期刊
DNA REPAIR
卷 81, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.dnarep.2019.102666
关键词
8-OxoG; RNA damage; AUF1; PCBP1; RNA decay; Apoptosis
资金
- Ministry of Education, Culture, Sports, Science, and Technology of Japan
- MEXT-supported Program for the Strategic Research Foundation at Private Universities [S1411042]
- [16K07260]
- [22370003]
- [26340040]
Reactive oxygen species (ROS) are produced during normal cellular metabolism, and various oxidized compounds are formed by the ROS attack. Among oxidized bases, 8-oxo-7,8-dihydroguanine (8-oxoG) is most abundant and seems important with respect to the maintenance and transfer of genetic information. The accumulation of 8-oxoG in messenger RNA may cause errors during codon anticodon pairing in the translation process, which may result in the synthesis of abnormal proteins. Organisms that use oxygen as the source of energy production must therefore have some mechanisms to eliminate the deleterious effects of RNA oxidation. Recently, we found two protein factors, AUF1 and PCBP1, which each have a different binding capacity to oxidized RNA. Evidence demonstrated that AUF1 is involved in the specific degradation of oxidized RNA, and that PCBP1 has a function of inducing cell death to eliminate severely damaged RNA.
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