Article
Nanoscience & Nanotechnology
Jaehyun Park, Seokhee Jo, Yeong Mi Lee, Gurusamy Saravanakumar, Junseok Lee, Dongsik Park, Won Jong Kim
Summary: The study utilized specific enzymes with high activity in cancer for cancer diagnosis and tumor-targeted drug delivery. NQO1, an over-expressed enzyme in certain tumor types, inhibits oxidative stress and reacts with QPA to induce micellar structure dissociation for drug release. These findings suggest that NQO1-responsive polymeric micelles have potential for improving therapeutic efficacy in anticancer drug delivery.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Biochemistry & Molecular Biology
Mario Culebras, Mahboubeh Pishnamazi, Gavin M. Walker, Maurice N. Collins
Summary: The study successfully synthesized hydrogels using lignin, a non-valorized biopolymer, crosslinked with PEGDGE. The ratio of crosslinker used influenced the structural and chemical properties of the resulting hydrogels, with increased crosslinker amount leading to smaller pore size and higher swelling capacity. Paracetamol release test showed higher drug diffusion for hydrogels produced with a lignin:PEGDGE ratio of 1:1.
Article
Biochemistry & Molecular Biology
Fasih Bintang Ilhami, Kai-Chen Peng, Yi-Shiuan Chang, Yihalem Abebe Alemayehu, Hsieh-Chih Tsai, Juin-Yih Lai, Yu-Hsuan Chiao, Chen-Yu Kao, Chih-Chia Cheng
Summary: The newly developed DOX/5-ALA-loaded A-PPG micelles exhibited excellent light and pH-responsive behavior, allowing rapid drug release within 1-2 minutes of laser irradiation. This led to enhanced cellular uptake and rapid production of reactive oxygen species in cancer cells, ultimately inducing apoptotic cell death through endocytosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nanoscience & Nanotechnology
De-Chao Yang, Shuai Wang, Xiao-Lu Weng, Hong-Xia Zhang, Jian-Yong Liu, Zhonghui Lin
Summary: A smart nanocarrier, named singlet oxygen-responsive nanoparticle (SOR-NP), was developed by introducing singlet oxygen-sensitive aminoacrylate linkers into copolymers for light-controlled drug release and combination cancer treatment. The nanocarrier successfully relieved the aggregation of encapsulated photosensitizers, resulting in bright fluorescent signals and high levels of reactive oxygen species for mediating cell death via photodynamic therapy. The light-triggered drug release and combined anticancer effects were validated in cancer cells and tumor-bearing mice, offering a promising strategy for tumor-specific drug release and selective photodynamic-chemo combination treatment.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Biochemistry & Molecular Biology
Yanggui Wu, Senbin Chen, Jintao Zhu
Summary: The article introduces the construction of supramolecular polymer micelles using H-bond technology, loaded with chemotherapeutic drugs and photothermal agents for synergistic chemo-/photothermal therapies. These nanomedicines have enhanced drug loading capacity, transport performance, and stimuli-responsive drug release.
Article
Chemistry, Multidisciplinary
Ilaria Biancacci, Federica De Lorenzi, Benjamin Theek, Xiangyang Bai, Jan-Niklas May, Lorena Consolino, Maike Baues, Diana Moeckel, Felix Gremse, Saskia von Stillfried, Asmaa El Shafei, Karina Benderski, Armin Azadkhah Shalmani, Alec Wang, Jeffrey Momoh, Quim Pena, Eva Miriam Buhl, Johannes Buyel, Wim Hennink, Fabian Kiessling, Josbert Metselaar, Yang Shi, Twan Lammers
Summary: Cancer nanomedicines rely on the EPR effect for efficient target site accumulation. This study longitudinally studied the dynamics of the EPR effect during nanotherapy and found that the extent of nanomedicine tumor accumulation is predictive for therapy outcome. It also showed that the interindividual heterogeneity in EPR-based tumor accumulation significantly increases during treatment, especially for more efficient double-dose nanotaxane therapy. These findings highlight the importance of the EPR effect in nanomedicine treatment.
