期刊
CHINESE CHEMICAL LETTERS
卷 30, 期 10, 页码 1704-1716出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cclet.2019.06.039
关键词
Fluorescent probe; Protein vicinal dithiols; Arsenical probe; Thiol redox; Reaction-based probe
资金
- National Natural Science Foundation of China [21572093, 21778028]
- 111 Project
The vicinal dithiol motif is widely present in proteins, and is critical for proteins' structures and functions. In recent years, a variety of fluorescent probes with high specificity and outstanding optical properties for sensing protein vicinal dithiols have been developed. In this review, we summarized the fluorescent probes of protein vicinal dithiols in literature. These probes are classified into four types based on their acceptor sites, i.e., biarsenical probes, monoarsenical probes, dimaleimide probes and diacrylate probes. Through analyzing the properties of different probes, we expect that this review would help readers further understand the structural factors of these probes and provide the design strategy for novel fluorescent probes with improved properties. (C) 2019 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
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