersberg
Summary: The role of upper mediastinal lymphadenectomy in distal esophageal or gastroesophageal junction adenocarcinomas remains controversial, with the incidence of upper mediastinal lymph node metastases being up to 10%. Data on survival and recurrent laryngeal nerve palsy rates are limited and inconclusive.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Gastroenterology & Hepatology
Desley M. G. Van Zoggel, Eva L. K. Voogt, Ineke G. Van Lijnschoten, Jeltsje S. Cnossen, Geert-Jan Creemers, Joost Nederend, Johanne G. Bloemen, Grard A. P. Nieuwenhuijzen, Pim J. W. A. Burger, Sabine G. G. F. Lardenoije, Harm J. T. Rutten, Mark J. Roef
Summary: This study aimed to analyze the correlation between PET/CT response and final histopathological outcomes in locally recurrent rectal cancer patients. The results showed that PET/CT response was a significant predictor of the negative resection margin rate, and had some consistency with the histopathological TRG categories.
COLORECTAL DISEASE
(2022)
Article
Gastroenterology & Hepatology
Thijs H. J. B. Janssen, Laura F. C. Fransen, Fanny F. B. M. Heesakkers, Annemarie C. P. Dolmans-Zwartjes, Krishna Moorthy, Grard A. P. Nieuwenhuijzen, Misha D. P. Luyer
Summary: This study investigated the impact of prehabilitation on postoperative outcomes in patients undergoing minimally invasive esophagectomy. The results showed that prehabilitation led to a shorter hospital stay, reduced ICU readmission rate, and clinically relevant improvement in postoperative recovery and morbidity rate.
DISEASES OF THE ESOPHAGUS
(2022)
Article
Oncology
S. H. J. Ketelaers, R. G. Orsini, G. A. P. Nieuwenhuijzen, H. J. T. Rutten, J. W. A. Burger, J. G. Bloemen
Summary: This study focused on the outcomes of diverting ostomy in elderly patients with advanced rectal cancer after low anterior resection (LAR). The results showed that most elderly patients successfully reversed their ostomy with limited complications, but there is still a risk of non-reversal and ostomy recreation over time.
Article
Gastroenterology & Hepatology
Stijn H. J. Ketelaers, Lieke Dhondt, Nikki van Ham, Ansgar S. Harms, Harm J. Scholten, Grard A. P. Nieuwenhuijzen, Harm J. T. Rutten, Jacobus W. A. Burger, Johanne G. Bloemen, F. Jeroen Vogelaar
Summary: This study evaluated the outcomes of continuous wound infusion (CWI) after colorectal cancer surgery within an enhanced recovery protocol. The results showed that CWI could reduce the consumption of opioids after surgery, while maintaining adequate pain control and enhanced recovery, which is particularly valuable for older patients.
COLORECTAL DISEASE
(2022)
Review
Oncology
Stijn H. J. Ketelaers, Anne Jacobs, An-Sofie E. Verrijssen, Jeltsje S. Cnossen, Irene E. G. van Hellemond, Geert-Jan M. Creemers, Ramon-Michel Schreuder, Harm J. Scholten, Jip L. Tolenaar, Johanne G. Bloemen, Harm J. T. Rutten, Jacobus W. A. Burger
Summary: Non-operative management is an important alternative treatment option for elderly and frail rectal cancer patients, aiming to avoid debilitating symptoms, improve quality of life, and prolong survival.
Article
Surgery
Eva L. K. Voogt, Stefi Nordkamp, Desley M. G. van Zoggel, Alette W. Daniels-Gooszen, Grard A. P. Nieuwenhuijzen, Johanne G. Bloemen, Geert-Jan Creemers, Jeltsje S. Cnossen, Gesina van Lijnschoten, Jacobus W. A. Burger, Harm J. T. Rutten, Joost Nederend
Summary: This study investigated the agreement between magnetic resonance tumour regression grade (mrTRG) and pathological regression grade (pTRG) in patients with locally recurrent rectal cancer (LRRC). The reproducibility of mrTRG was found to be limited among radiologists and the agreement with pTRG was low. However, a shorter interval between MRI and surgery improved the agreement and if assessed by a dedicated radiologist, mrTRG could predict good responders.
