Article
Entomology
Feixue Ban, Yuwei Zhong, Lilong Pan, Lijuan Mao, Xiaowei Wang, Yinquan Liu
Summary: The study found that simultaneous infection of plants by two viruses results in more severe symptoms, but does not significantly alter the performance and preference of whiteflies. Coinfection suppresses the transcription of genes involved in the JA signaling pathway in plants.
JOURNAL OF ECONOMIC ENTOMOLOGY
(2021)
Article
Multidisciplinary Sciences
Ian W. Campbell, Karthik Hullahalli, Jerrold R. Turner, Matthew K. Waldor
Summary: In this study, the authors investigated the effect of pathogen dose on the initiation of infection in the mouse gut using Citrobacter rodentium as a model. They found that host bottlenecks prevent infections by eliminating invading pathogens, and the size of the pathogen's founding population in female mice is controlled by a severe bottleneck. The disruption of the microbiota was found to be the dominant bottleneck, while the loss of the critical virulence island led to a contraction in the diversity of the pathogen population.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Camilla Sacco Botto, Slavica Matic, Amedeo Moine, Walter Chitarra, Luca Nerva, Chiara D'Errico, Chiara Pagliarani, Emanuela Noris
Summary: Drought stress is a major factor affecting agricultural production by negatively impacting plant growth and metabolism. Previous research has shown that viruses, such as the tomato yellow leaf curl virus, can enhance a plant's ability to tolerate both drought and heat stress. However, the underlying mechanisms for this induced drought tolerance need further investigation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Chiara Pagliarani, Amedeo Moine, Walter Chitarra, Luca Nerva, Marco Catoni, Raffaela Tavazza, Slavica Matic, Marta Vallino, Francesca Secchi, Emanuela Noris
Summary: A study showed that the C4 protein of tomato yellow leaf curl virus (TYLCSV) can enhance drought tolerance in tomato plants by delaying the onset of stress-related features, improving water use efficiency, and facilitating rapid post-rehydration recovery. Specific anatomical and hydraulic traits play a key role in the stress resilience associated with the C4 protein. These findings provide new insights into the mechanism through which such proteins tune the plant-virus interaction.
HORTICULTURE RESEARCH
(2022)
Review
Infectious Diseases
Patrick R. Lennard, Pieter S. Hiemstra, Peter H. Nibbering
Summary: The combination of host defence peptides (HDPs) and antibiotics shows promise in the treatment of antimicrobial resistant (AMR) bacterial infections. Despite biases in the current literature, studies suggest that effective combinations of HDPs and antibiotics hold potential for future treatment of AMR infections.
Article
Multidisciplinary Sciences
Yaara Finkel, Avi Gluck, Aharon Nachshon, Roni Winkler, Tal Fisher, Batsheva Rozman, Orel Mizrahi, Yoav Lubelsky, Binyamin Zuckerman, Boris Slobodin, Yfat Yahalom-Ronen, Hadas Tamir, Igor Ulitsky, Tomer Israely, Nir Paran, Michal Schwartz, Noam Stern-Ginossar
Summary: The study reveals that SARS-CoV-2 infection leads to a global reduction in translation and accelerated degradation of cytosolic cellular mRNAs. It also impairs the translation of transcripts induced in response to infection, probably mediated by inhibition of nuclear mRNA export.
Article
Plant Sciences
Kristie Bruinsma, Cristina Rioja, Vladimir Zhurov, Maria Estrella Santamaria, Vicent Arbona, Marie Navarro, Marc Cazaux, Philippe Auger, Alain Migeon, Nicky Wybouw, Thomas Van Leeuwen, Isabel Diaz, Aurelio Gomez-Cadenas, Miodrag Grbic, Maria Navajas, Vojislava Grbic
Summary: The mechanisms underlying host adaptation and specialization in tomato-adapted spider mites were compared, revealing that although both mites use similar mechanisms to counteract tomato defenses, the specialist mite is better equipped to cope with these defenses.
Article
Virology
Yanxiang Ren, Xiaorong Tao, Dawei Li, Xiuling Yang, Xueping Zhou
Summary: The ty-5 gene confers effective resistance to various geminiviruses, including tomato yellow leaf curl virus and beet curly top virus. Southern blotting and quantitative polymerase chain reaction analyses showed significantly less viral DNA accumulation in the ty-5 line. Knockdown of Pelota expression also converted a tobacco plant from a susceptible host to a resistant host against geminiviruses.
Editorial Material
Parasitology
Catherine J. Merrick
Summary: The newly discovered epigenetic mark, histone lactylation, found in humans, is also present in malaria parasites and may have significant roles in the epigenetic regulation of Plasmodium.
TRENDS IN PARASITOLOGY
(2023)
Article
Agronomy
Jing Liu, Jianbin Lan, Peiping Zhang, Longfeng Yu, Feiyan Huang, Xuehong Wu, Jia Liu, Yuan Sui
Summary: In this study, it was found that pectic oligosaccharide (POS) can inhibit blue mold and black rot in kiwifruit after harvest, as well as improve the fruit's resistance to decay pathogens. POS upregulated the expression of defense-related and antioxidant enzyme genes, leading to increased enzyme activity and induced defense responses in the fruit. POS-treated fruit maintained higher firmness and total phenolic compounds, and exhibited reduced weight loss.
