期刊
DRUG DEVELOPMENT RESEARCH
卷 80, 期 7, 页码 878-892出版社
WILEY
DOI: 10.1002/ddr.21577
关键词
antiproliferation; cyanobacteria; pyrazolo[4; 3-e][1; 2; 4] triazole; SAR
资金
- [1781611002]
The naturally occurring phyco-constituent nostocine A, bearing the pyrazolotriazine scaffold in its structural frame, belongs to an organic class of pharmacologically curious candidates with a remarkable anticancer activity. This review summarizes the chemistry of numerous synthetic strategies of demethylated nostocine as nornostocine derivatives, in which the substitutes are connected to a few functionalities with the pyrazolotriazine moiety at N-1, C-3, and C-5 positions. These strategies may provide a framework to design and develop a novel potent anticancer drug candidate(s) with an augment of structure activity relationship related to anticancer activities.
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