Article
Oncology
Vincent C. J. van de Vlasakker, Teun B. M. van den Heuvel, Anouk Rijken, Simon W. Nienhuijs, Stijn H. J. Ketelaers, An-Sofie E. Verrijssen, Harm J. Rutten, Grard A. P. Nieuwenhuijzen, Jacobus W. A. Burger, Ignace H. J. T. de Hingh
Summary: For patients with advanced rectal cancer that has metastasized to the peritoneum, a multimodality treatment consisting of intraoperative radiotherapy (IORT), cytoreductive surgery, and hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) may improve prognosis. This study reports on 30 patients who underwent this treatment, with comparable results to separate treatments described in the literature. Thus, multimodality treatment can be considered for select patients.
Article
Gastroenterology & Hepatology
Stijn H. J. Ketelaers, Nikki van Ham, Kirsten A. A. J. van Pelt, Thomas Timmers, Grard A. P. Nieuwenhuijzen, Harm J. T. Rutten, Jacobus W. A. Burger, Johanne G. Bloemen
Summary: A study developed an interactive application called StoManager to guide patients throughout the entire process of ostomy surgery and evaluated patient satisfaction and implementation. The results showed that patients were very satisfied with StoManager, with above average usability scores, and most patients did not require home nursing care services at discharge. This suggests that support through an interactive application can improve self-management and reduce healthcare consumption.
COLORECTAL DISEASE
(2023)
Article
Oncology
Cas de Jongh, Lianne Triemstra, Arjen van der Veen, Lodewijk AA. Brosens, Grard AP. Nieuwenhuijzen, Jan HMB. Stoot, Wobbe O. de Steur, Jelle P. Ruurda, Richard van Hillegersberg
Summary: This study assessed the quality of gastric cancer surgery using a photo-scoring method and implemented quality control measures during the LOGICA trial. The results showed that high radicality and nodal yield were indicators of good quality D2-gastrectomy. However, the photo-scoring method used in the study needs further improvement.
Article
Surgery
Stefi Nordkamp, Jan M. van Rees, Kim van den Berg, David M. Mens, Davy M. J. Creemers, Heike M. U. Peulen, Geert-Jan Creemers, Grard A. P. Nieuwenhuijzen, Jip L. Tolenaar, Johanne G. Bloemen, Joost Rothbarth, Harm J. T. Rutten, Cornelis Verhoef, Jacobus W. A. Burger
BRITISH JOURNAL OF SURGERY
(2023)
Article
Surgery
Stefi Nordkamp, Floor Piqeur, Kim van den Berg, Jip L. Tolenaar, Irene E. G. van Hellemond, Geert-Jan Creemers, Mark Roef, Gesina van Lijnschoten, Jeltsje S. Cnossen, Grard A. P. Nieuwenhuijzen, Johanne G. Bloemen, Lien Coolen, Joost Nederend, Heike M. U. Peulen, Harm J. T. Rutten, Jacobus W. A. Burger
Summary: This study aimed to evaluate the oncological outcomes of patients with locally recurrent rectal cancer with a pCR, and compare them with patients without a pCR. Patients with a pCR had superior oncological outcomes. A watch-and-wait approach may be considered in highly selected patients to improve quality of life without compromising oncological outcomes.
BRITISH JOURNAL OF SURGERY
(2023)
Article
Surgery
Anouk Hiensch, Elles Steenhagen, Jonna K. van Vulpen, Jelle P. Ruurda, Grard A. P. Nieuwenhuijzen, Ewout A. Kouwenhoven, Richard P. R. Groenendijk, Donald L. van der Peet, Camiel Rosman, Bas P. L. Wijnhoven, Mark I. van Berge Henegouwen, Hanneke W. M. van Laarhoven, Richard van Hillegersberg, Peter D. Siersema, Anne M. May
Article
Oncology
Yuchao Liu, Zijia Liu, Liangyan Zhang, Yuelun Zhang, Ningchen Zhang, Yue Han, Le Shen
Summary: This study found an association between preoperative 6-min walk distance and postoperative complications in patients undergoing laparoscopic gastrointestinal cancer surgery.
