Article
Nutrition & Dietetics
Mireille N. M. van Poppel, Rosa Corcoy, David Hill, David Simmons, Leire Mendizabal, Mirella Zulueta, Laureano Simon, Gernot Desoye, Juan M. Adelantado Perez, Alexandra Kautzky-Willer, Juergen Harreiter, Peter Damm, Elizabeth Mathiesen, Dorte M. Jensen, Lise Lotte T. Andersen, Fidelma Dunne, Annunziata Lapolla, Maria G. Dalfra, Alessandra Bertolotto, Mireille van Poppel, Judith G. M. Jelsma, Frank J. Snoek, Sander Galjaard, Ewa Wender-Ozegowska, Agnieszka Zawiejska, Roland Devlieger
Summary: The interaction between polymorphisms of the MTNR1B gene and lifestyle interventions during pregnancy was assessed. It was found that women with certain genotypes had an increased risk of gestational diabetes, and physical activity intervention may be more effective in reducing maternal insulin resistance, cord blood C-peptide, and cord blood leptin.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Endocrinology & Metabolism
Helen L. Tanner, Hui Ting Ng, Grace Murphy, Helen L. Barrett, Leonie K. Callaway, H. David McIntyre, Marloes Dekker Nitert
Summary: This study aimed to determine the association between fasting maternal ketone levels and low carbohydrate intake during pregnancy.
Article
Obstetrics & Gynecology
Hanna Gyllensten, Karin Haby, Marie Berg, Asa Premberg
Summary: The study evaluated the costs and clinical outcomes of adding the Mighty Mums antenatal lifestyle intervention to standard antenatal care. Results showed that participants in the intervention group had higher costs but also reduced gestational weight gain, particularly in the per protocol population.
BMC PREGNANCY AND CHILDBIRTH
(2021)
Article
Endocrinology & Metabolism
Jihong Liu, Sara Wilcox, Ellen Wingard, Gabrielle Turner-McGrievy, Brent Hutto, Judith Burgis
Summary: The study found that antenatal behavioral lifestyle intervention had a favorable impact on total gestational weight gain in overweight African American women but not obese African American women. Additionally, fewer adverse perinatal outcomes were observed in the intervention group compared to the standard care group.
Article
Food Science & Technology
Gordana Kendel Jovanovic, Suzana Jankovic, Sandra Pavicic ZeZelj
Summary: This study aimed to investigate the effect of an educational program on nutrition knowledge, diet quality, lifestyle, and nutritional status of schoolchildren. The results showed that the program significantly improved nutrition knowledge, diet quality, lifestyle, and nutritional status of the children. The promotion of a Mediterranean diet and lifestyle is important for the future health and wellbeing of children.
FRONTIERS IN SUSTAINABLE FOOD SYSTEMS
(2023)
Review
Nutrition & Dietetics
Salvatore Fanara, Maria Aprile, Salvatore Iacono, Giuseppe Schiro, Alessia Bianchi, Filippo Brighina, Ligia Juliana Dominguez, Paolo Ragonese, Giuseppe Salemi
Summary: Studies on nutritional factors and physical activity in the development of multiple sclerosis have gained increasing interest. Mediterranean diet has shown positive effects on MS, while caution is needed due to potential side effects. Physical activity has positive effects on disease progression and patient outcomes, with combined exercises considered more effective.
Article
Multidisciplinary Sciences
Chee Wai Ku, Shu Hui Leow, Lay See Ong, Christina Erwin, Isabella Ong, Xiang Wen Ng, Jacinth J. X. Tan, Fabian Yap, Jerry Kok Yen Chan, See Ling Loy
Summary: The time period before, during, and after pregnancy is a unique opportunity to improve the metabolic health of mothers and their offspring through interventions that promote sustained healthy lifestyle behaviors. This study identified barriers such as time constraints, poor baseline knowledge, and lack of relevant data sources, and enabling factors such as motivation, support, and a holistic delivery platform for information and feedback.
