期刊
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
卷 35, 期 4, 页码 700-707出版社
HIGHER EDUCATION PRESS
DOI: 10.1007/s40242-019-9020-x
关键词
Scaffold; Demineralized bone matrix; Bovine serum albumin; Cell adhesion
资金
- Double Ten Project of Changchun City, China [16ss12]
- Scientific and Technological Achievements Transformation Project of Jilin Province, China [20170307024YY]
- District(School, Institute) Cooperation Special Project of Changchun City, China [17DY024]
- Key Technology Research and Development Projects of Jilin Province, China [20180201056YY]
- Science and Technology Development Medical Health Project of Jilin Province, China [20190304032YY]
As a scaffold material for bone tissue engineering, demineralized bone matrix(DBM) has such a limited ability to load cells and growth factors that the surface of the DBM scaffold was modified with bovine serum albumin( BSA) with different concentrations to improve the protein structure and physicochemical properties of the scaffold surface so as to enhance the adhesion of the cells. And the appropriate BSA concentration was explored. Compared with DBM, the scaffold with BSA coating had a smaller pore size and a lower porosity, also, the degradation rate was accelerated and the hydrophilic property was improved. Cells adhesion was observed inside the DBM sca ffold before and after it had been modified, and the BSA modified scaffold had a good cell compatibility. When the concentration of BSA was 20 mg/mL, the adhesion ability of the cells to modified scaffold was significantly increased, and the cell proliferation was facilitated.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据