Article
Gastroenterology & Hepatology
Julien Kirchgesner, Rishi J. Desai, Maria C. Schneeweiss, Laurent Beaugerie, Sebastian Schneeweiss, Seoyoung C. Kim
Summary: Combination therapy with vedolizumab and thiopurines is associated with a lower risk of treatment failure compared to vedolizumab monotherapy in patients with CD, but the effect is less pronounced in UC.
Review
Immunology
Reza Yarani, Ali Shojaeian, Oana Palasca, Nadezhda T. Doncheva, Lars Juhl Jensen, Jan Gorodkin, Flemming Pociot
Summary: This review discusses the differential regulation of miRNAs in inflammatory bowel disease (IBD) and their potential diagnostic and therapeutic applications. Through literature curation and computational analysis, a consensus set of differentially expressed miRNAs in mucosal tissues was obtained. The role of these miRNAs and their potential targets in IBD are highlighted.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Tatsuki Noguchi, Soichiro Ishihara, Motoi Uchino, Hiroki Ikeuchi, Koji Okabayashi, Kitaro Futami, Shinji Tanaka, Hiroki Ohge, Hisashi Nagahara, Kazuhiro Watanabe, Michio Itabashi, Kinya Okamoto, Yoshiki Okita, Tsunekazu Mizushima, Yusuke Mizuuchi, Kazutaka Yamada, Yoshifumi Shimada, Yu Sato, Hideaki Kimura, Kenichi Takahashi, Koya Hida, Yusuke Kinugasa, Junji Okuda, Koji Daito, Fumikazu Koyama, Hideki Ueno, Takayuki Yamamoto, Tsunekazu Hanai, Atsuo Maemoto, Koji Oba, Yoichi Ajioka, Kenichi Sugihara
Summary: Patients with longstanding inflammatory bowel disease, such as ulcerative colitis and Crohn's disease, are at high risk of developing intestinal cancers. This study found significant differences between intestinal cancers associated with ulcerative colitis and Crohn's disease. Crohn's disease-associated cancers were diagnosed at more advanced stages, detected less frequently by surveillance, and had a poorer prognosis compared to those associated with ulcerative colitis.
JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Biochemical Research Methods
Florent Clerc, Karli R. Reiding, Noortje de Haan, Carolien A. M. Koeleman, Agnes L. Hipgrave Ederveen, Natalia Manetti, Viktoria Dotz, Vito Annese, Manfred Wuhrer
Summary: This study investigates the associations of immunoglobulin A1 and A2 glycosylation with inflammatory bowel diseases (IBD). Differences in IgA O- and N-glycosylation between patient groups were found to be associated with the diseases, and a statistical model was constructed to predict the disease group of the patients. These findings contribute to the development of noninvasive biomarkers for IBD and improvement in patient care.
JOURNAL OF PROTEOME RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Arshdeep Singh, Vandana Midha, Ramit Mahajan, Shruti Verma, Chandan Kakkar, Jasmine Grover, Dharmatma Singh, Ramandeep Kaur, Abhishek Masih, Namita Bansal, Catherine Wall, Ajit Sood
Summary: Malnutrition and sarcopenia are common in patients with inflammatory bowel disease (IBD), and the prevalence is similar in patients with ulcerative colitis (UC) and Crohn's disease (CD). Threshold values of different parameters of nutritional assessment can be used to identify malnutrition.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Amy L. Lightner, Sarah Vogler, John McMichael, Xue Jia, Miguel Regueiro, Taha Qazi, Scott R. Steele
Summary: While UC patients were more likely to have neoplasia detected during colonoscopy, the rates of progression from LGD and HGD to adenocarcinoma were equivalent in UC and CD, suggesting consistent endoscopic surveillance strategies for all IBD patients.
