期刊
CURRENT OPINION IN CHEMICAL BIOLOGY
卷 50, 期 -, 页码 37-44出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2019.02.005
关键词
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资金
- National Institutes of Health
- Bill and Melinda Gates Foundation
- Merck
- Hoffmann La-Roche
- L. S. Skaggs Presidential Endowed Chair
The zebrafish is a model organism that allows in vivo studies to be performed at a scale usually restricted to in vitro studies. As such, the zebrafish is well suited to in vivo screens, in which thousands of small molecules are tested for their ability to modify disease phenotypes in zebrafish disease models. Numerous approaches have been developed for modeling human diseases in zebrafish, including mutagenesis, transgenesis, pharmacological approaches, wounding, and exposure to infectious or cancerous agents. We review the various strategies for modeling human diseases in zebrafish and discuss important considerations when developing zebrafish models for use in in vivo small molecule screens.
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