Review
Oncology
Matteo Pavone, Rosa Autorino, Nicolo Bizzarri, Giuditta Chilorio, Vincenzo Valentini, Giacomo Corrado, Gabriella Ferrandina, Gabriella Macchia, Maria Antonietta Gambacorta, Giovanni Scambia, Denis Querleu
Summary: Ovarian transposition is an established method for protecting the ovaries from radiation, while surgical procedures for protecting the uterus are still under investigation. This study conducted a systematic review of uterine displacement techniques and performed dose simulation to assess the radiation dose received by the uterus. The results showed that the transposition approach was the most protective.
Article
Oncology
Silvia Ministrini, Maria Bencivenga, Federica Filippini, Gianni Mura, Carlo Milandri, Maria Antonietta Mazzei, Giulio Bagnacci, Mattia Berselli, Manlio Monti, Paolo Morgagni, Leonardo Solaini, Daniele Marrelli, Stefania Piccioni, Stefano De Pascale, Luigina Graziosi, Rossella Reddavid, Fausto Rosa, Claudio Belluco, Guido Tiberio
Summary: The Italian Research Group for Gastric Cancer developed a prospective database to evaluate the impact of a pragmatic attitude on the management of stage IV gastric cancer patients. The study found that different metastatic sites did not affect survival rates, but multiple metastatic sites were associated with worse survival. Patients who could undergo curative resection had better survival rates. A more accurate diagnostic workup and staging had a favorable impact on survival.
Article
Oncology
Luca Lambertini, Fabrizio Di Maida, Anna Cadenar, Samuele Nardoni, Antonio Andrea Grosso, Francesca Valastro, Pietro Spinelli, Riccardo Fantechi, Agostino Tuccio, Gianni Vittori, Andrea Mari, Lorenzo Masieri, Andrea Minervini
Summary: The aim of this study was to evaluate the functional outcomes of Florence intracorporeal neobladder (FloRIN) configuration technique performed with a stentless procedure. The results showed that the stentless procedure was associated with shorter console time and lower estimated blood loss compared to the stent group. There were no significant differences in terms of perioperative features and mid-term functional outcomes between the two groups.
Article
Oncology
Geun-Jeon Kim, Jooin Bang, Hyun-Il Shin, Sang-Yeon Kim, Dong -Il Sun
Summary: This study evaluated the outcome of tonsillar cancer managed with neoadjuvant chemotherapy followed by surgery. The results showed that neoadjuvant chemotherapy reduced tumor volume and pathological adverse features, significantly decreasing the need for adjuvant therapy. A greater reduction in tumor volume predicted a complete pathologic response. There was no significant difference in survival rates between the groups.
Article
Oncology
Alexandra Nassar, Stylianos Tzedakis, Ugo Marchese, Gaanan Naveendran, Remy Sindayigaya, Martin Gaillard, Francois Cauchy, Mickael Lesurtel, Brice Gayet, Olivier Soubrane, David Fuks
Summary: This study identified recurrence between the two stages and a larger tumor size in the future liver remnant as critical factors contributing to the failure of two-stage hepatectomy for bilobar colorectal liver metastases. These findings have important clinical implications for the selection and evaluation of TSH surgery.
Letter
Oncology
Michele Fiore, Gian Marco Petrianni, Gabriele D'Ercole, Pasquale Trecca, Sara Ramella
Review
Oncology
Harry Farrow, Oliver J. Pickering, James A. Gossage, Philip H. Pucher
Summary: The inclusion or exclusion of the thoracic duct in radical esophagectomy for esophageal cancer is a controversial issue. While removing the thoracic duct may increase lymph node yield, it may also lead to higher morbidity without any survival benefit.
Article
Oncology
Xiaokun Li, Siyuan Luan, Chi Zhang, Weili Kong, Xin Xiao, Haowen Zhang, Jianfeng Zhou, Yushang Yang, Yang Xu, Yong Qiang, Pinhao Fang, Yi Shen, Yong Yuan
Summary: This study proposes a new staging system based on ypTNM stage and cN status for early stage ESCC patients after nCRT. The new ypTNM-cN staging system demonstrates superior predictive ability and classification efficacy compared to the AJCC 8th ypTNM staging system. It provides new insights for accurately stratifying ypI stage ESCC patients.