POSTHARVEST BIOLOGY AND TECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Anita Gola, Michael G. Dorrington, Emily Speranza, Claudia Sala, Rochelle M. Shih, Andrea J. Radtke, Harikesh S. Wong, Antonio P. Baptista, Jonathan M. Hernandez, Gastone Castellani, Iain D. C. Fraser, Ronald N. Germain
Summary: The study reveals that immune cells in the liver also exhibit zonation, which is regulated by microbiome sensing by liver sinusoidal endothelial cells and plays a crucial role in host defense. Immune cells concentrate asymmetrically around periportal regions in the liver, and this spatial polarization is more efficient in protecting against systemic bacterial dissemination compared to a uniform distribution. Liver sinusoidal endothelial cells actively sense the microbiome and orchestrate the localization of immune cells to optimize host defense.
Article
Pharmacology & Pharmacy
Amirah Abdul Rahman, Wan Zurinah Wan Ngah, Rahman Jamal, Suzana Makpol, Roslan Harun, Norfilza Mokhtar
Summary: Therapeutic potential of hydroxychavicol (HC) and epigallocatechin-3-gallate (EGCG) against cancer cells has been reported, but high concentrations are required. In this study, low combination doses of EGCG+HC were found to have a synergistic effect in inhibiting the growth of glioma cells. The treatment also induced cell death and arrested the cell cycle at S phase. The combination therapy altered the expression of specific genes and pathways involved in tumor progression. This research provides valuable insights for the development of glioma cancer therapies.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Plant Sciences
Xiaoshi Liu, Wei Huang, Zhenqian Zhai, Tushu Ye, Chengwei Yang, Jianbin Lai
Summary: This article summarizes the research progress on the interaction between host plants and geminiviruses, including the role of phosphorylation and lipidation in controlling the activity and localization of viral factors; as well as the interference of ubiquitination and histone modification by viral components. The dynamic competition on protein modifications between host defense and geminivirus efficient infection, as well as the potential applications of protein modifications in geminivirus resistance, are also discussed.
PLANT CELL AND ENVIRONMENT
(2021)
Article
Virology
Vitor Batista Pinto, Ayane Fernanda Ferreira Quadros, Marcio Tadeu Godinho, Jose Cleydson Silva, Poliane Alfenas-Zerbini, F. Murilo Zerbini
Summary: The evolutionary dynamics of the bipartite begomovirus Tomato severe rugose virus (ToSRV) was evaluated in cultivated and non-cultivated hosts by biolistically inoculating tomato and Nicandra physaloides plants with an infectious clone. Results showed different nucleotide substitution rates in the two hosts. Interestingly, the number of substitutions decreased over time, suggesting the presence of bottlenecks during systemic infection.
Article
Biochemical Research Methods
Yuan You, Zhihao Jiang
Summary: This protocol describes a novel technique called eINTACT for isolating biotin-labeled nuclei from Arabidopsis plant cells that have received Xanthomonas bacterial effectors. By using streptavidin-coated magnetic beads, this method allows the isolation of high-quality nuclei from bacterial effector-targeted host cells in native infection contexts.
Article
Virology
Nirbhay Kushwaha, Ashish Kumar Singh, Saumik Basu, Supriya Chakraborty
ARCHIVES OF VIROLOGY
(2015)
Article
Biotechnology & Applied Microbiology
R. Vinoth Kumar, Achuit Kumar Singh, Ashish Kumar Singh, Tribhuwan Yadav, Saumik Basu, Nirbhay Kushwaha, Brotati Chattopadhyay, Supriya Chakraborty
JOURNAL OF GENERAL VIROLOGY
(2015)
Article
Plant Sciences
Saumik Basu, Nirbhay Kumar Kushwaha, Ashish Kumar Singh, Pranav Pankaj Sahu, R. Vinoth Kumar, Supriya Chakraborty
JOURNAL OF EXPERIMENTAL BOTANY
(2018)
Article
Plant Sciences
Veerendra Kumar Sharma, Nirbhay Kushwaha, Saumik Basu, Ashish Kumar Singh, Supriya Chakraborty
PHYSIOLOGY AND MOLECULAR BIOLOGY OF PLANTS
(2015)
Article
Plant Sciences
Mansi, Nirbhay Kumar Kushwaha, Ashish Kumar Singh, Mir Jishan Karim, Supriya Chakraborty
MOLECULAR PLANT PATHOLOGY
(2019)
Article
Plant Sciences
Ved Prakash, Archana Singh, Ashish Kumar Singh, Tamas Dalmay, Supriya Chakraborty
Article
Biotechnology & Applied Microbiology
Saumik Basu, Ashish Kumar Singh, Divya Singh, Sanjeeb Kumar Sahu, Supriya Chakraborty
Summary: Mixed viral infections in fields are common and exacerbate disease severity, causing crop loss. AC2 and AV2 proteins of ToLCGuV enhance ToLCNDV accumulation and suppress gene silencing machinery.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Article
Plant Sciences
T. Namgial, A. K. Singh, N. P. Singh, A. Francis, D. Chattopadhyay, A. Voloudakis, S. Chakraborty
Summary: Nicotiana tabacum exhibits recovery response towards tomato leaf curl Gujarat virus. Transcriptome analysis revealed the differential expression of defense-related genes. Genes encoding for cysteine protease inhibitor, hormonal- and stress-related to DNA repair mechanism are found to be involved in the recovery process.