Article
Environmental Sciences
Jian Lu, Yun Yang, Lianhua Zhu, Meng Li, Wenping Xu, Cheng Zhang, Jiagao Cheng, Liming Tao, Zhong Li, Yang Zhang
Summary: Natural pyrethrins induce oxidative stress, DNA damage and liver toxicity in both human HepG2 cells and zebrafish. The observed chronic toxicity may lead to irreversible DNA damage and severe toxic effects on cells. In conclusion, hepatotoxicity of natural pyrethrins poses a risk to human health by causing liver degeneration and steatosis.
Article
Multidisciplinary Sciences
Katrina Rosenberger, Michael Simmler, Jan Langbein, Christian Nawroth, Nina Keil
Summary: Current evidence suggests that frequent exposure to situations in which captive animals can solve cognitive tasks may have positive effects on stress responsiveness and thus on welfare. However, confounding factors often hamper the interpretation of study results. In this study, we used human-presented object-choice tests to assess the effect of long-term cognitive stimulation on behavioural and cardiac responses of female domestic goats in subsequent stress tests. Our results highlight the need to consider ontogenetic and genetic variation when assessing stress responsiveness and when interacting with goats.
Article
Immunology
Marcello Dallio, Lorenzo Ventriglia, Mario Romeo, Flavia Scognamiglio, Nadia Diano, Martina Moggio, Marina Cipullo, Annachiara Coppola, Athanasios Ziogas, Mihai G. Netea, Alessandro Federico
Summary: This study highlighted the immunological effects of an environmental chemical and plastic-derived compound in the induction of trained immunity in a healthy cohort for the first time.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Engineering, Environmental
Victoria G. Christensen, Erin A. Stelzer, Barbara C. Eikenberry, Hayley T. Olds, Jaime F. LeDuc, Ryan P. Maki, Alisha M. Saley, Jack Norland, Eakalak Khan
Summary: This study compared cyanotoxin mixture models to microcystin models, finding that comprehensive models explained more variability. The research demonstrated that cyanotoxin mixture models were able to simulate observations exceeding regulatory guidelines.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Shuang Liu, Guofeng Xu, Mingquan Huang, Li Fu, Xue Jiang, Meng Yang
Summary: The study revealed that co-exposure to BPA and BPAF induced intracellular stress in KGN cells, leading to apoptosis. The mixture of BPA and BPAF was found to promote KGN cell apoptosis through the ASK1-JNK signaling pathway.
ARABIAN JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Physical
Mateus D. Maximino, Cibely S. Martin, Priscila Alessio
Summary: This study evaluated the effects of BPA on membrane models and found that BPA interacts with the membrane, potentially altering the shape and morphology of lipid bilayers. Furthermore, BPA was found to have an affinity for the membrane, which could lead to different implications or effects in cells.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Biology
Laura K. Lopez, Michael A. Gil, Philip H. Crowley, Pete C. Trimmer, Amelia Munson, Isaac Y. Ligocki, Marcus Michelangeli, Andrew Sih
Summary: While research has extensively explored the physiological effects of multiple environmental stressors, the role of behavioural and life-history plasticity in mediating these effects has been neglected. This study presents a conceptual framework that links animal behaviour to energy allocation pathways, elucidating the impact of multiple stressors on fitness. The framework highlights how small-scale behavioural changes and trade-offs in energy allocation and escape strategies contribute to the complex effects of stressors on organisms. Considering animal behaviour in stressor research can enhance our understanding and inform future studies.
BIOLOGICAL REVIEWS
(2023)
Article
Environmental Sciences
Anna Maria Becker, Heike Marquart, Torsten Masson, Carolin Helbig, Uwe Schlink
Summary: Personal exposure feedback through wearable or installed sensors can lead to behavior changes, particularly with noise and temperature feedback, while results on behavior adaptation to avoid air pollution are mixed. Most studies reported increased awareness and knowledge from exposure feedback, but further research is needed on the impact of visual feedback.
CURRENT POLLUTION REPORTS
(2021)
Article
Ecology
Michael J. Williamson, Emma J. Tebbs, Terence P. Dawson, Henry J. Thompson, Catherine E. Head, David M. P. Jacoby
Summary: This study utilizes satellite remote sensing to collect data on coral reefs' exposure to multiple environmental stressors and develops a toolbox for monitoring such exposure. Through an analysis of coral reefs worldwide, the study identifies factors such as depth, current, and sea surface temperature that contribute to environmental stress exposure.