Article
Polymer Science
Muhammad Suhail, Chih-Wun Fang, Arshad Khan, Muhammad Usman Minhas, Pao-Chu Wu
Summary: The study aimed to develop CS/CBP-co-PAA hydrogels for controlled release of diclofenac sodium. Characterizations and experiments were conducted to understand drug release behavior at different pH levels. The prepared hydrogel showed controlled release of the drug according to the Korsmeyer-Peppas model.
Review
Polymer Science
Geun-Woo Jin, N. Sanoj Rejinold, Jin-Ho Choy
Summary: Polymeric micelles, as carriers for therapeutic compounds, have attracted attention due to their ability to solubilize poorly water-soluble drugs, biocompatibility, and accumulation in tumors. Additional functionality can be achieved through surface modification and stimuli-sensitive groups. This review highlights the development of multifunctional polymeric micelles in cancer therapy, including applications in tumor imaging and theragnosis.
Article
Chemistry, Multidisciplinary
Zhaokui Jin, Yanhong Duo, Yang Li, Meng Qiu, Mengna Jiang, Quan Liu, Penghe Zhao, Tian Yang, Weiyuan Liang, Han Zhang, Yihai Cao, Qianjun He
Summary: The study presents a novel gasothermal therapy concept, utilizing light-sensitive nanomaterial to generate cancer-causing gas in the tumor microenvironment for tumor cell eradication, with promising therapeutic efficacy demonstrated in preclinical experiments.
Review
Chemistry, Physical
Jorieke Weiden, Maartje M. C. Bastings
Summary: DNA nanostructures have emerged as a versatile platform for controlled drug delivery, offering unparalleled control over structural and functional parameters. Recent applications in therapeutic drug delivery show promising alternatives to conventional nanomaterials, but further research is needed to understand biodistribution, final fate, and controlled drug release aspects.
CURRENT OPINION IN COLLOID & INTERFACE SCIENCE
(2021)
Review
Health Care Sciences & Services
Petr Chytil, Libor Kostka, Tomas Etrych
Summary: Water-soluble polymer carriers, covalently attached to low-molecular-weight drugs using biodegradable spacers, are important in drug delivery systems. Synthetic polymer biomaterials based on HPMA copolymers are recognized as serious candidates for nanomedicine due to their unique properties. The main impact of HPMA polymer-based drug carriers is the improvement of targeting ability, especially through the EPR effect.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Engineering, Biomedical
Ren Zhu, Qi He, Zhiling Li, Yuhao Ren, Yixian Liao, Zejun Zhang, Quan Dai, Chengying Wan, Sihui Long, Lingyi Kong, Wenpei Fan, Wenying Yu
Summary: Many chemotherapeutic drugs and photosensitizers face challenges such as poor solubility, unspecific delivery, and uncontrollable release, which limit their biomedical applications. In this study, a novel type of ROS-cleavable hydrophilic diselenide nanoparticles was designed to overcome these limitations, allowing for precise and controlled release of the hydrophobic drug and photosensitizer. The NIR-controlled release of the drugs led to on-demand synergistic chemo-/photodynamic therapeutic effects, maximizing tumor growth suppression and minimizing side effects.
ACTA BIOMATERIALIA
(2022)
Article
Engineering, Biomedical
Haijing Qu, Han Chen, Wei Cheng, Yanjun Wang, Yangyang Xia, Linghao Zhang, Buyong Ma, Rong Hu, Xiangdong Xue
Summary: We propose a supramolecular assembly strategy to enhance drug loading, tumor targeting, and delivery simplicity for hydrophilic drugs. By co-assembling with other drugs, we validate the effectiveness of this strategy and demonstrate its application in anti-tumor activities.
ACTA BIOMATERIALIA
(2023)
Article
Polymer Science
Valeria Friuli, Silvia Pisani, Bice Conti, Giovanna Bruni, Lauretta Maggi
Summary: This article discusses the challenge in the pharmaceutical sector of developing controlled release oral dosage forms for poorly soluble drugs. The researchers successfully prepared polymeric nanofibers loaded with two model drugs using the electrospinning technique. These nanofibers were then incorporated into tablet formulations, resulting in improved release performances.