JOURNAL OF CROHNS & COLITIS
(2021)
Article
Medicine, Research & Experimental
Ziyu Lian, Jingyi Hu, Cheng Cheng, Yajun Liu, Lei Zhu, Hong Shen
Summary: This study found that patients with active ulcerative colitis (UC) have higher inflammatory response and lower nutritional status compared to those in remission. The controlling nutritional status (CONUT) score showed negative correlation with laboratory parameters and positive correlation with inflammatory markers. The CONUT score could potentially be a biomarker to assess disease activity in UC.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2023)
Article
Public, Environmental & Occupational Health
Kasper Monsted Pedersen, Yunus Colak, Signe Vedel-Krogh, Camilla Jannie Kobylecki, Stig Egil Bojesen, Borge Gronne Nordestgaard
Summary: The study found that smoking was associated with an increased risk of ulcerative colitis, while offering potential protection against Crohn's disease. However, genetic evidence did not support a causal relationship between smoking intensity and the development of these inflammatory bowel diseases.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Antoine Meyer, Catherine Dong, Corinne Casagrande, Simon S. M. Chan, Inge Huybrechts, Genevieve Nicolas, Fernanda Rauber, Renata Bertazzi Levy, Christopher Millett, Bas Oldenburg, Elisabete Weiderpass, Alicia K. Heath, Tammy Y. N. Tong, Anne Tjonneland, Cecilie Kyro, Rudolf Kaaks, Verena A. Katzke, Manuela M. Bergman, Domenico Palli, Giovanna Masala, Rosario Tumino, Carlotta Sacerdote, Sandra M. Colorado-Yohar, Maria-Jose Sanchez, Olof Grip, Stefan Lindgren, Robert Luben, Marc J. Gunter, Yahya Mahamat-Saleh, Marie-Christine Boutron-Ruault, Franck Carbonnel
Summary: The study found that consuming unprocessed/minimally processed foods is associated with a lower risk of Crohn's disease, but not with the risk of ulcerative colitis.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Julian Hercun, Justin Cote-Daigneault, Raymond G. Lahaie, Carole Richard, Ramses Wassef, Pierre Poitras
Summary: The study found that Crohn's disease can develop postoperatively with an increasing cumulative incidence over time. Preoperative predictive factors are limited and should not determine candidacy for surgery. Most patients have favorable outcomes with medical therapy, while 16% of Crohn's disease patients require pouch removal.
DISEASES OF THE COLON & RECTUM
(2021)
Article
Gastroenterology & Hepatology
Anika Varma, Jennifer Weinstein, Jamison Seabury, Spencer Rosero, Ellen Wagner, Christine Zizzi, Elizabeth Luebbe, Nuran Dilek, Michael McDermott, John Heatwole, Lawrence Saubermann, Larissa Temple, Scott Rogoff, Chad Heatwole
Summary: This study aimed to identify the most prevalent and impactful symptoms in patients with Crohn's disease (CD) and to determine the modifying factors associated with a higher disease burden in CD.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Scott Friedberg, David Choi, Thomas Hunold, Natalie K. Choi, Nicole M. Garcia, Emma A. Picker, Nathaniel A. Cohen, Russell D. Cohen, Sushila R. Dalal, Joel Pekow, Atsushi Sakuraba, Noa Krugliak Cleveland, David T. Rubin
Summary: In this study, the authors reported a large real-world experience with the use of upadacitinib in patients with ulcerative colitis and Crohn's disease. They found that upadacitinib was rapidly effective and safe, even in patients who had prior exposure to tofacitinib.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Hamed Khalili, Niclas Hakansson, Kevin Casey, Emily Lopes, Jonas F. Ludvigsson, Andrew T. Chan, Simon S. M. Chan, Ola Olen, Alicja Wolk
