Review
Gastroenterology & Hepatology
Marla Dubinsky, Alison Potts Bleakman, Remo Panaccione, Toshifumi Hibi, Stefan Schreiber, David Rubin, Axel Dignass, Isabel Redondo, Theresa Hunter Gibble, Cem Kayhan, Simon Travis
Summary: Bowel urgency is one of the most common and disruptive symptoms experienced by patients with ulcerative colitis, and it has a significant negative impact on quality of life and psychosocial functioning. There is a need for responsive and reliable patient-reported outcome measures to assess the severity of bowel urgency and provide evidence of treatment benefits in clinical trials.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Junguang Liu, Xiaolin Wang, Hekai Chen, Shiwen Mei, Wenlong Qiu, Jianqiang Tang
Summary: This study aimed to assess the risk factors, oncological outcomes, and quality of life (QoL) of refractory anastomotic leakage (RAL) after laparoscopic intersphincteric resection (LsISR). Non-left colic artery preservation, neoadjuvant chemoradiotherapy, and lower anastomosis height were identified as independent risk factors for anastomotic leakage. Neoadjuvant chemoradiotherapy was the only independent risk factor for RAL. RAL patients had poor QoL and worse functional outcomes.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Editorial Material
Gastroenterology & Hepatology
Chung Sang Tse, Melissa G. Hunt, Lily A. Brown, James D. Lewis
Summary: The diagnosis of IBD brings about significant changes in the lives of most adults. Despite advancements in treatment options, medical and surgical intervention alone may not be enough to completely restore health and prevent long-term disability due to the incurable nature of IBD.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Manol Jovani, Wenjie Ma, Kyle Staller, Amit D. Joshi, Po-Hong Liu, Long H. Nguyen, Paul Lochhead, Yin Cao, Idy Tam, Kana Wu, Edward L. Giovannucci, Lisa L. Strate, Andrew T. Chan
Summary: This study aimed to explore the association between bowel movement frequency and incident diverticulitis. The results showed an inverse association between more frequent bowel movements and the risk of developing diverticulitis. This association was not modified by age, BMI, physical activity, laxative use, or fiber intake.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Obstetrics & Gynecology
Ida E. K. Nilsson, Sigvard Akervall, Mattias Molin, Ian Milsom, Maria Gyhagen
Summary: This study aimed to describe the severity and impact of anal incontinence among women with 2 previous deliveries 2 decades after birth and to analyze the relative effect of 1 vs 2 obstetrical anal sphincter injuries in comparison with no obstetrical anal sphincter injuries and the possible influence of obstetrical anal sphincter injury on other pelvic floor disorders. The results showed that obstetrical anal sphincter injuries significantly increased the incidence and severity of anal incontinence, but had no significant effect on other pelvic floor disorders or lower urinary tract symptoms. This information is important for healthcare economics, clinical practice, and policy.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Gastroenterology & Hepatology
Eric D. Shah, Brian E. Lacy, William D. Chey, Lin Chang, Darren M. Brenner
Summary: Tegaserod demonstrated significant clinical efficacy in treating irritable bowel syndrome with constipation in women, providing symptom relief and exhibiting good tolerability, with no significant cardiovascular events observed in patients with low cardiac risk factors.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Andrea Kulyk, Leigh Anne Shafer, Lesley A. Graff, James Stone, Kelcie Witges, Laura E. Targownik, Charles N. Bernstein
Summary: This study aimed to assess the association between different symptoms and disease activity in inflammatory bowel disease (IBD). The results showed that fatigue was the most common symptom, while urgency was strongly associated with disease activity. Different symptoms have different impacts on subjective and objective measurements of IBD.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Gastroenterology & Hepatology
Silvio Danese, Jacinda Tran, Geert D'Haens, David T. Rubin, Nobuo Aoyama, Wen Zhou, Dapo Ilo, Xuan Yao, Yuri Sanchez Gonzalez, Remo Panaccione
Summary: This post hoc analysis evaluated the effects of upadacitinib on fatigue, bowel urgency, and abdominal pain in patients with ulcerative colitis. The results showed that upadacitinib induction treatment significantly reduced abdominal pain and bowel urgency, and also improved fatigue symptoms.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Amy Kassebaum-Ladewski, David M. Poppers, Darren M. Brenner
Summary: Patients with chronic idiopathic constipation and irritable bowel syndrome with constipation play a crucial role in self-reporting symptoms, as understanding their symptoms and severity is essential for effective treatment. Patients are often reluctant to discuss bowel symptoms with healthcare providers, and differences in sex, health literacy, and age can impact symptom reporting. Negative patient-physician relationships and dissatisfaction with care may lead patients to seek alternative treatments, emphasizing the importance of adopting a patient-centered communication style to establish a shared understanding.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Pediatrics
Bo Zhou, Wenquan Niu, Fangyu Liu, Yuan Yuan, Kundi Wang, Jing Zhang, Yunfeng Wang, Zhixin Zhang
Summary: This study identified five potential risk factors for recurrent respiratory tract infection among Chinese preschool-aged children, with asthma playing a leading role. Factors such as allergy, initial use of antibiotics, and breastfeeding may have a dose-dependent effect on susceptibility to recurrent respiratory tract infections.