Article
Biochemistry & Molecular Biology
Ana Ciric, Dorde Medarevic, Bojan Calija, Vladimir Dobricic, Milena Rmandic, Tanja Barudzija, Andelija Malenovic, Ljiljana Djekic
Summary: The entrapment procedure of a poorly water soluble drug was studied to investigate its effect on the physicochemical and drug release performances of chitosan/xanthan polyelectrolyte complexes (PECs). Different drug entrapment procedures and chitosan-to-xanthan mass ratios were observed to affect the formation of PECs, leading to controlled drug release with zero-order kinetics.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Multidisciplinary
Wuyu Mao, Jie Tang, Liqun Dai, Xinyu He, Jie Li, Larry Cai, Ping Liao, Ruotian Jiang, Jingwei Zhou, Haoxing Wu
Summary: A novel strategy has been developed to create highly fluorescent Huaxi-Fluor probes that exhibit significantly increased fluorescence upon forming the bioorthogonal reaction product, pyridazine. These probes have large Stokes shifts and high quantum yields, with emission wavelengths fine-tunable from 556 to 728 nm by manipulating the fluorophore skeleton. Highly photo-stable and biocompatible, these probes are suitable for live cell organelle visualization without washing steps and imaging tumors in live small animals to depths of 500 μm by two-photon excitation.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Nanoscience & Nanotechnology
Haonan Li, Jiayu Sun, Hongyan Zhu, Haoxing Wu, Hu Zhang, Zhongwei Gu, Kui Luo
Summary: Dendritic polymers with highly branched three-dimensional architectures and low viscosity have great potential in various biomedical applications. Despite most review articles focusing on drug or gene delivery, there is still a lack of discussion on their function as cancer diagnosis agents.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2021)
Review
Chemistry, Medicinal
Lili Pan, Yu Ma, Xiaoai Wu, Huawei Cai, Feng Qin, Haoxing Wu, YunChun Li, Zhiyun Jia
Summary: Porphyrins and their derivatives have been extensively studied for their effectiveness in cancer treatment and medical imaging, showing potential in tumor cell localization, photodynamic therapy, and various imaging modalities. The limitations and future prospects of porphyrin-based compounds in tumor therapy are also discussed.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Yayue Wang, Chang Zhang, Haoxing Wu, Ping Feng
Article
Biochemistry & Molecular Biology
Jiayu Sun, Jie Li, Hongbao Sun, Chunling Li, Haoxing Wu
Summary: The study presents the concise synthesis of a series of aryl-functionalized cyclobutene analogues using commercially available starting materials, demonstrating their suitability as stable substrates for bioorthogonal tetrazine ligation.
Article
Chemistry, Applied
Yuan Zou, Xiaoai Wu, Haotian Li, Lu Yang, Chaoqun Zhang, Haoxing Wu, Yiwen Li, Li Xiao
Summary: Solar-driven water steam generation technology shows great potential for seawater desalination and wastewater purification. A metal-phenolic network-coated cellulose foam was developed, demonstrating high water evaporation rate and anti-oil-fouling ability. The foam's superb hydrophilicity and underwater lipophobicity enable efficient water steam generation even in oil-polluted seawater.
CARBOHYDRATE POLYMERS
(2021)
Article
Chemistry, Applied
Yu Fu, Jianhua Zhang, Yilin Wang, Jie Li, Jianxu Bao, Xu Xu, Chaoqun Zhang, Yiwen Li, Haoxing Wu, Zhipeng Gu
Summary: Hydrogels with antioxidative and antibacterial properties, incorporating reduced polydopamine nanoparticles, have been designed for accelerated wound healing. The hydrogels exhibited excellent antioxidative properties and antibacterial activity, protecting cells from oxidative stress and preventing infections. Both in vitro and in vivo studies confirmed the effectiveness of these hydrogels as dressings for accelerated wound healing.