SCIENTIFIC REPORTS
(2022)
Article
Environmental Sciences
Farah Nawabi, Franziska Krebs, Laura Lorenz, Arim Shukri, Adrienne Alayli, Stephanie Stock
Summary: Health literacy plays a crucial role during pregnancy and there is a lack of studies and interventions in this area. The GeMuKi trial aimed to improve health literacy in pregnant women through a lifestyle intervention, and found that the intervention had no significant effect on general health literacy but had a positive association with pregnancy specific knowledge.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Endocrinology & Metabolism
Friedrich C. Jassil, Alisia Carnemolla, Helen Kingett, Jacqueline Doyle, Amy Kirk, Neville Lewis, Gemma Montagut, Parastou Marvasti, David Boniface, Adrian Brown, Kusuma Chaiyasoot, Roxanna Zakeri, Jessica Mok, Kalpana Devalia, Chetan Parmar, Rachel L. Batterham
Summary: The aim of the study was to investigate the impact of a 12-month adjunctive lifestyle intervention on weight loss and health outcomes after bariatric surgery. Results showed significant reductions in body weight, fat mass, and improvements in health-related quality of life and depressive symptomatology. However, the adjunctive lifestyle program implemented immediately after surgery had no favorable impact upon weight loss and health outcomes.
Review
Multidisciplinary Sciences
Sze Mun Thor, Jun Wern Yau, Amutha Ramadas
Summary: The scoping review examined recent interventions to manage MetS among Southeast Asians, categorizing them into nutrition, physical activity, and multi-intervention approaches. Studies mainly focused on the effects of interventions on various components of MetS, with significant improvements observed particularly in waist circumference. More research from different countries in Southeast Asia is needed to further understand the impacts of dietary interventions and address gaps in knowledge for designing effective interventions for this population.
Article
Obstetrics & Gynecology
P. Acosta-Manzano, B. Leopold-Posch, D. Simmons, R. Devlieger, S. Galjaard, R. Corcoy, J. M. Adelantado, F. Dunne, J. Harreiter, A. Kautzky-Willer, P. Damm, E. R. Mathiesen, D. M. Jensen, L. L. Andersen, M. Tanvig, A. Lapolla, M. G. Dalfra, A. Bertolotto, E. Wender-Ozegowska, A. Zawiejska, D. J. Hill, F. J. Snoek, J. G. M. Jelsma, G. Desoye, M. N. M. van Poppel
Summary: The study found that sedentary behavior during pregnancy may be associated with the expression of genes related to lipid transport in the placenta of obese pregnant women, while physical activity is hardly related to transporter mRNA. Strategies aimed at reducing sedentary behavior during pregnancy could help modulate placental gene expression to prevent unfavorable fetal and maternal outcomes.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Article
Endocrinology & Metabolism
Josefine Jonsson, Kristina M. Renault, Sonia Garcia-Calzon, Alexander Perfilyev, Angela C. Estampador, Kirsten Norgaard, Mads Vendelbo Lind, Allan Vaag, Line Hjort, Kim F. Michaelsen, Emma Malchau Carlsen, Paul W. Franks, Charlotte Ling
Summary: Maternal obesity can lead to epigenetic changes in offspring, impacting growth and disease risk. Lifestyle interventions during pregnancy may alter DNA methylation in offspring, influencing lean mass and growth.
Article
Endocrinology & Metabolism
Hanako Nakajima, Hiroshi Okada, Yuta Yoshimura, Toru Tanaka, Goji Hasegawa, Kazuteru Mitsuhashi, Noriyuki Kitagawa, Takuro Okamura, Yoshitaka Hashimoto, Takafumi Senmaru, Emi Ushigome, Naoko Nakanishi, Masahiro Yamazaki, Masahide Hamaguchi, Michiaki Fukui
Summary: This study aimed to evaluate the risk of ketosis in individuals with type 1 diabetes taking SGLT2 inhibitors, and to investigate the relationship between nutritional assessment, glycemic status, CPR index, and body composition. The results showed that younger age and a low ratio of basal to bolus insulin were associated with an increased risk of ketosis after taking SGLT2 inhibitors.
