期刊
CURRENT OPINION IN CELL BIOLOGY
卷 58, 期 -, 页码 120-125出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2019.03.007
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资金
- European Research Council [CoG 648050]
- MRC [MC_UU_00007/13, MR/J00913X/1] Funding Source: UKRI
The importance of three-dimensional chromatin organisation in genome regulation has never been clearer. But in spite of the enormous technological advances to probe chromatin organisation in vivo, there is still a lack of mechanistic understanding of how such an arrangement is achieved. Here we review emerging evidence pointing to an intriguing role of nuclear RNA in shaping large-scale chromatin structure and regulating genome function. We suggest this role may be achieved through the formation of a dynamic nuclear mesh that can exploit ATP-driven processes and phase separation of RNA-binding proteins to tune its assembly and material properties.
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