Comprehensive single cell mRNA profiling reveals a detailed roadmap for pancreatic endocrinogenesis

A Peninsular Structure Coordinates Asynchronous Differentiation with Morphogenesis to Generate Pancreatic Islets

(2019) Nadav Sharon et al.   CELL

Neurog3-Independent Methylation Is the Earliest Detectable Mark Distinguishing Pancreatic Progenitor Identity

(2019) Jing Liu et al.   DEVELOPMENTAL CELL

Defining multistep cell fate decision pathways during pancreatic development at single‐cell resolution

(2019) Xin‐Xin Yu et al.   EMBO JOURNAL

p120ctn-Mediated Organ Patterning Precedes and Determines Pancreatic Progenitor Fate

(2019) Pia Nyeng et al.   DEVELOPMENTAL CELL

Optimal-Transport Analysis of Single-Cell Gene Expression Identifies Developmental Trajectories in Reprogramming

(2019) Geoffrey Schiebinger et al.   CELL

Identification of Enteroendocrine Regulators by Real-Time Single-Cell Differentiation Mapping

(2019) Helmuth Gehart et al.   CELL

Inferring population dynamics from single-cell RNA-sequencing time series data

(2019) David S. Fischer et al.   NATURE BIOTECHNOLOGY

Dynamics of chromatin marks and the role of JMJD3 during pancreatic endocrine cell fate commitment

(2018) Xin-Xin Yu et al.   DEVELOPMENT

Understanding human fetal pancreas development using subpopulation sorting, RNA sequencing and single-cell profiling

(2018) Cyrille Ramond et al.   DEVELOPMENT

ROCK-nmMyoII, Notch and Neurog3 gene-dosage link epithelial morphogenesis with cell fate in the pancreatic endocrine-progenitor niche

(2018) Eric D. Bankaitis et al.   DEVELOPMENT

Defining Lineage Potential and Fate Behavior of Precursors during Pancreas Development

(2018) Magdalena K. Sznurkowska et al.   DEVELOPMENTAL CELL

RNA velocity of single cells

(2018) Gioele La Manno et al.   NATURE

Endocrine lineage biases arise in temporally distinct endocrine progenitors during pancreatic morphogenesis

(2018) Marissa A. Scavuzzo et al.   Nature Communications

Lineage dynamics of murine pancreatic development at single-cell resolution

(2018) Lauren E. Byrnes et al.   Nature Communications

Modelling the endocrine pancreas in health and disease

(2018) Mostafa Bakhti et al.   Nature Reviews Endocrinology

Single-Cell Transcriptome Profiling of Mouse and hESC-Derived Pancreatic Progenitors

(2018) Nicole A.J. Krentz et al.   Stem Cell Reports

EGFR signalling controls cellular fate and pancreatic organogenesis by regulating apicobasal polarity

(2017) Zarah M. Löf-Öhlin et al.   NATURE CELL BIOLOGY

Single cell transcriptomic profiling of mouse pancreatic progenitors

(2017) Diana E. Stanescu et al.   PHYSIOLOGICAL GENOMICS

Foxa2 and Pdx1 cooperatively regulate postnatal maturation of pancreatic β-cells

(2017) Aimée Bastidas-Ponce et al.   Molecular Metabolism

Precommitment low-levelNeurog3expression defines a long-lived mitotic endocrine-biased progenitor pool that drives production of endocrine-committed cells

(2016) Matthew E. Bechard et al.   GENES & DEVELOPMENT

Diffusion pseudotime robustly reconstructs lineage branching

(2016) Laleh Haghverdi et al.   NATURE METHODS

Bicaudal C1 promotes pancreatic NEUROG3+ endocrine progenitor differentiation and ductal morphogenesis

(2015) L. A. Lemaire et al.   DEVELOPMENT

SOX4 cooperates with neurogenin 3 to regulate endocrine pancreas formation in mouse models

(2015) Eric E. Xu et al.   DIABETOLOGIA

Feedback control of growth, differentiation, and morphogenesis of pancreatic endocrine progenitors in an epithelial plexus niche

(2015) Eric D. Bankaitis et al.   GENES & DEVELOPMENT

Notum deacylates Wnt proteins to suppress signalling activity

(2015) Satoshi Kakugawa et al.   NATURE

Cell Cycle–Dependent Differentiation Dynamics Balances Growth and Endocrine Differentiation in the Pancreas

(2015) Yung Hae Kim et al.   PLOS BIOLOGY

Insm1 promotes endocrine cell differentiation by modulating the expression of a network of genes that includes Neurog3 and Ripply3

(2014) A. B. Osipovich et al.   DEVELOPMENT

An Integrated Cell Purification and Genomics Strategy Reveals Multiple Regulators of Pancreas Development

(2014) Cecil M. Benitez et al.   PLoS Genetics

Spatiotemporal patterns of multipotentiality in Ptf1a-expressing cells during pancreas organogenesis and injury-induced facultative restoration

(2013) F. C. Pan et al.   DEVELOPMENT

Gene Regulatory Networks Governing Pancreas Development

(2013) H. Efsun Arda et al.   DEVELOPMENTAL CELL

A Notch-dependent molecular circuitry initiates pancreatic endocrine and ductal cell differentiation

(2012) H. P. Shih et al.   DEVELOPMENT

Planar Cell Polarity Controls Pancreatic Beta Cell Differentiation and Glucose Homeostasis

(2012) Cedric Cortijo et al.   Cell Reports

Sox9+ ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas

(2011) J. L. Kopp et al.   DEVELOPMENT

Neurogenin3 initiates stepwise delamination of differentiating endocrine cells during pancreas development

(2011) Mathieu Gouzi et al.   DEVELOPMENTAL DYNAMICS

Pancreas organogenesis: From bud to plexus to gland

(2011) Fong Cheng Pan et al.   DEVELOPMENTAL DYNAMICS

Neurogenin3 inhibits proliferation in endocrine progenitors by inducing Cdkn1a

(2010) T. Miyatsuka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Ectopic Expression of Pax4 in the Mouse Pancreas Converts Progenitor Cells into α and Subsequently β Cells

(2009) Patrick Collombat et al.   CELL

Pancreatic neurogenin 3-expressing cells are unipotent islet precursors

(2009) R. Desgraz et al.   DEVELOPMENT

Neurog3 gene dosage regulates allocation of endocrine and exocrine cell fates in the developing mouse pancreas

(2009) Sui Wang et al.   DEVELOPMENTAL BIOLOGY

Pancreatic Exocrine Duct Cells Give Rise to Insulin-Producing β Cells during Embryogenesis but Not after Birth

(2009) Myriam Solar et al.   DEVELOPMENTAL CELL

MFng Is Dispensable for Mouse Pancreas Development and Function

(2009) P. Svensson et al.   MOLECULAR AND CELLULAR BIOLOGY

Induction of pancreatic islet cell differentiation by the neurogenin–neuroD cascade

(2007) Rosa Gasa et al.   DIFFERENTIATION