CARBOHYDRATE POLYMERS
(2021)
Article
Chemistry, Multidisciplinary
Wuyu Mao, Weijie Chi, Xinyu He, Chao Wang, Xueyi Wang, Haojie Yang, Xiaogang Liu, Haoxing Wu
Summary: In this study, a generalizable molecular design strategy was reported to construct ultra-fluorogenic dyes by simple substitution at the meso-positions of various far-red and NIR fluorophores. The probes showed significant fluorescence turn-on ratios in the range of 586-806 nm. These results will greatly expand the applications of bioorthogonal chemistry in NIR bioimaging and biosensing.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Xiaoyang Zhang, Hui Xu, Jie Li, Dunyan Su, Wuyu Mao, Guohua Shen, Lin Li, Haoxing Wu
Summary: Nucleic acid templated chemistry significantly accelerated the bioorthogonal cleavage, allowing two mutually orthogonal fluorogenic cleavage reactions to be simultaneously conducted in live cells for the first time.
CHEMICAL COMMUNICATIONS
(2022)
Review
Chemistry, Organic
Hongbao Sun, Qinghe Xue, Chang Zhang, Haoxing Wu, Ping Feng
Summary: Bioorthogonal chemistry, particularly tetrazine-based reactions, has gained significant attention for its applications in biological systems, such as cellular labeling, live-cell imaging, diagnosis, drug release, and oncotherapy. However, limited commercial starting materials for de novo tetrazine synthesis have led to the exploration of derivatization approaches to enhance the applications of tetrazine bioorthogonal reactions. This review summarizes recent advances in tetrazine scaffold-based derivatizations and highlights both the advantages and limitations of these methods in bioorthogonal chemistry.
ORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Chemistry, Organic
Wei Shi, Jie Li, Xinyu He, Siming Zhou, Hongbao Sun, Haoxing Wu
Summary: A series of BODIPY probes with wide emission range were prepared via modification, and successfully used in live-cell imaging.
Article
Chemistry, Organic
Yayue Wang, Guohua Shen, Jie Li, Wuyu Mao, Hongbao Sun, Ping Feng, Haoxing Wu
Summary: This study reports the bioorthogonal cleavage of methylene tetrazines with ether or ester linkages in the presence of trans-cyclooctene. This approach allows for the controlled release of molecules with phenol or carboxylic acid moieties and has potential applications in various biomedical fields.
Article
Chemistry, Multidisciplinary
Fang Yuan, Hongbao Sun, Cheng Yang, Haojie Yang, Lili Pan, Xiaoyang Zhang, Rong Tian, Lingjun Li, Wei Chen, Xiaoai Wu, Haoxing Wu
Summary: A Cu(I)-promoted difluorocarbene-derived method for the synthesis of 19F/18F-trifluoromethyl triazoles using KF/K18F as the fluorine source is reported. This approach efficiently generates a variety of 5-trifluoromethyl-1,2,3-triazoles with good yields and high functional group compatibility. The reaction is suitable for late-stage functionalization of bioactive molecules and 18F-trifluoromethylation of iodotriazoles, providing a practical synthetic methodology for the development of triazole drugs and 18F-radiotracers for positron emission tomography.
CHINESE CHEMICAL LETTERS
(2023)
Article
Chemistry, Physical
Huan Cao, Jinyao Zhu, Jianhua Zhang, Lei Yang, Xutong Guo, Rong Tian, Haoxing Wu, Yiwen Li, Zhipeng Gu
Summary: This study reports the in situ fabrication of various types of robust and multifunctional natural polyphenolic hydrogels using natural polyphenol (extracts) and formaldehyde. The results show that the chemical structure of polyphenol molecules can be well maintained after the gelation process, allowing the hydrogels to inherit the merits of polyphenol molecules, such as UV shielding, radical scavenging, and antibacterial properties. In vitro and in vivo experiments further confirm that the hydrogels can perform a skin protection and repair role, making them suitable for biomedical applications.
CHEMISTRY OF MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Huan Cao, Lei Yang, Rong Tian, Haoxing Wu, Zhipeng Gu, Yiwen Li
Summary: Polyphenolic materials are fascinating and versatile bioinspired materials that can delicately regulate cell activities through both cell-material contact-dependent and contact-independent interactions. Comprehensive understanding of the relationship between material properties and desired biomedical applications at the cellular and molecular level can accelerate the translation of polyphenolic platforms from the lab to clinic.
CHEMICAL SOCIETY REVIEWS
(2022)