PEDIATRIC RESEARCH
(2021)
Article
Gastroenterology & Hepatology
Chloe Melchior, Esther Colomier, Ines A. Trindade, Mahrukh Khadija, Johann P. Hreinsson, Hans Tornblom, Magnus Simren
Summary: The study found that factors such as stool frequency, GI and overall somatic symptom severity, psychological distress, and GI-specific anxiety have a significant impact on the reduced quality of life in irritable bowel syndrome patients.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2022)
Article
Gastroenterology & Hepatology
Jeffrey A. Berinstein, Shirley A. Cohen-Mekelburg, Gillian M. Greenberg, Daniel Wray, Sameer K. Berry, Sameer D. Saini, A. Mark Fendrick, Megan A. Adams, Akbar K. Waljee, Peter D. R. Higgins
Summary: This study aimed to evaluate the effectiveness of a care coordination-based strategy in improving symptom burden and reducing healthcare costs for high-risk patients with inflammatory bowel disease (IBD). The results showed that patients in the care coordination intervention group demonstrated improvement in symptom scores compared to those in the usual care group, but there was no significant difference in healthcare charges related to IBD.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Surgery
Brenig L. Gwilym, Philip Pallmann, Cherry-Ann Waldron, Emma Thomas-Jones, Sarah Milosevic, Lucy Brookes-Howell, Debbie Harris, Ian Massey, Jo Burton, Phillippa Stewart, Katie Samuel, Sian Jones, David Cox, Annie Clothier, Adrian Edwards, Christopher P. Twine, David C. Bosanquet
Summary: This study examined the accuracy of preoperative predictions of outcomes by healthcare professionals and risk prediction tools for major lower limb amputation. Surgeons and anaesthetists were found to predict 30-day outcomes more accurately than most risk prediction tools. The best method for predicting mortality incorporated healthcare professional estimation.
BRITISH JOURNAL OF SURGERY
(2022)
Article
Gastroenterology & Hepatology
Kyle Staller, Ola Olen, Jonas Soderling, Bjorn Roelstraete, Hans Tornblom, Braden Kuo, Long H. Nguyen, Jonas F. Ludvigsson
Summary: The study found that previous use of antibiotics was associated with an increased risk of developing irritable bowel syndrome (IBS), particularly among those with multiple antibiotic dispensations.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Infectious Diseases
Oscar Moreno-Perez, Esperanza Merino, Jose-Manuel Leon-Ramirez, Mariano Andres, Jose Manuel Ramos, Juan Arenas-Jimenez, Santos Asensio, Rosa Sanchez, Paloma Ruiz-Torregrosa, Irene Galan, Alexander Scholz, Antonio Amo, Pilar Gonzalez-delaAleja, Vicente Boix, Joan Gil
Summary: This study found that Post-acute COVID-19 syndrome was detected in about half of COVID-19 survivors, with mostly mild symptoms. Radiological and spirometric changes were observed in less than 25% of patients, and no baseline clinical features behaved as independent predictors of Post-acute COVID-19 syndrome development.
JOURNAL OF INFECTION
(2021)
Article
Gastroenterology & Hepatology
Sophie Parker, Olafur Palsson, David S. Sanders, Magnus Simren, Ami D. Sperber, Hans Tornblom, Heidi Urwin, William Whitehead, Imran Aziz
Summary: Individuals with celiac disease can experience gastrointestinal symptoms despite adhering to a gluten-free diet. This study found that half of the individuals with celiac disease who adhered to a gluten-free diet had functional gastrointestinal disorders, which was twice the rate compared to a matched control group. Furthermore, these individuals were more likely to have anxiety, depression, somatization, and reduced quality of life. Addressing gut-brain interaction disorders may improve outcomes in this specific group of patients.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Medicine, General & Internal
Esther Colomier, Chloe Melchior, Joost P. Algera, Johann P. Hreinsson, Stine Storsrud, Hans Tornblom, Lukas Van Oudenhove, Olafur S. Palsson, Shrikant Bangdiwala, Ami D. Sperber, Jan Tack, Magnus Simren
Summary: The study found that a significant proportion of individuals globally report meal-related abdominal pain, which is associated with other gastrointestinal and non-gastrointestinal symptoms, psychological distress, healthcare utilization, and quality of life. Individuals who frequently experience meal-related abdominal pain are more likely to be diagnosed with DGBI and seek medical help more often.