REMOTE SENSING IN ECOLOGY AND CONSERVATION
(2022)
Article
Behavioral Sciences
David M. Lyons, Sarah Ayash, Alan F. Schatzberg, Marianne B. Muller
Summary: Laboratory mouse models play a crucial role in bridging the gap between basic neuroscience and applied stress research. This study examines the ecological validity of social defeat stressors in mouse models of emotional vulnerability and resilience. It was found that the majority of the reviewed reports (95%) focus on males, and many reports (71%) discuss vulnerability and resilience. Limited ecological validity leads to increased vulnerability and decreased resilience. Elements of limited ecological validity include repeated exposure to defeat stressors without opportunities to avoid or escape from pre-screened aggressive conspecifics, which is not representative of naturalistic conditions. Research is needed to establish causality and determine if ecologically valid stressors can build resilience in both sexes of mice.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Marine & Freshwater Biology
Jie Gu, Liangzhong Li, Xiaogang Yin, Mengyuan Liang, Yuanhui Zhu, Min Guo, Linjun Zhou, Deling Fan, Lili Shi, Guixiang Ji
Summary: This study investigated the effects of life-cycle exposure to environmental concentrations of BPF on zebrafish reproduction and offspring development. The results showed that BPF exposure increased oxidative stress levels, induced gonadal apoptosis, and reduced zebrafish spawning. Additionally, through maternal transfer, BPF significantly affected the development of the offspring, resulting in decreased hatching rate, spontaneous movements, heart rate, body length, and locomotor behavior. Gene expression related to oxidative stress, apoptosis, and neurodevelopment was also altered in the offspring.
AQUATIC TOXICOLOGY
(2022)
Article
Environmental Sciences
Junjie Ao, Xiaona Huo, Jiangtao Zhang, Yuchan Mao, Guohua Li, Jiangfeng Ye, Yuhua Shi, Fan Jin, Shihua Bao, Jun Zhang
Summary: The study indicates that environmental exposure to bisphenol analogues is associated with an increased risk of unexplained recurrent miscarriage (URM), with a dose-response pattern observed for BPAF, BPAP, and BPB. Older women, aged 30 years or above, may be more vulnerable to the effects of these chemicals.
ENVIRONMENTAL RESEARCH
(2022)
Article
Biophysics
Mateus D. Maximino, Carla Y. Silva, Dalita G. S. M. Cavalcante, Cibely S. Martin, Aldo E. Job, Osvaldo N. Oliveira, Priscila Alessio
Summary: The research shows that BPA affects the fluidity of DPPC monolayers and induces wrinkling and distortion in DPPC GUVs in a concentration-dependent manner. Fresh BPA solutions decrease CHO cell viability, whereas aged, aggregated BPA solutions do not have the same effect and may even increase CHO viability. The results suggest size-dependent effects of BPA, which could be relevant for its endocrine-disrupting effects.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Environmental Sciences
Futu Chen, Jarvis T. Chen, Jaime E. Hart, Brent A. Coull, Madeleine K. Scammell, MyDzung T. Chu, Gary Adamkiewicz
Summary: Understanding the clustering patterns of environmental and social stressors in low to medium-income, urban households is essential for addressing health disparities. This study examined household-level exposures and potential predictors of these joint exposures in two environmental justice communities in the Greater Boston area. The findings revealed that environmental and social stressors clustered in socially disadvantaged households, with housing type, housing tenure, and location of the residence being strong predictors. Renters and multi-family residents were at a higher risk of experiencing high exposures to these stressors.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Enrique Escarda-Castro, Maria Paz Herraez, Marta Lombo
Summary: This study investigated the genotoxic and epigenotoxic effects of bisphenol A (BPA) during cardiomyocyte differentiation. The results showed that BPA exposure led to changes in gene expression related to heart differentiation, as well as DNA damage and alteration in histone acetylation. BPA seriously interferes with the process of cardiomyocyte differentiation, potentially impacting cardiogenesis in vivo.
ENVIRONMENTAL POLLUTION
(2021)
Editorial Material
Public, Environmental & Occupational Health
Casey L. Daniel, Natalie R. Gassman
PREVENTIVE MEDICINE
(2018)
Review
Biochemical Research Methods
Natalie R. Gassman, Nathaniel W. Holton
CURRENT OPINION IN BIOTECHNOLOGY
(2019)
Article
Multidisciplinary Sciences
Kevin J. Lee, Cortt G. Piett, Joel F. Andrews, Elise Mann, Zachary D. Nagel, Natalie R. Gassman
Article
Biochemistry & Molecular Biology
Faisal Hayat, Manoj Sonavane, Mikhail V. Makarov, Samuel A. J. Trammell, Pamela McPherson, Natalie R. Gassman, Marie E. Migaud
Summary: This study provides a comprehensive characterization of pyridones and their formation, identifying a ribosylated form of one of the pyridones that causes cell death. The research demonstrates that this form of pyridone leads to autophagy-related cell death at physiological levels found in the plasma of AKI patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Mikhail Makarov, Faisal Hayat, Briley Graves, Manoj Sonavane, Edward A. Salter, Andrzej Wierzbicki, Natalie R. Gassman, Marie E. Migaud
Summary: NAD(+) and NADH are essential for cellular enzymatic reactions and changes in their levels can cause cellular dysfunction. NRH, like NADH and NADPH, is prone to degradation and its degradation can lead to cell-specific cytotoxicity. Further research is needed to understand the mechanisms of NADH degradation and its impact on cell function.