Summary: This study found that certain healthy eating patterns were associated with a lower risk of older-onset Crohn's disease, but not with the risk of ulcerative colitis.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Gastroenterology & Hepatology
Shahana Prakash, Tomohiro Tanaka, Divya Ashat
Summary: Indeterminate colitis (IC) is a subtype of inflammatory bowel disease (IBD) with features of both Crohn's disease (CD) and ulcerative colitis (UC). This study examines the characteristics of patients hospitalized with IC in the United States (US) and compares them with patients admitted with CD and UC. The study also analyzes trends in cost and length of stay.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2023)
Article
Gastroenterology & Hepatology
Linmin Hu, Siqing Wu, Yuelong Shu, Kai Su, Chunliang Wang, Danni Wang, Qiangsheng He, Xinyu Chen, Wenjing Li, Ningning Mi, Peng Xie, Jinyu Zhao, Shiyong Zhang, Jinqiu Yuan, Jianbang Xiang, Bin Xia
Summary: Maternal smoking during pregnancy has an impact on the risk of Crohn's disease in adult offspring. Personal smoking and genetic risk amplify this effect.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Gastroenterology & Hepatology
Tessa Straatmijer, Vince B. C. Biemans, Marijn Visschedijk, Frank Hoentjen, Annemarie de Vries, Adriaan A. van Bodegraven, Alexander Bodelier, Nanne K. H. de Boer, Gerard Dijkstra, Noortje Festen, Carmen Horjus, Jeroen M. Jansen, Bindia Jharap, Wout Mares, Fiona D. M. van Schaik, Cyriel Ponsioen, Tessa Romkens, Nidhi Srivastava, Michael M. P. J. A. van der Voorn, Rachel West, Janneke van der Woude, Marije D. J. Wolvers, Marieke Pierik, Andrea E. van der Meulen-de Jong, Marjolijn Duijvestein
Summary: This study compared the effectiveness and safety of vedolizumab and tofacitinib in anti-TNF-exposed patients with UC. The results showed that tofacitinib was associated with superior effectiveness outcomes compared with vedolizumab, along with comparable safety outcomes.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Tessa Straatmijer, Fiona D. M. van Schaik, Alexander G. L. Bodelier, Marijn Visschedijk, Annemarie C. de Vries, Cyriel Y. Ponsioen, Marieke Pierik, Ad A. van Bodegraven, Rachel L. West, Nanne K. H. de Boer, Nidhi Srivastava, Tessa E. H. Romkens, Jildou Hoekstra, Bas Oldenburg, Gerard Dijkstra, Janneke C. van der Woude, Mark Lowenberg, Zlatan Mujagic, Vince B. C. Biemans, Andrea E. Van der Meulen-de Jong, Marjolijn Duijvestein
Summary: The aim of this study was to evaluate the effectiveness and safety of 24 months of tofacitinib use in patients with ulcerative colitis in the Netherlands. The results showed that 31.8% of patients achieved corticosteroid-free clinical remission after 24 months of tofacitinib treatment. The main side effects were skin reactions and headaches.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Ophthalmology
Judith M. J. Veugen, Suryan L. Dunker, Petra F. G. Wolffs, Paul H. M. Savelkoul, Bjorn Winkens, Frank J. H. M. van den Biggelaar, Rudy M. M. A. Nuijts, Mor M. Dickman
Summary: This study analyzed real-world practice patterns and graft survival after corneal transplantation for infectious keratitis in the Netherlands. The most common indication for transplantation was viral keratitis, followed by bacterial and Acanthamoeba keratitis. HLA matching did not provide a significant survival benefit, while emergency procedures and grafts sized >8.5 mm had poor survival. Acanthamoeba had a worse prognosis in therapeutic keratoplasty compared to viral and bacterial keratitis.