Article
Gastroenterology & Hepatology
Yuying Luo, Suzi A. Camey, Shrikant Bangdiwala, Olafur S. Palsson, Ami D. Sperber, Laurie A. Keefer
Summary: This study found that 40% of individuals globally meet the diagnosis criteria for DGBI. Compared to those without DGBI, respondents with DGBI were more likely to use prescription pain medications, with significant variation between countries. Factors associated with higher usage of pain medications among DGBI patients included living in a small community, increased anxiety, depression or somatization, increased stress concern or embarrassment about bowel functioning, and having multiple anatomical DGBI diagnoses.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Gastroenterology & Hepatology
Simon R. Knowles, David Skvarc, Alexander C. Ford, Olafur S. Palsson, Shrikant I. Bangdiwala, Ami D. Sperber, Antonina Mikocka-Walus
Summary: This study used the Rome Foundation Global Epidemiology Survey database to evaluate the impact of individual disorders of gut-brain interaction (DGBI), gastrointestinal anatomical regions, and the number of overlapping DGBI on overall quality of life, as well as by age and sex. The study found that quality of life significantly worsened with an increasing number of overlapping DGBI. Men with DGBI reported better quality of life than women, and those aged >65 years reported better quality of life than those <65 years. Age, sex, number of overlapping DGBI, somatization, anxiety, depression, and functional experiences relating to DGBI were significant predictors of poorer physical and mental quality of life.
Article
Gastroenterology & Hepatology
David M. Rodrigues, Pierre Poitras, Andrew G. Day, Ami D. Sperber, Olafur Palsson, Shrikant I. Bangdiwala, Stephen J. Vanner
Summary: This study used data from the Rome Foundation Global Epidemiology Study to explore the prevalence of 22 disorders of gut-brain interaction (DGBI) in Canada. The results showed that the prevalence of DGBI in Canada is similar to other countries, with functional constipation, functional diarrhea, and unspecified functional bowel disorders being the most common. DGBI have a significant impact on the well-being of Canadians, highlighting the need for further research and education.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Gastroenterology & Hepatology
Johann P. Hreinsson, Reuben K. M. Wong, Jan Tack, Peter Whorwell, Marc A. Benninga, Viola Andresen, Bruno Bonaz, Suck Chei Choi, Enrico S. Corazziari, Javier Santos, Shin Fukudo, Motoyori Kanazawa, Xuicai Fang, Shrikant I. Bangdiwala, Ami D. Sperber, Olafur S. Palsson, Magnus Simren
Summary: This study compared the prevalence of gut-brain interaction disorders (DGBI) between Asia and Western Europe, and found that DGBI is generally more prevalent in Western Europe, which is associated with severe psychological and non-GI somatic symptoms.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Review
Health Care Sciences & Services
John M. Hollier, Tianta A. Strickland, Michael Fordis, Miranda A. L. van Tilburg, Robert J. Shulman, Debbe Thompson
Summary: This study collected the critiques of a guided imagery therapy (GIT) mobile app from children with functional abdominal pain disorders (FAPDs) and their caregivers. The participants completed a software evaluation, a System Usability Scale survey, and were interviewed. The results showed that the participants rated the app's usability favorably and made suggestions for improvement, including adding scenery and animations and implementing rewards.
JMIR FORMATIVE RESEARCH
(2023)
Meeting Abstract
Psychiatry
Dan Dumitrascu, Tamar Freud, Abdulrahman Ismaiel, Shrikant I. Bangdiwala, Olafur Palsson, Ami Sperber
PSYCHOTHERAPY AND PSYCHOSOMATICS
(2022)
Meeting Abstract
Psychiatry
Dan Dumitrascu, Tamar Freud, Abdulrahman Ismaiel, Shrikant I. Bangdiwala, Olafur Palsson, Ami Sperber
PSYCHOTHERAPY AND PSYCHOSOMATICS
(2022)
Meeting Abstract
Gastroenterology & Hepatology
Ines A. Trindade, Johann P. Hreinsson, Chloe Melchior, Joost P. Algera, Esther Colomier, Hans Tornblom, Douglas A. Drossman, Jan F. Tack, Olafur S. Palsson, Shrikant I. Bangdiwala, Ami D. Sperber, Magnus Simren
Meeting Abstract
Gastroenterology & Hepatology
Johann P. Hreinsson, Hans Tornblom, Jan F. Tack, Douglas A. Drossman, William E. Whitehead, Shrikant I. Bangdiwala, Ami D. Sperber, Olafur Palsson, Magnus Simren
Meeting Abstract
Gastroenterology & Hepatology
I-Hsuan Huang, Jolien Schol, Rutaba Khatun, Florencia Carbone, Karen Van Den Houte, Esther Colomier, Lukas M. Balsiger, Hans Tornblom, Tim Vanuytsel, Elias Sundelin, Magnus Simren, Olafur S. Palsson, Shrikant I. Bangdiwala, Ami D. Sperber, Jan F. Tack
Meeting Abstract
Gastroenterology & Hepatology
Yuying Luo, Suzi Camey, Shrikant I. Bangdiwala, Olafur S. Palsson, Ami D. Sperber, Laurie Keefer
Meeting Abstract
Gastroenterology & Hepatology
Daniel W. Bushyhead, Rutaba Khatun, Shrikant I. Bangdiwala, Olafur S. Palsson, Ami D. Sperber, Eamonn M. Quigley