DIABETES OBESITY & METABOLISM
(2023)
Article
Nutrition & Dietetics
Mingxuan Cui, Xuening Li, Chen Yang, Linlin Wang, Lulu Lu, Shilong Zhao, Qianying Guo, Peng Liu
Summary: Carbohydrates play a crucial role in blood glucose control in pregnant women with gestational diabetes. A carbohydrate-restricted dietary pattern may delay the use of insulin and improve lipid metabolism in GDM pregnancy. Nutritional status may not be significantly affected under carbohydrate-restricted dietary intervention, while high fasting plasma glucose in early pregnancy is a risk factor for combined insulin therapy with carbohydrate-restricted diet.
Article
Endocrinology & Metabolism
Lingli Cai, Cheng Li, Yufei Wang, Yifei Mo, Jun Yin, Xiaojing Ma
Summary: This study found that weight loss intervention improved body composition and metabolism in overweight and obese adults, with no significant change in GDF15 levels. The increase of GDF15 was associated with metabolic improvements, suggesting it could be an indicator to evaluate metabolic improvements in overweight and obese individuals.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2021)
Review
Endocrinology & Metabolism
Gernot Desoye, Lene Ringholm, Peter Damm, Elisabeth R. Mathiesen, Mireille N. M. van Poppel
Summary: Despite progress in blood glucose control, pregnancy in women with type 1 diabetes still poses risks for the fetus. Good glycemic control reduces the risk of fetal overgrowth, but hyperglycemia can still lead to fetal overnutrition and adiposity. Preventing fetal adiposity requires revised goal setting and continuous glucose monitoring.
Article
Endocrinology & Metabolism
Louise L. Stentebjerg, Lene R. Madsen, Rene K. Stoving, Lise Lotte T. Andersen, Christina A. Vinter, Claus B. Juhl, Dorte M. Jensen
Summary: This study aimed to investigate glucose metabolism during pregnancy in women who had undergone Roux-en-Y gastric bypass (RYGB). The study found that women with RYGB were more susceptible to hypoglycemia and hyperglycemia compared with control participants. Further research is needed to explore the association between hypoglycemia and fetal growth restriction in women with RYGB.
Article
Peripheral Vascular Disease
Gustaf L. Isaksson, Lise H. Nielsen, Yaseelan Palarasah, Dorte M. Jensen, Lise L. T. Andersen, Kirsten Madsen, Claus Bistrup, Jan S. Jorgensen, Per G. Ovesen, Boye L. Jensen
Summary: Pregnant women with type-1 diabetes have an increased risk of preeclampsia with kidney injury and cardiovascular complications. Urine excretion of plasmin and soluble membrane attack complex (sC5b-9) is elevated in severe preeclampsia.
JOURNAL OF HYPERTENSION
(2023)
Article
Biochemistry & Molecular Biology
Julia T. Stadler, Mireille N. M. van Poppel, Christian Wadsack, Michael Holzer, Anja Pammer, David Simmons, David Hill, Gernot Desoye, Gunther Marsche
Summary: Pregravid obesity is a major risk factor for pregnancy complications and cardiovascular events in children. However, the biological mechanisms underlying these adverse outcomes are not well understood. Impairment of HDL function in obese and GDM-complicated pregnancies may have long-term effects on maternal and offspring health.
Article
Public, Environmental & Occupational Health
Teresa Gisinger, Zahra Azizi, Pouria Alipour, Juergen Harreiter, Valeria Raparelli, Karolina Kublickiene, Maria Trinidad Herrero, Colleen M. Norris, Khaled El Emam, Louise Pilote, Alexandra Kautzky-Willer
Summary: This study aimed to investigate whether sex and gender factors have an impact on access to healthcare and cardiovascular outcomes of individuals with diabetes across different countries. The analysis of data from Canadian and European surveys revealed that gender differences existed in diabetes monitoring and that countries with higher gender inequality had higher risk of cardiovascular diseases and hospitalizations in diabetes patients.