Article
Otorhinolaryngology
Sorina R. Simon, Monse W. M. Wieland, Charlotte Hendriks, Walmari Pilz, Antonio Schindler, Bjorn Winkens, Laura W. J. Baijens
Summary: This study described the training process of observers for the Dynamic Imaging Grade of Swallowing Toxicity (DIGEST) scale in fiberoptic endoscopic evaluation of swallowing (FEES), determined observer agreement on DIGEST in FEES, explored the effect of bolus consistency on observer agreement, and explored criterion validity of DIGEST in FEES. The study found that observer agreement on DIGEST improved after specific training, and bolus consistency had an effect on observer agreement. A manual with well-defined descriptions can optimize the reproducibility of DIGEST measurements.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Article
Pediatrics
Nanja Bevers, Els Van de Vijver, Arta Aliu, Ashkan Rezazadeh Ardabili, Philippe Rosias, Janneke Stapelbroek, Imke A. Bertrams Maartens, Cathelijne van de Feen, Hankje Escher, Annemarie Oudshoorn, Sarah Teklenburg, Saskia Vande Velde, Bjorn Winkens, Maarten Raijmakers, Anita Vreugdenhil, Marieke J. Pierik, Patrick F. van Rheenen
Summary: This study aimed to determine whether intravenous or oral iron suppletion is superior in improving physical fitness in anemic children with inflammatory bowel disease (IBD). The study found that a single dose of IV iron was more effective in quickly improving physical fitness compared to oral iron, but there were no differences between oral and IV therapies at 3 and 6 months after initiation of therapy.
JOURNAL OF PEDIATRICS
(2023)
Article
Gastroenterology & Hepatology
Ashkan Rezazadeh Ardabili, Dirk van Esser, Dion Wintjens, Mia Cilissen, Debbie Deben, Zlatan Mujagic, Fritzi Russ, Laurents Stassen, Adriaan A. Van Bodegraven, Dennis Wong, Bjorn Winkens, Daisy Jonkers, Marielle Romberg-Camps, Marie J. Pierik
Summary: A remote monitoring tool, called the PRIQ, has been developed and validated to assess infections in IBD patients, enabling personalized medicine based on adequate benefit-risk assessments.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Medicine, General & Internal
Lindsay Spekreijse, Rob Simons, Bjorn Winkens, Frank van den Biggelaar, Carmen Dirksen, Marjolijn Bartels, Ronald de Crom, Oege Goslings, Maurits Joosse, Jocelyn Kasanardjo, Peter Lansink, Theodorus Ponsioen, Nic Reus, Jan Schouten, Rudy Nuijts
Summary: This study evaluates the safety, effectiveness, and cost-effectiveness of immediate sequential bilateral cataract surgery (ISBCS) versus delayed sequential bilateral cataract surgery (DSBCS). The results show that ISBCS is non-inferior to DSBCS in terms of safety and effectiveness, and it is superior in cost-effectiveness.
Article
Ophthalmology
Magali M. S. Vandevenne, Tos T. J. M. Berendschot, Bjorn Winkens, Frank J. H. M. van den Biggelaar, Nienke Visser, Mor M. Dickman, Robert P. L. Wisse, Robert-Jan H. J. Wijdh, Abhijit Sinha Roy, Rohit Shetty, Rudy M. M. A. Nuijts
Summary: This study aims to compare the effectiveness of standard corneal crosslinking (sCXL) and customized corneal crosslinking (cCXL) in terms of flattening the cornea and preventing keratoconus progression. Treating only the affected zone could minimize the risk of damaging surrounding tissues and promote faster wound healing.
Article
Gastroenterology & Hepatology
Ayla Thijssen, Ramon-Michel R. Schreuder, Roger Fonolla, Quirine van der Zander, Thom Scheeve, Bjorn Winkens, Sharmila Subramaniam, Pradeep Bhandari, Peter de With, Ad Masclee, Fons van der Sommen, Erik Schoon
Summary: Computer-aided diagnosis systems (CADx) can improve colorectal polyp (CRP) optical diagnosis. An explainable AI CADx was developed to automatically generate textual descriptions of CRPs, and its performance was analyzed using BLI images of 55 CRPs. The CADx showed high performance for surface descriptors, while the description of size and pits-distribution need improvement. Explainable AI can enhance the understanding and trust in CADx.
