Review
Environmental Sciences
Luis Daniel Martinez-Razo, Alejandra Martinez-Ibarra, Edgar Ricardo Vazquez-Martinez, Marco Cerbon
Summary: DEHP, considered an endocrine disruptor chemical (EDC), is widely used in the plastic industry and can have negative effects on placental development and function, potentially impacting fetal growth. Research indicates that DEHP and MEHP can impair key processes in placental development and affect various placental functions. Clinical evidence also supports the connection between DEHP exposure and adverse pregnancy outcomes and pathologies.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Engineering, Environmental
Xia Li, Jianpeng Li, Sijia Hao, Ailing Han, Yayu Yang, Guozhen Fang, Jifeng Liu, Shuo Wang
Summary: A enzyme mimic material inspired by serine proteases was developed to degrade DEHP, which was then immobilized onto RC membranes for continuous recycling degradation. This biocatalytic membrane showed effective DEHP degradation and good stability, offering a promising biomaterial for water decontamination and liquid food depollution.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Chemistry, Applied
Yuting Liang, Zhi Jiang, Wenfeng Shangguan
Summary: This study investigated the photocatalytic reaction behavior of DEHP over surface platinized TiO2, with the oxidation state of platinum found to be crucial in determining the photocatalytic activity. Platinized titania with oxidized Pt species showed higher photocatalytic activity compared to metallic Pt. Photocatalysis coupled with thermal catalysis can enhance the degradation of DEHP, and Pt oxide, particularly PtO, can improve the photocatalytic oxidation efficiency by promoting the separation efficiency of photo generated carriers.
Article
Biology
Yukiko Tando, Hitoshi Hiura, Asuka Takehara, Yumi Ito-Matsuoka, Takahiro Arima, Yasuhisa Matsui
Summary: Maternal exposure to DEHP induces DNA hypermethylation of spermatogenesis-related gene promoters in fetal testicular germ cells in F1 mice, leading to downregulation of gene expression in spermatogonia and subsequent defects in spermatogenesis.
Article
Biotechnology & Applied Microbiology
Shivani Popli Goyal, Tripti Agarwal, Vijendra Mishra, Ankur Kumar, Chakkaravarthi Saravanan
Summary: This study identified two strains of Lactobacillus (Lactobacillus rhamnosus GG and Lactobacillus plantarum MTCC 25,433) that can rapidly adsorb over 85% of DEHP. The adsorption of DEHP was affected by cell wall polysaccharides, proteins, lipids, and peptidoglycan. These findings suggest that these Lactobacillus strains could be potential strategies for detoxification of DEHP-contaminated foods.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2023)
Review
Environmental Sciences
Wing Sum Kwan, Vellaisamy A. L. Roy, Kwan Ngok Yu
Summary: DEHP, widely used as a plasticizer in consumer products, has been linked to adverse health effects, prompting the need for toxicological assessment. Zebrafish embryos have become a popular in vivo model for studying DEHP toxicity, aiming to assess both acute and chronic effects on different developmental stages.
Article
Biochemistry & Molecular Biology
Jing Dong, Hui Fu, Yuanyuan Fu, Mingdan You, Xudong Li, Chaonan Wang, Kunkun Leng, Yuan Wang, Jie Chen
Summary: Exposure to DEHP during pregnancy can impair hippocampal synaptic plasticity in male offspring, affecting synaptic structure and dendritic spine development, possibly through the downregulation of the Rac1/PAK/LIMK1/cofilin signaling pathway. Female offspring did not show these alterations in hippocampal structure.
ACS CHEMICAL NEUROSCIENCE
(2021)
Article
Biodiversity Conservation
Xianxu Li, Qian Wang, Can Wang, Zhongkang Yang, Jinhua Wang, Lusheng Zhu, Dexin Zhang, Jun Wang
Summary: This study investigated the acute and chronic toxicity of DEHP on zebrafish, focusing on oxidative damage, neurotoxicity, and DNA damage in the liver. The results showed that DEHP enhanced oxidative stress, lipid peroxidation, and cytotoxicity in zebrafish liver, leading to DNA damage. The severity of the effects was positively correlated with the concentration of DEHP.