ACS CHEMICAL BIOLOGY
(2021)
Article
Biology
Elise K. Mann, Kevin J. Lee, Dongquan Chen, Luciana Madeira da Silva, Valeria L. Dal Zotto, Jennifer Scalici, Natalie R. Gassman
Summary: This study establishes a relationship between persistent DNA damage and increased PD-L1 expression in ovarian tumors, suggesting DNA damage may be used as a potential biomarker for immunotherapy. The strongest correlation between DNA damage and PD-L1 expression was observed in mucinous ovarian tumors.
Article
Biochemistry & Molecular Biology
Kevin J. Lee, Griffin Wright, Hannah Bryant, Leigh Ann Wiggins, Valeria L. Dal Zotto, Michele Schuler, Christopher Malozzi, Michael Cohen, Natalie R. Gassman
Summary: Vitamin D supplementation reduced Doxorubicin-induced cardiotoxicity by decreasing reactive oxygen species and mitochondrial damage, without compromising the anticancer efficacy of Doxorubicin against TNBC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Griffin Wright, Manoj Sonavane, Natalie R. Gassman
Summary: STAT3 is identified as a novel regulator of XRCC1, with its activation through the IL-6 signaling pathway increasing the expression level of XRCC1 and impacting its role in triple negative breast cancer. The upregulation of XRCC1 is associated with the aggressiveness and chemotherapeutic resistance in cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Kimiko L. Krieger, Jie H. Gohlke, Kevin J. Lee, Danthasinghe Waduge Badrajee Piyarathna, Patricia D. Castro, Jeffrey A. Jones, Michael M. Ittmann, Natalie R. Gassman, Arun Sreekumar
Summary: This study found that prostate cancer in African American patients has more severe DNA damage, indicating dysfunction in the base excision repair pathway and metabolic rewiring, which can explain the poorer outcomes in African American men compared to European American men with prostate cancer.
Article
Chemistry, Medicinal
Luxene Belfleur, Manoj Sonavane, Arlet Hernandez, Natalie R. Gassman, Marie E. Migaud
Summary: DHA undergoes aging during storage and exhibits differences in relative abundance of isomers when reconstituted in an aqueous solution. Hence, it is important to consider the composition and concentration of DHA isomers and the equilibration time in solution when conducting experiments with DHA.
CHEMICAL RESEARCH IN TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Griffin M. Wright, Natalie R. Gassman
Summary: Dysregulation of DNA repair is a characteristic of cancer. This study identifies STAT3 as a novel transcriptional regulator of XRCC1 in triple-negative breast cancers. Glucose challenge increases STAT3 activation, promoting XRCC1 expression in different cell types. Prolonged exposure to high glucose leads to overexpression of XRCC1, which can be reversed by restricting glucose intake and down-regulating STAT3 activation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Arlet Hernandez, Manoj Sonavane, Kelly R. Smith, Jensyn Seiger, Marie E. Migaud, Natalie R. Gassman
Summary: Dihydroxyacetone (DHA), the active ingredient in sunless tanning products and a byproduct of e-cigarette combustion, has various effects on cells including cell cycle arrest, reactive oxygen species generation, and mitochondrial dysfunction. In this study, the toxic effects of millimolar doses of DHA on HepG3 cells were investigated, revealing suppression of glycolysis and oxidative phosphorylation pathways and altered mTOR signaling. Increased mitochondrial reactive oxygen species and mitochondrial-specific injury led to cell cycle arrest and cell death through a non-classical apoptotic mechanism.
Article
Biophysics
Noa Gilat, Dena Fridman, Hila Sharim, Sapir Margalit, Natalie R. Gassman, Yael Michaeli, Yuval Ebenstein
Summary: Mapping DNA damage and repair sites is crucial for understanding the impact of environmental exposures, genotoxicity, and human health. The RADD-seq technique allows for precise localization of DNA damage and repair sites, shedding light on cellular repair mechanisms and identifying genomic hotspots prone to mutation.
BIOPHYSICAL REPORTS
(2021)
Article
Multidisciplinary Sciences
Manoj Sonavane, Faisal Hayat, Mikhail Makarov, Marie E. Migaud, Natalie R. Gassman