ENDOSCOPY INTERNATIONAL OPEN
(2023)
Article
Gerontology
Marlot Kruisbrink, Rixt Zijlstra, Rik Crutzen, Tanja A. C. Dorresteijn, Bjorn Winkens, Gertrudis I. J. M. Kempen
Summary: This study examined whether participant characteristics moderated the effects of two cognitive behavioral interventions on concerns about falling in older community-dwelling individuals. Secondary analyses of two RCTs were conducted, involving the group intervention A Matter of Balance - Netherlands (AMB-NL) (n = 540) and individual AMB - Home (n = 389) intervention. Marginal models were used for moderation assessment, including single and multiple moderator models. A total of 19 characteristics were assessed. Moderating effects were found for living situation, fall history, symptoms of depression, perceived general health, ADL disability, cognitive status, and consequences of falling-loss of independence subscale. Effects varied by intervention, time point, and type of model.
JOURNAL OF APPLIED GERONTOLOGY
(2023)
Editorial Material
Gastroenterology & Hepatology
Ashkan Rezazadeh Ardabili, Adriaan A. Van Bodegraven
Summary: This article is linked to the paper by Everhov et al.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Gastroenterology & Hepatology
L. M. Janssen, A. Rezazadeh Ardabili, M. J. L. Romberg-Camps, B. Winkens, R. J. van den Broek, J. Hulst, H. J. A. Verwijs, D. Keszthelyi, D. M. A. E. Jonkers, A. A. van Bodegraven, M. J. Pierik, Z. Mujagic
Summary: Abdominal pain is common in patients with IBD in remission and is associated with psychosocial factors. A more holistic treatment approach for patients with IBD suffering from abdominal pain may improve quality of care and subjective wellbeing.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Critical Care Medicine
Michelle R. Baggerman, Ingeborg M. Dekker, Bjorn Winkens, Steven W. M. Olde Damink, Sandra N. Stapel, Peter J. M. Weijs, Marcel C. G. van de Poll
Summary: This study investigated the association between visceral obesity, BMI and 90-day mortality in critically ill patients. The results showed no significant association between visceral obesity and BMI with 90-day mortality, although obesity and visceral obesity tended to be associated with improved 90-day mortality.
JOURNAL OF CRITICAL CARE
(2023)
Meeting Abstract
Gastroenterology & Hepatology
A. Rezazadeh Ardabili, D. van Esser, D. Wintjens, M. Cilissen, D. Deben, Z. Mujagic, F. Russ, L. Stassen, A. van Bodegraven, D. Wong, B. Winkens, D. Jonkers, M. Romberg-Camps, M. Pierik
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Gastroenterology & Hepatology
Reinier C. A. van Linschoten, Fenna M. Jansen, Renske W. M. Pauwels, Lisa J. T. Smits, Femke Atsma, Wietske Kievit, Dirk J. de Jong, Annemarie C. de Vries, Paul J. Boekema, Rachel L. West, Alexander G. L. Bodelier, Ingrid A. M. Gisbertz, Frank H. J. Wolfhagen, Tessa E. H. Romkens, Maurice W. M. D. Lutgens, Adriaan A. van Bodegraven, Bas Oldenburg, Marieke J. Pierik, Maurice G. V. M. Russel, Nanne K. de Boer, Rosalie C. Mallant-Hent, Pieter C. J. ter Borg, Andrea E. van der Meulen-de Jong, Jeroen M. Jansen, Sita Jansen, Adrianus C. I. T. L. Tan, C. Janneke van der Woude, Frank Hoentjen
Summary: The study aimed to assess the clinical outcomes of increased adalimumab dose intervals versus conventional dosing in patients with stable remission of Crohn's disease. The results showed that increasing the adalimumab dose intervals to 3 weeks and further to 4 weeks was non-inferior for maintaining stable remission, and this approach reduced the risk of infections and healthcare costs.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2023)