FRONTIERS IN PUBLIC HEALTH
(2023)
Editorial Material
Endocrinology & Metabolism
Mireille N. M. van Poppel, Peter Damm, Elisabeth R. R. Mathiesen, Lene Ringholm, Cuilin Zhang, Gernot Desoye
Summary: In pregnancies of women with obesity or diabetes, neonates are often overgrown. This article focuses on possible growth deviations earlier in pregnancy and their potential contribution to neonatal overgrowth, suggesting that early-pregnancy growth reduction followed by in utero catch-up growth may confer a higher risk of obesity in later life.
Article
Endocrinology & Metabolism
Julia Bandres-Meriz, Christina Kunz, Jesper F. Havelund, Nils J. Faergeman, Alejandro Majali-Martinez, Regina Ensenauer, Gernot Desoye
Summary: The study found that the metabolome of pregnant women with overweight/obesity is already altered early in pregnancy due to changes in C-peptide. Lipid and amino acid metabolites related to obesity and insulin play a key role in these alterations.
INTERNATIONAL JOURNAL OF OBESITY
(2023)
Article
Biochemistry & Molecular Biology
Maja Peric, Marina Horvaticek, Veronika Tandl, Ivona Beceheli, Alejandro Majali-Martinez, Gernot Desoye, Jasminka Stefulj
Summary: Serotonin signaling is important for regulating placental development and functions. Maternal metabolic disturbances associated with obesity and gestational diabetes may affect placental serotonin homeostasis. High glucose downregulates serotonin transporter (SERT) and monoamine oxidase A (MAOA), and upregulates tryptophan hydroxylase 1 (TPH1) at 6.5% oxygen. Low oxygen levels (2.5%) upregulate SERT and downregulate TPH1 expression. Insulin specifically upregulates SERT at 2.5% oxygen. These findings suggest that maternal metabolic alterations can impact placental serotonin homeostasis.
Article
Endocrinology & Metabolism
Anna Dieberger, Barbara Obermayer-Pietsch, Juergen Harreiter, Gernot J. Desoye, Mireille N. M. van Poppel, DALI Core Investigator grp
Summary: Maternal physical activity and sedentary time during pregnancy are associated with neonatal anthropometry and cord blood parameters, with potential differences based on offspring sex. Moderate-to-vigorous physical activity is associated with lower neonatal fat mass in male offspring, while mean sedentary time is associated with lower cord blood C-peptide in female offspring.
INTERNATIONAL JOURNAL OF OBESITY
(2023)
Article
Nutrition & Dietetics
Anne Timm, Karoline Kragelund Nielsen, Helle Molsted Alvesson, Dorte Moller Jensen, Helle Terkildsen Maindal
Summary: Using couple interviews can enhance our understanding of motivation in changing diet and physical activity behaviors among women and their partners affected by recent GDM, thus promoting health behavior change.
Article
Nutrition & Dietetics
Marie-Therese Weiser-Fuchs, Elena Maggauer, Mireille N. M. van Poppel, Bence Csapo, Gernot Desoye, Harald C. Koefeler, Andrea Groselj-Strele, Slave Trajanoski, Herbert Fluhr, Barbara Obermayer-Pietsch, Evelyn Jantscher-Krenn
Summary: This study found that sialylated human milk oligosaccharides (HMOs) are associated with impaired glucose homeostasis in pregnancy, suggesting potential implications for gestational diabetes mellitus (GDM).
Article
Endocrinology & Metabolism
Nanna Husted Jensen, Karoline Kragelund Nielsen, Inger Katrine Dahl-Petersen, Ulla Kampmann, Peter Damm, Per Ovesen, Elisabeth Reinhardt Mathiesen, Christina Anne Vinter, Emma Davidsen, Maja Thogersen, Anne Timm, Lise Lotte Torvin Andersen, Sine Knorr, Dorte Moller Jensen, Helle Terkildsen Maindal
Summary: The Face-it trial is a randomized controlled trial for women with recent gestational diabetes mellitus (GDM) and their families. The penetration and participation rates were acceptable, with participating women showing slight differences in characteristics based on partner participation status.
BMJ OPEN DIABETES RESEARCH & CARE
(2023)