ECOLOGICAL INDICATORS
(2022)
Article
Environmental Sciences
Ling Yang, Jiao Zou, Zhenle Zang, Liuyongwei Wang, Zhulin Du, Dandan Zhang, Yun Cai, Minghui Li, Qiyou Li, Junwei Gao, Haiwei Xu, Xiaotang Fan
Summary: Using a human cerebral organoid model, researchers found that DEHP exposure inhibited cell proliferation and increased apoptosis, impairing the morphogenesis of the human cerebral cortex. DEHP exposure disrupted neurogenesis and neural progenitor migration, possibly due to dysplasia of radial glia cells. RNA sequencing analysis showed that DEHP-induced disorder in cell-extracellular matrix interactions might play a crucial role in the neurodevelopment of human cerebral organoids.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Pengfei Hou, Wenting Dai, Yanshan Jin, Fengqi Zhao, Jianxin Liu, Hongyun Liu
Summary: This study demonstrates that DEHP exposure has adverse effects on lactation, including energy insufficiency, inflammation activation, oxidative stress aggravation, and disturbance of milk production. These findings are important for understanding the health risks of the plastic additive DEHP on female lactation dysfunction.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Environmental Sciences
Qiutang Wang, Yanwen Xu, Wenchao Du, Ying Yin, Xuan Wu, Feifei Sun, Rong Ji, Hongyan Guo
Summary: Understanding the distribution of DEHP in agricultural soils is crucial for future risk evaluation. This study found that, after 60 days, 46.3% and 95.4% of DEHP in red and black soil, respectively, were either mineralized or transformed into non-extractable residues (NERs). DEHP was mainly distributed in humic substances as NERs, with humin having the highest concentration. DEHP was more bioavailable in black soil compared to red soil. Planting Brassica chinensis L. limited the mineralization of DEHP in black soil and increased the extractable residues, but had no significant effect in red soil. These findings provide valuable information for the risk assessment of DEHP in different soil types.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Jiwon On, Shin-Hye Kim, Jeongae Lee, Mi Jung Park, Sang-Won Lee, Heesoo Pyo
Summary: This study aimed to evaluate the levels of urinary DEHP metabolites and their RMRs in obese children in South Korea, and to investigate the potential of RMRs for assessing the risks for childhood obesity. The research found that RMRA2 was negatively associated with BMI percentile and weight percentile.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Environmental Sciences
Yue Tao, Chong Feng, Jiaming Xu, Lu Shen, Jianhua Qu, Hanxun Ju, Lilong Yan, Weichang Chen, Ying Zhang
Summary: This study investigated the impact of DEHP and DBP on nitrification microbial communities, related genes, and key enzyme activities in black soil. The results showed that DEHP and DBP inhibited urease activity during ammonia oxidation, reduced the copy number of amoA gene, and led microorganisms to use inorganic nitrogen as a nitrogen source. During nitrite oxidation, DEHP and DBP decreased the copy number of nxrA gene and the abundance of chemoautotrophic nitrifying bacteria. Path analysis results indicated that DEHP and DBP mainly affected AOB and NOB through direct or indirect pathways.
Article
Environmental Sciences
Abdoul Salam Issiaka Abdoul Magid, Md Shafiqul Islam, Yali Chen, Liping Weng, Yang Sun, Xingping Chang, Bin Zhou, Jie Ma, Yongtao Li
Summary: This study investigated the competitive adsorption of DBP and DEHP on biochar, finding that DEHP had a significantly higher adsorption capacity than DBP, and oxidized biochar showed higher adsorption capacities than fresh biochar. Competitive adsorption between DEHP and DBP was observed in binary component systems, with DEHP being preferred due to stronger hydrophobic interaction with biochar.
Article
Environmental Sciences
Hai'e Xu, Wanshuang Cao, Hongliang Sun, Shougang Zhang, Pan Li, Surong Jiang, Caiyun Zhong
Summary: Studies have shown that DEHP induced significant hormetic effects at environmentally relevant concentrations (12 and 36 μg/L), leading to U-shaped or inverted U-shaped responses in gene expression levels related to stress response (CAT, GST, and MgGLYZ) and antioxidant enzyme activities (SOD and CAT). The metabolic profiles revealed that DEHP generally caused monophasic response in osmotic regulation (homarine) and biphasic response (hormesis) in energy metabolism (glucose, glycogen, and amino acids). These findings can assist in ecological risk assessment of DEHP and determination of hormetic dose responses.
FRONTIERS IN MARINE SCIENCE
(2021)